Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: polycystic + mri + kidney  Related to the article below (Last Update: 8/5/2008)

"I was a walking Time Bomb on Ortho Evra"
Lawyers and Settlements - Jul 16, 2008
This really threw a wrench into my life because I have polycystic ovaries, so being on birth control pills was the only thing that kept me from ovulating ...
Source: Google News

Appearance of autosomal recessive polycystic kidney disease in magnetic resonance imaging and RARE- … -
S Kern, LB Zimmerhackl, F Hildebrandt, B Ermisch- … - Pediatric Radiology, 2000 - Springer
... Abstract Purpose. To describe the appearance of autosomal recessive polycystic kidney
disease (ARPKD) on MRI and RARE-MR urogra- phy. Materials and methods. ...

… is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney … -
JM Shillingford, NS Murcia, CH Larson, SH Low, R … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences
... be a general feature of PKD, we next examined the status of the mTOR pathway in
polycystic mouse models ... H) Kidney volumes were measured by MRI scanning of ...

… Measurement of Renal Cysts and Parenchyma Using MRI: Phantoms and Patients with Polycystic Kidney … -
KT Bae, PK Commean, J Lee - Journal of Computer Assisted Tomography, 2000 - jcat.org
... Parenchyma Using MRI: Phantoms and Patients with Polycystic Kidney Disease
Kyongtae T. Bae, Paul K. Commean, and Jeongrim Lee Abstract ...

MRI of hemorrhagic renal cysts in polycystic kidney disease. -
PL Hilpert, AC Friedman, PD Radecki, DF Caroline, … - AJR Am J Roentgenol, 1986 - ncbi.nlm.nih.gov
... DG, Kressel HY. Nine patients with polycystic kidney disease were examined
by MRI, CT, and sonography. MRI distinguished among simple ...

Screening a living kidney donor for polycystic kidney disease using heavily T2-weighted MRI. -
MS Zand, J Strang, M Dumlao, D Rubens, E Erturk, O … - Am J Kidney Dis, 2001 - ncbi.nlm.nih.gov
Am J Kidney Dis. 2001 Mar;37(3):612-9. Screening a living kidney donor for
polycystic kidney disease using heavily T2-weighted MRI. ...

Diagnosing fetal urinary tract abnormalities: benefits of MRI compared to ultrasonography -
J POUTAMO, R VANNINEN, K PARTANEN, P KIRKINEN - Acta Obstetricia Et Gynecologica Scandinavica, 2000 - Blackwell Synergy
... slightly enlarged on ultrasound. MRI also missed one dominant polycystic
kidney dis- ease with only one small cyst. In one fetus with ...

… ) pat associated with tuberous sclerosis complex, adult polycystic kidney disease, and hypomelanosis … -
BHJ Eussen, G Bartalini, L Bakker, P Balestri, C … - British Medical Journal, 2000 - jmg.bmj.com
... who have TSC and childhood onset polycystic kidney disease have ... examination, which
included fundoscopy, renal and cardiac ultrasound, and brain MRI. ...

Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney … -
P RUGGENENTI, A REMUZZI, P ONDEI, G FASOLINI, L … - Kidney International, 2005 - pt.wkhealth.com
... iohexol plasma clearance versus magnetic resonance imaging (MRI) and iothalamate ...
Consortium for Radiologic Imaging Studies of Polycystic kidney disease (CRISP ...

Volume Progression in Polycystic Kidney Disease -
JJ Grantham, VE Torres, AB Chapman, LM Guay- … - New England Journal of Medicine, 2006 - content.nejm.org
... ISI][Medline]; Bae KT, Commean PK, Lee J. Volumetric measurement of renal cysts
and parenchyma using MRI: phantoms and patients with polycystic kidney disease. ...

Therapeutic approaches in autosomal dominant polycystic kidney disease (ADPKD): is there light at … -
G Walz - Nephrology Dialysis Transplantation, 2006 - ERA-EDTA
... Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease followed
241 ADPKD patients by sequential magnetic resonance imaging (MRI) measurements. ...

Source: Google Scholar
 
 
We like to thank you for visiting Iconocast. We have a favor to ask you. You found Iconocast easily through a search engine such as Google. If you like the information on this page and you also like others to find this page easily we like to ask you to place a link to this page from your own web site. This is all we ask you. Your valuable link makes it easier for search engines to find this page. To make it even easier, please place this html code on your home page: <a href="http://www.iconocast.com/"> eMarketing and Health Info </a>. Thank you.  

Polycystic Kidney Disease: MRI Provides An Early Alert To Progression

Article continues below and (thank you)
 
A new method using magnetic resonance imaging (MRI) accurately tracks structural changes that predict functional changes earlier than standard blood and urine tests in people with autosomal dominant polycystic kidney disease (PKD), according to a study funded by the National Institutes of Health (NIH). PKD is a common inherited condition characterized by cysts that grossly distort the kidneys and liver and by high blood pressure and brain aneurysms (bulges in arteries). Findings are in the May 18 issue of the New England Journal of Medicine.

Researchers found that both small and large cysts and both kidneys grew continuously at steady rates, seemingly tailored to the individual with PKD, regardless of patient age. These structural changes correlate with losses in kidney function, suggesting that MRI can be used to track the major contributor to the progression of PKD, an advance that could speed the discovery of new therapies.

"There is so much variability in the loss of kidney function among PKD patients, even within families with the same altered gene, that it was assumed that cysts and kidneys must grow at variable rates. So it's quite remarkable to find cysts and kidneys in individuals growing at uniform and predictable rates," said Catherine M. Meyers, M.D., a kidney specialist at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). "Our experience is still limited, but this method appears very promising."

The Consortium for Radiological Imaging Studies of Polycystic Kidney Disease (CRISP) enrolled 241 patients, ages 15 to 46 years, with autosomal dominant PKD and normal to mild losses in kidney function (stage 1 or 2). The researchers developed MRI techniques to reliably and accurately produce 3-dimensional images from which cysts and kidneys, and the proportion of the kidneys occupied by cysts, could be measured. Changes in cyst and kidney volume were compared to standard blood and urine tests of kidney function and to a specialized test measuring how fast the kidneys filtered a substance called iothalamate from the blood.

"Being able to predict how quickly a disease will progress--rather than waiting years for it to actually happen--should speed up trials of potential therapies. Up to now we had to observe patients for years before we could tell if a therapy was working," said lead author Jared J. Grantham, M.D., a kidney specialist at the University of Kansas School of Medicine in Kansas City and long-time advocate for PKD patients. "It should now be possible to test potential therapies earlier in the disease, when therapies are more likely to prevent kidney failure."

Already, the new MRI method is receiving closer scrutiny. CRISP patients have been asked to stay for another 4 years of MRI monitoring, and about 100 of them are planning to join NIDDK's HALT-PKD trial (www.pkd.wustl.edu/pkd-tn), the first intervention trial to use the MRI method along with standard tests of kidney function. HALT-PKD enrolled its first patient in January 2006 to learn if careful blood pressure control and ACE-inhibitors or angiotensin receptor blockers (ARBs) can prevent progression of PKD.

CRISP clinical centers are at the University of Kansas Medical Center in Kansas City, Emory University in Atlanta, Mayo Clinic in Rochester, Minn., and the University of Alabama at Birmingham. Washington University in St. Louis analyzed the MRI images and study data.

As many as half a million people in the United States and 4 to 6 million world-wide are estimated to have PKD. In autosomal dominant PKD, the most common form, symptoms usually appear between the ages of 30 and 40 and include back and side pain and headaches. Half of patients develop kidney failure, on average around age 54; 23,000 were on dialysis or had a transplant for kidney failure in 2003, making it this country's fourth leading cause of kidney failure. More information about PKD is available from NIDDK at www.niddk.nih.gov and from the PKD Foundation at http://www.pkdcure.org and 1-800-PKD-CURE.

There is no cure and no specific treatment for PKD, but careful blood pressure control and using ACE-inhibitors or ARBs, types of blood pressure medicines, significantly delays or prevents kidney disease and failure from diabetes and other causes by reducing protein in the urine and preventing damage to the small blood vessels in the kidneys. Earlier trials of these treatments in PKD were not definitive, possibly because a small number of patients were involved.

NIDDK's National Kidney Disease Education Program (http://www.nkdep.nih.gov) aims to raise awareness of the seriousness of kidney disease, the importance of testing those at high risk, and the availability of treatment to prevent or slow kidney failure.

The National Institutes of Health (NIH) -- The Nation's Medical Research Agency -- includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases.

Mary Harris
harrismm@mail.nih.gov
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
http://www.niddk.nih.gov
 
 
 
Google
Web www.iconocast.com
 
 
 

 

Continue News With: News2 ; News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page