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Recent News and Articles on the Keywords: cancer + colon + web  Related to the article below (Last Update: 8/5/2008)

Icahn Calls Bristol Bid Too Low, Weighs ImClone Split (Update2)
Bloomberg -
ImClone and Bristol-Myers are testing Erbitux, currently approved to treat head and neck tumors as well as colon malignancies, for use in lung and cancer ...IMCL - BMY
Breast cancer: What you need to know
Food Consumer, IL -
High levels of IGF-1 have been linked to elevated risk of prostate cancer, breast cancer and colon cancer, according to a study published in the December ...
Clarient Announces $8 Million Accounts Receivable Financing ...
PR-Inside.com (Pressemitteilung), Austria -
The Company is also developing new, proprietary "companion" diagnostic markers for therapeutics in breast, prostate, lung and colon cancers, ...CLRT
Grillo: Researching Vitamin D
Daily Camera, CO -
The most evidence from scientific studies concerns colon cancer. For a current review from the Harvard School of Public Health, ...
Early cancer detection increases survival
Altoona Mirror, PA - Jul 31, 2008
To check for colon cancer: Get regular colon cancer testing. There are several tests to check for colon cancer. Talk to your doctor about these tests, ...
Lung Cancer Screening Study Corrected
Wall Street Journal - Jul 30, 2008
Unlike for colon cancer and breast cancer, regular screening isn't common for lung cancer, the largest cancer killer. No study has clearly shown that ...
BioInform's Surfing Report: Web-Based Tools and Algorithms ...
bio1nf0rm (subscription), NY - Aug 1, 2008
It includes more than 500 cases including hepatic, colon, and oral cancer, and can be accessed here. The University of Minnesota BBD Pathway Prediction ...
Eight-Year Melanoma Remission is Among Early Cancer Treatment Results
MarketWatch - Jul 13, 2008
Based on experience and relevant lab research to date, staff members expect the best results for: melanoma, pancreatic cancer, colon cancer, renal (kidney) ...
Major League Baseball, Stand Up To Cancer announce groundbreaking ...
MLB.com - Jul 15, 2008
The web site - www.standup2cancer.org - is being used as a tool for fund raising and to develop an online community for those who are affected by cancer. ...
Cancer. The Problem and Solution.
Canada Free Press, Canada - Aug 1, 2008
Reuben was diagnosed with colon cancer a year or so earlier, had chemo and surgery, pronounced ?clear? only to find six or seven months later it had ...
Source: Google News

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability -
S Markowitz, J Wang, L Myeroff, R Parsons, L Sun, … - Science, 1995 - sciencemag.org
... that you are using a browser that does not support current Web standards ... Inactivation
of the type II TGF-beta receptor in colon cancer cells with microsatellite ...

Microsatellite instability in cancer of the proximal colon -
SN Thibodeau, G Bren, D Schaid - Science, 1993 - sciencemag.org
... that you are using a browser that does not support current Web standards ... Science
266: 728-730 | PDF ? Gene defect identified in common hereditary colon cancer. ...

… between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer -
S Zhong, AH Wyllie, D Barnes, CR Wolf, NK Spurr - Carcinogenesis, 1993 - Oxford Univ Press
... Press. ARTICLES. Relationship between the GSTM1 genetic polymorphism and
susceptibility to bladder, breast and colon cancer. S Zhong ...

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential -
M Tsujii, S Kawano, RN DuBois - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
Natl. Acad. Sci. USA Vol. 94, pp. 3336-3340, April 1997 Medical Sciences.
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential ...

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. -
FS Leach, NC Nicolaides, N Papadopoulos, B Liu, J … - Cell, 1993 - ncbi.nlm.nih.gov
... Web applications. More information here... ... Related Links. The human mutator gene
homolog MSH2 and its association with hereditary nonpolyposis colon cancer. ...

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts -
BC Giovanella, JS Stehlin, ME Wall, MC Wani, AW … - Science, 1989 - sciencemag.org
... possibly that you are using a browser that does not support current Web standards ...
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. ...

Cancer of the Colon: The Influence of the No-Touch Isolation Technic on Survival Rates -
RB Turnbull Jr, K Kyle, FR Watson, J Spratt - CA: A Cancer Journal for Clinicians, 1968 - Am Cancer Soc
... Kenneth Kyle, Frank R. Watson and John Spratt Rates Cancer of the Colon: The Influence
of ... http://caonline.amcancersoc.org the World Wide Web at: The online ...

p21WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells -
SY Archer, S Meng, A Shei, RA Hodin - Proceedings of the National Academy of Sciences, 1998 - National Acad Sciences
Vol. 95, Issue 12, 6791-6796, June 9, 1998. Cell Biology p21 WAF1 is required for
butyrate-mediated growth inhibition of human colon cancer cells. ...

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer -
SS Wang, ED Esplin, JL Li, L Huang, A Gazdar, J … - Science, 1998 - sciencemag.org
... or possibly that you are using a browser that does not support current Web standards. ...
Reports. Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer. ...

Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells -
BH Park, B Vogelstein, KW Kinzler - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences
... Medical Sciences Genetic disruption of PPAR decreases the tumorigenicity
of human colon cancer cells. Ben Ho Park * , Bert Vogelstein ...

Source: Google Scholar

Regular colonoscopy with follow-up treatment if needed can help prevent colon cancer in patients with ulcerative colitis, new research suggests. Likewise, the use of anti-inflammatory drugs, such as aspirin and ibuprofen, seems to reduce the risk as well.

By contrast, the presence of "pseudopolyps" in the colon seems to raise the risk of cancer.

Ulcerative colitis is one of two principal inflammatory bowel diseases, the other one being Crohn's disease. With the disease, severe inflammation can occur throughout the colon (also called the large intestine) resulting in pain and bloody diarrhea. Pseudopolyps, a common occurrence with the disease, look like real polyps, but are actually the result of inflammation that surrounds a small portion of intestine.

People with ulcerative colitis are known to be at increased risk for colon cancer and the only way to completely eliminate this risk is to remove the colon and rectum, an operation that most patients want to avoid. Thus, there is a need to identify risk factors for colon cancer in such patients to prevent the disease or at least diagnosis it at an early, treatable stage.

There are limited data regarding the risk factors for colorectal cancer in ulcerative colitis patients, Dr. Edward V. Loftus, from the Mayo Clinic in Rochester, Minnesota, and colleagues note in the journal Gastroenterology. Regular colonoscopy and a commonly used drug called 5-ASA could potentially reduce the risk, but these two factors have never been investigated in the same study.

The researchers assessed risk factors for colorectal cancer by analyzing data from 188 ulcerative colitis patients with the cancer and 188 similar patients without it.

A history of pseudopolyps was tied to a 2.5-fold increased risk of colorectal cancer, the report indicates.

Most of the other factors studied had the opposite effect. Surveillance colonoscopy, smoking, and use of steroids, aspirin, NSAIDs (ibuprofen, etc), and 5-ASA all seemed to protect against colon cancer with risk reductions ranging from 50 to 90 percent. After 5 years, however, 5-ASA use was no longer significantly linked to a reduced risk.

Previous reports have also suggested that NSAIDs, steroids and smoking have protective effects against ulcerative colitis-related cancer. The common reason appears to be that each has anti-inflammatory effects that reduce the risk of cancer.

"These results suggest that, in a population matched for extent and duration of chronic ulcerative colitis, surveillance colonoscopy and use of anti-inflammatory medications may reduce the risk of cancer," the authors conclude.

SOURCE: Gastroenterology, June 2006.

Copyright © 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

New Method Gauges Weight-Loss Surgery Risk

Five key characteristics may single out those patients most at risk for fatal complications from gastric bypass weight-loss surgeries, researchers report.

Gastric bypass surgery is a procedure performed on the morbidly obese to help them lose weight by manipulating the size of their stomachs. After surgery, patients' stomachs can only hold small amounts of food, preventing overeating and stimulating more quickly the feeling of fullness.

While considered a safe procedure, gastric bypass does come with risks.

"Our findings show that for the low-risk group of patients, gastric bypass surgery is a very safe option. For those patients in the highest risk category, we should look at performing lower-risk or a number of smaller procedures to reduce the potential risk," study author Dr. Eric DeMaria, director of bariatric surgery at Duke University Medical Center, said in a prepared statement.

However, before this study, there was "no clinically useful system to help determine which patients would be at highest risk of dying after gastric bypass surgery," DeMaria said. "We developed a scoring system that is based on five easy-to-identify patient characteristics that can help us decide whether or not a specific patient is a good candidate for surgery and what the probable risks would be."

To devise the scoring system, a team of Duke surgeons studied data on outcomes of 2,075 bariatric surgery patients treated at Virginia Commonwealth University in Richmond between 1995 and 2004.

Thirty-one of the patients died within 90 days of their surgery. Based on these patients' histories, the researchers found that five characteristics increased the risk of death or complications from bariatric surgery:

  • BMI (body mass index -- a calculation of weight versus height) of higher than 50. The normal range is between 18.5 and 25.
  • Being male.
  • Hypertension -- the condition is typically related to cardiovascular diseases, which can also increase risk.
  • Pulmonary embolus [clot] risk -- if patients have had or are at risk for having a blood clot in the lung, their risk may be increased.
  • Being over the age of 45.

"In using our system, each one of the five characteristics is worth one point. Those patients with a score of zero are at the least risk, while those with five points are at the highest risk," DeMaria said.

Only three of the 957 patients in the study who were classified as low-risk died -- a mortality rate of just 0.31 percent -- while 19 out of 999 (1.9 percent) medium-risk patients died. In contrast, nine out of the 119 high-risk patients died -- a mortality rate of 7.56 percent, the researchers noted.

The findings could have implications for treatment decision-making, DeMaria said.

"Many people see gastric bypass surgery as an option to use only when all other approaches to weight loss have failed," he explained. "However, our system shows that this strategy may need to be reconsidered. If patients put off surgery while they attempt other therapies that ultimately don't work, over time, they risk moving into a higher-risk category as they gain more weight, get older or develop hypertension. In these cases, delays can make surgery even riskier."

DeMaria presented the results of the study and the new scoring system at the annual meeting of the American Society for Bariatric Surgery, in San Francisco.

More information

Head to the Columbia University Department of Surgery to read more about gastric bypass surgery.

 
 
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