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Recent News and Articles on the Keywords: new + autism + overgrowth  Related to the article below (Last Update: 8/5/2008)

Global Health Trax Joins Fight Against Autism With Jenny McCarthy ...
PR Newswire (press release), NY - Jul 18, 2008
"We admire and praise the autism community and Jenny McCarthy for their inspiring passion and commitment to find help for this heart-breaking disorder," ...
July 19: Fight Against Autism: Global Health Trax Supports Jenny ...
Eworldwire (press release), NJ - Jul 15, 2008
... detox of metals, and anti-fungals for yeast overgrowth that plagued his intestines." Global Health Trax (GHT) supports the autism community's efforts to ...
Source: Google News

Evidence of Brain Overgrowth in the First Year of Life in Autism -
E Courchesne, R Carper, N Akshoomoff - JAMA, 2003 - Am Med Assoc
... growth phase involves the rapid and large overgrowth within the ... By adolescence and
adulthood, brain size in autism is not ... A new MRI study of 8- to 46-year-old ...

Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long- … -
E Courchesne, K Pierce - Current Opinion in Neurobiology, 2005 - Elsevier
... Another possibility is that brain overgrowth in autism is the ... include glial activation
and might also include a compensatory production of new neurons and ...

Brain development in autism: Early overgrowth followed by premature arrest of growth -
E Courchesne - Mental Retardation and Developmental Disabilities Research …, 2004 - doi.wiley.com
... of toddlers with autism, have opened a whole new area of research and discovery.
Recent studies have now shown that abnormal brain overgrowth occurs during the ...

Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal … -
E Courchesne, K Pierce - International Journal of Developmental Neuroscience, 2005 - Elsevier
... studies and the relationship to overall brain size 3. New MRI and HC studies show
early brain overgrowth then premature cessation of growth in autism 3.1. ...

Brain weight in autism: Normal in the majority of cases, megalencephalic in rare cases -
E Courchesne, RA Muller, O Saitoh - Neurology, 1999 - AAN Enterprises
... New York:Plenum Press and Basic Books, 1968. ... R. Carper, and N. Akshoomoff Evidence
of Brain Overgrowth in the First Year of Life in Autism JAMA, July 16 ...

The neurobiology of autism: New pieces of the puzzle -
MT Acosta, PL Pearl - Current Neurology and Neuroscience Reports, 2003 - Springer
... regulation of brain growth in autism, characterized by early overgrowth followed
by ... The Neurobiology of Autism: New Pieces of the Puzzle ? Acosta and Pearl ...

Macrocephaly, epilepsy, autism, dysmorphic features, and mental retardation in two sisters: a new … -
KH Orstavik, P Stromme, J Ek, A Torvik, OH … - British Medical Journal, 1997 - jmg.bmj.com
... mental retardation in two sisters: a new autosomal recessive ... and N. Akshoomoff Evidence
of Brain Overgrowth in the First Year of Life in Autism JAMA, July ...

… aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new … -
P Whiteley, P Shattock - ett, 2002 - Expert Opinion
... data has reported the presence of new opi- oid ... origin in the urine of people with
autism [87 ... symptoms or merely reflects opportunistic fungal overgrowth as a ...

A question of balance: a proposal for new mouse models of autism -
CL Murcia, F Gulden, K Herrup - International Journal of Developmental Neuroscience, 2005 - Elsevier
... While few new details have emerged since the ... behavioral problems such as those found
in autism. ... The temporary overgrowth of the cerebral cortex reported in ...

The immune response in autism: a new frontier for autism research -
P Ashwood, S Wills, J Van de Water - Journal of Leukocyte Biology, 2006 - Soc Leukocyte Biology
... in this window] [in a new window], Table ... pediatric gastroenterology and general autism
clinics have ... phenolic amines (tylenol), bacterial overgrowth with greater ...

Source: Google Scholar

New studies suggest brain overgrowth in 1-year-olds linked to development of autism

Researchers observe link between post-natal behavioral symptoms

Boca Raton, FL, December 8, 2007 – Brain overgrowth in the latter part of an infant’s first year may contribute to the onset of autistic characteristics, according to research presented today at the American College of Neuropsychopharmacology (ACNP) annual meeting. These findings support concurrent research which has found brain overgrowth in autistic children as young as two years old.

Lead researcher Joseph Piven, M.D., Director of the Neurodevelopmental Disorders Research Center at the University of North Carolina, Chapel Hill and an ACNP member, says that behavioral studies of infants at high risk for autism suggest that the onset of most behavioral symptoms which define the disorder, such as problems with and social interaction, also occur at about age one. “One reason these findings are important is because early post-natal onset raises the possibility that there may be a window for early treatment and prevention that could be identified by future studies,” Piven says.

Autism, a pervasive developmental disorder characterized by severe deficits in social interaction and communication, is associated with a restricted range of activities and interests, as well as stereotyped repetitive behaviors such as lining up toys in a certain way or requiring basic routines.

In normal brain development, neuronal connections are eliminated through a process called “pruning.” This process refines normal brain connections and increases the efficiency of remaining connections in the brain. Piven says one possibility is that there is less pruning in children with autism and therefore, their brains become larger than in children without autism.

Piven cautions that while the study seems to suggest a link between brain overgrowth and autism, there are many variants of autism among children, so the ways in which autistic children develop and are affected by brain growth can vary greatly.

Piven says he will continue to study brain development in autism through a study which is part of the new Autism Centers of Excellence funded by the National Institutes of Health. This study will examine more than 500 infant siblings of autistic individuals with magnetic resonance imaging at the University of North Carolina, Children’s Hospital of Philadelphia, Washington University of St. Louis and the University of Washington in Seattle. Siblings of autistic children will be examined at 6, 12 and 24 months. Some of them are expected to develop autistic behavior during the course of the study.

Previous studies of both brain development on MRI and behavioral development have not been conducted in children this young, at risk for an autism spectrum disorder. This study will provide important new information on brain changes in infancy that are associated with the development of autistic symptoms.

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ACNP, founded in 1961, is a professional organization of more than 700 leading scientists, including four Nobel Laureates. The mission of ACNP is to further research and education in neuropsychopharmacology and related fields in the following ways: promoting the interaction of a broad range of scientific disciplines of brain and behavior in order to advance the understanding of prevention and treatment of disease of the nervous system including psychiatric, neurological, behavioral and addictive disorders; encouraging scientists to enter research careers in fields related to these disorders and their treatment; and ensuring the dissemination of relevant scientific advances.
 
 
 
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