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Recent News and Articles on the Keywords: new + prevents + 359  Related to the article below (Last Update: 8/5/2008)

A Practical "ABCDE" Approach to the Metabolic Syndrome
RedOrbit, TX -
In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), chlorthalidone was shown to have the same efficacy for ...

Christian Science Monitor
Why US parks put land purchases on hold
Christian Science Monitor, MA - Jul 29, 2008
So instead of his land becoming a new jewel in an expanded national park, he may now sell to developers who would carve his ranch into 40-acre ?ranchettes. ...
Hot Topics
School Library Journal - Jul 31, 2008
ISBN 978-1-59716-359-0. Gr 3-5?Greene admirably distills the dramatic events of the devastating 1911 fire in which 146 factory workers died. ...
HIV Integrase Inhibitors ? Out of the Pipeline and into the Clinic
New England Journal of Medicine (subscription), MA - Jul 23, 2008
N Engl J Med 2008;359:339-354. [Free Full Text] Cooper DA, Steigbigel RT, Gatell JM, et al. Subgroup and resistance analyses of raltegravir for resistant ...
SPSS Reports 2008 Second Quarter, First Half Results
WELT ONLINE, Germany - Jul 29, 2008
More than 250000 public sector, academic and commercial customers rely on SPSS technology to help increase revenue, reduce costs and detect and prevent ...SPSS
Advent Software Achieves Record Quarterly Revenue of $64.0 Million ...
Earthtimes (press release), UK - Jul 29, 2008
The service will leverage Advent's custodial data infrastructure (ACD) to aggregate data from multiple vendors to help prevent non-compliant transactions ...ADVS
Students With Chronic Diseases
RedOrbit, TX - Aug 3, 2008
By Taras, Howard Brennan, Jesse J ABSTRACT BACKGROUND: To educate children with chronic diseases in the least restrictive environment, schools must prevent, ...

AtlantaBraves.com
Blanco succeeding in leadoff spot
AtlantaBraves.com, GA - Aug 2, 2008
In his previous 10 games entering Saturday, he had hit .359 (14-for-39) with three doubles. Still, if Schafer isn't deemed ready and they don't feel Josh ...

San Diego Union Tribune
Tons of questions
San Diego Union Tribune, United States - Aug 3, 2008
That averaged 359 tons per home site. The analysis also showed the average cost for most Rancho Bernardo properties was $63000, while the average cost for ...
RELIGIOUS AUTHORITIES IN KYRGYZSTAN PLAY POLITICS
Eurasia Daily Monitor, DC - Jul 22, 2008
Christian organizations of various dimensions, including Russian Orthodox churches, account for 359, with four Catholic communities and 307 protestant ...
Source: Google News

prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase: a new -
T M?nzel, S Kurz, S Rajagopalan, M Thoenes, WR … - J Clin Invest, 1996 - pubmedcentral.nih.gov
... A new action for an old drug. ... Concurrent hydralazine administration prevents
nitroglycerin-induced hemodynamic tolerance in ... 1994 May 1;310(2):352?359. ...

… interventions to prevent HIV infection are urgently needed: New priorities for behavioral research … -
JA Kelly, DA Murphy, KJ Sikkema, SC Kalichman - American Psychologist, 1993 - content.apa.org
... We need community-based interventions to prevent more HIV infection. ... New York:
Wiley. ... Journal of the American Medical Association, 264, 359-365. ...

A New Structural Class of Proteasome Inhibitors that Prevent NF-?B Activation -
RT Lum, SS Kerwar, SM Meyer, MG Nelson, SR Schow, … - Biochemical Pharmacology, 1998 - Elsevier
... with 5 ?Ci of [?- 32 P]ATP (>5000 Ci/mmol, New England Nuclear ... like activity of the
proteasome is sufficient to prevent LPS-induced ... FEBS Lett 359 (1995), pp. ...

Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo -
C Indolfi, EV Avvedimento, A Rapacciuolo, ED … - Nature Medicine, 1995 - nature.com
... Does the new angiotensin converting enzyme inhibitor Cilazapril prevent restenosis
after ... RS, & Mitchell, MS) 53-62 (Liss, New York, 1989). ... 359, 67-70 (1992 ...

Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, … -
EH Ohlstein, SA Douglas, CP Sung, TL Yue, C Louden … - Proceedings of the National Academy of Sciences of the …, 1993 - pubmedcentral.nih.gov
... Carvedilol, a new antihypertensive, prevents oxidation of human low density lipoprotein
by macrophages and copper. ... Nature. 1992 Sep 3;359(6390):67?70. ...

Angiotensin Blockade Prevents Type 2 Diabetes by Formation of Fat Cells -
AM Sharma, J Janke, K Gorzelniak, S Engeli, FC … - Hypertension, 2002 - Am Heart Assoc
... the hypothesis that RAS blockade prevents diabetes by ... risk patients, will also include
the new development of ... 2002; 359: 995?1003.[CrossRef][Medline]; Janke J ...

Achromatic anamorphic prism pair -
FC Luecke? - US Patent 5,596,456, 1997 - freepatentsonline.com
... The achromatic design prevents a directional shift in the output beam with ... Assignee:
New Focus, Inc. ... Field of Search: 359/831,837,668,669,670 372/100 369/112. ...

Audiovisual documentation of oral consent: a new method of informed consent for illiterate … -
O Benitez, D Devaux, J Dausset - The Lancet, 2002 - Elsevier
... To document the consent process and prevent falsification, we ... Wuky, Quality of informed
consent: a new measure of ... The Lancet Volume 359, Issue 9315 , 20 April ...

Use of misoprostol in third stage of labour -
C Shannon, B Winikoff - The Lancet, 2002 - Elsevier
... Council, One Dag Hammarskjold Plaza, New York, NY ... stage of labour The Lancet, Volume
359, Issue 9307 ... we believe that oxytocin prophylaxis prevents an important ...

The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its … -
GJ Blackwell, WG Duncombe, RJ Flower, MF Parsons, … - British Journal of Pharmacology, 1977 - pubmedcentral.nih.gov
... weak anti-phospholipase activity in platelets, also prevents aggregation by ... 1969
Oct;17(4):359?371. ... M, Svensson J, Samuelsson B. Thromboxanes: a new group of ...

Source: Google Scholar

You can teach an old dog new tricks: anti-malarial prevents cancer in mice

New data generated by a team of researchers from St Jude Children’s Research Hospital, Memphis, and Scripps Research Institute, Jupiter, have indicated that the antimalarial drug chloroquine effectively prevents cancer in mouse models of two distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia. As discussed in the accompanying commentary by Chi Dang, from Johns Hopkins University School of Medicine, Baltimore, these results complement an old epidemiology study suggesting that malarial prophylaxis with chloroquine diminished the incidence of Burkitt lymphoma.

In the study, chloroquine was shown to inhibit the development of Myc-induced lymphomas (a mouse model of Burkitt lymphoma) and to inhibit the development of lymphomas in ATM-deficient mice (a mouse model of ataxia telangiectasia). By contrast, chloroquine did not inhibit the development of lymphomas in p53-deficient mice. Further analysis indicated that chloroquine induced cellular features of autophagy (self-eating) and mediated its effects by inducing lysosomal stress and provoking a p53-dependent cell death. The authors therefore suggested that modulating autophagy, either using chloroquine or other approaches, might provide a new avenue for the development of anticancer therapeutics.

TITLE: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

AUTHOR CONTACT:
Michael B. Kastan
St. Jude Children’s Research Hospital, Memphis, Tennessee, USA.
Phone: (901) 495-3968; Fax: (901) 495-3966; E-mail: michael.kastan@stjude.org.

John L. Cleveland
The Scripps Research Institute, Jupiter, Florida, USA.
Phone: (561) 799-8808; E-mail: jcleve@scripps.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33700

ACCOMPANYING COMMENTARY TITLE: Antimalarial therapy prevents Myc-induced lymphoma

AUTHOR CONTACT:
Chi V. Dang
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Phone: (410) 955-2411; Fax: (410) 955-0185; E-mail: cvdang@jhmi.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34503

 
 
 
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