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Recent News and Articles on the Keywords: 0.20 + web + cancer  Related to the article below (Last Update: 8/4/2008)

Alexion Reports Second Quarter 2008 Results
PR Newswire (press release), NY - Jul 29, 2008
In addition, Alexion is pursuing development of an anti-CD200 monoclonal antibody as a treatment for patients with cancer, and evaluating development of ...ALXN
Source: Google News

Evaluation of an internet support group for women with primary breast cancer -
AJ Winzelberg, C Classen, GW Alpers, H Roberts, C … - Cancer, 2003 - doi.wiley.com
... 2003 American Cancer Society. DOI 10.1002/cncr.11174 KEYWORDS: internet,
primary breast carcinoma, social support group, web, cancer. ...

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression … -
TR Golub, DK Slonim, P Tamayo, C Huard, M … - Science, 1999 - sciencemag.org
... In these cases, the PS scores are much lower (median PS = 0.20 and 0.34, respectively ...
Details are provided on our Web site. ... S. Turc-Carel, et al., Cancer Genet. ...

Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2 -
MC King, JH Marks, JB Mandell - Science, 2003 - sciencemag.org
... that you are using a browser that does not support current Web standards. ... Relative
with ovarian cancer, Mother or sister, 50, 0.20, 0.08, 0.04, 0.32, 3.5, <10 -6 ...

Use of information resources by patients with cancer and their companions -
EM Basch, HT Thaler, W Shi, S Yakren, D Schrag - Cancer, 2004 - doi.wiley.com
... resource use was 0.75 (kappa coefficient 0.20), and the concor ... of Internet use by
patients with cancer, but little ... information gath- ering on the web and other ...

[CITATION] Thinkhealth. com: A Web Site to Promote Early Detection and Screening for Breast Cancer
BR Krohn, RE Slocum
-

Information Gathering Over Time by Breast Cancer Patients -
MJ Satterlund, KD McCaul, AK Sandgren - Journal of Medical Internet Research, 2003 - pubmedcentral.nih.gov
... greater internet use ( r= 0.26, r= 0.20, and r ... Efforts to evaluate cancer information
on the Internet ... conducted a systematic evaluation of Web sites identified ...

Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search -
JR Smith? - Science, 1996 - sciencemag.org
... using a browser that does not support current Web standards ... 2. Linkage results for
susceptibility to prostate cancer and nine ... D1S466, 5.1, 2.41, 0.20, 4.71, 0.000001 ...

[PDF] Systematic variation in gene expression patterns in human cancer cell lines -
DT Ross, U Scherf, MB Eisen, CM Perou, C Rees, P … - Nat Genet, 2000 - microarray.icmb.utexas.edu
... and organs 1?4 . The DTP has assessed many molecular features of the cells related
to cancer and chemothera ... 0.60 0.20 -0.20 -0.60 >8X 4X 2X 1X 2X 4X >8X Fig. ...
-

Protective association of aspirin/NSAIDs and esophageal cancer: A systematic review and meta- … -
DA Corley, K Kerlikowske, R Verma, P Buffler - Gastroenterology, 2003 - Elsevier
... Cochrane collaboration, Bio- sis, and Web of Science ... b Cancer Prevention Study II,
prospective national volunteer ... 0.43?0.78; test for homogeneity, P 0.20). ...

[PDF] Interleukin-1 polymorphisms associated with increased risk of gastric cancer -
EM El Omar, M Carrington, WH Chow, KEL McColl, JH … - Nature, 2000 - eprints.gla.ac.uk
... (n ? 58) IL-1B 2 31=IL-1B ? 3954 0.527 0.171 0.275 0.027 -0.20 2.3 0.13 ... Gastric cancer
controls IL-1B 2 31=IL-1B 2 511 0.699 0.002 0.000 0.298 1.00 426.6 ...
-

Source: Google Scholar
 
 

Non-small cell lung cancer: disease control rate may be a more powerful predictor of survival than tumor shrinkage

 
 
Researchers evaluate the effectiveness of a new antitumoral therapy by looking at how tumors respond to it. But in the case of advanced non-small cell lung cancer ( NSCLC ), there may be a better way to assess effectiveness. A new Southwest Oncology Group ( SWOG ) study, led by a team of researchers at University of California Davis Cancer Center, suggests that an alternative measurement – " disease control rate " – may be a more powerful predictor of survival than tumor shrinkage.

" If validated, this 'early look' statistical measure could enhance efficacy assessment, with broad implications for the design of future cancer clinical trials for advanced non-small cell lung cancer," said Primo N. Lara, at UC Davis Cancer Center and lead author of the new study.

Lara and his colleagues defined the disease control rate as the percentage of patients who have a partial or complete response to an investigational treatment plus those whose disease stabilizes.

" In the past, we have used the complete response rate plus the partial response rate, or CR + PR, as our sole efficacy measure," Lara said. " The disease control rate, DCR, is the complete response rate plus the partial response rate plus the rate of patients with stabilized disease, or DCR = CR + PR + SD. This measure may better predict how a new drug will affect survival."

In their study, the investigators pooled data from 984 patients with advanced non-small cell lung cancer who participated in three randomized SWOG trials of Platinum-based chemotherapy regimens.

Of the 886 patients who were alive two months after beginning treatment, 62 percent had stable disease, meaning their cancer had not progressed since entering the clinical trial. Another 19 percent had a complete or partial response, meaning their tumors had disappeared or reduced in size. Adding the two measures together yielded a disease control rate of 81 percent.

When Lara and his colleagues compared the disease control rate to the standard measure ( CR+PR ), they found that the disease control rate had a much stronger association with survival.

Lung cancer is the leading cause of cancer death among both men and women in the United States. According to the American Cancer Society, an estimated 174,470 people will get lung cancer this year, and 162,460 will die from it. Non-small cell lung cancer accounts for about 80 percent of lung cancer cases.

Source: University of California, Davis - Health System, 2006
 
 
 
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