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Recent News and Articles on the Keywords: rheumatoid arthritis + arthritis + rheumatoidarthritis  Related to the article below (Last Update: 8/4/2008)

Stroke rehab may be poorer for arthritis patients
Reuters UK, UK -
By Michelle Rizzo NEW YORK (Reuters Health) - People with rheumatoid arthritis who suffer a stroke are likely to have lower functional ability subsequently ...
Behavioral Comorbidities in Rheumatoid Arthritis
Psychiatric Times, NY -
While tremendous therapeutic advancements have been made, patients with rheumatoid arthritis (RA) have a myriad of comorbidities, including fatigue, ...

ChattahBox
FDA Panel Backs Rheumatoid-Arthritis Drug
Wall Street Journal - Jul 29, 2008
By JARED A. FAVOLE WASHINGTON -- A panel of medical experts on Tuesday backed Roche Holding AG's rheumatoid arthritis drug Actemra, despite safety concerns ...
FDA Panel Backs Roche Rheumatoid Arthritis Drug, Actemra dBTechno
FDA Panel Backs New Drug for Moderate or Severe Rheumatoid Arthritis eFluxMedia
FDA Panel Backs Roche?s Rheumatoid Arthritis Drug TheMedGuru
Chatter Shmatter - Reuters
all 147 news articles »  OTC:RHHBY - SWF:RO - SWF:HUE
In Good Health ? Respect your elders ... keep them cool
Frederick News Post (subscription), MD - 35 minutes ago
The Arthritis & Osteoporosis Center of Maryland is looking for volunteers to participate in a study of an investigational drug for rheumatoid arthritis. ...
FDA: Roche's Actemra Appears Effective in Rheumatoid Arthritis
Wall Street Journal - Jul 25, 2008
By JARED A. FAVOLE and ANITA GREIL Roche Holding AG's Actemra appears effective at treating rheumatoid arthritis, a disease that can destroy joints and ...
Roche arthritis drug works: FDA staff Reuters
Place Your Biotech Bets Motley Fool
Roche arthritis drug works - US FDA staff Forbes
Reuters
all 26 news articles »  OTC:RHHBY - SWF:RO - SWF:HUE

BBC News
UK?s Nice Nixes Second Tries With Rheumatoid Arthritis Meds
Wall Street Journal Blogs, NY - Jul 21, 2008
... try with another one of several big-selling drugs for rheumatoid arthritis after a patient has failed treatment with a different medicine in the class. ...
Outcry at Government drug watchdog's plan to cut arthritis treatments Telegraph.co.uk
Restricting arthritis drugs ?a prescription for pain? Times Online
Arthritis drug access 'curbed' BBC News
News-Medical.net - Reuters
all 151 news articles »
*ROCHE: FDA COMMITTEE RECOMMENDS ACTEMRA FOR TREATMENT OF ...
華富財經, Hong Kong - Jul 29, 2008
In relation to the stock quote service (the "Quote Service") information, the stock price, trade volume and turnover are provided by The Stock Exchange of ...

Oneindia
Arthritis May Double Heart Attack
Oneindia, India - Jul 31, 2008
Patients with rheumatoid arthritis are twice as likely to suffer a heart attack, suggests a new study. Rheumatoid arthritis, lupus, and related autoimmune ...
Joint Inflammation and Heart Disease Linked Newswise (press release)
all 12 news articles »
Genetics, lifestyle affect bone density
Daytona Beach News-Journal, FL - Aug 3, 2008
Even though you can't change your race, your genes, or the fact that you have rheumatoid arthritis, there are risk factors that you can avoid and treatment ...
When health problems are skin deep
Chester DailyLocal.com,  USA -
"It's very often similar in its clinical presentation and radiographically to rheumatoid arthritis," he said, adding that a blood test can determine if a ...
Source: Google News

… American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis … -
FC Arnett, SM Edworthy, DA Bloch, DJ McShane, JF … - Arthritis Rheum, 1988 - ncbi.nlm.nih.gov
Arthritis Rheum. 1988 Mar;31(3):315-24. The American Rheumatism Association 1987
revised criteria for the classification of rheumatoid arthritis. ...

… of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis -
C Bombardier, L Laine, A Reicin, D Shapiro, R … - New England Journal of Medicine, 2000 - content.nejm.org
... EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. ...
of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis," N Engl ...

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis -
PE Lipsky, DMFM van der Heijde, EW St Clair, DE … - New England Journal of Medicine, 2000 - content.nejm.org
... cell wall arthritis of mice. Ann Rheum Dis 66: 452-457 [Abstract] [Full Text];
O'Dell, JR (2007). The BeSt Way to Treat Early Rheumatoid Arthritis?. ...

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)-Fc … -
LW Moreland, SW Baumgartner, MH Schiff, EA Tindall … - New England Journal of Medicine, 1997 - content.nejm.org
... Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon gamma is
highly expressed in synovium of rheumatoid arthritis compared with ...

… vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis The CLASS Study … -
FE Silverstein, G Faich, JL Goldstein, LS Simon, T … - JAMA, 2000 - Am Med Assoc
... Design The Celecoxib Long-term Arthritis Safety Study (CLASS), a double ... 8059 patients (
18 years old) with osteoarthritis (OA) or rheumatoid arthritis (RA) were ...

… monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. -
MJ Elliott, RN Maini, M Feldmann, JR Kalden, C … - Lancet, 1994 - ncbi.nlm.nih.gov
... and define a new direction for the treatment of rheumatoid arthritis. ... Arthritis,
Rheumatoid/pathology; Arthritis, Rheumatoid/therapy*; Dose-Response Relationship ...

… alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant … -
R Maini, EW StClair, F Breedveld, D Furst, J … - Lancet, 1999 - informedpharmacotherapy.com
... Infliximab in rheumatoid arthritis: An ATTRACTive option? ... Patients in all arms
had recalcitrant rheumatoid arthritis of comparable severity. ...

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis -
JM Bathon, RW Martin, RM Fleischmann, JR Tesser, … - New England Journal of Medicine, 2000 - content.nejm.org
... Therapeutic Strategies for Rheumatoid Arthritis. NEJM 350: 2591-2602 [Full Text];
Mease, P (2004). TNF{alpha} therapy in psoriatic arthritis and psoriasis. ...

Etanercept Therapy in Rheumatoid Arthritis: A Randomized, Controlled Trial -
LW Moreland, MH Schiff, SW Baumgartner, EA Tindall … - Annals of Internal Medicine, 1999 - annals.highwire.org
... The American Rheumatism Association 1987 revised criteria for the classification
of rheumatoid arthritis Arthritis Rheum. 1988;31:315-24.[Medline]. 22. ...

American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis -
DT Felson, JJ Anderson, M Boers, C Bombardier, D … - Arthritis Rheum, 1995 - doi.wiley.com
... From the Committee on, Outcome Measures in Rheumatoid Arthritis Clinical Trials,
a ... MPH, Jennifer J. Anderson, PhD: Boston University Arthritis Center, Boston ...

Source: Google Scholar
 
 

Rheumatoid arthritis and osteoarthritis, role for Wnt-7b

 
 
The cellular signaling protein Wnt, which is involved in embryonic development and cancer, contributes to disease progression of both rheumatoid arthritis and osteoarthritis.

Wnt is best known as a proto-oncogene because its disruption can lead to cancer in various organs such as colon, lung, and breast. However, mounting evidence also points to its involvement in arthritic joint disease. Comprehensive analysis of the entire Wnt gene family in the progression of arthritis has been lacking until now.

Researchers at Shinshu University School of Medicine in Nagano, Japan, examined 19 members of the Wnt gene family to determine exactly which of these genes were involved in arthritic joint disease.

This extensive study, performed under the direction of Shigeyuki Wakitani, at the Department of Orthopedic Surgery, Shinshu University School of Medicine, examined joint tissue from patients who underwent total knee replacement for rheumatoid arthritis ( RA ), osteoarthritis ( OA ), or non-arthritic injury.

Using several molecular methods, Wakitani's group identified Wnt-7b and -10a as genes that were significantly upregulated in the arthritic knee tissues.
However, protein expression studies revealed that only Wnt-7b was produced in arthritic joints, with strong protein localization to the synovium ( or joint lining ) and weak localization to cartilage and bone.
In addition, strong Wnt-7b expression most frequently correlated with areas of high inflammation.

The authors also examined whether inflammatory cytokines were produced in primary cartilage and synovial cells from arthritic versus normal joints.
While OA cells did not differ from controls, primary RA cells produced TNF-a, IL-1beta and IL-6 at levels 2- to 4-fold above controls.
Importantly, this effect could be replicated in normal cells when they were engineered to express Wnt-7b, demonstrating the importance of Wnt-7b in the inflammatory response of RA.

The findings identify a role for Wnt-7b in arthritic processes. Arthritic diseases manifest differently depending on the type, with RA exhibiting inflammation of the synovium and loss of cartilage and bone and OA exhibiting narrowing of joint space, loss of protective cartilage, and growth of bone cysts ( or osteophytes ).

Interestingly, Wnt-7b was strongly upregulated within joints at sites of disease manifestation: mainly in synovium of RA but in synovium, cartilage, osteophyte, and bone of OA. In addition, the findings that Wnt-7b was frequently found at sites of inflammation and elicited an inflammatory response are consistent with inflammation as a hallmark of RA disease.

" More specific analyses such as gain-of-function and loss-of-function study of Wnt-7b will give us a clue which Wnt-7b would be an important pathobiological factor in rheumatoid arthritis," added Nakamura. Future studies will investigate the role of Wnt and its signaling partners in arthritic joint destruction. Further delineation of the Wnt signaling pathway in arthritic progression may provide future therapies for the growing number of arthritis suffers.

According to The National Center for Health Statistics, over 42 million US adults, or 20% of the population, complained of arthritic symptoms in 2002.

Source: American Journal of Pathology, 2005
 
 
 
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