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Recent News and Articles on the Keywords: protein + bone + growth  Related to the article below (Last Update: 8/5/2008)

Protein Key to Control Growth of Blood Cells
Earthtimes (press release), UK -
In the current study, they found that mice genetically engineered to lack the Lnk protein had 10 times the normal amount of HSCs in their bone marrow. ...
Breast cancer: What you need to know
Food Consumer, IL -
Low-protein diet: The vegetarians on a low-protein diet had a significantly lower level of insulin-like growth factor 1, known as IGF-1, which promotes cell ...
Maren Schmidt: Best brains require good nutrition :
Craig Daily Press, CO -
Serve fresh fruit and vegetables and whole grains to satisfy Make sure that a child?s diet provides adequate protein. Too much protein can be as bad as too ...
Columnist needs glass of milk
Ithaca Journal, NY -
As T. Colin Campbell and I both know, bone is a tissue in ongoing renewal ? it is formed and resorbed (?Milk shouldn't be considered healthy,? July 26. ...

Oneindia
Protein Linked To Bone Marrow
Oneindia, India - Jul 23, 2008
... stimulated the production of a protein called Kit ligand that triggers the growth of pigment cells, which turned the mice's skin darker than normal. ...

Malaysia Star
The science of energy healing
Malaysia Star, Malaysia - Aug 2, 2008
2 Hz for nerve regeneration, 7 Hz for bone growth, 10 Hz for ligament healing, 15, 20, and 72 Hz for stimulation of capillary formation, and 25 and 50 Hz ...
Stanford Study of Dark-Skinned Mice Leads to Protein Linked to ...
MarketWatch - Jul 20, 2008
The results may lead to new treatments for bone marrow failure in humans. The protein, called p53, has been dubbed the "guardian of the genome" for its ...

Modesto Bee
Russian teen going home after Modesto doctors save leg
Modesto Bee, CA -
During the 4?-hour operation, the surgical team reinforced the fibula and tibia with bone grafts and packed the wound with growth protein to promote healing ...
Soy - Not So Fast
What Doctors Don't Tell You, UK - Aug 4, 2008
As a legume high in both protein and fat, it yields numerous products, many of which are now part of large industries. Among the traditional products are ...

Ortho SuperSite
Osteoinductive growth factors can aid bone growth in orthopedic ...
Ortho SuperSite, NJ - Jul 7, 2008
By Susan M. Rapp Six years after FDA approval of the first bone growth factor, a bone morphogenetic protein, researchers and clinicians still seek a better ...
Source: Google News

Fibroblast growth factor receptor 3 is a negative regulator of bone growth. -
C Deng, A Wynshaw-Boris, F Zhou, A Kuo, P Leder - Cell, 1996 - ncbi.nlm.nih.gov
Cell. 1996 Mar 22;84(6):911-21. Click here to read Fibroblast growth factor
receptor 3 is a negative regulator of bone growth. Deng ...

… bone growth and morphogenesis via parathyroid hormone related-protein-dependent and-independent … -
SJ Karp - Development, 2000 - dev.biologists.org
... Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid
hormone related-protein-dependent and -independent pathways. ...

… growth factor beta family members present in bone-inductive protein purified from bovine bone -
AJ Celeste, JA Iannazzi, RC Taylor, RM Hewick, V … - Proc Natl Acad Sci US A, 1990 - pubmedcentral.nih.gov
... Copyright notice. Identification of transforming growth factor beta family members
present in bone-inductive protein purified from bovine bone. ...

Serum bone Gla-protein as a marker of bone growth in children and adolescents: correlation with age, … -
JS Johansen - Journal of Clinical Endocrinology & Metabolism, 1988 - Endocrine Soc
... Serum bone Gla-protein as a marker of bone growth in children and adolescents:
correlation with age, height, serum insulin-like growth factor I, and serum ...

Regulation of growth plate chondrogenesis by bone morphogenetic protein-2.
F De Luca, KM Barnes, JA Uyeda, S De-Levi, V Abad, … - Endocrinology, 2001 - ncbi.nlm.nih.gov
Click here to read Regulation of growth plate chondrogenesis by bone morphogenetic
protein-2. De Luca F, Barnes KM, Uyeda JA, De-Levi S, Abad V, Palese T ...

… growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, … -
SE Harris, LF Bonewald, MA Harris, M Sabatini, S … - J Bone Miner Res, 1994 - ncbi.nlm.nih.gov
Effects of transforming growth factor beta on bone nodule formation and expression
of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline ...

Recombinant bone morphogenetic protein-7 as an intracorporal bone growth stimulator in unstable …
M Laursen, K Hoy, ES Hansen, J Gelineck, FB … - Eur Spine J, 1999 - ncbi.nlm.nih.gov
... Recombinant bone morphogenetic protein-7 as an intracorporal bone growth stimulator
in unstable thoracolumbar burst fractures in humans: preliminary results. ...

Growth factors for bone growth and repair: IGF, TGF? and BMP -
TA Linkhart, S Mohan, DJ Baylink - Bone, 1996 - Elsevier
... E:. and Gabbitas, B. Bone morphogenetic protein 2 increases insulin-like growth
factor I and II transcripts and polypeptide levels in bone cell cultures. ...

Recombinant human bone morphogenetic protein induces bone formation -
EA Wang, V Rosen, JS D'Alessandro, M Bauduy, P … - Proc Natl Acad Sci US A, 1990 - pubmedcentral.nih.gov
... Human transforming growth factor-beta complementary DNA sequence and ... A, Lietze
A. Solubilized and insolubilized bone morphogenetic protein. ...

… JunB Promoter That Acts as a Transforming Growth Factor-?, Activin, and Bone Morphogenetic Protein … -
LJC Jonk, S Itoh, CH Heldin, P ten Dijke, W … - Journal of Biological Chemistry, 1998 - ASBMB
... of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming
Growth Factor- , Activin, and Bone Morphogenetic Protein-inducible Enhancer *. ...

Source: Google Scholar

Researchers discover protein that controls bone growth

Discovery may lead to new treatments for bone diseases affecting skeletal growth

A research team led by Dr. Pierre Moffatt of the Shriners Hospital for Children in Montreal and McGill University’s Department of Human Genetics has uncovered the molecular mechanism by which the protein osteocrin controls bone growth – a discovery that may have important implications for people suffering from bone diseases affecting skeletal growth. The team’s findings appear in the December 14 edition of the Journal of Biological Chemistry.

Osteocrin is a small protein produced by the body’s bone-forming cells, or osteoblasts. In this study, mice that were genetically engineered to over-express osteocrin developed hunchbacks and elongated bones. This led Dr. Moffatt and his colleagues to the discovery that osteocrin locally controls the bone's supply of a hormone known as CNP, which plays an important role in the regulation of bone growth.

“The osteocrin gene was discovered as part of a project to identify novel bone genes that might have possible therapeutic actions,” explained Dr. Moffatt. "The project focused on the identification of classes of genes which are particularly attractive to medical researchers because they can be potentially exploited to develop new drug-based therapies."

Most of the research was initially carried out at Phenogene and Enobia Pharma, two Montreal-based biotech companies, but it was finalized in Dr. Moffatt’s lab at the Shriners Hospital for Children in Montreal.

“This fundamental research could pave the way to the rationalized design of new molecules which could have beneficial effects in various disorders that impair bone growth, particularly in children,” said Dr. Moffatt.

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Note: The full text of the study is available online at www.jbc.org/cgi/content/abstract/282/50/36454

 

 

 

 

 

 

 
 
 
 
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