Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: alzheimers + distinguishes + 0.29  Related to the article below (Last Update: 8/4/2008)


HealthJockey.com
'Biomarkers' May Help Spot, Track Alzheimer's
U.S. News & World Report, DC - Jul 29, 2008
"It's one thing to distinguish the sick group from the healthy group and another to see if you can predict from the healthy group who gets the disease," ...
MRI May Be Useful For Early Alzheimer's Diagnosis InjuryBoard.com
Researchers Say MRI?s May Help Diagnose Alzheimer's Disease TopNews
all 105 news articles »

Wall Street Journal
A War's Innocents
Wall Street Journal - Jul 31, 2008
They casually distinguish between the engine sounds of US Chinook and Apache helicopters overhead, and on New Year's Eve they argue about whether the bangs ...
Power3 Medical Products Advances the Diagnostic Capabilities of ...
MarketWatch - Jul 10, 2008
"One of the most critical issues in medicine is the ability to distinguish Alzheimer's disease from other forms of dementia and other neurological and ...OTC:PWRM

Chatter Shmatter
Tarenflurbil Does Not Prevent Decline Among Patients With Mild ...
DG News - Jul 30, 2008
... Dr. Green said in his oral presentation on July 29 here at the 2008 International Conference on Alzheimer's Disease (ICAD), but it failed to distinguish ...
Elan, Wyeth's Alzheimer Drug News Doesn't Please Investors Seeking Alpha
all 299 news articles »
Early-diagnosis blood tests for Alzheimer's disease in development
Los Angeles Times, CA - Jul 25, 2008
It measures 59 protein markers in the blood that distinguish people with Alzheimer's disease from those with Parkinson's disease as well as those without ...
?I Hope They Know...The Essential Handbook on Alzheimer's Care?,
Mass Media Distribution LLC (press release), FL - Jul 15, 2008
What distinguishes this book from others in the field is the inclusion of newer concept of art therapy exemplified by patients? art work interpreted by a ...
ReGen Therapeutics Plc Joins International OTCQX
MarketWatch - Jul 14, 2008
"As an International OTCQX-listed company, ReGen Therapeutics distinguishes itself as one of the most prestigious companies trading over-the-counter in the ...LON:RGT - OTC:CMTX
Research making sense of the nose and tongue
San Francisco Chronicle,  USA - Jul 24, 2008
Hastings' machine measures a person's unique olfactory IQ in several ways: the ability to correctly identify a smell; to distinguish one odor from a ...
PBT2 Shows Promise for Mild Alzheimer's Disease in Preliminary ...
DG News - Jul 30, 2008
The PBT2 50-mg dose failed to distinguish itself from placebo. However, Dr. Cummings said that the 250-mg dose achieved a significant reduction in beta-42 ...
PTSD leaves physical footprints on the brain
San Francisco Chronicle,  USA - Jul 27, 2008
The disorder, neurologists are now learning, can also lead to long-term maladies, such as Alzheimer's and dementia. The quest is to understand how the ...
Source: Google News

Alzheimer Type -
EB Fishman, C Siek, D MacCallum, D Bird - Ann NeuroI, 1986 - doi.wiley.com
... for describing the molecular forms of AChE distinguishes two classes of ... Brains of
Patients with Dementia of the Alzheimer Type and ... 5) 76.0 & 2.1 1.33 5 0.29b (6 ...

Effectiveness of treatment with donepezil hydrochloride and changes in regional cerebral blood flow … -
T Yoshida, S Ha-Kawa, M Yoshimura, K Nobuhara, T … - Annals of Nuclear Medicine, 2007 - Springer
... frontal lobe function and distinguishes complete responders ... ADAS Alzheimer?s disease
assessment scale ... Spoken language ability -0.14 0.00 -0.29 -0.29 ...

Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage … -
BT Gold, DA Balota, MJ Cortese, SD Sergent- … - Neuropsychologia, 2005 - Elsevier
... as logical paragraph recall cannot distinguish between the ... and Stroke and the
Alzheimer's Disease and ... tests were significant, all P's > 0.29, indicating that ...

Outcomes for patients with dementia from the Cleveland Alzheimers Managed Care Demonstration -
PA Clark, DM Bass, WJ Looman, CA McCarthy, S … - Aging and Mental Health, 2004 - ingentaconnect.com
... A third characteristic distinguishes between patients who live ... istrative record
information from the Alzheimer?s Association. ... 0.78 0.30 0.80 0.29 0.77 0.32 ...

Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's … -
WE Klunk, JW Pettegrew, CA Mathis Jr - US Patent 6,168,776, 2001 - freepatentsonline.com
... Klunk et al., "Beta-Amyloid Probes which Cross the Blood-Brain Barrier and Distinguish
Homogenates of Alzheimer's and Control Brain", Society for Neuroscience ...

Neurochemical Dissection of Synaptic Pathology in Alzheimer's Disease -
P Davidsson, K Blennow - International Psychogeriatrics, 2005 - Cambridge Univ Press
... in different brain regions in early-onset (EAD) and late-onset (LAD) Alzheimer?s
disease ... f 0.16 [p < .0001]; 0.82 f 0.23 [p < .001]; 0.89 f 0.29 [p < .OOOl ...

Mapping of temporal and parietal cortex in progressive nonfluent aphasia and Alzheimer's disease … -
R Zahn, M Buechert, J Overmans, J Talazko, K … - Psychiatry Research: Neuroimaging, 2005 - Elsevier
... disease-specific brain regions that distinguish PNA from ... to Establish a Registry
for Alzheimer's Disease (CERAD ... 1.71 ? 0.28; NC: m = 1.95 ? 0.29) and parietal ...

Typology of Alzheimer's disease: findings from CERAD data -
GG Fillenbaum, MA Woodbury - Aging and Mental Health, 1998 - ingentaconnect.com
... Page 5. Typology of Alzheimer?s disease 109 ... It is the latter characteristic which
distinguishes this pure type from all other neuropsychology pure types. ...

Everyday action in dementia: Evidence for differential deficits in Alzheimer's disease versus … -
T GIOVANNETTI, KS SCHMIDT, JL GALLO, N SESTITO, DJ … - Journal of the International Neuropsychological Society, 2006 - Cambridge Univ Press
... vascular dementia (VaD; n 5 25) versus Alzheimer?s disease ... inher- ent to free recall
and distinguishes patients with ... of 18) 10.9 4.5 9.7 3.9 21.2 0.229 0.29 ...

Activation of LA-N-2 Cell Phospholipase D by Amyloid Beta Protein (25?35) -
IN Singh, G Sorrentino, JN Kanfer - Neurochemical Research, 1998 - Springer
... cesses eventually resulting in Alzheimer's disease may have begun decades prior
to any overt signs or symp- toms of the disease (5 ... 3 H]PtdETOH a 0.29 0.08 0.39 ...

Source: Google Scholar
 
 

Non-invasive MRI technique distinguishes between Alzheimer's and frontotemporal dementia

 
 
A non-invasive magnetic resonance imaging ( MRI ) technique called arterial spin labeling is just as accurate as invasive scanning techniques in distinguishing Alzheimer's disease from frontotemporal dementia ( FTD ) in the brains of elderly people.

The study, led by Norbert Schuff, at the San Francisco VA Medical Center ( SFVAMC ), used arterial spin labeling to measure perfusion, or blood flow, in the areas of the brain affected by the two diseases.

" Blood flow indicates brain activation," said Schuff. " So the area with less blood flow is the area affected by disease."

In the study, arterial spin labeling successfully distinguished between Alzheimer's patients, FTD patients, and people without dementia.

Frontotemporal dementia is a degenerative condition involving the front part of the brain. It is the second-most common dementia after Alzheimer's disease, which mainly affects other brain areas such as the hippocampus and the temporal lobe. In their early stages, the two diseases present similar symptoms, making accurate diagnosis difficult, said Schuff.

In its later stages, FTD affects social conduct, social inhibitions, and personality, while Alzheimer's is a progressive impairment of multiple cognitive functions, often involving memory decline.

" Progression of frontotemporal dementia is usually faster than Alzheimer's, and the underlying pathology is different, so it is important to know the difference," Schuff observed.

Currently, brain blood flow can be measured using positron emission tomography ( PET ) and single proton emission computerized tomography ( SPECT ).
However, these techniques involve injecting patients with radioactive tracers.

In addition, Schuff noted, they can be expensive -- about $2,000 for a PET scan -- can take up to half a day to perform, and are not widely available. " So if you can acquire blood flow information with MRI, that would be very beneficial. MRI is totally non-invasive, making it much safer for patients. It's more widely available, it's cheaper, and arterial spin labeling can be done in ten minutes together with a conventional MRI scan."

MRI is a non-radioactive imaging technique that measures the magnetic alignment of protons in the body.
In arterial spin labeling, a technique invented by researchers at the University of Pennsylvania, protons in arterial blood are magnetically aligned in the opposite direction from the rest of the protons in blood and brain tissue.
By measuring the intensity of the magnetic signal from these so-called inversely polarized protons when they reach the brain, researchers can calculate the amount of blood flow, and thus neuron activity, in a particular section of the brain.

In the study, Schuff and his researchers measured brain perfusion in 24 Alzheimer's patients, 21 FTD patients, and 25 control subjects without dementia.
The subjects were 62 to 90 years old, with an average age of just under 63.
They were studied using an MRI system with a magnetic field strength of 1.5 Tesla, a common system in clinics and hospitals in the United States.
The researchers successfully used arterial spin labeling to replicate PET and SPECT data on brain perfusion in all subjects.
They also found that the perfusion data, added to structural information about the brain obtained with conventional MRI, significantly improved the classification of FTD from normal aging. Thus, "we gained specificity and sensitivity," said Schuff.

Schuff emphasized that because this was a research study, the aim of which was to accurately replicate PET and SPECT perfusion data, it did not prove that arterial spin labeling can be used to diagnose an individual patient.

The next step for future research, he said, is to demonstrate that the perfusion abnormalities correlate with specific clinical symptoms. "At the moment, we have just dichotomized patients into Alzheimer's and FTD," he said. " But of course cognitive impairment is usually more complex -- you have a range of impairments."

The technique has the potential to distinguish other types of dementia as well. Schuff plans to study a larger sample in a clinical setting, with the goal of determining whether this is possible. " Once we have a large database of images," he predicted, " we can better determine what is normal, and then compare an individual subject with this normal range."

Source: University of California - San Francisco, 2005
 
 
 
Google
Web www.iconocast.com
 
 
 

 

Continue News With: News2 ; News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page