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Recent News and Articles on the Keywords: prostate cancer + cancer + active  Related to the article below (Last Update: 8/5/2008)

Exposure To Agent Orange Linked To Prostate Cancer In Vietnam Veterans
Science Daily (press release) -
"Here we report on the largest study to date of Vietnam War veterans exposed to Agent Orange and the incidence of prostate cancer." Chamie also said that, ...

Chatter Shmatter
MDs urged to end prostate screening in elderly men
The Associated Press -
NEW YORK (AP) ? Doctors should stop routine prostate cancer screening of men over age 75 because there is more evidence of harm than benefit, a federal task ...
New Guidelines Rule Out Prostate Screening for Men Over 75 Forbes
Guidelines Recommend Men Stop Getting Routine Blood Tests for ... RedOrbit
Task force recommends against PSA screening in men over 75 HemOncToday
all 553 news articles »
Agent Orange exposure increases prostate cancer risk in veterans ...
TMCnet -
_ Veterans exposed to the herbicide Agent Orange are twice as likely to get prostate cancer as other veterans, University of California-Davis researchers ...
Cancer registry releases county review
Mt. Vernon Register-News, IL -
Prostate cancer had similar numbers in Southern Illinois. Clinton County reported 122 cases; Effingham County 177; Fayette County 97; Hamilton County 36; ...
Diatos Launches Two International Multi-center Phase II Clinical ...
PharmaLive.com (press release), PA -
Two international trials will evaluate the safety and efficacy of DTS-201 as a second line therapy for patients with hormone refractory prostate cancer and ...
Breast cancer: What you need to know
Food Consumer, IL -
High levels of IGF-1 have been linked to elevated risk of prostate cancer, breast cancer and colon cancer, according to a study published in the December ...
Indevus Pharmaceuticals Announces Third Quarter Fiscal 2008 ...
MarketWatch -
The Company's approved products include SANCTURA(R) and SANCTURA XR(TM) for overactive bladder, VANTAS(R) for advanced prostate cancer, SUPPRELIN(R) LA for ...IDEV
Hollis-Eden Commences Phase I/II Clinical Trial with APOPTONE? in ...
ADMET.net (press release), UK - Aug 4, 2008
The Phase I/II open-label dose ranging study, being conducted with the Prostate Cancer Clinical Trial Consortium (PCCTC), will evaluate the safety, ...HEPH
Dr. Mohit Narang Latest Physician to Join Alliance Hematology Oncology
Central Penn Business Journal, PA -
Dr. Narang has been an active participant in many clinical research trials and developed particular interests in prostate cancer and breast cancer, ...
Erectile dysfunction may be "normal" with age
Reuters India, India -
Using data from more than 3800 participants in the European Randomized Study on Screening for Prostate Cancer, Korfage and her colleagues assessed whether ...
Source: Google News

Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer -
X Chen, H Thakkar, F Tyan, S Gim, H Robinson, C … - nature.com
... Constitutively active Akt in prostate cancer cells, and inhibition of Akt
activity and apoptosis by PI-3 kinase inhibitors. Growth ...

Prostate cancer in a transgenic mouse -
NM Greenberg, F DeMayo, MJ Finegold, D Medina, WD … - Proc Natl Acad Sci US A, 1995 - pubmedcentral.nih.gov
... Isolation of biologically active ribonucleic acid from sources enriched in ... Cancer
Res ... androgen-dependent secretory proteins of the mouse dorsolateral prostate. ...

Suramin, an Active Drug for Prostate Cancer: Interim Observations in a Phase I Trial -
MA Eisenberger, LM Reyno, DI Jodrell, VJ Sinibaldi … - jnci, 1993 - jnci.oxfordjournals.org
... Suramin, an Active Drug for Prostate Cancer: Interim Observations in a Phase I Trial. ...
Suramin is active against hormone-refractory prostate cancer. ...

Lower Prostate Cancer Risk in Men with Elevated Plasma Lycopene Levels Results of a Prospective … -
PH Gann, J Ma, E Giovannucci, W Willett, FM Sacks, … - Cancer Research, 1999 - AACR
... window], Table 4 ORs and 95% CIs for prostate cancer according to plasma lycopene
at baseline and random assignment to active ?-carotene supplements or placebo. ...

Specific association of human telomerase activity with immortal cells and cancer -
NW Kim, MA Piatyszek, KR Prowse, CB Harley, MD … - Science, 1994 - sciencemag.org
... of the nucleosomal cores relative to that of H1 has in- creased when compared to
results of previous stud- ies in which the cores were static rather than active ...

[PDF] THE DEVELOPMENT OF ANDROGEN-INDEPENDENT PROSTATE CANCER -
BJ Feldman, D Feldman - Nature Reviews Cancer, 2001 - nature.com
... These results indicate that the AR is transcriptionally active in some models of
recurrent prostate cancer and can increase cell proliferation at the low ...

EAU Guidelines on Prostate Cancer -
G Aus, CC Abbou, M Bolla, A Heidenreich, HP Schmid … - European Urology, 2005 - Elsevier
... Active treatment (surgery or radiation) is mostly recommended for patients with ... become
an option for selected patients with hormone refractory prostate cancer. ...

… Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2 -
AL Hsu, TT Ching, DS Wang, X Song, VM Rangnekar, … - Journal of Biological Chemistry, 2000 - ASBMB
... Consequently, overexpression of constitutively active Akt protects prostate
cancer cells from celecoxib-exerted apoptosis. Studies ...

Active Surveillance for Prostate Cancer: For Whom? -
L Klotz - Journal of Clinical Oncology, 2005 - jco.ascopubs.org
... REVIEW ARTICLE. Active Surveillance for Prostate Cancer: For Whom? Laurence
Klotz. From the University of Toronto, Division of Urology ...

Immunotherapy of Hormone-Refractory Prostate Cancer With Antigen-Loaded Dendritic Cells -
EJ Small, P Fratesi, DM Reese, G Strang, R Laus, … - Journal of Clinical Oncology, 2000 - jcojournal.org
... active immunotherapy with autologous dendritic cells that were loaded ex vivo with
a fusion protein containing PAP is a novel approach to prostate cancer ...

Source: Google Scholar

Active Compounds in Fungus - Potential Prostate Cancer Treatment

A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer. The main action of the fungus: disrupting androgen receptor activity and impeding the proliferation of cancerous cells.

Over the past 3-4 decades much scientific research has dealt with the medicinal properties of different fungi. One of the important characteristics of fungi is the ability to fight cancer in a number of ways; however most of the research has been concentrated on how fungi affect the immune system. In this research, conducted by Dr. Ben-Zion Zaidman, under the direction of Prof. Eviatar Nevo and Prof. Solomon Wasser from the Institute of Evolution at the University of Haifa, and Dr. Jamal Mahajna from the Migal Galilee Technology Center, the researchers examined how fungi fight cancer from within cells. "Up to now, research has been based on enhancing the immune system with high-molecular-weight polysaccharides that act through specific receptors in cell membranes. We concentrated our research on low-molecular-weight secondary metabolites that can penetrate the cells and act at the molecular level from within the cell itself," explained Dr. Zaidman.

 

According to Dr. Zaidman, prostate cancer, one of the most common cancers found among men in the Western World, is controlled by the androgen receptor, especially at the initial stages of development of the disease. Therefore, all of the current medications used to treat prostate cancer work to reduce the production of androgens or to interfere with their function via the androgen receptor.

At the first stage of the research, 201 organic extracts from 68 types of fungi were produced with solvents such as ether, ethyl acetate and ethanol. These solvents are used to select molecules that are small enough to act from within the cells. Of the 201 extracts, 11 were found to deter androgen receptor activity by more than 40%. In further testing, 169 extracts were tested for cancer cell growth inhibition. In this study, 14 extracts were found to be active in inhibiting prostate cancer cells.

From among the active extracts, those from Ganoderma lucidum were found to be the most effective in inhibiting the function of the androgen receptor and controlling vital development of cancerous cells. "The results of this research are particularly interesting from a commercial aspect. Potential possibilities exist to establish research and development of bioactive metabolites from Ganoderma lucidum that could yield an anti-prostate cancer drug," remarked Dr. Zaidman.
 
 
 
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