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Recent News and Articles on the Keywords: heart + disease + link  Related to the article below (Last Update: 8/5/2008)

Experts Urge Research on Sleep Apnea-Heart Disease Link
Washington Post, United States - Jul 28, 2008
MONDAY, July 28 (HealthDay News) -- Large-scale studies should be conducted to determine the exact link between sleep apnea and heart disease, ...

Voice of America
Ten Percent of Healthy People Injured from Silent Strokes
Voice of America -
The Framingham Heart Study began sixty years ago in Framingham, a town in the American state of Massachusetts. Much of what doctors know about heart disease ...
McMaster study looks at link between diesel fumes and diabetes
Daily Commercial News, Canada -
?The objective of this research is thus to study the prevalence of heart disease and diabetes in relation to diesel exhaust exposure while controlling for ...
Taking Depression to Heart
U.S. News & World Report, DC - Aug 1, 2008
1 (HealthDay News) -- Scientists have long observed a link between depression and heart disease. Now there's research to help pinpoint the symptoms of ...

PRESS TV
Migraine linked to heart disease risk
PRESS TV, Iran - Aug 3, 2008
A recent study published in Neurology reports a genetic link between the risk of heart disease, migraine with aura, and a genetic variant carried by 11 ...
Peripheral Arterial Disease: Diagnosis and Management
RedOrbit, TX -
For CME credit and the answers, see the link on our Web site at mayoclinicproceedings.com. 1. Rosamond W, Regal K, Friday G, et al; American Heart ...

HealthJockey.com
Depression could primarily cause cardiovascular trouble
HealthJockey.com, India - Aug 4, 2008
Hopefully, an added bonus will be to reduce the risk of developing or suffering from heart disease.? Even though a review of epidemiologic data, ...
Adults Who Eat Eggs for Breakfast Lose 65% More Weight
istockAnalyst.com, OR -
Protein in optimal health: Heart disease and type 2 diabetes. Am J Clin Nutr. 2008;87(suppl):1571S-5S. v. United States Agricultural Department, ...
Doctors urge study of link between heart disease, sleep apnea
MetroWest Daily News, MA - Jul 28, 2008
By Chris Dettro Two major heart groups called Monday for large-scale medical studies to determine the link between heart disease and the different forms of ...
Study finds heart disease, depression link
Vancouver Sun,  Canada - Jul 17, 2008
In the first study of its kind, researchers found a significant link between depression and heart disease among women but not among men. ...
Source: Google News

Chronic infections and coronary heart disease: is there a link? -
J Danesh, R Collins, R Peto - Lancet, 1997 - ncbi.nlm.nih.gov
... Chronic infections and coronary heart disease: is there a link? Danesh J,
Collins R, Peto R. Clinical Trial Service Unit, Nuffield ...

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? -
JS Yudkin, M Kumari, SE Humphries, V Mohamed-Ali - Atherosclerosis, 2000 - Elsevier
... reserved. Review article. Inflammation, obesity, stress and coronary heart
disease: is interleukin-6 the link? star, open. John S ...

Sex Differences in Physiological Responses to Stress and in Coronary Heart Disease: A Causal Link? -
CM Stoney, MC Davis, KA Matthews - Psychophysiology, 1987 - Blackwell Synergy
... and in Coronary Heart Disease: A Causal Link? CATHERINE M. STONEY, MARY C. DAVIS,
AND KAREN A. MATTHEWS University of Pittsburgh, Pittsburgh, Pennsylvania ...

Fibrinogen: a possible link between social class and coronary heart disease. -
HL Markowe, MG Marmot, MJ Shipley, CJ Bulpitt, TW … - British Medical Journal (Clinical research ed.), 1985 - pubmedcentral.nih.gov
... 1985 November 9; 291(6505): 1312?1314. Copyright notice. Fibrinogen: a possible
link between social class and coronary heart disease. ...

… in Cardiovascular Disease Enterprises Part II: The Aging Heart in Health: Links to Heart Disease -
EG Lakatta, D Levy - Circulation, 2003 - Am Heart Assoc
... In a similar vane, the focus of this article is on the potential link between
age-associated changes in the heart and clinical cardiac disease outcomes. ...

Dental disease and risk of coronary heart disease and mortality. -
F DeStefano, RF Anda, HS Kahn, DF Williamson, CM … - BMJ: British Medical Journal, 1993 - pubmedcentral.nih.gov
... Dental disease is associated with an increased risk of coronary heart disease,
particularly in ... Links to PubMed are also available for Selected References. ...

Social conditions as fundamental causes of disease -
BG Link, J Phelan - J Health Soc Behav, 1995 - JSTOR
... Shrout, Patrick, Bruce Link, Bruce Dohrenwend, Andrew Skodal, Ann Stueve, and Jerold
Mirotznik. ... "Epidemiology and Health Policy: Coronary Heart Disease." Pp. ...

Link between heart disease, cholesterol, and Alzheimer's disease: A review -
DL Sparks, TA Martin, DR Gross, JC Hunsaker - Microscopy Research and Technique, 2000 - doi.wiley.com
Page 1. Link Between Heart Disease, Cholesterol, and Alzheimer?s Disease: A Review ...
At this writing, we have been 289 LINK BETWEEN HEART DISEASE AND AD Page 4. ...

Depression as a predictor for coronary heart disease a review and meta-analysis -
R Rugulies - American Journal of Preventive Medicine, 2002 - Elsevier
... doi:10.1016/S0749-3797(02)00439-7 How to Cite or Link Using DOI (Opens New ... Depression
as a predictor for coronary heart disease a review and meta-analysis 1. ...

Fibrinogen: a link between chronic infection and coronary heart disease. -
P Patel, D Carrington, DP Strachan, E Leatham, P … - Lancet, 1994 - ncbi.nlm.nih.gov
... Fibrinogen: a link between chronic infection and coronary heart disease. Patel P,
Carrington D, Strachan DP, Leatham E, Goggin P, Northfield TC, Mendall MA. ...

Source: Google Scholar

Researchers Reveal Missing Link in a Heart Disease Pathway

University of Michigan scientists and their colleagues have helped characterize a previously unknown link in the chain of biochemical reactions implicated in some forms of heart disease.

The finding provides a new target for future drug therapies.

A team led by U-M structural biologist John Tesmer obtained a high resolution image of three proteins caught in the act of transferring chemical signals inside a cell. Two of the proteins in the complex had previously been linked to heart disease, and Tesmer's team was able to resolve "the missing link" between them, he said.

"We've trapped all three proteins together, and we've learned how they interact. Essentially, it's a previously unrecognized pathway that one could target to treat cardiovascular disease," said Tesmer, a research associate professor at the Life Sciences Institute and an associate professor at the Medical School.

The work is reported in Friday's edition of the journal Science.

Two proteins in the trio had previously been linked to heart disease: G-alpha-q and RhoA.

Scientists have known for some time that patients suffering from high blood pressure and other maladies release hormones, such as angiotensin, that can trigger an abnormal growth of cardiac cells that sometimes leads to heart disease.

They also knew that these hormones, after binding to receptors on the surface of cells, activate G-alpha-q. Further along in the signaling pathway, RhoA, a protein that regulates cell growth and gene expression, also had been tied to heart disease.

The missing pieces of the puzzle were the intermediaries that relay cellular signals from G-alpha-q to RhoA. Tesmer and his colleagues have now determined the atomic structure of one of those go-betweens, an enzyme called p63RhoGEF. Scientists use such structures to study how molecules interact---and how one might block their function therapeutically.

Tesmer's lab captured a group portrait of all three proteins---G-alpha-q, p63RhoGEF and RhoA---in X-ray crystallographic images. Concurrently, animal studies conducted by German colleagues confirmed the interactions between these substances, as well as their importance to smooth-muscle function.

Tesmer's co-authors on the Science paper are Aruna Shankaranarayanan, Cassandra Coco, Marc Ridilla and Mark Nance of the U-M Life Sciences Institute; Chris Evelyn and Richard Neubig of the U-M Department of Pharmacology; and Susanne Lutz, Christiane Vettel, Doris Baltus and Thomas Wieland of the University of Heidelberg.

The work was supported by a Medical Faculty Mannheim grant, the American Heart Association, the National Institutes of Health, the American Cancer Society, the National Cancer Institute, the National Institute of General Medical Science, the Michigan Economic Development Corporation, the Michigan Technology Tri-Corridor, and the U.S. Department of Energy.

Related Links:
U-M Life Sciences Institute: http://lsi.umich.edu
 
 
 
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