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Recent News and Articles on the Keywords: lung + biomarkers + aid  Related to the article below (Last Update: 8/5/2008)

Epigenomics AG Reports First Half of 2008 Results
FOXBusiness -
The first clinical study demonstrated that a panel of two proprietary biomarkers detected 79% of lung cancer patients using bronchial lavage specimens at a ...FRA:ECX - DGX - EBR:ONCOB
Gene Profiles Might Help Guide Lung Cancer Care
Atlanta Journal Constitution,  USA - Jul 20, 2008
"Many biomarkers as developed often don't hold up across institutions," he said. "Early on, studies are done in an unblended way, at one institution. ...
Biomarkers Study Goes on...SAGE - a WHO Project
Newswire Today (press release), UK - Jul 20, 2008
Other tests include blood pressure, vismesion, lung function test, timed walk, grip strength, cognitive and blood tests". SAGE assumes significance with ...
Rosetta Genomics Completes Acquisition of Parkway Clinical ...
PR Newswire (press release), NY - Jul 24, 2008
... standardized test to aid pathologists in differentiating between the many possible tumors in the lung and pleura. Based on several microRNA biomarkers, ...
Rosetta Genomics Completes Acquisition of Parkway Clinical ... PharmaLive.com (press release)
all 13 news articles »  ROSG
Rosetta Genomics Completes Acquisition of Parkway Clinical ...
GenomicsProteomics.com (press release), UK - Jul 25, 2008
... standardized test to aid pathologists in differentiating between the many possible tumors in the lung and pleura. Based on several microRNA biomarkers, ...ROSG
Illumina, Avantome, Roche, Metabolon, UT Health Science Center ...
Pharmacogenomics Reporter (subscription), NY - Jul 23, 2008
Toyota Tsusho America and Nippon Kayaku have formed a joint venture that will focus on discovering and selling novel biomarkers and biomarker-based tests ...ILMN - TSE:RBM - PINK:NPKYF

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Source: Google News

[PDF] Gene-promoter hypermethylation as a biomarker in lung cancer -
SA Belinsky - Nature Reviews Cancer, 2004 - nature.com
... BIOMARKER IN LUNG CANCER ... used as a molecular marker system in screening for early
lung cancer. ... another approach for devel- oping DNA-based assays to aid in the ...
-

Predicting Lung Cancer by Detecting Aberrant Promoter Methylation in Sputum 1 -
WA Palmisano, KK Divine, G Saccomanno, FD … - Cancer Research, 2000 - AACR
... Our biomarker approach should also aid the sensitivity and accuracy of other diagnostic
approaches for lung cancer that are currently receiving much attention. ...

Chemopreventive potential of thiol conjugates of isothiocyanates for lung cancer and a urinary … -
FL Chung, D Jiao, CC Conaway, TJ Smith, CS Yang, … - Journal of Cellular Biochemistry, 1997 - doi.wiley.com
... J. Cell. Biochem. Suppl. 27:76?85. 1998 Wiley-Liss, Inc. Key words: thiol conjugates;
isothiocyanates; lung cancer prevention; urinary biomarker ...

… of Surfactant Proteins A and D Are Useful Biomarkers for Interstitial Lung Disease in Patients with … -
H TAKAHASHI, Y KUROKI, H TANAKA, T SAITO, K … - American Journal of Respiratory and Critical Care Medicine, 2000 - Am Thoracic Soc
... Some serum biomarkers seem to have overcome these problems ... alveoli, the increased
permeability of lung vessels, the ... Supported by a grant-in-aid for scientific ...

Development of proteomic patterns for detecting lung cancer -
X Xiao - Disease Markers, 2003 - IOS Press
... C. Kittas and A. Koutselinis, Expression of metallothionein in lung carcinoma:
correlation ... obtained by SELDI-TOF: potential for new biomarkers to aid in the ...

Prospects for lung-cancer screening -
JL Mulshine, CI Henschke - The Lancet, 2000 - Elsevier
... 16. Biomarker characterisation of early lung cancer may not only aid early
detection but also identify targets for treatment. The ...

Are biomarkers useful treatment aids for promoting health behavior change? An empirical review -
JB McClure - American Journal of Preventive Medicine, 2002 - Elsevier
... Are biomarkers useful treatment aids for promoting ... They employed a variety of biomarkers,
including expired ... CYP2D6 genetic marker for lung cancer susceptibility ...

Proteomic patterns of tumour subsets in non-small-cell lung cancer -
K Yanagisawa, Y Shyr, BJ Xu, PP Massion, PH Larsen … - The Lancet, 2003 - Elsevier
... 3 Thus, the proteins identified by these studies might be useful as novel biomarkers
for detection and classification of lung cancers and lead us to a better ...

High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung … -
MS Yakubovskaya, V Spiegelman, FC Luo, S Malaev, A … - Int J Cancer, 1995 - ncbi.nlm.nih.gov
... of these mutations were detected with the aid of EPCR ... potential use of ras mutation
as a biomarker for exposure ... may be at higher risk of developing lung cancer ...

Prevention of mouse lung tumors by budesonide and its modulation of biomarkers -
MA Pereira, Y Li, WT Gunning, PM Kramer, F Al- … - Carcinogenesis, 2002 - Oxford Univ Press
... The lungs were harvested and evaluated for tumors with the aid of a microscope. ... Effect
of budesonide on potential biomarkers in lung tumors Seven days prior ...

Source: Google Scholar

Biomarkers in blood aid lung cancer diagnosis

Last Updated: 2007-12-18 16:12:00 -0400 (Reuters Health)

By David Douglas

NEW YORK (Reuters Health) - Four proteins in the blood appear to be useful in helping to establish a diagnosis of lung cancer, North Carolina-based researchers report in the Journal of Clinical Oncology.

Lead investigator Dr. Edward F. Patz, Jr., told Reuters Health that his group believes that a combination of these biomarkers may be helpful in determining the probability of lung cancer in patients whose diagnosis can't be determinate by imaging studies.

Patz and colleagues at Duke University Medical Center, Durham note that currently there is no blood test for lung cancer, but blood biomarkers could be "enormously valuable."

In an effort to develop appropriate biomarkers, the researchers investigated six serum proteins and found that four, collectively, were promising -- carcinoembryonic antigen, retinol binding protein, alpha-1-antitrypsin, and squamous cell carcinoma antigen.

The team examined blood samples from 50 patients with newly diagnosed lung cancer and 50 "controls" without lung cancer. A validation set of 49 patients and 48 controls were also investigated.

Measurement of the four protein markers correctly classified all of the patients and controls at least 75 percent of the time.

The researchers used a "classification tree" to help them determine the probability of cancer based on protein levels. "People whose samples landed in one of three bins at the bottom of the tree had a 90-percent chance of having cancer," said Patz in a statement. "Other bins indicated risks as low as 10 percent."

Patz concluded that "additional trials will help us refine the role of this panel in diagnosing patients with lung cancer."

SOURCE: Journal of Clinical Oncology, December 10, 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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