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Recent News and Articles on the Keywords: lucidum + active + compounds  Related to the article below (Last Update: 8/5/2008)


Cancer Monthly
What We Eat Can Determine Our Fate
Cancer Monthly, NC - Jul 10, 2008
The major active compound in green tea, EGCG, affects various cancer signaling pathways, and may help reduce the invasiveness of breast, pancreatic, colon, ...
Source: Google News

Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma Lucidum -
S El-Mekkawy, MR Meselhy, N Nakamura, Y Tezuka, M … - Phytochemistry, 1998 - Elsevier
... extract of the fruiting bodies of Ganoderma lucidum together with ... The structures
of the isolated compounds were determined by ... were found to be active as anti ...

Biologically active compounds from Aphyllophorales (polypore) fungi. -
JK Zjawiony - Journal of Natural Products, 2004 - pubs.acs.org
... a major source of pharmacologically active substances ... Finally, numerous compounds
with cardiovascular, phytotoxic ... polypores such as Ganoderma lucidum (Reishi or ...

… non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds -
TK Yun - Mutation Research-Fundamental and Molecular Mechanisms of …, 2003 - Elsevier
... study based on population and identification of active compounds in ginseng ... soybean
lecithin, spinach, Sesamum indicum, Ganoderma lucidum, caffeine, biochanin A ...

[PDF] Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum -
X Liu, JP Yuan, CK Chung, XJ Chen - Cancer Lett, 2002 - bioguru.cn
... highly oxygenated triterpene, as well as 12 other compounds, which were isolated
from a methanol extract of G. lucidum, were found to be active as anti-HIV-1 ...

Isolation and characterization of an active compound from black soybean [Glycine max (L.) Merr.] and … -
HF Liao, CJ Chou, SH Wu, KH Khoo, CF Chen, SY Wang - Anti-Cancer Drugs, 2001 - anti-cancerdrugs.com
... The active fraction 5, denoted as PSBS, had an ... BS and demonstrated that this compound
markedly inhibits ... of polysaccharides from Ganoderma lucidum, 18 Grifola ...

Ganoderma Lucidum (Reishi) in Cancer Treatment -
D Sliva - Integrative Cancer Therapies, 2003 - ict.sagepub.com
... INTEGRATIVE CANCER THERAPIES 2(4); 2003 359 Table 1. Biologically Active Compounds
in Ganoderma lucidum Compound Function/Outcome References ...

… determination of salidroside and specnuezhenide in the fruits of Ligustrum lucidum Ait by high … -
L Shi, Y Ma, Z Cai - Biomedical Chromatography, 1998 - doi.wiley.com
... It was reported that the fruit of L. lucidum Ait contained other water-soluble
active compounds in addition to SAL and SPN. However ...

… liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active … -
Y Kimura, M Taniguchi, K Baba - Anticancer Res, 2002 - ncbi.nlm.nih.gov
... of the triterpenoid fraction of G. lucidum might be ... Next, we attempted to isolate
the active substance(s ... Compound I was isolated from the acidic fraction as an ...

Cellular and physiological effects of Ganoderma lucidum (Reishi) -
D Sliva - Mini Rev Med Chem, 2004 - ingentaconnect.com
... THE WHOLE MUSHROOM The isolation, identification, and characterization of biologically
active compounds of Ganoderma lucidum may provide new and important ...

[PDF] Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. -
JH Jiang, V Slivova, T Valachovicova, K Harvey, D … - International Journal of Oncology, 2004 - 147.52.72.117
... apoptosis. Different biologically active compounds with possible anticancer
activities were recently isolated from Ganoderma lucidum. For ...
-

Source: Google Scholar

Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer

A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer. The main action of the fungus: disrupting androgen receptor activity and impeding the proliferation of cancerous cells.

Over the past 3-4 decades much scientific research has dealt with the medicinal properties of different fungi. One of the important characteristics of fungi is the ability to fight cancer in a number of ways; however most of the research has been concentrated on how fungi affect the immune system. In this research, conducted by Dr. Ben-Zion Zaidman, under the direction of Prof. Eviatar Nevo and Prof. Solomon Wasser from the Institute of Evolution at the University of Haifa, and Dr. Jamal Mahajna from the Migal Galilee Technology Center, the researchers examined how fungi fight cancer from within cells. "Up to now, research has been based on enhancing the immune system with high-molecular-weight polysaccharides that act through specific receptors in cell membranes. We concentrated our research on low-molecular-weight secondary metabolites that can penetrate the cells and act at the molecular level from within the cell itself," explained Dr. Zaidman.

According to Dr. Zaidman, prostate cancer, one of the most common cancers found among men in the Western World, is controlled by the androgen receptor, especially at the initial stages of development of the disease. Therefore, all of the current medications used to treat prostate cancer work to reduce the production of androgens or to interfere with their function via the androgen receptor.

At the first stage of the research, 201 organic extracts from 68 types of fungi were produced with solvents such as ether, ethyl acetate and ethanol.

These solvents are used to select molecules that are small enough to act from within the cells. Of the 201 extracts, 11 were found to deter androgen receptor activity by more than 40%. In further testing, 169 extracts were tested for cancer cell growth inhibition. In this study, 14 extracts were found to be active in inhibiting prostate cancer cells.

From among the active extracts, those from Ganoderma lucidum were found to be the most effective in inhibiting the function of the androgen receptor and controlling vital development of cancerous cells. "The results of this research are particularly interesting from a commercial aspect.

Potential possibilities exist to establish research and development of bioactive metabolites from Ganoderma lucidum that could yield an anti-prostate cancer drug," remarked Dr. Zaidman.
 
 
 
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