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Recent News and Articles on the Keywords: new + cancer + pokemon  Related to the article below (Last Update: 8/4/2008)

Discovered Vision Protein Named After Pikachu
Nintendo World Report, CA - Jul 30, 2008
In 2005, a gene involved in cancer was named Pokemon, short for POK erythriod myeloid ontogenic factor. The name was changed to Zbtb7 after Nintendo ...
Numerous life questions to ask God
GwinnettHerald.com, GA - Jul 11, 2008
I toured the room shared by three stair-step brothers who proudly showed me their favorite toys and Pokemon cards. I talked to a young man who just ...
Summer campers plan big event for Bloomfield family
MPNnow.com, NY - Jul 22, 2008
The father was a minister in a local church until he fell ill with non-Hodgkin?s lymphoma, a cancer of the immune system. Despite treatment, he is now in ...
Source: Google News

The Transcription Factor Pokemon: A New Key Player in Cancer Pathogenesis -
T Maeda, RM Hobbs, PP Pandolfi - Cancer Research, 2005 - AACR
... Review Articles. The Transcription Factor Pokemon: A New Key Player in Cancer
Pathogenesis. Takahiro Maeda , Robin M. Hobbs and Pier Paolo Pandolfi ...

Role of the proto-oncogene Pokemon in cellular transformation and ARF repression -
T Maeda, RM Hobbs, T Merghoub, I Guernah, A Zelent … - Nature, 2005 - nature.com
... To test this hypothesis we therefore assessed the role of Pokemon in cancer
pathogenesis through a direct genetic approach. Top of page ...

Regulation of the p14ARF-Mdm2-p53 pathway: An overview in breast cancer -
A Agrawal, J Yang, RF Murphy, DK Agrawal - Experimental and Molecular Pathology, 2006 - Elsevier
... or Link Using DOI (Opens New Window) Copyright ... Protein, Suppressor/Activator, Cancer,
Component triggered, Ref. Pokemon, Suppressor, Breast, lung, colon, bladder ...

Molecular Target-Based Treatment of Human Cancer: Summary of the 10th International Conference on … -
A Zelent, K Petrie, Z Chen, R Lotan, M Lubbert, MS … - Cancer Research, 2005 - AACR
... Pier Paolo Pandolfi (Memorial Sloan-Kettering Cancer Center, New York, NY) presented
evidence that PLZF-related protein POKEMON (also called LRF, FBI-1, and ...

Pokemon's cancer role revealed
M Paterlini - Research news, 2005 - genomebiology.com
... Pokemon's cancer role revealed [20 January 2005]. Important new insights into
neoplastic development provided by report in. Scientists at Memorial Sloan ...
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Pokemon Represses Arf in Promoting Cellular Transformation -
WS El-Deiry - landesbioscience.com
... important, because the Pokemon protein plays such a crucial role in the formation
of cancer, it could prove to be an effective target for new drug therapies.". ...
-

Overexpression of Pokemon in non-small cell lung cancer and foreshowing tumor biological behavior as …
ZH Zhao, SF Wang, L Yu, J Wang, H Chang, WL Yan, J … - Lung Cancer, 2008 - ncbi.nlm.nih.gov
... Expression of transcription factor Pokemon in non-small cell lung cancer and ... Int
J Cancer. 2005]; A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and ...

A New Way to Prevent Pokemon Seizures -
J Parra - Journal Watch Pediatrics and Adolescent Medicine, 2005 - Mass Med Soc
... A New Way to Prevent Pokemon Seizures. ... Parra and colleagues applied a new
digital-filtering technique to an especially epileptogenic segment of Pokemon. ...
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The ?Pokemon?(ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer
A Salas, A Vega, RL Milne, M Garc?a-Magari?os, ? … - Clinical Medicine: Oncology - doaj.org
... Issn: 11779314. EIssn: Year: 2008. Volume: 2. Issue: pages/rec.No: 357-362. Key
words, breast cancer ; ZBTB7 ; POKEMON ; association study ; case-control. ...
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What your patients are reading on WebMD
TV Avoiding'Pokemon'Seizures From, V Games - medscape.com
... Avoiding 'Pokemon' Seizures From TV, Video Games. The Epilepsy ... ago that French fries
contain the cancer-causing chemical ... As Reported by The New York Times. Green ...

Source: Google Scholar
 
 

Pokemon, a new cellular oncogene essential for the development of cancer

 
 
Scientists at Memorial Sloan-Kettering Cancer Center ( MSKCC ) identified a new cellular oncogene essential for the development of cancer.
The investigators named the gene Pokemon ( for POK Erythroid Myeloid Ontogenic factor ).

The work was published in the journal Nature.

Oncogenes are genes that, when mutated or dysfunctional, lead normal cells to become cancerous.

" There are a number of genes that can cause cancer, the so-called oncogenes, but Pokemon is unique in that it is needed for other oncogenes to cause cancer." said MSKCC cancer geneticist Pier Paolo Pandolfi, the senior author of the study. " More important, because the Pokemon protein plays such a crucial role in the formation of cancer, it could prove to be an effective target for new drug therapies."

Pokemon works by controlling the pathways that are required to transform normal cells to cancerous ones.
The researchers found that when they "knocked out" the Pokemon gene in mice, that transformation was blocked and cells do not become cancerous.
A drug that could block the protein's function in the same way could be a powerful anticancer agent.

The investigators confirmed Pokemon's cancer-causing role by inserting the oncogene into mice.
Pokemon does its damage by repressing the function of other proteins, including a tumor suppressor called ARF.
The mice developed aggressive, fatal forms of lymphoma.

In further work, using a technique called tissue micro arrays to study tumor samples from people with many types of cancer, they confirmed that Pokemon is present in very high levels in certain types of B-cell and T-cell lymphomas.
They also found that tumors with high levels of Pokemon protein were much more likely to be aggressive.

"Pokemon is a member of a family of proteins that are known to be transcription factors and are mutated in human cancer," said Takahiro Maeda, who was the paper's first author. " It is likely that the protein plays a role in solid tumors as well, and we now have means to specifically interfere with the activity of these transcription factors."

Source: Memorial Sloan-Kettering Cancer Center, 2005
 
 
 
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