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Recent News and Articles on the Keywords: genetics + smoking + heart  Related to the article below (Last Update: 8/5/2008)


Voice of America
Ten Percent of Healthy People Injured from Silent Strokes
Voice of America -
They include atrial fibrilation, high blood pressure, heart disease, diabetes and cigarette smoking. The American Stroke Association says people who think ...
Brain Aerobics Could Be Key to Famous Heart Doctor?s Longevity ...
Live-PR.com (Pressemitteilung), Austria - Aug 4, 2008
04.08.2008 10:01:31 The late pioneer heart surgeon Michael DeBakey attributed his longevity to genetics and not smoking. However, Alzheimer?s disease and ...
Exercise cuts some of smoking's risks -- but it's a fact that ...
Los Angeles Times, CA - Aug 1, 2008
Age, how long they've been smoking and how much they smoke are factors. Genetics and physiology might also play a part in how the body handles the damage ...
My brain on drugs
PR CannaZine (press release), UK - Aug 4, 2008
Wish now, I had quit smoking right then and there. Anyway, drug caused my heart to race now and again and so eventually switched off it to Zoloft. ...

Oneindia
Genetic Variations Up Youngsters
Oneindia, India - Jul 17, 2008
However, Dr. Robert Weiss, professor of human genetics at the University of Utah and lead author of the study, says: "We know that people who begin smoking ...
Alaskan Eskimos' High Rates Of Artery Plaque Could Be From High ...
Science Daily (press release) - Jul 13, 2008
Even with a heart-healthy diet and exercise, smoking is a powerful and overwhelming stimulus for developing atherosclerosis, Roman said. ...
Omega-3 rather than genetics is key to lack of CHD in Japanese?
TheHeart.Org, NY - Jul 28, 2008
Pittsburgh, PA and Shiga, Japan - The low rate of atherosclerosis and heart disease in Japanese people may be related to their very high levels of ...
Men who can't cope with their wives? cancer may not be love rats
Vanguard, Nigeria - Aug 2, 2008
What to keep in mind: Lack of exercise, poor diet, smoking, genetics and stress are key contributors. Get it checked every time you visit the doctor. ...

Sky News
Genetic Variations Influence Nicotine Addiction For Young Smokers
Medical News Today, UK - Jul 11, 2008
According to lead author Robert Weiss, Ph.D., professor of human genetics at the University of Utah, says: "We know that people who begin smoking at a young ...
U. finds genetic link to nicotine addiction Deseret News
all 67 news articles »

WELT ONLINE
Doctors release new policy on cholesterol screening
Baltimore Sun, United States - Jul 7, 2008
Often, as in the case of Miller, the culprit is genetics. But for others, it is linked to what some say is an "epidemic" of obesity among American ...
CBS
all 757 news articles »
Source: Google News

… Enzyme Locus With Hypertension and Blood Pressure in Men but Not Women in the Framingham Heart … -
CJ O'Donnell, K Lindpaintner, MG Larson, VS Rao, … - Circulation, 1998 - Am Heart Assoc
... or 2 equals 0 (no genetic variance), and ... body mass index, diabetes mellitus, cigarette
smoking, alcohol consumption ... the presence of ischemic heart disease, and ...

… markers of coronary artery disease: association between VDR genotype, smoking, and aromatic DNA … -
FJ Van Schooten, A Hirvonen, LM Maas, BA De Mol, … - FASEB J, 1998 - ncbi.nlm.nih.gov
... enzymes glutathione S-transferases (GSTs), and genetic polymorphisms in ... 41 patients
who underwent open heart surgery was analyzed for smoking-related DNA ...

… genetic and environmental factors. Associations between the TaqI B RFLP in the CETP gene and smoking … -
DJ Freeman, BA Griffin, AP Holmes, GM Lindsay, D … - Arteriosclerosis, Thrombosis, and Vascular Biology, 1994 - Am Heart Assoc
... 14, 336-344, Copyright ? 1994 by American Heart Association. ... and subfraction
distribution by genetic and environmental ... in the CETP gene and smoking and obesity. ...

A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population -
MD Li, JZ Ma, R Cheng, RT Dupont, NJ Williams, KM … - BMC Genet, 2003 - biomedcentral.com
... MD, Kim H, Gagnon F, Rozek LS, Edwards KL, Jarvik GP :Multiple genome-wide analysis
of smoking behavior in the Framingham Heart Study. BMC Genetics 2003, 4 ...

[BOOK] Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart -
WD Travis - 2004 - books.google.com
... Genetic and molecular alterations 21 Genetic susceptibility 24 ... lymphomas Metastatic
tumours to the heart Pericardia ... cases can be attributed to tobacco smoking. ...

Genetic risk and behavioural change -
TM Marteau - BMJ, 2001 - pubmedcentral.nih.gov
... among people who learn that they have a genetic vulnerability to ... in relation to three
important health problems: cancer, heart disease, and smoking. ...

Prospective Study of Coronary Heart Disease Incidence in Relation to Fasting Total Homocysteine, … -
AR Folsom, FJ Nieto, PG McGovern, MY Tsai, MR … - Circulation, 1998 - Am Heart Assoc
... and folate, as well as several genetic variants associated ... history of a
physician-diagnosed heart attack, prior MI ... to CHD in this sample: smoking status ( ...

Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study -
JS Pankow, AR Folsom, M Cushman, IB Borecki, PN … - Atherosclerosis, 2001 - Elsevier
... nongenetic determinants of coronary heart disease, preclinical ... center, education,
cigarette smoking status and ... program, the expected genetic covariance between ...

Influence of Apolipoprotein E, Smoking, and Alcohol Intake on Carotid Atherosclerosis National Heart … -
L Djousse, RH Myers, MA Province, SC Hunt, JH … - Stroke, 2002 - Am Heart Assoc
... Smoking influences the association between apolipoprotein E and ... Lung, and Blood
Institute Family Heart Study ... O, Herbeth B, Siest G. Genetics strongly determines ...

Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease -
N Jeerooburkhan, LC Jones, S Bujac, JA Cooper, GJ … - Hypertension, 2001 - Am Heart Assoc
... at high risk of fatal coronary heart disease ... Acute inhalation of cigarette smoke
increases lower respiratory ... A. Association studies of genetic polymorphisms and ...

Source: Google Scholar

Heart Attack Risk From Smoking Due to Genetics
Rochester, N.Y. – December 19, 2007 – Heart attacks among cigarette smokers may have less to do with tobacco than genetics. A common defect in a gene controlling cholesterol metabolism boosts smokers’ risk of an early heart attack, according to a new study in Annals of Noninvasive Electrocardiology. The findings also show that smokers without the defect normally have heart attacks no sooner than their non-smoking peers.

Although the link between smoking and heart disease was established decades ago, the reasons for that link were unclear. More recent studies suggest smoking interferes with cholesterol metabolism, lowering smokers’ levels of high-density lipoprotein, the good cholesterol that protects against heart-attack risk. An estimated 55 to 60 percent of smokers face the added risk of a defective gene that also lowers levels of the protective high-density lipoprotein. Therefore, the combination of smoking plus a defective gene substantially accentuates the risk of heart attacks in these patients..

Researcher Ilan Goldenberg, M.D., and colleagues were the first to evaluate both smoking history and the genetic trait in heart-attack patients. They found that smokers with the genetic defect had their first heart attack eight to nine years earlier than non-smokers. Smokers with a healthy version of the gene had their first heart attack only three years earlier than non-smokers, a difference the researchers considered non-significant.

“Since the frequency of this ‘bad’ gene in the general population is about 60 percent, many people who smoke have a high risk of experiencing a heart attack at a young age,” Goldenberg said. “This finding should increase awareness for smoking cessation.”

_________________________________________________________________
This study is published in Annals of Noninvasive Electrocardiology. Media wishing to receive a PDF of this article may contact medicalnews@bos.blackwellpublishing.net.

To view the abstract for this article, please click here.

Ilan Goldenberg, M.D., is a Research Associate Professor in the Cardiology Unit of the University of Rochester Medical Center’s Department of Medicine and the Heart Institute and Neufeld Research Institute at Sheba Medical Center in Tel Hashomer, Israel. Dr. Goldenberg can be reached for questions at Ilan.Goldenberg@heart.rochester.edu.

The Annals of Noninvasive Electrocardiology is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field. For more information, please visit www.blackwellpublishing.com/anec.

Media Contact

Sean Wagner
Public Relations Specialist
350 Main St.

Malden, MA 02148
United States
781-388-8550 (phone)
781-338-8550 (fax)
swagner@bos.blackwellpublishing.com
 
 
 
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