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Recent News and Articles on the Keywords: cancer + insulin + breast  Related to the article below (Last Update: 8/5/2008)

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Telegraph.co.uk
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Source: Google News

[PDF] Circulating concentrations of insulin-like growth factor-I and risk of breast cancer -
SE Hankinson, WC Willett, GA Colditz, DJ Hunter, … - Lancet, 1998 - mcgill.ca
... Transforming growth factor- induced cell growth inhibition in human breast cancer
cells is mediated through insulin-like growth factor-binding protein-3 action ...
-

… growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer -
D Yee - Molecular Endocrinology, 1989 - Endocrine Soc
... ARTICLES. Analysis of insulin-like growth factor I gene expression in malignancy:
evidence for a paracrine role in human breast cancer. ...

Insulin resistance and breast-cancer risk. -
PF Bruning, JM Bonfrer, PA van Noord, AA Hart, M … - Int J Cancer, 1992 - ncbi.nlm.nih.gov
Int J Cancer. 1992 Oct 21;52(4):511-6. Insulin resistance and breast-cancer risk.
Bruning PF, Bonfrer JM, van Noord PA, Hart AA, de Jong-Bakker M, Nooijen WJ. ...

Insulin-like growth factor receptor expression and function in human breast cancer -
KJ Cullen - Cancer Research, 1990 - AACR
... Home page CL Chernicky, H Tan, L Yi, JR L. de Mola, and J Ilan Treatment of murine
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… insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer … -
AJ Stewart, MD Johnson, FE May, BR Westley - Journal of Biological Chemistry, 1990 - ASBMB
... Enhancement of Insulin-Like Growth Factor Signaling in Human Breast Cancer: Estrogen
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… the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast … -
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Insulin and related factors in premenopausal breast cancer risk -
ME Del Giudice, IG Fantus, S Ezzat, G McKeown- … - Breast Cancer Research and Treatment, 1998 - Springer
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… kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer -
X Zhang, D Yee - feedback, 2005 - biomedcentral.com
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… of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells -
Y Oh, HL Muller, H Pham, RG Rosenfeld - Journal of Biological Chemistry, 1993 - ASBMB
... Chem. Home page S. Fanayan, SM Firth, and RC Baxter Signaling through the Smad Pathway
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Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast … -
Y Oh, HL Muller, G Lamson, RG Rosenfeld - Journal of Biological Chemistry, 1993 - ASBMB
... Estrogen receptor-negative Hs578T human breast cancer cells secrete insulin-like
growth factor binding protein (IGFBP)-3 and IGFBP-4 as major binding protein ...

Source: Google Scholar

Keeping insulin in check important in breast cancer

Last Updated: 2007-12-12 10:34:10 -0400 (Reuters Health)

By Megan Rauscher

NEW YORK (Reuters Health) - Women with breast cancer and elevated insulin levels face a significantly higher risk of death than their counterparts with lower insulin levels, research suggests.

Study investigator Dr. Melinda L. Irwin, from Yale University's School of Public Health, New Haven, Connecticut, urges breast cancer survivors to talk to their doctor about how to lower their insulin levels. "Breast cancer patients should take proven steps to lower their blood insulin levels, including exercise and eating a diet rich in fruits and vegetables and low in fat," she said.

The findings of the study were reported at the American Association for Cancer Research's Sixth International Conference on Frontiers in Cancer Prevention in Philadelphia.

Insulin is known to stimulate the growth of breast cancer cells in the laboratory, but few studies have examined the link between insulin levels and breast cancer prognosis.

To investigate, Irwin and colleagues examined data 689 for women who were enrolled in the Health, Eating, Activity and Lifestyle (HEAL) study at the time they were diagnosed with breast cancer. None of the women had diabetes at the outset. At study enrollment and over several years or until death, researchers analyzed blood levels of C-peptide -- a marker of how much insulin the body is producing.

They found that women with the highest C-peptide levels at the time of breast cancer diagnosis had almost twice the risk of death compared to women with lower C-peptide levels.

For women with invasive breast cancer -- meaning the cancer has spread throughout the breast tissue or to surrounding tissues -- the risk of death was three times higher in those with high C-peptide levels compared with women with low C-peptide levels.

The risk of death associated with higher C-peptide levels was particularly high among women in their 40s. "The higher death rate among younger women suggests that these women may have had more aggressive tumors, possibly related to tumor genetics or family history, Irwin noted in a statement.

"Our findings clearly show that C-peptide and most likely insulin, in and of itself, is a marker for breast cancer prognosis," she added.

Dr. Craig B. Thompson, director of the Abramson Cancer Center at the University of Pennsylvania, who moderated a press conference that detailed the study results, said the study illustrates the importance of controlling insulin levels in women with breast cancer.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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