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Recent News and Articles on the Keywords: autism diagnosis + autism + early  Related to the article below (Last Update: 8/5/2008)

Autism 'chaos' as one-third wait over year for diagnosis
Irish Independent, Ireland -
They said delays in diagnosing children who may have autism could result in a crucial "window of opportunity" for early intervention being missed, ...
Grim message on autism Irish Independent
all 2 news articles »
Autism diagnosis shakes family
Billings Gazette,  USA -
By LUELLA N. BRIEN Marlene and John Hauck had to learn a new version of normal that came into their lives when their son Jared was diagnosed with autism. ...

KING5.com
Autistic Portland boy found near Mount Saint Helens
Seattle Post Intelligencer -
AP PORTLAND ? Crews have found an 11-year-old autistic boy missing since Saturday in the backcountry near Mount Saint Helens. The Skamania County sheriff's ...
11-year-old autistic boy found safe after 2 nights in wilderness The Columbian
Missing Autistic Boy Found eFluxMedia
Missing autistic boy found KPOJ
Longview Daily News - KOMO News
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Experts, educators trade tips at autism conference
Centre Daily Times, PA -
Holtzer, an autistic support teacher for kindergarten through second grade in Greensburg, and Bradish, a classroom assistant, learned the technique during ...

News & Observer
Autism and culture
News & Observer, NC -
"One of the great achievements we've had in the US is people are starting to talk more about autism." Experts say earlier diagnosis of children with autism ...

Times Online
Lincolnshire school failed autistic boy who cried during 11-plus
Times Online, UK -
A ruling that a grammar school had been wrong to refuse to make special provisions for an autistic pupil sitting its entrance examination was welcomed by ...
UPDATED: School failed to meet the needs of disabled boy, says ... Grantham Today
all 3 news articles »
Traveling with an autistic child
CNN - Aug 4, 2008
"It starts the dialog," says Shannon Gunn, who tells everyone she meets who might otherwise be put off by Lennon's odd behavior that he is autistic and his ...
Autism at About.Com - Welcome to a Wealth of Resources
About - News & Issues, NY - 45 minutes ago
Autism.About.Com is actually just one of over 700 websites on the About.com network. About.com itself is a part of the New York Times Company. ...
Parents of autistic boy file lawsuit
The Star-Ledger - NJ.com, NJ -
BY RALPH R. ORTEGA The parents of an autistic Hunterdon County boy who was left strapped in a car seat on a parked school bus for 4 1/2 hours on a hot ...

Ozarks First
Little Autism Patients Find Furry Therapy
Ozarks First, MO -
And then Mowery came up with an idea: breed more guinea pigs to help out other autistic children. "I don't ask for nothing in return," Mowery says. ...
Source: Google News

Movement analysis in infancy may be useful for early diagnosis of autism -
P Teitelbaum, O Teitelbaum, J Nye, J Fryman, RG … - Proceedings of the National Academy of Sciences of the …, 1998 - pubmedcentral.nih.gov
... Copyright ? 1998, The National Academy of Sciences. Psychology. Movement analysis
in infancy may be useful for early diagnosis of autism. ...

Early recognition of children with autism: A study of first birthday home videotapes -
J Osterling, G Dawson - Journal of Autism and Developmental Disorders, 1994 - Springer
... One way that insight has been gained into the early development of children ... later
diagnosed with childhood psychosis, 6 of whom had a diagnosis of autism. ...

Practice parameter: Screening and diagnosis of autism Report of the Quality Standards Subcommittee … -
PA Filipek, PJ Accardo, S Ashwal, GT Baranek, EH … - Neurology, 2000 - AAN Enterprises
... 3-7 Early diagnosis of autism and early intervention facilitates earlier educational
planning, provisions for family supports and education, management of ...

[BOOK] Children With Autism: Diagnosis and Interventions to Meet Their Needs
C Trevarthen - 1998 - Jessica Kingsley Publishers

Long-term outcome for children with autism who received early intensive behavioral treatment -
JJ McEachin, T Smith, OI Lovaas - The Science of Mental Health, 2001 - books.google.com
... Autism and Early Intervention 254 ... very young (less than 40 months if mute, less than
46 months if echolalic) and had re -ceived a diagnosis ofautism from a ...

A Screening Instrument for Autism at 18 Months of Age: A 6-Year Follow-up Study. -
G BAIRD, FRC Paed, T CHARMAN, S BARON-COHEN, A COX … - Journal of the American Academy of Child & Adolescent …, 2000 - jaacap.com
... established algorithm cutoff for an autism diagnosis (Lord et ... false-negative children
with autism reached criterion ... record parental report of early concern: age ...

[PDF] Early intervention in autism -
G Dawson, J Osterling - The effectiveness of early intervention, 1997 - depts.washington.edu
... early intervention program for children with autism. ... This is the average age at which
an initial diagnosis of autism is first made (Siegel, Pliner, Eschler ...

Blind Ratings of Early Symptoms of Autism Based upon Family Home Movies. -
JL ADRIEN, P LENOIR, J MARTINEAU, A PERROT, L … - Journal of the American Academy of Child & Adolescent …, 1993 - jaacap.com
... scored in the same way by two diagnosis-blind raters. They were both psychiatrists
who had collaborated on studies related to early symptoms in autism and were ...

Cerebral Lobes in Autism: Early Hyperplasia and Abnormal Age Effects -
RA Carper, P Moses, ZD Tigue, E Courchesne - Neuroimage, 2002 - Elsevier
... EARLY HYPERPLASIA OF CEREBRAL LOBES IN AUTISM ... diagnostic evaluation by Dr. Cathy
Lord (Uni- versity of Chicago; an expert in the diagnosis of autism who was ...

Prevalence of Autism in a US Metropolitan Area -
M Yeargin-Allsopp, C Rice, T Karapurkar, N … - JAMA, 2003 - Am Med Assoc
... At the same time, studies are suggesting that some children with autism respond
well to early, intense educational ... Because the diagnosis of autism is based ...

Source: Google Scholar
 
 

Key To Early Diagnosis Of Autism May Be In The Placenta

Article continues below and (thank you)

 
Researchers at Yale School of Medicine have discovered in the placenta what may be the earliest marker for autism, possibly helping physicians diagnose the condition at birth, rather than the standard age of two or older.

The findings are reported in the June 26 online issue of Biological Psychiatry. Autism is a developmental disorder that has a profound effect on socialization, communication, learning and other behaviors. In most cases, onset is early in infancy. Information on the earliest development aspects of autism in children has been limited even though approximately one in every 200 children is diagnosed with an Autism Spectrum Disorder (ASD). The earlier the diagnosis is made, the greater the treatment impact.

Current studies are searching for characteristics in children at risk for ASD so that the diagnosis can be made prior to age one. The ideal time for diagnosis would be at birth, according to senior author on the study Harvey J. Kliman, M.D., research scientist in the Department of Obstetrics, Gynecology & Reproductive Sciences at the Yale School of Medicine.

In previous work, Kliman had observed an unusual pathologic finding in the placentas from children with Asperger Syndrome, an ASD condition which, like autism, impairs the ability to relate to others.

"By serendipity, at a dinner party I happened to sit next to George M. Anderson, a research scientist in the Yale Child Study Center who had access to many cases of children with ASD," said Kliman. "We realized that by working together we might be able to determine if this placental abnormality could be a useful clinical marker."

With the help of Andrea Jacobs-Stannard, a student in Kliman's laboratory, and Katarzyna Chawarska and Fred R. Volkmar of the Yale Child Study Center, the group designed a study to see if the placental abnormality, specifically the presence of trophoblast inclusions, was a marker for ASD. The multidisciplinary team of Yale researchers compared placentas from 13 children with ASD to those from 61 unaffected children for the presence of trophoblast inclusions.

They found that the placentas from ASD children were three times more likely to have the inclusions. Kliman and the team identified trophoblast inclusions by performing microscopic examinations of placental tissues.

"We knew that trophoblast inclusions were increased in cases of chromosome abnormalities and genetic diseases, but we had no idea whether they would be significantly increased in cases of ASD," said Kliman. "These results are consistent with studies by others who have shown that ASD has a clear genetic basis."

Trophoblast inclusions reflect abnormal folding of microscopic layers in the placenta and appear to result from altered cell growth. Kliman likened the presence of trophoblast inclusions to an automobile check-engine-light. "When the light goes on it simply means that something is not right," said Kliman. "If the light is on and there is, for example, steam coming from under the hood, then it is likely that the radiator is leaking. However, if the check engine light is on and there is nothing obviously wrong, then the car should be carefully checked."

The Yale team plans to replicate the evaluation with larger multi-center and prospective studies. They will examine the placentas of the children in the study in greater detail to gain insight into the biological basis of the inclusions in ASD.

Volkmar said, "If the work is confirmed by the next series of studies, then the finding of trophoblast inclusions at the time of birth in the absence of any obvious genetic abnormalities would be an indication to have a child examined by a specialist to determine the presence of ASD."

###

Harvey Kliman can be reached at harvey.kliman@yale.edu

Citation: Biological Psychiatry, Published online (June 26, 2006)

Contact: Karen N. Peart
Yale University
 
 
 
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