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Recent News and Articles on the Keywords: cancer + thyroid + test  Related to the article below (Last Update: 8/4/2008)

Exelixis starts thyroid cancer treatment test
Bizjournals.com, NC - Jul 21, 2008
Exelixis Inc. started a late-stage clinical trial of a treatment for medullary thyroid cancer. The South San Francisco company (NASDAQ: EXEL) will test the ...EXEL
Health calendar
Asheville Citizen-Times, NC -
THYROID DISFUNCTION: Learn how to heal the thyroid, 6:30 pm Aug. 12, Earth Fare South, 1856 Hendersonville road, Asheville. Free; pre-registration required. ...

Malaysia Star
The science of energy healing
Malaysia Star, Malaysia - Aug 2, 2008
... breast cancer 95, nasopharyngeal cancer 69, lymphoma 54, colorectal cancer 49, liver cancer 45, thyroid cancer 8, osteosarcoma 4, and other types. ...
Future imperfect
Nashua Telegraph, NH - Aug 3, 2008
Those whose chests were radiated are at risk for breast cancer, thyroid cancer and lung cancer; those who received radiation in the pelvic area could suffer ...
Any Lab Test Now Offering Blood Test for Breast Cancer Detection
EVLiving - Jul 30, 2008
In addition to the BT Test, Any Lab Test Now offers numerous standard healthcare tests including cholesterol, glucose, liver function, thyroid, STD?s, ...
Blood Vessel Drug May Treat Advanced Thyroid Cancer
About - News & Issues, NY - Jul 8, 2008
When thyroid cancer is advancing aggressively, metastasizes to other locations, and becomes resistant to the usual treatment of radioiodine, the treatment ...
Rebuilding their lives with Finn
Brunswick Times Record,  United States - Jul 30, 2008
She had a thyroid test, acupuncture, massage and saw an orthopedic doctor, but nothing worked. She tried yoga, but the lump in her back grew bigger and the ...
Hidden in plain view
Science News - Jul 18, 2008
These studies included about 1300 tissue samples from various cancer types, including lung, thyroid, liver, colon and breast cancer. ...
Fatigue: When To Rest And When To Worry
WBZ, MA - Jul 30, 2008
Barbara was actually disappointed when her test results came back normal. "I was seriously hoping that I had an issue with my thyroid," she joked, ...
Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III ...
FOXBusiness - Jul 11, 2008
"Melanoma is considered the deadliest form of skin cancer and among the most difficult to treat," said Robert J. Spiegel, MD, chief medical officer and ...SGP - SGP-B - OTC:CMTX
Source: Google News

Outcome of Differentiated Thyroid Cancer with Detectable Serum Tg and Negative Diagnostic 131I Whole … -
F Pacini, L Agate, R Elisei, M Capezzone, C … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc
... Measurement of serum Tg. Starting in 1974, serum Tg became a routine test
in thyroid cancer patients. Serum Tg was measured by home ...

… with Recombinant Human TSH Useful in the Follow-Up of Differentiated Thyroid Cancer after Thyroid -
EL Mazzaferri, RT Kloos - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc
... Wilcoxon rank-sum test or ANOVA was applied to detect differences among means ... review
board approved our ongoing follow-up study of patients with thyroid cancer. ...

Quality-of-life changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy. -
KH Dow, BR Ferrell, C Anello - Thyroid, 1997 - ncbi.nlm.nih.gov
... QOL tools available to evaluate QOL in patients with thyroid cancer. The purposes
of this longitudinal, repeated-measures study were to: (1) test a new ...

… AND OFF THYROID SUPPRESSIVE THERAPY IN THE FOLLOW-UP OF PATIENTS WITH DIFFERENTIATED THYROID CANCER -
F PACINI, R LARI, S MAZZEO, L GRASSO, D TADDEI, A … - Clinical Endocrinology, 1985 - Blackwell Synergy
... non-toxic goitre and in patients with metastatic thyroid cancer (Schlumberger ei ...
Tg autoantibodies as assessed by passive haemoagglutination (Thyroid Test Kit. ...

… Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid -
DS Cooper, GM Doherty, BR Haugen, RT Kloos, SL Lee … - Thyroid, 2006 - liebertonline.com
... Serum thyroglobulin levels can be elevated in most thyroid diseases and is an
in- sensitive and nonspecific test for thyroid cancer (23). R3. ...

… case-control study testing the hypothesis that seafood increases the risk of thyroid cancer -
E Glattre, T Haldorsen, JP Berg, I Stensvold, K … - Cancer Causes and Control, 1993 - Springer
... risk relationship between seafood consumption and thyroid cancer. ... the excellent data
of the Cancer Registry of ... Health Screening Service and test the possible ...

… Human Thyrotropin and Thyroid Hormone Withdrawal for the Detection of Thyroid Remnant or Cancer 1 -
BR Haugen, F Pacini, C Reiners, M Schlumberger, PW … - Journal of Clinical Endocrinology & Metabolism, 1999 - Endocrine Soc
... life measures between treatment groups were made using the Wilcoxon signed rank
test within each ... For patients with cancer outside the thyroid bed, an ...

thyroid cancer and thyroid nodules: evidence for the prolonged effects of radiation on the thyroid -
AB Schneider - Journal of Clinical Endocrinology & Metabolism, 1993 - Endocrine Soc
... carried out using a score test of the null hypothesis 0 = 0. To evaluate whether
the dose-response trend ... 2). Thyroid cancer and thyroid nodules were rare in ...

… and Outcome of Medullary Thyroid Cancer: Experience in 10,864 Patients with Nodular Thyroid -
R Elisei, V Bottici, F Luchetti, G Di Coscio, C … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc
... MA 1998 Prophylactic thyroidectomy, based on direct genetic testing, in patients
at ... F, Elisei R, Fugazzola L, Cola A, Pinchera A 1991 Medullary thyroid cancer. ...

Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies -
E Ron, JH Lubin, RE Shore, K Mabuchi, B Modan, LM … - Radiat Res, 1995 - JSTOR
... the large difference in thyroid cancer incidence did not influence the slope of
the dose response significantly in either the atomic bomb sur- vivors (test for ...

Source: Google Scholar
 
 

Blood test for thyroid cancer may detect recurrence early

 

 
A blood test for thyroid cancer can detect persistent or recurrent disease even before doctors can find any trace of a tumor, according to a new study.
The findings suggest that people treated for the disease should be examined regularly for early signs of recurrence.

The study, by researchers at The Ohio State University ( OSU ) Comprehensive Cancer Center ( CCC ), examined how well a test for thyroid cancer can predict whether the disease will recur.

The findings were published in the Journal of Clinical Endocrinology & Metabolism.

The test measures a protein known as thyroglobulin ( Tg ), which is made by thyroid-cancer cells.
The measurement is taken after a person is injected with a relatively new drug known as thyrotropin alfa, or Thyrogen.
The drug allows Tg testing without the sometimes debilitating side effects of hypothyroidism that otherwise accompany the test when stimulation testing is done.

“We were surprised to find that even with relatively low thyroglobulin levels, and even when there is no sign of a tumor, about 80 percent of patients had a recurrence of their cancer within three to five years,” says first author Richard T. Kloos, associate professor of internal medicine and of radiology.

“This indicates that we are detecting these tumors very early, and that time and diligence may be needed to find them.”

The study also found that even when Tg levels are very low or undetectable, about 2 to 5 percent of patients still have a recurrence after three to five years.

“Currently, some thyroid-cancer treatment guidelines say that these patients may never need further testing, but our data contradict that,” says Kloos, co-director of the Thyroid Cancer Unit at the OSU CCC.

Thyroid cancer is usually treated surgically by removing the thyroid gland, followed by drinking radioactive iodine to kill any remaining cancer cells. Patients must then take synthetic thyroid hormone for life.

With all thyroid cells eliminated, the Tg level should be zero, and its presence later signals a possible return of the disease.
Sometimes, however, low levels of Tg can be present following treatment, and slowly decline over time.

In the past, Tg testing required that patients stop taking their synthetic thyroid hormone several weeks before the test.

“That worked fairly well, except that some people became miserable after they stopped taking their synthetic thyroid hormone and became hypothyroid,” Kloos says. “Some patients claimed that they'd rather die of their disease than go through that regularly.”

Withdrawing from thyroid hormone can cause fatigue, weight gain, constipation, mental dullness, lethargy, depression and other symptoms.

Thyrogen, approved for use in 1998, allowed people to have a stimulated Tg test and continue taking the synthetic hormone.

The study sought to help interpret the results of the Thyrogen-assisted Tg test. It involved 107 patients ( 88 women and 19 men; average age 36 years ) treated for papillary, follicular or Hurthle cell thyroid cancer. Following surgery and radioactive iodine treatment, the patients were injected with Thyrogen and tested for Tg levels between January 1999 and March 2001.

The patients were divided into three groups based on their Tg reading. Group 1 patients had Tg levels below 0.5 ng/dL, group 2 had Tg levels of 0.6 to 2.0, and Group 3 had Tg levels greater than 2.0.

After three to five years, the researchers found recurrent tumors in about 80 percent of the patients with Tg levels above 2.0, and in about 2 percent of those with Tg levels below 0.5.

An estimated 25,690 new cases of thyroid cancer are expected in 2005, with 19,190 of those expected to occur in women; 1,490 people are expected to die of the disease. In addition, about 330,000 living Americans have been treated for thyroid cancer, about 20 percent of whom are likely to have a recurrence.

Source: Ohio State University, 2005
 
 
 
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