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Recent News and Articles on the Keywords: bacterial + ibs + overgrowth  Related to the article below (Last Update: 8/5/2008)

Phase 3 Rifaximin Trial for Non-Constipation IBS
EndoNurse, AZ - Jul 9, 2008
Rifaximin, a gut-specific antibiotic, may be a strong candidate for the treatment of IBS by targeting small intestinal bacterial overgrowth. ...
Source: Google News

Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome -
M Pimentel, EJ Chow, HC Lin - American Journal of Gastroenterology, 2000 - Blackwell Synergy
... (2002) Do antibiotics influence IBS?. ... (2001) Small intestinal bacterial overgrowth
is associated with irritable bowel syndrome: the cart lands ...

Small Intestinal Bacterial Overgrowth A Framework for Understanding Irritable Bowel Syndrome -
HC Lin - JAMA, 2004 - Am Med Assoc
... CLINICIAN'S CORNER Small Intestinal Bacterial Overgrowth ... Context Irritable bowel
syndrome (IBS), which affects 11% to 14% of the population, is a puzzling ...

… of MMC Is Found in IBS Subjects with Abnormal Lactulose Breath Test, Suggesting Bacterial Overgrowth -
M Pimentel, EE Soffer, EJ Chow, Y Kong, HC Lin - Digestive Diseases and Sciences, 2002 - Springer
... described an association between irritable bowel syndrome (IBS) and abnormal lactulose
breath test, suggesting small intestinal bacterial overgrowth (SIBO). ...

Detection of Bacterial Overgrowth in IBS Using the Lactulose H2 Breath Test: Comparison with 14C-d- … -
B Walters, SJ Vanner - The American Journal of Gastroenterology, 2005 - Blackwell Synergy
... OBJECTIVES Recent reports suggest bacterial overgrowth is commonly associated with
irritable bowel syndrome (IBS) when diagnosed using the lactulose hydrogen ...

Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case- … -
A LUPASCU, M GABRIELLI, EC LAURITANO, E … - Alimentary Pharmacology & Therapeutics, 2005 - Blackwell Synergy
... in the Primary Treatment and Retreatment of Bacterial Overgrowth in IBS. ... 2007) Restless
Legs Syndrome in Patients with Irritable Bowel Syndrome: Response to ...

… and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth -
G Nucera, M Gabrielli, A Lupascu, EC Lauritano, A … - Alimentary Pharmacology & Therapeutics, 2005 - Blackwell Synergy
... and Retreatment of Bacterial Overgrowth in IBS. ... (2006) Bacteria and irritable bowel
syndrome: The evidence for small intestinal bacterial overgrowth. ...

Small intestinal bacterial overgrowth in patients with irritable bowel syndrome -
I Posserud, PO Stotzer, ES Bj?rnsson, H … - British Medical Journal, 2007 - gut.bmj.com
... ABSTRACT Background: Small intestinal bacterial overgrowth (SIBO) has been proposed
to be common in irritable bowel syndrome (IBS), with altered small-bowel ...

Lactulose breath testing, bacterial overgrowth, and IBS: just a lot of hot air? -
WL Hasler - Gastroenterology, 2003 - Elsevier
... The pathogenesis of irritable bowel syndrome (IBS) is poorly understood. Recently,
small intestinal bacterial overgrowth was proposed to contribute to IBS ...

Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel … -
M Pimentel, EJ Chow, HC Lin - American Journal of Gastroenterology, 2003 - Blackwell Synergy
... the treatment of small intestinal bacterial overgrowth. ... Methane Production in IBS
Correlates With ... (2007) Probiotics and irritable bowel syndrome: a rationale ...

Small intestinal bacterial overgrowth and the irritable bowel syndrome -
SM Riordan, CJ McIver, VM Duncombe, MC Thomas, A … - American Journal of Gastroenterology, 2001 - Blackwell Synergy
... Rome I criteria for irritable bowel syndrome (IBS). A high proportion (78%) were
considered to have small intestinal bacterial overgrowth (SIBO) based on LBHT ...

Source: Google Scholar

Discriminating Between A Bacterial Overgrowth And IBS Using Simple Breath Test
The gastrointestinal (GI) tract is colonized by bacteria immediately after birth; Escherichia coli, Streptococci and Clostridi are the first bacteria harboured by the colon, followed by anaerobic Enterococci, Lattobacilli and Bacteroidi. These commensal bacteria inhabiting the human intestine (i.e., intestinal microflora) participate in the development and maintenance of gut sensory and motor functions, including the promotion of intestinal propulsive activity; on the other hand, intestinal motility represents one of the major control systems of gut microflora, though the sweeping of excessive bacteria from the lumen. There is emerging evidence indicating that changes in this bi-directional interplay contribute to the pathogenesis of gut diseases, such as small intestinal bacterial overgrowth (SIBO).

Many factors affect the type and distribution of the bacteria along the GI tract, starting from the type of delivery and nursing in the first days of life, up to the food habits during the adult life: a SIBO is often present in adult population of westernized countries, because of poor daily intake of fibres and faecal stasis; such an overgrowth contributes to a chronic inflammation on intestinal mucosa and development of symptoms, such as abdominal pain, diarrhoea or stipsis.
These symptoms look like those of inflammatory bowel diseases (IBS) and, unfortunately, most of these patients with a bacterial overgrowth are inappropriately treated with topically-active non-steroidal anti-inflammatory agents. In fact, these compounds have no antibacterial activity and, therefore, they do not remove the causative factors of the symptoms (bacterial overgrowth) and are likely to provoke even severe adverse events.

The "breath test" is a recently developed test, which is able to detect elevated concentrations of hydrogen in the expired air. In presence of a SIBO, dietary carbohydrates are metabolised with production of massive amounts of hydrogen that are eliminated with the breath. Thus, the "breath test" consists in administering 50-75 grams of lactulose and assaying the concentrations of hydrogen in the expired air; if these concentrations exceed 10 to 20 part per million, the subject is suspected to have a SIBO and should be appropriately treated with antibiotics.

Clinicians should be encouraged to perform a "breath test" to promptly identify a bacterial overgrowth, because the disorder has several systemic consequences ranging from malabsorption of lipids and liposoluble vitamins and loss of electrolytes, to a more severe translocation of bacteria (usually, gram-negative and aerobic bacteria, such as Escherichia, Proteus, Enterobacter and Klebsiella) from the GI tract to extraintestinal tissues; all these factors may lead to sepsis and multiorgan failure.

Today, there is an effective treatment for bacterial overgrowth, which is rapidly corrected by the use of locally acting non-absorbable antibiotics, such as rifaximin polimorph A, which reverses the process (intestinal bacterial overgrowth) and prevents the cascade of events leading from intestinal low-grade inflammation to symptom development.


Source: Jing Zhu
World Journal of Gastroenterology
 
 
 
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