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Recent News and Articles on the Keywords: 0.31 + web + 58,900  Related to the article below (Last Update: 8/5/2008)

HFF, Inc. Reports Second Quarter 2008 Financial and Transaction ...
American Digital Networks (press release), MD - 52 minutes ago
Such information and filings are available publicly and may be obtained from the Company's web site at www.hfflp.com or upon request from the HFF, ...HF
Best of the Best from the preps pages from Troy/Rochester
Detroit Free Press, United States - Aug 3, 2008
She also finished as the catcher who handled the school's best pitching staff ever (Jordan Wheatley was 25-3 with a 0.31 ERA, Kristen Fleming went 11-1 with ...LON:BEST
Fiserv Reports Second Quarter 2008 Results
Trading Markets (press release), CA - Jul 29, 2008
The company will discuss its second quarter 2008 results on a conference call and web cast at 4 pm CDT on July 29. To register for the event and to access ...
Nexity Financial Second Quarter Results Trading Markets (press release)
all 295 news articles »  NXTY - FISV - TSCC

WELT ONLINE
Aladdin Knowledge Systems Reports Second Quarter 2008 Financial ...
MarketWatch - Jul 21, 2008
Released Aladdin eSafe v6.2 Proxy, offering organizations more options in control and flexibility for secure Web gateway deployment. ...
NetLogic Microsystems Announces Record Second Quarter 2008 ... Trading Markets (press release)
Phoenix Technologies Ltd. Reports Third Quarter FY2008 Financial ... Earthtimes (press release)
all 773 news articles »  PTEC - ALDN - NETL

Earthtimes (press release)
Acura Pharmaceuticals, Inc. Reports Second Quarter 2008 Financial ...
CNNMoney.com (press release) - Jul 30, 2008
You are encouraged to review other important risk factors relating to our operations on our web site at www.acurapharm.com under the link, "Company Risk ...
IAC Reports Q2 Results MSN Money
all 1,402 news articles »  ACUR - KG

RTT News
Omnicare Reports Second Quarter Results
Genetic Engineering News (press release), NY - Jul 31, 2008
The conference call will be webcast live at Omnicare's Web site at www.omnicare.com by clicking on "Investors" and then on "Conference Calls," and will be ...
Nalco Continues Delivering Rapid Revenue Growth Trading Markets (press release)
Shutterfly Announces Second Quarter 2008 Financial Results TMC Net
all 526 news articles »  NLC - OCR - SFLY
CB Richard Ellis Group, Inc. Reports Second Quarter 2008 Revenue ...
WELT ONLINE, Germany - Jul 29, 2008
A live webcast will be accessible through the Investor Relations section of the Company?s Web site at www.cbre.com. The direct dial-in number for the ...CBG
Yuan Falls, Heads for Smallest Monthly Gain Since March 2007
Bloomberg - Jul 30, 2008
The currency climbed 0.31 percent in July, less than the average monthly gain of 1.07 percent in the previous six months. China's economy grew at the ...

Techtree.com
Cubist Pharmaceuticals Reports First $100 Million Revenue Quarter ...
WELT ONLINE, Germany - Jul 17, 2008
Additional information can be found at Cubist?s web site at www.cubist.com. Cubist and CUBICIN are registered trademarks of Cubist Pharmaceuticals, ...
eBay Inc. Reports Second Quarter 2008 Results Trading Markets (press release)
all 62 news articles »  CBST - EBAY - DYAX
American Medical Systems Reports Second Quarter Revenue of $129.8 ...
MarketWatch - Jul 29, 2008
A live web cast of the call will be available through the Company's corporate website at www.AmericanMedicalSystems.com and available for replay three hours ...AMMD
Source: Google News

Co-adapted foraging traits in a guild of orb-weaving spiders
CW Olive - Oecologia, 1981 - Springer
... Mesh width -0.58 -0.51 Fall 0.8 Paturon length -0.47 -0.31 Web height 0.25 0.83
Hub 0.7 Fang length - 0.24 - 0.14 Retreat -- 1.8 Web area -0.02 -0.12 category. ...

The calculation of web impact factors -
P Ingwersen - Journal of Documentation, 1998 - ingentaconnect.com
... Countries in impact Web- IF Web- IF A/ inv. WIF /Web- IF web pages ... Finland 0.791
0.42 0.37 ?1.69 7.52 313,085 7. Japan 0.404 0.31 0.09 1.11 1.44 1,826,051 ...

[PS] Overview of the TREC-8 Web Track -
D Hawking, E Voorhees, N Craswell, P Bailey - Proc. of TREC-8 - research.microsoft.com
... Relevant set Relevant set 711 0.31 0.31 ... Groups which submitted exactly corresponding
runs in the Ad Hoc and Small Web Tasks were asked to supply runids and ...
-

Effect of Scale on Food Web Structure -
ND Martinez - Science, 1993 - sciencemag.org
... Also in line with the convention, an eighth food web property, connectance, is inferred
tobe scale-dependent and to decrease as the number ofspecies increases ...

A comparison of sources of links for academic Web Impact Factor calculations -
M Thelwall - Journal of Documentation, 2002 - emeraldinsight.com
... for Glamorgan does not reflect its real Web site size, which may be due to the
AltaVista being unable to index it meaningfully due to its design around ... 0.31** ...

Does ?authority? mean quality? predicting expert quality ratings of Web documents -
B Amento, L Terveen, W Hill - Proceedings of the 23rd annual international ACM SIGIR …, 2000 - portal.acm.org
... based metrics to compare with the expert ratings, we had to analyze the web
neighborhood surrounding ... 0.48 41 15 0.37 39 10 0.26 41 7 0.17 42 13 0.31 0.32 Table ...

A Meta-Analysis of Response Rates in Web-or Internet-Based Surveys -
C Cook, F Heath, RL Thompson - Educational and Psychological Measurement, 2000 - epm.sagepub.com
... For these populations, e-mail and Web surveys may have only minor coverage problems.
(Dillman, 2000, p. 356) Noteworthy Factors ... Topic sensitive? 0.11 0.31 ...

Predicting the use of web-based information systems: self-efficacy, enjoyment, learning goal … -
MY Yi, Y Hwang - International Journal of Human-Computer Studies, 2003 - Elsevier
... d. ability to use favorite Web site 0.19 0.78 0.31 0.56 0.12 0.20 0.29 3.
Enjoyment a. have fun using0.11 0.24 0.95 0.46 0.48 0.47 0.07 ...

As we may perceive: finding the boundaries of compound documents on the web
P Dmitriev - 2008 - portal.acm.org
... does best for all three categories of web sites. ... content outlinks filename title
directory L 1 0.23 0.28 0.31 0.31 0.26 L 2 0.31 0.41 0.38 0.34 0.13 L 3 0.24 ...

[PDF] WebQual: a measure of Web site quality
ET Loiacono, RT Watson, DL Goodhue - 2002 Marketing Educators? Conference: Marketing Theory and …, 2002 - terry.uga.edu
Page 1. 1 WebQual?: A Measure of Web Site Quality Eleanor T. Loiacono ... 0037
Page 2. 2 WebQual?: A Measure of Web Site Quality Eleanor T ...

Source: Google Scholar
 
 

FLAP inhibitor reduces markers linked to cardiac risk

 

 
A study suggests that use of a investigational drug, DG-031, that inhibits a specific protein in patients with genetic variants that increase the risk for myocardial infarction, reduced the levels of inflammatory markers associated with risk of myocardial infarction.

In 2003, through a population-based, genome-wide study involving hundreds of myocardial infarction patients and their family members in Iceland, deCODE Genetics, a biopharmaceutical company, discovered variations in the gene encoding FLAP, or 5-lipoxygenase activating protein, that double the risk of the disease.

Hakon Hakonarson, of deCODE Genetics, Reykjavik, Iceland and colleagues conducted a study to determine the effect of an inhibitor of FLAP on levels of biomarkers associated with myocardial infarction risk.

The branch of the leukotriene pathway linked to risk of myocardial infarction, through the activity of FLAP, leads to the production of leukotriene B4, which is a potent mediator of arterial inflammation.

The researchers' previously published findings indicate that myocardial infarction patients, both those with and without the at-risk variants of the FLAP gene, produce more leukotriene B4 than do controls.
This suggests that the up-regulation of the leukotriene pathway contributes to risk of the disease, both through genetic and environmental factors, primarily by promoting inflammation in atherosclerotic plaques and increasing their propensity to rupture.
By inhibiting the function of FLAP and thereby down-regulating the activity of the leukotriene pathway, the risk of myocardial infarction may be decreased.

Rresearchers used DG-031, an inhibitor of FLAP.

The trial included myocardial infarction patients who carry at-risk variants in the FLAP gene or in the leukotriene A4 hydrolase gene.

Of 268 patients screened, 191 were carriers of at-risk variants in FLAP ( 87 percent ) or leukotriene A4 hydrolase ( 13 percent ).

Individuals were enrolled in April 2004 and were followed up by designated cardiologists from the Landspitali University Hospital in Iceland until September 2004.

Patients were first randomized to receive 250 mg/d of DG-031, 500 mg/d of DG-031, 750 mg/d of DG-031, or placebo.

After a 2-week washout period, patients received DG-031 if they had received placebo first or placebo if they had received DG-031 first. Treatment periods lasted for 4 weeks.

The researchers found that levels of several biomarkers linked to arterial inflammation and risk of myocardial infarction decreased.

In response to 750 mg/d of DG-031, production of leukotriene B4 was significantly reduced by 26 percent and myeloperoxidase was significantly reduced by 12 percent.

The higher 2 doses of DG-031 produced a nonsignificant reduction in C-reactive protein ( 16 percent ) at 2 weeks.
However, there was a more pronounced reduction ( 25 percent ) in C-reactive protein ( CRP ) at the end of the washout period that was significant and persisted for another 4 weeks thereafter.

An 8-day, open-label follow-up study with 75 patients with the same genetic and disease profile as in the Phase IIa was conducted to further examine the effect of DG031 on CRP and myeloperoxidase.
The results of this study showed that the 750mg/d dose of DG031, when administered as 250 mg 3 times daily resulted in a 38 percent reduction in CRP levels, as well as a 31 percent reduction in myeloperoxidase levels measured 6 hours after dosing on day 8.

In both studies, the FLAP inhibitor DG-031 was well-tolerated and was not associated with any serious adverse events.

Source: Journal of American Medical Association, 2005
 
 
 
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