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Recent News and Articles on the Keywords: stem cell + stemcell + hearts  Related to the article below (Last Update: 8/5/2008)

UGA prof awarded $9.2M stem cell research grant
Atlanta Journal Constitution,  USA -
His own research focuses on the use of stem cells in understanding diabetes and cardiovascular disease. "The heart is an organ that doesn't repair itself," ...
UGA stem cell researchers awarded $9.2M grant Bizjournals.com
all 27 news articles »

ABC News
Defying Western Science, Chinese Biotech Pursues Untested Stem ...
InformationWeek, NY -
Although Beike Biotechnology's promising iPS stem cell treatment is unproven, hundreds of patients are paying to receive the treatment in China, ...
Scientists report a breakthrough in stem cell production Boston Globe
Stem Cell Researchers Make Healthy Cells from Sick Patients? Skin findingDulcinea
Personalized Stem Cells One Step Closer to Reality ABC News
The Money Times
all 132 news articles »  OTC:SCII
Osiris Announces Second Quarter 2008 Financial Results Conference Call
MarketWatch -
the leader in stem cell therapeutics, announced today that it will report its financial results for the quarter ended June 30, 2008, on Thursday, August 7, ...
Osiris Announces Second Quarter 2008 Financial Results Conference Call Centre Daily Times
all 13 news articles »  OSIR

LifeNews.com
Michigan Panel to Decide This Month on Human Embryo Research Proposal
LifeNews.com, MT -
In January, Right to Life of Michigan launched a new stem cell research educational campaign designed to counteract lawmakers who support the proposal. ...

코리아타임즈
Seoul Bans Hwang's Stem Cell Research
코리아타임즈, South Korea - Jul 31, 2008
The South Korean government Friday decided to disapprove a request by disgraced scientist Hwang Woo-suk to resume human stem cell research, dealing a blow ...
Global Stem Cell Forum in China Showcases Cutting Edge Research ...
FOXBusiness - Jul 25, 2008
Dr. Yong-Jian Geng, MD, Ph.D, Director of the Heart Failure and Stem Cell Research Lab at the Texas Heart Institute and Professor of Medicine at the ...
Beike Uses Research Forum to Showcase its Stem Cell Therapies
istockAnalyst.com, OR - Aug 1, 2008
Stem cells will not necessarily find the correct nerve to repair without coaxing, according to the experts. They believe a set of simple stem cell ...
San Francisco Chronicle Examines Efforts To Revise Rules ...
Medical News Today (press release), UK - Aug 4, 2008
The San Francisco Chronicle on Wednesday examined efforts by human embryonic stem cell research advocates to revise rules that prohibit compensating women ...
Stem cell czar: UM researcher leads alternative effort
MiamiHerald.com, FL - Jul 29, 2008
Some researchers believe they are also ''multipotent,'' meaning that a heart stem cell can turn into a brain or kidney or other cell, although not all 220 ...
Brighter Smiles: Can teeth save lives?
Saugus Advertiser, MA -
What are stem cells? They are your body?s basic building blocks. Meaning one stem cell has the ability to grow additional cells of its kind or change into ...
Source: Google News

Autologous bone-marrow stem-cell transplantation for myocardial regeneration -
C Stamm, B Westphal, HD Kleine, M Petzsch, C … - The Lancet, 2003 - Elsevier
... antibody against the human stem-cell marker AC133 ... CD34?) subpopulation of bone-marrow
stem cells that have ... used the CliniMACS magnetic cell separation device ...

Bone marrow stem cells regenerate infarcted myocardium -
D Orlic, J Kajstura, S Chimenti, DM Bodine, A Leri … - Pediatric Transplantation, 2003 - Blackwell Synergy
... Rapid turnover of connexin43 in the adult rat heart. ... of mouse pluripotent hematopoietic
stem cells mobilized into ... colony stimulating factor and stem cell factor ...

Stem cell differentiation requires a paracrine pathway in the heart -
A BEHFAR, LV ZINGMAN, DM HODGSON, JM RAUZIER, GC … - The FASEB Journal, 2002 - FASEB
... Differentiation, Survival, and Function of Embryonic Stem Cell Derived Endothelial
Cells for Ischemic Heart Disease Circulation, September 11, 2007; 116 ...

Genetically selected cardiomyocytes from differentiating embronic stem cells form stable … -
MG Klug, MH Soonpaa, GY Koh, LJ Field - Journal of Clinical Investigation, 1996 - pubmedcentral.nih.gov
... Mol Cell Biol ... In vitro chamber specification during embryonic stem cell cardiogenesis ...
ventricular myosin light chain-2 gene is independent of heart tube formation ...

[PDF] Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts -
CE Murry, MH Soonpaa, H Reinecke, H Nakajima, HO … - Nature, 2004 - uiowa.edu
... No transdifferentia- tion into cardiomyocytes was detectable when using these genetic
techniques to follow cell fate, and stem-cell-engrafted hearts showed no ...
-

… of Metastatic Renal-Cell Carcinoma after Nonmyeloablative Allogeneic Peripheral-Blood Stem-Cell -
R Childs, A Chernoff, N Contentin, E Bahceci, D … - New England Journal of Medicine, 2000 - content.nejm.org
... Conclusions Nonmyeloablative allogeneic stem-cell transplantation can induce ... of
metastatic renal-cell carcinoma in ... Hematology Branch, National Heart, Lung, and ...

Generalized Potential of Adult Neural Stem Cells -
DL Clarke, CB Johansson, J Wilbertz, B Veress, E … - Science, 2000 - sciencemag.org
... the finding of beating hearts of apparent normal anatomy in chimeric mouse embryos
having a very large contribution of neural stem cell-derived cells in the ...

Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart -
C Toma, MF Pittenger, KS Cahill, BJ Byrne, PD … - Circulation, 2002 - Am Heart Assoc
... RJ Bache, and J. Zhang Autologous stem cell transplantation for myocardial repair
Am J Physiol Heart Circ Physiol ... and BJ Martin Mesenchymal Stem Cells and Their ...

Stromal Cell-Derived Factor-1a Plays a Critical Role in Stem Cell Recruitment to the Heart After … -
JD Abbott, Y Huang, D Liu, R Hickey, DS Krause, FJ … - Circulation, 2004 - Am Heart Assoc
... Stromal Cell?Derived Factor-1 Plays a Critical Role in Stem Cell Recruitment to
the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing ...

Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic … -
AT Askari, S Unzek, ZB Popovic, CK Goldman, F … - The Lancet, 2003 - Elsevier
... of skeletal myoblasts into the infarcted heart in the ... and filgrastim administration
on stem-cell engraftment and ... and SD 4 weeks after cell transplantation (12 ...

Source: Google Scholar

Stem-cell patch may fix damaged hearts

Last Updated: 2007-12-13 10:00:52 -0400 (Reuters Health)

LONDON - Scientists have made two significant advances in developing a stem-cell patch to repair the damage caused to the heart after an attack.

Sian Harding of London's Imperial College said on Thursday her team had successfully matured beating heart cells in a laboratory dish for up to seven months and developed a biocompatible scaffold to form the basis of a patch.

The idea is to stitch or glue a patch of new tissue derived from embryonic stem cells over the damaged area of the heart to make the muscle viable again.

During a heart attack, or myocardial infarct, part of the heart muscle loses its blood supply and the oxygen-starved cells die, causing scarring.

"We really would like to cover the area of the infarct scar as much as possible, so it might be quite a large patch," Harding said in an interview.

"We think the patch itself will stop the scar expanding, which is one of the big problems when you have a myocardial infarction because the scar becomes weak and can bulge out."

The biomaterial developed for the patch is designed to have the same elasticity as heart muscle and can also be programmed to degrade safely in anything from two weeks upwards.

Several groups around the world are working on different ways to use stem cells in heart repair but a key challenge is to get cells to function properly.

By showing stem cell-derived heart cells can beat in a coordinated fashion for months on end, the Imperial team believes their patch should function smoothly alongside normal heart muscle, without causing abnormal heart rhythms.

Harding, who will present her research at a UK Stem Cell Initiative conference, said initial human trials of the patch could be underway within five years -- after safety studies on animals and tests to see if the new cells are rejected.

Stem cells are controversial but the field received a boost last month when researchers reported they had turned ordinary human skin cells into batches of cells that looked and acted like embryonic stem cells, without using human eggs or embryos.

"That is a very promising development," Harding said. "They have made heart muscles from those cells and this technique has the potential both for getting round the ethical problems and for producing patient-specific cells."

Making stem cells from a patient's own tissue would avoid the problems of transplant rejection.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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