Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: brain + drug + combination  Related to the article below (Last Update: 8/5/2008)

Drug combo may improve cancer therapy efficacy
Newstrack India, India - Aug 2, 2008
Further, this drug combination showed enhanced efficacy at stalling tumour growth in an orthotopic mouse model of GBM. The authors revealed that combining ...
You?re Checked Out, but Your Brain Is Tuned In
New York Times, United States -
Much of the research on the topic has focused on the bad company it tends to keep, from depression and overeating to smoking and drug use. ...
Epilepsy Drug May Help Alcoholics Recover From Dependence, Small ...
Science Daily (press release) - Aug 4, 2008
Alcohol problems, alone or in combination with illicit drug problems, account for 40 percent of admissions to addiction treatment programs each year, ...

Boston Globe
Health Winners & Losers: Elan
TheStreet.com -
The company said that at 48 weeks, the sustained virologic response (SVR) rate in the boceprevir-combination arm, with patients taking pegintron and rebetol ...
Safety Scares Hit Elan, Biogen And Schering Forbes
New PML Cases Mar Tysabri's Two-Year Anniversary in MS BioWorld Online
Biogen Idec (BIIB) Sinks on TYSABRI PML Fears, Wall Street Comments... StreetInsider.com (subscription)
all 220 news articles »  ELN - BIIB - OTC:SHRGY
Do drugs control your life?
Triumph, Nigeria -
The overdose in-take of any of these drugs or its combination gives the addict his or her desired psychedelic satisfaction. Chloroquine tablets ranging from ...
Alzheimer's drug offers fresh hope
Financial Times, UK - Jul 29, 2008
Successful treatment might require a triple combination of drugs, to fight plaques and tangles and boost neurotransmitter activity, he said.
Tau drug shows early promise in Alzheimer's Reuters
all 630 news articles »
Vitamin C Shows Promise as Cancer Treatment
Washington Post, United States -
And even if the treatment works, it's not a cure but would likely be used in combination with other drugs, the researchers said. Still, the research does ...

HealthNewsDigest.com
FDA 101: Dietary Supplements
HealthNewsDigest.com, NY -
For example, folic acid supplements may make a claim about reducing the risk of birth defects of the brain and spinal cord. Using supplements improperly can ...
Impotence drugs help treat brain tumours
Reuters - Jul 28, 2008
"The combination of vardenafil and adriamycin resulted in longer survival and smaller tumour size," Black said. The blood-brain barrier is a molecular ...
Alzheimer's Research Holds Promise
TIME - Jul 31, 2008
Potentially, a combination of drug therapies ? designed to prevent both plaques and tangles ? may prove effective in slowing the progression of the disease. ...
Source: Google News

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease … -
RB Kim, MF Fromm, C Wandel, B Leake, AJ Wood, DM … - Journal of Clinical Investigation, 1998 - pubmedcentral.nih.gov
... of infected individuals: identification by the combination of in ... Brain viral burden
in HIV infection ... of lymphocyte surface expression and drug-unrelated function ...

… of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to … -
AH Schinkel, JJ Smit, O van Tellingen, JH Beijnen, … - Cell, 1994 - ncbi.nlm.nih.gov
... some of the side effects in patients treated with a combination of carcinostatics
and P ... in selectively enhancing the access of a range of drugs to the brain. ...

… of free oxygen radicals in combination with magnesium ameliorate perinatal hypoxic-ischemic brain … -
M Thordstein, R Bagenholm, K Thiringer, I Kjellmer - Pediatr Res, 1993 - ncbi.nlm.nih.gov
1993 Jul;34(1):23-6. Scavengers of free oxygen radicals in combination with magnesium
ameliorate perinatal hypoxic-ischemic brain damage in the rat. ...

Hypoxic-ischemic brain injury in the newborn. Cellular mechanisms and potential strategies for … -
AJ du Plessis, MV Johnston - Clin Perinatol, 1997 - ncbi.nlm.nih.gov
... will require elucidation of the complex inter-relationships between mechanisms of
cellular injury, brain development, and the combination of therapies ...

Oxaliplatin/cisplatin (L-OHP/CDDP) combination in heavily pretreated ovarian cancer -
… , C Garrino, P Chollet, E Brain, M Fereres, C … - European Journal of Cancer, 1997 - Elsevier
... P. Souli&, A. Bensma?ine, C. Garrino, P. Chollet, E. Brain, M. M ... with associated
morbidity) are the limiting toxicities of the three-drug combination at full ...

Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during … -
AA Harrison, YT Liem, A Markou - Neuropsychopharmacology, 2001 - ncbi.nlm.nih.gov
... in brain stimulation reward observed during withdrawal from nicotine or amphetamine
in rats (ie, increased reward). By contrast, the same drug combination ...

Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and … -
CW Bradberry, JB Nobiletti, JD Elsworth, B Murphy, … - Journal of Neurochemistry, 1993 - Blackwell Synergy
... Cocaine and cocaethylene: Microdialysis comparison of the brain drug levels and ... may
also contribute significantly to the effects of the drug combination. ...

… , CCNU, and vincristine (PCV 3) combination chemotherapy in the treatment of malignant brain tumors.
VA Levin, MS Edwards, DC Wright, ML Seager, TP … - Cancer Treat Rep, 1980 - ncbi.nlm.nih.gov
1980 Feb-Mar;64(2-3):237-44. Modified procarbazine, CCNU, and vincristine (PCV 3)
combination chemotherapy in the treatment of malignant brain tumors. ...

Brain tumor chemotherapy: an evaluation of agents in current use for phase II and III trials.
MS Edwards, VA Levin, CB Wilson - Cancer Treat Rep, 1980 - ncbi.nlm.nih.gov
... combination with adjunctive drug therapies holds some promise for improving the
disappointing results obtained thus far with chemotherapy for malignant brain ...

… trial in small cell carcinoma of the lung: comparison of combination chemotherapy-radiation therapy … -
LH Maurer, M Tulloh, RB Weiss, J Blom, L Leone, O … - Cancer, 1980 - ncbi.nlm.nih.gov
... the effects of prophylactic whole brain irradiation; and 2 ... was seen in LD when
combination chemotherapy was ... remission was greater with three drugs than with one ...

Source: Google Scholar

Drug combination shrinks breast cancer metastases in brain

SAN ANTONIO, Texas--A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber Cancer Institute investigators at the San Antonio Breast Cancer Symposium.

Lapatinib (Tykerb) and capecitabine (Xeloda) were paired in an extension of a Phase 2 clinical trial in which lapatinib given alone shrank brain metastases significantly in six percent of 241 patients.

In the extension trial, capecitabine was added to lapatinib in 49 patients whose metastases -- cancerous colonies in the brain spread from their primary cancer -- had progressed while on treatment. With the combination therapy, brain metastases shrank by 20 percent or more in 18 patients (37 percent) and shrank by at least 50 percent in 10 patients (20 percent), reported Nancy Lin, MD, of Dana-Farber's Breast Oncology Center.

"Very few medications have shown activity in the treatment of brain metastases, particularly in HER-2-positive metastatic breast cancer patients," said Lin, who led the study with Eric Winer, MD, director of the Dana-Farber Breast Oncology Center. "Therefore, these data are quite encouraging, and further studies are warranted."

The data (abstract 6076) will be presented on Sunday, Dec. 16 at 7 a.m. CT.

Lapatinib is an oral small-molecule drug from GlaxoSmithKline that is approved along with capecitabine for treating patients with advanced or metastatic breast cancer whose tumors are driven by the abnormal growth signal, HER-2, and who have already undergone therapy including trastuzumab (Herceptin), a taxane drug, and an anthracycline compound. Lapatinib, like trastuzumab, blocks the HER-2 signal.

Up to one-third of women with advanced, HER-2-positive breast cancer may develop metastases to the brain.

"Although radiation treatment is often effective, as women live longer with metastatic cancer, some develop worsening of brain metastases despite radiation," said Lin. "Because cancer in the brain can have a major impact on quality of life, it is important to have treatment options to address this problem."

###

The study was sponsored in part by GlaxoSmithKline.

Dana-Farber Cancer Institute (www.dana-farber.org) is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute.
 
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.