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Recent News and Articles on the Keywords: melatonin + hypertension + may  Related to the article below (Last Update: 8/5/2008)


Irish Independent
10 ways to get more sleep
Irish Independent, Ireland - Aug 4, 2008
Make sure you eat early in the evening and try to chomp on foods that contain melatonin, a substance that helps regulate your body clock. ...

Business Wire (press release)
World?s First Extreme Relaxation Beverage is Premiere Sponsor at ...
Business Wire (press release), CA -
Harnessing the natural calming effects of melatonin, valerian root and rose hips to ?slow your roll? and capture a stress-free state of mind, ...
Integrative Way: Tummy upset? Melatonin may provide relief
Sacramento Bee,  USA - Jul 20, 2008
One potential alternative therapy for some of these disorders is melatonin, a hormone produced in the pineal gland in the brain and the intestines. ...
Wham: Daytime Bright Lighting and Melatonin a Benefit to Dementia ...
MedHeadlines, IL - Jul 16, 2008
It was interesting to see how the researchers also found that the use of melatonin supplements resulted in improved sleep. This research was reported in the ...
Cherry pick some sweet salads
Calgary Herald,  Canada - Jul 31, 2008
... juice lowers pain after a workout, prevents and rebuilds muscle damage. It also boosts melatonin production, which is important for the immune system.
How to ground jet lag
Abilene Reporter-News, TX - Jul 28, 2008
Cells in the suprachiasmatic nucleus respond to melatonin, the "dark hormone." Levels of melatonin begin climbing after dark, causing drowsiness in some ...
How do I try to beat jet-lag:
ScienceBlogs - Aug 1, 2008
once I pass security and have about an hour before take-off, I take clonapen (not sleeping pills and no, not melatonin, though some people swear about it ...
Sweet Dreams, Sweet Breath: MedGen Inc. Retains TransMedia Group ...
MarketWatch - Jul 21, 2008
"MedGen Inc. has hired us to introduce '4 Good Night's Sleep," www.4goodnightsleep.com , an all-natural melatonin strip that dissolves on your tongue ...

The Consumerist
We Review Drank, The "Anti-Energy" Drank
The Consumerist, NY - Jul 29, 2008
Melatonin: We release melatonin throughout the day, and supplements may help regulate deficiencies that might occur from jet lag or other sleep disorders. ...
The nightmare of sleep deprivation may soon be over
Times Online, UK - Jul 13, 2008
Recently Circadin, a preparation of melatonin, has been approved for prescription on the NHS for people of 55 and older who have been suffering from ...
Source: Google News

Daily Nighttime Melatonin Reduces Blood Pressure in Male Patients With Essential Hypertension -
FAJL Scheer, GA Van Montfrans, EJW van Someren, G … - Hypertension, 2004 - Am Heart Assoc
... who would benefit most from melatonin intake ... that support of circadian pacemaker
function may provide a new strategy in the treatment of essential hypertension. ...

Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. -
E Kilic, YG Ozdemir, H Bolay, H Kelestimur, T … - J Cereb Blood Flow Metab, 1999 - ncbi.nlm.nih.gov
... action of melatonin. However, melatonin also has vascular actions, and
pinealectomy may induce hypertension. The authors investigated ...

Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously … -
M Nava, Y Quiroz, N Vaziri, B Rodriguez-Iturbe - American Journal of Physiology- Renal Physiology, 2003 - Am Physiological Soc
... To our knowledge, the oral administration of melatonin for the treatment of
hypertension has not been tried previously. One of the reasons may be that when ...

Alterations of Nitric Oxide Synthase Expression With Aging and Hypertension in Rats -
TC Chou, MH Yen, CY Li, YA Ding - Hypertension, 1998 - Am Heart Assoc
... We proposed that the pathological condition of vessels in hypertension
may be responsible for an increase of iNOS expression. In ...

Melatonin: a major regulator of the circadian rhythm of core temperature in humans -
A Cagnacci - Journal of Clinical Endocrinology & Metabolism, 1992 - Endocrine Soc
... Patients With Essential Hypertension Hypertension, February 1 ... CA Czeisler Absence
of Detectable Melatonin and Preservation ... Integrative Comp Physiol, May 1, 2000 ...

Regulation of contraction and relaxation in arterial smooth muscle -
CM Rembold - Hypertension, 1992 - Am Heart Assoc
... P. Delagrange, E. Scalbert, and C. Capdeville-Atkinson Melatonin potentiates NE ...
Ca2+]i) Transients in Vascular Smooth Muscle Cells Hypertension, May 1, 1996; 27 ...

Influences of melatonin administration on the circulation of women -
A Cagnacci, S Arangino, M Angiolucci, E Maschio, … - American Journal of Physiology- Regulatory, Integrative and …, 1998 - Am Physiological Soc
... with essential hypertension (1). Thus melatonin administration seems to induce
beneficial effects on circulation of humans, and noteworthy benefits may be ...

Melatonin in Serum and the Pineal of Spontaneously Hypertensive Rats -
K Kawashima, A Nagakura, RJ Wurzburger, S Spector - Clinical and Experimental Hypertension, 1984 - informaworld.com
... the possibility that the pineal gland may play a ... and that an abnormality in melatonin
secretion might play a role in the pathogenesis of hypertension. ...

Melatonin and jet lag syndrome: experimental model and clinical implications.
GF Oxenkrug, PJ Requintina - CNS Spectr, 2003 - ncbi.nlm.nih.gov
... of melatonin in alleviating jet lag may be enhanced by administering it before,
during and after rapid transition through time zones; and hypertension may ...

Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat. -
SW Holmes, D Sugden - British Journal of Pharmacology, 1976 - pubmedcentral.nih.gov
... Copyright notice. Proceedings: The effect of melatonin on pinealectomy-induced
hypertension in the ... This may not be the complete list of references ...

Source: Google Scholar
 
 

Melatonin may cut hypertension

Melatonin, a naturally occurring hormone that can be taken orally to regulate sleep patterns, reduced the blood pressure (BP) of hypertensive women, claim Italian researchers.

 
The hormone is currently available in the US and countries such as Singapore and Thailand as a ‘dietary supplement'. In Europe, Australia and many other countries however it is a regulated as a medicine.

A previous study from Harvard Medical School reported that taking melatonin for three-weeks reduced the systolic BP of men with hypertension by six millimeters of mercury (mmHg), and diastolic BP by four mmHg.

The new study, published in the American Journal of Hypertension (Vol. 18, pp. 1614-1618), supports the hypothesis that melatonin reduces BP.

Although the study was limited to 18 middle-aged women, half of whom had hypertension, the results strongly indicate that prolonged intake of melatonin could improve the day-night BP rhythm.

The release of melatonin during the night has been related to the typical blood pressure drop during sleep. The current study sought to test if melatonin supplements could amplify the nighttime fall in BP.

The randomized, double blind, placebo-based study gave nine women either a placebo or a melatonin pill one hour before bedtime. The melatonin pill was formulated to quickly release 1mg of melatonin, and a further 2mg slowly. After three weeks of intervention the groups were crossed over.

“A 10 per cent decline of BP over daytime values is considered appropriate to reduce the cardiovascular risk,” said lead-author Angelo Cagnacci. “During placebo use only 39 per cent of the subjects reached this value, but this rate surged to 84 per cent during melatonin administration.”

The mechanism whereby melatonin reduces BP is unknown, but the researchers propose it is not merely due to the sleep-inducing effect of the hormone.

“Melatonin may exert cardiovascular effects that are independent of those on sleep,” said Cagnacci.

The authors recommended that the interactions with other antihypertensive therapies, which were not excluded or evaluated in this study, should be investigated.

“Longer clinical trials are necessary for a full exploration of the potential effects of melatonin,” concluded Cagnacci.

In 2003 UK scientists from the Cochrane Collaboration called for funding to back proper testing of melatonin in supplement form.

The market for natural sleep aids could be important. Over 12 million sleeping pill prescriptions are issued every year in the UK. In the US, over 70 million people are said to have sleeping problems.

The Committee on the Framework for Evaluating the Safety of Dietary Supplements published prototype monographs in 2003 for three supplements including melatonin, and is asking for comment and contributions to its information.

 
 
 
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