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Recent News and Articles on the Keywords: lung cancer + cancer surgery + benefits  Related to the article below (Last Update: 8/5/2008)

Gene Test Leads To Targeted Cancer Treatment
cbs4denver.com, CO -
Lung cancer is one of the deadliest forms of cancer. When it's caught early it can be treated, but most patients are diagnosed in the later stages of the ...
Radiofrequency Ablation Effective for Primary Lung Tumors and Lung ...
Cancer Consultants, ID - Aug 4, 2008
Radio waves flow through the probe to the site of cancer, thereby destroying the cells. RFA typically requires local anesthesia, no surgery, ...
In Gastric Cancer Antibiotics Following Surgery Reduce Risk of ...
Cancer Consultants, ID -
Patients diagnosed with gastric cancer may wish speak with their physician regarding their individual risks and benefits of treatment with antibiotics. ...
Lung cancer study launched
The Press Association - Aug 1, 2008
... test to identify patients at high risk of lung cancer recurrence after surgery and who may therefore benefit from adjuvant (additional) treatment. ...
Lung Cancer Screening Study Corrected Wall Street Journal
all 3 news articles »
Nastech Pharmaceutical Company Inc. Q2 2008 Earnings Call Transcript
Seeking Alpha, NY -
In oncology, we are pursuing indications in bladder cancer and lung cancer. Bladder cancer is the fifth most common cancer in the United States and seventh ...MRNA
Health & Fitness Calendar: Summer fun
Memphis Commercial Appeal, TN - Aug 3, 2008
21, 2-3 pm at the Wings Cancer Foundation, 100 N. Humphreys Blvd. Admission free. Support group open to all patients/families dealing with lung cancer. ...

New York Times
The Doctor?s World The Story Behind Kennedy?s Surgery
New York Times, United States - Jul 29, 2008
A daughter, Kara Kennedy Allen, had lung cancer in 2003. After some surgeons deemed the cancer inoperable, bolder surgeons operated. ...
Exercise Testing for Cancer Fails to Follow Guidelines
U.S. News & World Report, DC - Jul 29, 2008
In cancer care, exercise tests are used to determine the pre-surgical fitness of lung cancer patients. In cancer research, exercise tests are most often ...

Providence Journal
How Kennedy?s ability to tap leading doctors led to his surgery
Providence Journal, RI - Aug 1, 2008
A daughter, Kara Kennedy Allen, had lung cancer in 2003. After some surgeons deemed the cancer inoperable, bolder surgeons operated. ...

Daily Mail
My life was saved by the same knife-wielding robot that treated ...
Daily Mail, UK -
The machine can treat, for example, early-stage non-small cell lung cancer, spinal tumours and even areas which have already undergone irradiation. ...
Source: Google News

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy -
JG Paez, PA Janne, JC Lee, S Tracy, H Greulich, S … - Science, 2004 - sciencemag.org
... and geographic groups and argue for the benefit of population ... in Angiogenic Growth
Factor Levels After Gefitinib Treatment in Non-small Cell Lung Cancer. ...

Revisions in the International System for Staging Lung Cancer -
CF Mountain - Chest, 1997 - Am Coll Chest Phys
... C. Doddoli, S. Antoniotti, P. Thomas, and P. Auquier The Place of Patient Satisfaction
in Quality Assessment of Lung Cancer Thoracic Surgery Chest, November 1 ...

Chemotherapy for advanced non-small-cell lung cancer: how much benefit is enough? -
R Grilli, AD Oxman, JA Julian - Journal of Clinical Oncology, 1993 - jco.ascopubs.org
... Soria, T. Le Chevalier, and JP Pignon Benefits of Adding ... and R. Rosell Chemotherapy
plus Surgery versus Surgery Alone in Non-Small-Cell Lung Cancer N. Engl. ...

… Versus Best Supportive Care in Patients With Non-Small-Cell Lung Cancer Previously Treated With … -
FA Shepherd, J Dancey, R Ramlau, K Mattson, R … - Journal of Clinical Oncology, 2000 - jco.ascopubs.org
... Because the benefits of first-line chemotherapy for ... administration of second-line
treatment deserves careful ... chemotherapy for early-stage lung cancer, and they ...

… (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the … -
M Saunders, S Dische, A Barrett, A Harvey, G … - Radiotherapy and Oncology, 1999 - Elsevier
... monitoring of an area of lung given radical ... Nevertheless, differences between treatment
arms was observed in ... of all patients and those with squamous cancer. ...

… After Gefitinib Treatment in Patients With Non-Small-Cell Lung Cancer With Postoperative Recurrence -
T Mitsudomi, T Kosaka, H Endoh, Y Horio, T Hida, S … - Journal of Clinical Oncology, 2005 - jco.ascopubs.org
... a good predictor of clinical benefit of gefitinib in ... Molecular Analysis of Lung Cancer
Specimens After we ... samples were collected during surgery, rapidly frozen ...

… of Clinical Oncology Treatment of Unresectable Non-Small-Cell Lung Cancer Guideline: Update 2003 -
DG Pfister, DH Johnson, CG Azzoli, W Sause, TJ … - Journal of Clinical Oncology, 2004 - jcojournal.org
... included in the Non-Small Cell Lung Cancer Collaborative Group ... analysis, and the
lack of benefit seen in ... Treatment protocols tested in recent years have used ...

… Phase II Trial of Gefitinib for Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer -
M Fukuoka, S Yano, G Giaccone, T Tamura, K … - Journal of Clinical Oncology, 2003 - jco.ascopubs.org
... chemotherapy, quality of life benefits and survival ... practice guidelines for the
treatment of unresectable non- small-cell lung cancer: Adopted on ...

… Versus Placebo in the Treatment of Skeletal Metastases in Patients With Lung Cancer and Other Solid … -
LS Rosen, D Gordon, S Tchekmedyian, R Yanagihara, … - Journal of Clinical Oncology, 2003 - jcojournal.org
... This is the first large randomized trial to demonstrate a treatment benefit for
bisphosphonate therapy in patients with lung cancer and other solid tumors. ...

… in previously treated patients with refractory advanced non-small-cell lung cancer: results from a …
N Thatcher, A Chang, P Parikh, J Rodrigues Pereira … - The Lancet, 2005 - Elsevier
... accounts for about 80% of all cases of lung cancer. ... survival from the start of last
treatment of 4 ... 6 The small survival benefits obtained with these treatment ...

Source: Google Scholar

Benefits of surgery for lung cancer unclear

Evidence from clinical trials neither supports nor refutes a benefit for surgery as a treatment for the most common type of lung cancer, non-small cell lung cancer or NSCLC, according to findings from the first-ever systematic review to address this topic.

The review, which appears in the medical journal Thorax, involved 11 trials that included data on patients who underwent surgery for NSCLC. Six of the studies, which included more than 1000 patients, focused on surgery vs. no surgery, while the remaining five, which included over 1100 patients, compared various surgical approaches.

As noted, the results generally showed no survival advantage or disadvantage for surgery compared with non-surgical therapy, Dr. R. L. Manser, from St. Vincent's Hospital Melbourne in Victoria, Australia, and colleagues report.

In one small study, however, chemotherapy followed by surgery rather than by radiation treatment did seem to improve survival of patients with more advanced disease.

In terms of the surgical approach, more extensive tissue removal was often linked to better outcomes. For example, in a pooled analysis of three studies, the survival rate at four years was improved with a complete removal of lymph nodes. In another study, removal of an entire lobe of the lung appeared to reduce recurrence of early-stage disease compared with limited resection.

"It is difficult to draw conclusions" about the efficacy of surgery for NSCLC, the authors state. The results of ongoing trials may help clarify this issue, they add.

SOURCE: Thorax

Older dads seem to have sicklier babies

Findings from a recent study indicate that new fathers in their 40s and 50s are slightly more likely to have an infant with a low Apgar score than fathers in their 20s.

The Apgar score, which was first created in 1952, rates the newborn on five parameters: respiratory effort, heart rate, reflex irritability, muscle tone, and skin color with a value of 0 to 2 (worst to best) for each. Thus, a total score of 10 is optimal. The score is calculated at 1 and 5 minutes after birth.

In the last few years, several reports have linked advanced paternal age with various adverse pregnancy outcomes, including fetal death and preterm birth. However, little was known about the impact, if any, on the physical condition of the infant at birth.

To investigate, Dr. Yuelian Sun, from the University of Aarhus in Denmark, and colleagues analyzed data from more than 70,000 couples who had a first infant born between 1980 and 1996.

The team reports in the research journal Epidemiology that, compared with fathers in their 20s, those between 45 and 49 years of age and those 50 years of age or older were 64 percent and 49 percent more likely, respectively, to have an infant with a 1-minute Apgar score between 1 and 3.

Moreover, fathers 45 years of age or older were at increased risk of having an infant with a 5-minute Apgar score of less than 7.

"The biologic link between advanced paternal age and low Apgar scores is unknown," Sun and colleagues say. However, some studies have shown that "expression of specific paternal genes is crucial for the placental development and that chromosomal aberrations tend to increase with paternal age."

SOURCE: Epidemiology

Copyright © 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

Drug-resistant E. coli likely started in poultry

The food-contaminating bug E. coli -- which can cause diarrhea, urinary tract infections and more severe illness in humans -- appears to be developing resistance to antibiotics called fluoroquinolones in chickens, a study shows.

The problem is arising largely because of antibiotic treatment of the animals, which forces the microbes to mutate and become resistant. Food-borne resistant E. coli can then be transmitted to humans.

Action to interrupt the transmission of resistant bacteria from animals to humans may become necessary, the researchers say. Such measures could include "limiting antimicrobial use in food animals, adopting more hygienic food-processing and distribution practices, irradiating food, and improving kitchen hygiene."

In the late 1990s, Dr. James R. Johnson of the University of Minnesota in Minneapolis and colleagues obtained E. coli from 35 blood samples and 33 fecal samples from patients with food poisoning seen at a hospital in Barcelona. The investigators also evaluated 49 fecal specimens from chickens at three slaughterhouses in the area.They found that 30 of the human specimens and 30 of the chicken specimens were resistant to Cipro, a type of fluoroquinolone antibiotic, according to their report in The Journal of Infectious Diseases.

Resistant human isolates resembled the resistant chicken isolates in terms of virulence and their DNA sequence."These data provide the strongest molecular evidence available to date for a food (specifically chicken) source for potentially pathogenic fluoroquinolone-resistant E. coli in humans," Johnson and his team write.They emphasize that even though the resistant organisms from humans and chickens were less virulent than antibiotic-susceptible human E. coli isolates, "they are not benign." The resistant isolates are still capable of causing blood poisoning and acute urinary tract infections in humans.Once these findings are confirmed in other studies, the researchers conclude, they will "provide a compelling rationale for efforts to eliminate such organisms from the food supply."

SOURCE: Journal of Infectious Diseases
 
 
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