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Recent News and Articles on the Keywords: ohsu + 598 + web  Related to the article below (Last Update: 8/5/2008)

Alzheimer's drug trial at OHSU shows promise in some patients
Media Newswire (press release), NY -
The Phase 2 clinical trial was conducted at OHSU and 29 other sites around the nation with support from Elan Pharmaceuticals, Inc.., and Wyeth. ...
OHSU working on drug that takes the pleasure out of drinking alcohol
KPIC, OR - Aug 1, 2008
By Susan Harding and KATU Web Staff PORTLAND, Ore. - Oregon Health & Sciences University is developing a drug that could take the buzz out of drinking ...

The Money Times
Cartilage That Repairs Itself? New Research Reveals Important Clues
Science Daily (press release) - Jul 31, 2008
"We think there is something special about these mice," said Jamie Fitzgerald, Ph.D., assistant professor of orthopedics and rehabilitation in the OHSU ...
Mice genes could hold key to alcoholism cure kgw.com (subscription)
Mice that regenerate cartilage may help improve human injuries ... Thaindian.com
Natural cartilage repair in mice studied United Press International
all 26 news articles »
OHSU study on leg ulcers seeks volunteers
The Regal Courier, OR - Jul 30, 2008
Gregory Moneta, MD, of Oregon Health and Science University, is leading a research study on foot and leg ulcers in seniors, and residents in the local area ...

Gresham Outlook
OHSU on trail of alcoholism cure
Gresham Outlook, OR - Jul 29, 2008
... feed a sense of euphoria and pleasure, according to lead researcher Tamara Phillips, vice chair of the behavioral neuroscience department at OHSU. ...
OHSU Foundation names new president
Bizjournals.com, NC - Jul 8, 2008
Sigrid Button will assume the presidency of OHSU's nonprofit fundraising affiliate Aug. 18, replacing Stephen Sanders, who resigned June 1 due to illness. ...
OHSU chooses fundraising chief
The Oregonian - OregonLive.com, OR - Jul 9, 2008
OHSU on Tuesday named Sigrid Button as president of the OHSU Foundation. Button replaces Stephen Sanders, who resigned June 1 because of illness. ...
Znomics and Leading Chemist At Oregon Health & Science University ... MarketWatch
Signs of life (sciences) on the waterfront The Oregonian - OregonLive.com
Tuesday's Oregon business index The Oregonian - OregonLive.com
all 13 news articles »  OTC:ZNOM
Woman, life savers to meet in Arizona
Statesman Journal, OR - Aug 3, 2008
Molalla firefighters and paramedics got her to OHSU by helicopter and she survived to finish high school and college with honors. ...
OHSU Appoints New University Librarian
Media Newswire (press release), NY - Jul 14, 2008
Shaffer comes to OHSU from the University of Iowa, where he served as Assistant Director for Technology and Outreach at the Hardin Library for the Health ...

KING5.com
Injured climber airlifted off Mount Hood
Seattle Times, United States - Jul 6, 2008
The helicopter took the climber to OHSU Hospital. The man's name has not been released, but the sheriff's office says he is in his 30s and from out of ...
Injured climber recovering at Portland hospital KTVZ
Mount Hood climber recovering after fall The Oregonian - OregonLive.com
Man falls 100 feet down Mount Hood KEX
KPTV.com - Charleston Post Courier
all 63 news articles »
Source: Google News

Glomus tumor of the trachea -
RT Gowan, FM Shamji, DG Perkins, DE Maziak - The Annals of Thoracic Surgery, 2001 - Soc Thorac Surgeons
... full/72/2/598 on the World Wide Web at: The ... Park Rd, Portland, OR 97201; e-mail:
slaterm@ohsu.edu. ... 2001;72:598-600 Ann Thorac Surg Russell T. Gowan, Farid M ...

[CITATION] Overview of the ImageCLEFmed 2006 Medical Retrieval and Medical Annotation Tasks
H Miiller, T Deselaers, T Deserno, P Clough, E Kim … - Evaluation of Multilingual and Multi-modal Information …, 2007 - Springer
-

Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53 -
X Zeng, AJ Levine, H Lu - Proceedings of the National Academy of Sciences, 1998 - National Acad Sciences
... To whom reprint requests should be addressed. e-mail: LUH{at}OHSU.edu. ... The Emerging
p53 Gene Family J Natl Cancer Inst, April 7, 1999; 91(7): 594 - 598. ...

[PDF] Overview of the ImageCLEF 2007 Medical Retrieval and Annotation Tasks -
H Muller, T Deselaers, E Kim, J Kalpathy?Cramer, … - www-i6.informatik.rwth-aachen.de
... In 2006, this script was part of the submission web site, but performance problems
had us change this setup. ... OHSU-oshu cefq 598 0.1129 0.1307 0.2000 ...

Overview of the ImageCLEFmed 2006 Medical Retrieval and Medical Annotation Tasks -
H Muller, T Deselaers, TM Lehmann, P Clough, K … - Evaluation of Multilingual and Multi-modal Information …, 2006 - Springer
... Page 2. 596 H. Muller et al. found on the task web pages for ImageCLEFmed 2 and
the medical annotation ... OHSU, USA. ... Page 4. 598 H. Muller et al. ...

Percutaneous bioprosthetic venous valve: A long-term study in sheep -
D Pavcnik, BT Uchida, HA Timmermans, CL Corless, … - Journal of Vascular Surgery, 2002 - Elsevier
... Oregon Health Sciences University, L342, 3181 SW Sam Jackson Park Rd, Portland,
OR 97201 (e-mail: pavcnikd@ohsu.edu). ... 598 ... PREVIEW UPCOMING ARTICLES ON THE WEB ...

Trends in medical information retrieval on internet -
O Baujard, V Baujard, S Aurel, C Boyer, RD Appel - Computers in Biology and Medicine, 1998 - Elsevier
... 5 http://www.ohsu.edu/cliniweb/browse.html. ... in Biology and Medicine 28 (1998)
589?601 598 ... and in particular medical information discovery on the web remains a ...

[PDF] Iniciativas en espa?ol para la evaluaci?n de contenidos biom?dicos en internet
S Garc?a, E Montesinos, C Boyer - Consultado en - informaticamedica.org
... web que dispongan de informaci?n sobre salud, siendo deseable una plataforma
multiling?e que unifique experiencias. ... internet. BMJ 2002;324: 598-602 ...

Expression and ambivalence over expression of negative emotion: Psychometric analysis in the Women? … -
YL Michael, N Perrin, D Bowen, BB Cochrane, JP … - Journal of Women & Aging, 2005 - haworthpress.com
... Jackson Park Rd., CB 669, Portland, OR 97239-3098 (E-mail: michaely@ohsu.edu ...
17(1/2) 2005 Available online at http://www.haworthpress.com/web/JWA ? 2005 ... 598 ...

Supporting Exploratory Queries in Databases -
A Kadlag, AV Wanjari, J Freire, JR Haritsa - LECTURE NOTES IN COMPUTER SCIENCE, 2004 - Springer
... iisc.ernet.in 2 Computer Science & Engineering OGI/OHSU, Beaverton, Oregon ... install
a customized software for each of the Web services that ... 598 A. Kadlag et al. ...

Source: Google Scholar

OHSU Cancer Institute researcher discovers what fuels certain cancer mutation

ATLANTA– An Oregon Health & Science University Cancer Institute researcher has discovered that a particular hormone is responsible for driving a cancer enzyme to cause an often deadly red blood cell cancer.

Researchers working with the cancer mutation in the JAK2 enzyme have found that the enzyme is dependent on the hormone TNF-alpha to grow and cause a red blood cell cancer called polycythemia vera, said principal investigator Thomas Bumm, M.D., Ph.D., OHSU Cancer Institute member.

This research will be presented at the American Society of Hematology annual meeting in Atlanta on Monday, Dec. 10, at 3:30 p.m.

Polycythemia vera is a disease in which there are too many red blood cells in the bone marrow and blood, causing the blood to thicken. There is no cure.

Mice with normal TNF-alpha production and the JAK2 mutation developed the red blood cell disease very quickly – within two to three weeks. The blood became very thick, and they developed severe bone marrow fibrosis, excessive fibers in the bone marrow with a decrease in healthy cells. In contrast, mice without the hormone but carrying the JAK2 mutation had normal red blood cell levels and normal bone marrow.

The hormone, TNF-alpha is known as a highly potent hormone, but until now its role in cancer has not been well understood.

“If these specific hormones are understood, then there is hope to find a new way to fight these cancer cells by attacking the specific hormones triggering the cancer cells,” said Bumm, a fellow in hematology/ medical oncology, OHSU School of Medicine.

There are already drugs developed that target TNF-alpha used for patients with auto immune and inflammatory diseases such as rheumatoid arthritis. But the drugs have not been used for cancer patients. Bumm said one of the next steps will be to conduct studies on a larger mouse study and also testing these different drugs’ effect on this JAK2-induced cancer.

“Maybe one of these drugs will work on the mice and is safe so that we could begin testing the drugs on patients. At this point, there is no specific treatment for polycythemia vera cancer patients. Maybe we opened a new door to understand leukemia better and to fight it at a crucial root,” Bumm said.

Polycythemia vera is rare, about five in every 1 million people have it. Without treatment, about half the people who have polycythemia vera with symptoms die in less than two years.

Often, people with polycythemia vera have no symptoms for years. The earliest symptoms usually are weakness, fatigue, headache, light-headedness, shortness of breath and night sweats. Vision may be distorted, and a person may have blind spots or may see flashes of light. Bleeding from the gums and more bleeding than would be expected from small cuts are common. The skin, especially the face, may look red. A person may itch all over, particularly after bathing or showering.

###

This research is abstract #675.

The OHSU Cancer Institute is the only National Cancer Institute-designated center between Sacramento and Seattle. It comprises some 120 clinical researchers, basic scientists and population scientists who work together to translate scientific discoveries into longer and better lives for Oregon's cancer patients. In the lab, basic scientists examine cancer cells and normal cells to uncover molecular abnormalities that cause the disease. This basic science informs more than 200 clinical trials conducted at the OHSU Cancer Institute.

 
 
 
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