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Recent News and Articles on the Keywords: nipah + virus + 0.33  Related to the article below (Last Update: 8/5/2008)

NBAF's focus: The study of some very bad stuff
Manhattan Mercury, KS - Aug 3, 2008
The disease: According to the WHO, Nipah Virus was discovered in 1999 and found to cause disease in animals (including swine) and humans. ...
Hendra virus puts the horse world on high alert again
News-Medical.net, Australia - Jul 10, 2008
Laboratory tests are used to diagnose Hendra virus. Hendra virus is a close cousin of the Nipah virus also carried by fruit bats which is capable of causing ...
?Outbreak actions protected by law?
Malaysia Star, Malaysia - Jul 15, 2008
PUTRAJAYA: The Government?s actions in addressing the 1998-99 Nipah virus epidemic are protected by law, the Federal Court heard. ...

Sin Chew Jit Poh
Court To Hear Govt?s Final Bid Stop Pig Farmers? Suit
Sin Chew Jit Poh, Malaysia - Jul 12, 2008
The case is filed by 185 victims of the the Nipah Virus outbreak in 1999, claiming for losses suffered during the epidemic. The Federal Government together ...
Will climate change hit health?
Independent Online, South Africa - Jul 18, 2008
Another example according to Schoub is the Nipah virus, which broke out in Malaysia in the late 1990s and which also has a very high fatality rate of 40 ...
Flora mayor optimistic on bio lab chances
Jackson Clarion Ledger, MS - Aug 3, 2008
... facility where diseases such as foot and mouth disease, classical swine fever, African swine fever, Nipah virus and Japanese encephalitis are studied. ...

Manhattan Mercury
NBAF opponent: Anthrax case raises concerns
Lawrence Journal World, KS - Aug 2, 2008
These include foot-and-mouth disease, classical swine fever, African swine fever, Rift Valley fever, Nipah virus, Hendra virus and others. ...
State officials lobby for NBAF in Manhattan presentation Lawrence Journal World
all 36 news articles »
Kansas makes pitch for lab on animal disease threats
Kansas City Star, MO - Jul 31, 2008
... of the most contagious and potentially devastating maladies, including foot-and-mouth disease, classical swine fever, Rift Valley fever and Nipah virus. ...
New York, not Athens, safest location for NBAF
Online Athens, GA - Jul 19, 2008
Currently, there are three diseases DHS lists for study at NBAF that can be fatal to humans - Rift Valley fever, Nipah virus and Hendra virus. ...
[exclusive] National Bio and Agro Defense Facility: Feasibility Study
TheMemoryHole.org - Jul 15, 2008
... Contagious Bovine Pleuropneumonia, Japanese Encephalitis virus, Nipah virus, and Hendra virus. The feasibility report adds Avian Influenza viruses, ...
Source: Google News

The emergence of Nipah and Hendra virus: pathogen dynamics across a wildlife-livestock-human … -
P Daszak, RK Plowright, JH Epstein, J Pulliam, S … - Disease Ecology: Community Structure and Pathogen Dynamics, 2006 - books.google.com
... 192 DISEASE ECOLOGY Table 13.1 Nipah virus seroprevalence? n Pieropus spp ... P. vampyrus
P. vampyrus 28 7 7 12 24 78 15 2 1 4 13 35 0.54 0.29 0.14 0.33 0.54 0.45 ...

RNA synthesis during infection by Hendra virus: an examination by quantitative real-time PCR of RNA … -
PJ Wright, G Crameri, BT Eaton - Archives of Virology, 2005 - Springer
... M:F:HN:L for mRNA were 1.00:1.05:1.00:0.38:0.33:0.03, with ... Rollin PE,Anderson LJ,
BelliniWJ, Rota PA (2000) Molecular characterization of Nipah virus, a newly ...

[PDF] HSB -
F District, GPO Box - Health and Science Bulletin, 2004 - icddrb.org
... Antibodies to Nipah-like virus in bats (Pteropus lylei ... Primary (first-time dengue
virus exposure) infection was suspected ... Pericardial effusion 2 (0.33) 0 (0.00 ...

Risk factors for human disease emergence -
LH Taylor, SM Latham, MEJ Woolhouse - Philosophical Transactions: Biological Sciences, 2001 - JSTOR
... zoonotic 1.93 taxonomic division viruses 4.33 bacteria 0.71 fungi 0.33 protozoa
2.49 ... in Kenya and Somalia (WHO Press Release 1998), Nipah virus in Malaysia and ...

DIFFERENTIATED CULTURES OF PRIMARY HAMSTER TRACHEALAIRWAY EPITHELIAL CELLS -
RK ROWE, SL BRODY, A PEKOSZ - In Vitro Cellular & Developmental Biology-Animal, 2004 - bioone.org
... were plated on thin-layer collagen-coated 0.4-?m pore 0.33 cm 2 ... infectious diseases,
including SARS coronavirus (Buchholz et al., 2004), Nipah virus (Wong et ...

Potential effects of a keystone species on the dynamics of sylvatic plague -
C Ray, SK Collinge - Disease Ecology: Community Structure and Pathogen Dynamics, 2006 - books.google.com
... I. OO (-) 1.00 H Streams 0.99 (-) 0.46 (-) Roads 0.34 (-) 0.33 (-) Urbanization
0.28 ... these communities, but note that episodes of rinderpest virus in ungulates ...

Use of Diffusion-Weighted MR Imaging in Differential Diagnosis Between Intracerebral Necrotic Tumors … -
B Desprechins, T Stadnik, G Koerts, W Shabana, C … - American Journal of Neuroradiology, 1999 - Am Soc Neuroradiology
... Lutsep (10) reported 0.29?0.33 x 10 -3 mm 2 /sec for ischemic lesions ... CC Lee, YY
Sitoh, AP Auchus, BK Michael Lin, and F. Hui Nipah Virus Encephalitis: Serial ...

The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and … -
CR Parrish, Y Kawaoka - Annu. Rev. Microbiol, 2005 - Annual Reviews
... several sequences different from CPV-2, and the new virus was antigenically ... that
differ on average by about 17 nucleotides (<0.33%), distributed throughout the ...

Assay cartridges and methods for point of care instruments -
CQ Davis, JE Liljestrand, J Leland, M Blankfard, … - US Patent 20,070,031,283, 2007 - freepatentsonline.com
... virus; Newcastle disease virus (VVND); Nipah Virus; Norwalk virus ... West Nile virus;
Yellow fever virus; and South ... in size or 3.3????0.98????0.33??? in size. ...
-

[PDF] ENVIRONMENTAL EFFECTS OF INTENSIFICATION OF AGRICULTURE: LIVESTOCK PRODUCTION AND REGULATION
U Chakravorty, DK Fisher, C Umetsu - bus.ucf.edu
... The spread of SARS in 2003 revealed the danger of spreading an unknown virus in
a relatively short period of time via international travelers. ...

Source: Google Scholar

New drug approach may treat Nipah, other viruses

Last Updated: 2007-12-20 17:12:17 -0400 (Reuters Health)

By Maggie Fox

WASHINGTON - Carefully designed drugs may be able to treat a variety of new and dangerous viruses, including the Nipah, Hendra and Ebola viruses, researchers reported on Thursday.

They used an approach that has worked with newly designed AIDS drugs known as entry inhibitors, and found it effective against Nipah and Hendra viruses.

These drugs stop certain types of viruses from getting into cells and could provide the first treatment for the mysterious and deadly infections, which have only recently emerged, said Dr. Anne Moscona of Weill Cornell Medical College in New York.

Writing in the Journal of Virology, Moscona and colleagues said they found a piece of a related virus called a parainfluenza virus that will fit in between the attacking virus and the cells it infects.

"These peptides act like door jambs - their particular shapes prevent 'doors' in the viral 'fusion protein' from closing as they should," Cornell's Dr. Matteo Porotto said in a statement.

"The parainfluenza peptide's shape simply makes it a better door jamb," Porotto added.

"This is really proof of concept," Moscona cautioned in a telephone interview.

No drug is immediately available from the research, she said. "By understanding the mechanism of how they work and how to make them work better, we can design better ones that might be viable."

Nipah virus was first seen when it killed more than 100 people out of 257 infected in Malaysia in 1999. The Hendra virus was first seen in Australia in 1994, when it killed two people and many horses. They are genetically related and both are believed to be carried by bats.

Bats are also suspected of carrying Ebola virus, which has killed several hundred people in outbreaks across Africa - most recently 35 in Uganda this month.

Moscona's team has been working with another sort of virus called parainfluenza virus, which causes respiratory infections in children. They found a protein particle called a peptide taken from parainfluenza virus can stop Hendra and Nipah viruses from entering and infecting human cells.

"We've been urgently working on this because right now there's absolutely nothing that can be done to stop this fatal, transmissible illness," Moscona said.

The approach should work against a range of viruses that infect human cells by using a protein on the outside that changes shape to break in, Moscona said.

Currently, the peptides that the team has been working with do not last long in the body. A good drug would provide protection for a long time, and might be used both after patients became infected and, in the case of an outbreak, to protect people not yet infected, Moscona said.

"So, we are also developing methods of sustained-release - for example, encasing the peptide in a polymer pellet that would be injected under the skin. The pellet would then release the drug slowly over the course of a week. That could form a viable method suitable for stockpiling," she said.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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