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Recent News and Articles on the Keywords: deep + parkinsons + brain  Related to the article below (Last Update: 8/5/2008)

Neurostimulators help woman curb tremors
Arizona Republic, AZ - Aug 3, 2008
Deep brain stimulation - done in Arizona by only five doctors - has a 90 percent success rate in reducing symptoms dramatically, Shill said. ...
Deep Brain Pacemaker Offers Hope For Parkinson's Sufferers: 'Cross ...
Science Daily (press release) - Jul 11, 2008
This discovery supports Tass' research activities aiming at developing a therapy for Parkinson's disease. A new deep brain pacemaker is to bring cells out ...

Oneindia
Deep Brain Stimulation
Oneindia, India - Jul 24, 2008
Patients with treatment-resistant depression showed significant improvements in their condition after undergoing deep brain stimulation (DBS), ...
Future wiring of your mind
News-Herald.com, OH - Aug 3, 2008
Historically, persons suffering from Parkinson's Disease have been the subject of many operative techniques including brain tissue ablations and small ...
The Neglected Side of Parkinson's Disease
RedOrbit, TX - Aug 3, 2008
The striatum and substantia nigra are part of a group of deep nuclei within the brain called the basal ganglia, which control and facilitate normal movement ...
Man afflicted with Tourette pins hopes on rare surgery
Billings Gazette,  USA - Aug 4, 2008
The procedure, which has been successful for patients with Parkinson's disease, involves implanting electrodes into a deep part of the brain and connecting ...
Deep-Brain Stimulation Shows Promise
Medscape (subscription) - Jul 30, 2008
In 2006, it was estimated that 30000 to 40000 people worldwide with Parkinson's disease underwent deep-brain-stimulation surgery, as did between 30 and 50 ...
Deep Brain Stimulators Could Malfunction or Fail Under Certain ...
InjuryBoard.com, FL - Jul 29, 2008
In 1997, the Federal Food and Drug Administration (FDA) approved the use of deep brain stimulation to treat Parkinson?s Disease and certain other ...
Local actress recovering from brain surgery
9NEWS.com, CO - Jul 29, 2008
CLEVELAND - Actress Lucy Roucis, diagnosed with Parkinson's disease at the age of 27, has successfully gone through the first stage of Deep Brain ...

Oneindia
How Antidepressants And Cocaine Interact With Brain Cell Targets
Science Daily (press release) - Jul 30, 2008
"This research may also open the door to the development of new therapies for dopamine-neurotransmitter disorders such as Parkinson's disease, schizophrenia ...
Potential New Drug Target to Fight Tuberculosis Identified Cornell Chronicle
all 40 news articles »
Source: Google News

Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's … -
R Kumar - Neurology, 1998 - AAN Enterprises
... page VC Anderson, KJ Burchiel, P. Hogarth, J. Favre, and JP Hammerstad Pallidal
vs Subthalamic Nucleus Deep Brain Stimulation in Parkinson Disease Arch Neurol ...

Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease … -
W Ondo - Neurology, 1998 - AAN Enterprises
... Neurology. ARTICLES. Unilateral thalamic deep brain stimulation for refractory
essential tremor and Parkinson's disease tremor. W Ondo ...

The impact of deep brain stimulation on executive function in Parkinson's disease -
M Jahanshahi, CMA Ardouin, RG Brown, JC Rothwell, … - Brain, 2000 - Oxford Univ Press
... deep brain stimulation; Parkinson's disease; executive function; working memory;
cognition. DBS = deep brain stimulation; DLPFC = dorsolateral ...

Comparison of Pallidal and Subthalamic Nucleus Deep Brain Stimulation for Advanced Parkinson's … -
KJ Burchiel, VC Anderson, J Favre, JP Hammerstad - Neurosurgery, 1999 - neurosurgery-online.com
... Comparison of Pallidal and Subthalamic Nucleus Deep Brain Stimulation for Advanced
Parkinson's Disease: Results of a Randomized, Blinded Pilot Study. ...

Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain …
MJ During, MG Kaplitt, MB Stern, D Eidelberg - Hum Gene Ther, 2001 - ncbi.nlm.nih.gov
Hum Gene Ther. 2001 Aug 10;12(12):1589-91. Subthalamic GAD gene transfer in Parkinson
disease patients who are candidates for deep brain stimulation. ...

Deep brain stimulation for Parkinson?s disease -
AL Benabid - Current Opinion in Neurobiology, 2003 - Elsevier
... Copyright ? 2003 Elsevier Ltd. All rights reserved. Deep brain stimulation
for Parkinson?s disease. Alim Louis Benabid E-mail ...

Ablative Surgery and Deep Brain Stimulation for Parkinson's Disease. -
PA Starr, JL Vitek, RAE Bakay - Neurosurgery, 1998 - neurosurgery-online.com
... Ablative Surgery and Deep Brain Stimulation for Parkinson's Disease. Starr, Philip
A. MD, PhD; Vitek, Jerrold L. MD, PhD; Bakay, Roy AE MD. ...

Pallidotomy and deep brain stimulation of the pallidum and subthalamic nucleus in advanced … -
R Kumar, AM Lozano, E Montgomery, AE Lang - Mov Disord, 1998 - ncbi.nlm.nih.gov
Pallidotomy and deep brain stimulation of the pallidum and subthalamic nucleus in
advanced Parkinson's disease. Kumar R, Lozano AM, Montgomery E, Lang AE. ...

Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up. -
MC Rodriguez-Oroz, JA Obeso, AE Lang, JL Houeto, P … - Brain, 2005 - pt.wkhealth.com
... Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with
4 years follow-up. ... Deep Brain Stimulation for Parkinson's Disease Study Group. ...

Neuropsychological Outcome of GPi Pallidotomy and GPi or STN Deep Brain Stimulation in Parkinson's … -
LL Tr?panier, R Kumar, AM Lozano, AE Lang, JA … - Brain and Cognition, 2000 - Elsevier
... com on Neuropsychological Outcome of GPi Pallidotomy and GPi or STN Deep
Brain Stimulation in Parkinson?s Disease Lisa L. Tr?panier ...

Source: Google Scholar
 
 

Deep Brain Stimulation Offers Benefits Against Parkinson's

Article continues below and (thank you)
 
Deep brain stimulation via electrodes implanted on both sides of the brain markedly improves the motor skills of patients with advanced Parkinson's Disease, says a new long-term study by researchers at the University of Toronto and Toronto Western Hospital.

'We saw a pronounced decrease in the motor scores associated with Parkinson's Disease - the tremors, stiffness and slowness - and this benefit was persistent through the course of the long-term followup,' says Dr. Anthony Lang, professor in U of T's division of neurology, the Jack Clark Chair in Parkinson's Disease Research at the Centre for Research in Neurodegenerative Diseases and director of the Movement Disorders Clinic at Toronto Western Hospital, University Health Network.

He and his colleagues used the Unified Parkinson's Disease Rating Scale (UPDRS) to evaluate both the features of the disease as well as the side-effects of medication. They found motor scores decreased an average of 48 per cent. 'This is quite substantial when you compare it to other trials of therapy for Parkinson's Disease,' he says.

In the September issue of the Journal of Neurosurgery, Lang and his colleagues describe the first long-term followup of deep brain stimulation on the subthalamic nucleus (one of the deep nuclei in the brain that sits just above the area known as the midbrain). The subthalamic nucleus is part of the group that co-ordinates automatic movements.

Between 1996 and 2001, Lang and his colleagues followed 25 patients who had electrodes implanted into the region of the subthalamic nucleus on both sides of the brain; the electrodes were wired under the skin to pacemaker-like devices. The frequency and intensity of stimulation was adjusted; patients were monitored and evaluated prior to and after surgery while on and off medication.

When patients were off medication, the UPDRS score - which measures both motor skills and the ability of patients to perform daily living activities - improved after one year, decreasing by 42 per cent. Medication requirements also diminished substantially - dosages were reduced by 38 per cent one year after surgery and 36 per cent at their last evaluation.

Researchers believe the reduction in medication dosage may also partly account for the significant decrease in dyskinesia scores. Dyskinesia - abnormal involuntary movements - are side effects of medications like levodopa where patients exhibit rapid and repetitive motions of the limbs, face and neck or display slow, involuntary movements of the hands and feet.

'One of the important features we found is that not all symptoms of Parkinson's Disease respond equally to treatment,' notes Lang.

'Over time, the tremors, stiffness and, to a lesser extent, the slowness continue to respond to surgery and medication. But certain features of the illness such as speech, stability and difficulty with walking benefit less from therapy over the course of long-term followup.'

Lang warns that deep brain stimulation will not prevent the disease from worsening, slow its progression or prevent the development of later problems like dementia.

However, he says that younger patients like the ones in their study (average age of 57 at the time of surgery) with advanced Parkinson's Disease did experience sustained improvement in motor function for an average of two years after the procedure as well as a reduced need for medication.

Dr. Andres Lozano, the holder of the R.R. Tasker Chair in Stereotactic and Functional Neurosurgery at U of T and a neurosurgeon at Toronto Western Hospital, co-directed this research with Lang and the other members of their team - Galit Kleiner-Fisman, Jean Saint-Cyr and Elspeth Sime of Toronto Western Hospital and David Fisman of McMaster University.

This study was supported by the National Parkinson's Disease Foundation in the U.S., the Morton and Gloria Shulman Movement Disorders Centre at Toronto Western Hospital, the Jack Clark Chair in Parkinson's Disease Research at U of T, Medtronics in Minneapolis, Minn., and the Canadian Institutes of Health Research.
 
 
 
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