Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: cancer + epigenetic + web  Related to the article below (Last Update: 8/5/2008)

Next Generation Tool For Visualizing Genomic Data Introduced
Science Daily (press release) - Aug 4, 2008
Other genomic details, such as copy number variation, chromatin immunoprecipation data, and epigenetic modifications, can also be viewed in IGV. ...
A SOLICITATION OF THE NATIONAL INSTITUTES OF HEALTH AND THE ...
Trading Markets (press release), CA - Jul 18, 2008
... in Cancer-related Care; Antibody Array for Cancer Detection and Diagnosis; Novel and Improved Methods for Detecting Epigenetic Modifications; ...
NCI to Roll Out Cancer Molecular Analysis Portal to Integrate ...
bio1nf0rm (subscription), NY - Jul 18, 2008
As a result, he said, ?for the first time, we can integrate data from changes in the cancer cell on the DNA, RNA, and epigenetic levels. ...
Source: Google News

[PDF] The fundamental role of epigenetic events in cancer -
PA Jones, SB Baylin - Nat Rev Genet, 2002 - hosted.roswellpark.org
... EPIGENETIC EVENTS IN CANCER ... regulating the transcription of the mammalian genome
is enhancing our understanding of the epigenetic changes that occur in cancer. ...
-

DNA METHYLATION: Tying It All Together: Epigenetics, Genetics, Cell Cycle, and Cancer -
SB Baylin - Science, 1997 - sciencemag.org
... you are using a browser that does not support current Web standards. ... Further, their
results show how epigenetic and genetic aspects of cancer might be ...

Cancer epigenetics takes center stage -
AP Feinberg - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences
... Epigenetic alterations in cancer include global hypomethylation (4), hypomethylation
of individual genes (1), and hypermethylation of CpG islands (5), CpG-rich ...

DNA methylation and genetic instability in colorectal cancer cells -
C Lengauer, KW Kinzler, B Vogelstein - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
... Natl. Acad. Sci. USA Home page AP Feinberg Cancer epigenetics takes center stage
PNAS, January 16, 2001; 98(2): 392 - 394. [Full Text] [PDF], Home page, Am. ...

The epigenetic progenitor origin of human cancer -
AP Feinberg, R Ohlsson, S Henikoff? - Nat Rev Genet, 2006 - palgrave-journals.com
... We propose an epigenetic progenitor model in which cancer involves epigenetic
disruption of progenitor cells, an initiating mutation, and genetic and ...

Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction -
SB Baylin, JE Ohm - Nat Rev Cancer, 2006 - nature.com
... as gene-expression microarray analyses to identify genes that are re-expressed
following pharmacologi- cal reversal of epigenetic silencing in cancer cells 18 ...

Linking the epigenetic'language'of covalent histone modifications to cancer -
SB Hake, A Xiao, CD Allis - British Journal of Cancer, 2004 - nature.com
Full text access provided to Googlebot Access by Web Services. ... ChemPort | Brown R,
Strathdee G. (2002) Epigenomics and epigenetic therapy of cancer. ...

Cancer epigenetics -
RL Momparler - Oncogene, 2003 - nature.com
... tumor suppressor genes and an enhanced antineoplastic effect against tumor cells,
and should be investigated as a novel form of epigenetic therapy for cancer. ...

Dissecting Complex Epigenetic Alterations in Breast Cancer Using CpG Island Microarrays 1 -
PS Yan, CM Chen, H Shi, F Rahmatpanah, SH Wei, CW … - Cancer Research, 2001 - AACR
... 3 See our web site: http://www.missouri.edu/ hypermet. ... CpG island arrays: an application
toward deciphering epigenetic signatures of breast cancer. Clin. ...

The Role of DNA Methylation in Mammalian Epigenetics -
PA Jones, D Takai - Science, 2001 - sciencemag.org
... citing articles in: ISI Web of Science ... including chromosomal integrity, mental
retardation, and cancer. Understanding how epigenetic states are established and ...

Source: Google Scholar

Keeping at-risk cells from developing cancer

 

Researchers at Johns Hopkins have discovered that cancers arising from epigenetic changes - in this case the inappropriate activation of a normally silent gene - develop by becoming addicted to certain growth factors. Reporting online in next week’s Early Edition of the Proceedings of the National Academies of Sciences, the team shows that blocking this “addiction” can greatly prevent cancer growth.

“If this is translatable to people, it could be really exciting,” says Andrew Feinberg, M.D., professor of medicine, oncology and molecular biology and genetics and director of the Epigenetics Center at Hopkins. “It means we might be able to do something about at-risk cells before cancer develops, and treat these cells biochemically and specifically, rather than using current drugs that are nonspecific and kill everything in their path.”

The gene for growth factor IGF-II (insulin-like growth factor two) is one of several in the human genome that is controlled by imprinting - where one of the two copies of the gene is turned off, depending on which parent it came from. Normally, the IGF-II gene from your father is turned on and the one from your mother is turned off. Loss of this imprinting causes the activation of the maternal copy, leading to activation of both copies of the IGF-II gene, which has been associated with a fivefold increased frequency of intestinal tumors in people.

The Hopkins team tested mouse cells with imprinting intact, which have only one copy of IGF-II activated, and compared them to cells that had lost imprinting and have both copies of IGF-II activated. They found that normally imprinted cells respond to normal doses of growth factor and recover within 90 minutes. However, cells that had lost imprinting were activated by the smallest doses and continued to stay activated for more than 120 minutes.

“It’s like they were on a hair trigger, which was totally counterintuitive to what we might have predicted,” says Andre Levchenko, Ph.D., an assistant professor of biomedical engineering at Hopkins and co-director of the study. “You would expect in cells that have lost imprinting, and therefore have twice the amount of gene product, that it would take higher doses to activate the cell. In fact, the cell becomes hypersensitized while having too much IGF-II around.”

The researchers then wondered if blocking the cells’ response to IGF-II could block cancer growth in animals. Mice that develop colon cancer were given a drug that specifically blocks a cell’s ability to respond to IGF-II. These mice developed 70 percent fewer precancerous lesions than mice without treatment.

“Finding the molecular mechanism behind cancer development allowed us to use a specific drug to actually take care of these risky cells before the animal developed cancer,” says Feinberg. “It’s making us think about cancer prevention in a whole new way.”

###

The research was funded by the National Institutes of Health and the Swedish Cancer Research Foundation.

Authors on the paper are Atsushi Kaneda, Chiaochun Wang, Raymond Cheong, Winston Timp, Patrick Onyango, Bo Wen, Christine Iacobuzio-Donahue, Andre Levchenko and Feinberg of Hopkins; Rolf Ohlsson of Uppsala University in Uppsala, Sweden; Rita Andraos and Mark Pearson of Novartis Institute of Biomedical Research in Basel, Switzerland; and Alexei Sharov, Dan Longo and Minoru Ko of the National Institute on Aging in Baltimore, Md.

On the Web:

http://www.hopkinsmedicine.org/ibbs/research/epigenetics/
http://www.pnas.org/

 
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.