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Recent News and Articles on the Keywords: penn + upenn + behind  Related to the article below (Last Update: 8/5/2008)

That mighty male Sean Penn plays Harvey Milk.
Baltimore Sun, United States -
The men behind it are Michael London, Bruce Cohen and Dan Jinks, who won an Oscar for American Beauty. The director is the celebrated Gus Van Sant. ...

New York Daily News
Obama: Penn offers his two cents...
MSNBC -
Here's something we haven't seen in a while: advice from Mark Penn: "So here is a radical suggestion: Rather than sparring on the Republican playing field ...
Misinformation on Obama keeps coming Augusta Chronicle
The mother of all campaigns ? 2008 presidential race Statesman Journal
For Obama and McCain, speech proves a fickle ally DetNews.com
Irish Independent
all 521 news articles »
College football: Five questions to ponder as Penn State opens camp
Danville News, PA -
By Jeff McLane Could there be a season that Joe Paterno wanted to start any more than this one, his 43rd as head coach at Penn State? ...
Reading between the Lions | Penn State?s football program tarnished The Tribune-Democrat
Paterno, Bowden share similar path The Daily Collegian Online
ESPN ignored Penn State's work for integrity of sports The Patriot-News - PennLive.com
Gant Daily - York Daily Record
all 11 news articles »
Penn National's EVP of operations departs
CNNMoney.com -
NEW YORK (Associated Press) - Penn National Gaming Inc.'s executive vice president of operations, Leonard DeAngelo, has left the company, according to a ...
Penn National fires a VP Philadelphia Inquirer
all 6 news articles »  PENN

Maktoob Business (press release)
Penn plays to market
NEWS.com.au, Australia -
AXA'S Andrew Penn set a trend for the coming profit season today by reporting a number at or above forecasts, and punters backed him with a 6.1per cent ...
Axa Asia-Pacific surges after an earnings surprise The Australian
AXA profit slumps 75% The Age
Tough times ahead, Axa warns Sydney Morning Herald
Bloomberg - NEWS.com.au
all 76 news articles »  ASX:AXA
Webcast Alert: Second Quarter 2008 Financial Results Conference ...
WELT ONLINE, Germany -
Penn Virginia Corporation (NYSE:PVA) announces the following Webcast: What: Second Quarter 2008 Financial Results Conference Call When: August 7, ...PVA - PVR

NDTV.com
Franco, Penn turn gay lovers
NDTV.com, India -
Spider-Man star James Franco reveals that he felt awkward kissing Sean Penn in the upcoming movie Milk because it was more than just a peck on the cheek. ...

WSBT-TV
Ohio State eyes another Big 10 title
International Herald Tribune, France -
But an age-old question has emerged again at Penn State: Will this be the 81-year-old Paterno's last season on the sideline? _Michigan is in transition as ...
Ohio State football Columbus Dispatch
all 66 news articles »
Penn State football Q&A with Ron Musselman
Pittsburgh Post Gazette, PA - 42 minutes ago
MUSSELMAN: Penn State plays just one solid nonconference team the first four weeks -- Oregon State (Sept. 6) -- but the schedule gets much tougher after ...
Penn State Q&A with Ron Musselman Pittsburgh Post Gazette
all 2 news articles »
Organic Alliance Adds Dr. Gail Morrison as New Member to the ...
MarketWatch -
Over the last 20 years, Morrison has been actively involved in curricular design and implementation at Penn. She developed and implemented Curriculum ...PINK:ORGC - OTC:CMTX
Source: Google News

Building a large annotated corpus of English: the penn treebank -
MP Marcus, MA Marcinkiewicz, B Santorini - Computational Linguistics, 1993 - portal.acm.org
... Computer and Information Sciences, University of Pennsylvania, Philadelphia, PA ... raw
materials of the Penn Treebank form ... 3 The rationale behind developing such ...

[PDF] The Penn Treebank: Annotating predicate argument structure -
M Marcus, G Kim, MA Marcinkiewicz, R MacIntyre, A … - ARPA Human Language Technology Workshop, 1994 - acl.ldc.upenn.edu
... of Computer and Information Science University of Pennsylvania Philadelphia, PA ... of
the current Penn Treebank exceeds ... sentences which leave behind a semantically ...

[PDF] The modern molecular clock -
L Bromham, D Penn - Nature Reviews Genetics, 2003 - biols.susx.ac.uk
... biology? In this review we dis- cuss the history of the molecular clock and
the theory behind this unexpected and useful research tool. ...
-

Neuronal ensemble control of prosthetic devices by a human with tetraplegia -
… , M Saleh, AH Caplan, A Branner, D Chen, RD Penn, … - Nature, 2006 - nature.com
... 7, 8 , Maryam Saleh 9, 13 , Abraham H. Caplan 9 , Almut Branner 10 , David Chen
11 , Richard D. Penn 12 and ... A technician appears (AHC) behind the participant. ...

Nanoparticles for bioanalysis -
SG Penn, L He, MJ Natan - Current Opinion in Chemical Biology, 2003 - Elsevier
... Sharron G Penn *? , Lin He *? and Michael J Natan E-mail The Corresponding ... The driving
force behind the use of nanoparticles as tags in biological assays ...

[PDF] Adding Semantic Annotation to the Penn TreeBank -
P Kingsbury, M Palmer, M Marcus - Proceedings of the Human Language Technology Conference, 2002 - citeseer.comp.nus.edu.sg
... Mitch Marcus University of Pennsylvania Department of Computer Science 461A ... argument
structure for the Penn TreeBank II ... of the fire hydrant to behind the UPS ...

[PDF] Language Constructs for Distributed Real-Time Programming -
I Lee, V Gehlot - Proc. IEEE Real-Time Systems Symposium, 1985 - repository.upenn.edu
... http://repository.upenn.edu/cis reports/656 ... and Information Science University of
Pennsylvania Philadelphia, PA ... we explain the motivation behind the design of ...

[PDF] Making and reading microarrays -
VG Cheung, M Morley, F Aguilar, A Massimi, R … - Nature Genetics, 1999 - 51qe.cn
... 1 Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania
19104, USA. ... c, A genomic microarray, printed by the Penn robot. ...
-

[PDF] On the Dynamics and Significance of Low Frequency Components of Internet Load -
A Mukherjee - Internetworking: Research and Experience, 1994 - repository.upenn.edu
... Computer and Information Science Department University of Pennsylvania Philadelphia,
PA ... path from aura.cis.upenn.edu to ... we adopted and the rationale behind it. ...

Automated extraction of TAGs from the Penn Treebank -
J Chen, K Vijay-Shanker - Proceedings of the 6th International Workshop on Parsing …, 2000 - Springer
... the extracted LTIG, similar to our motivation behind extended extracted ... Technical
report, University of Pennsylvania. ... available at http://www.cis.upenn.edu/xtag ...

Source: Google Scholar

Researchers led by Penn vet uncover the delicate protein balance behind the immune system response

PHILADELPHIA -– A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue.

The Penn team, led by Christopher Hunter, chair of the Department of Pathobiology at Penn Vet, has identified the pathways that lead to the production of the signaling protein, or cytokine, Interleukin 10 (IL-10) which plays an important role in regulating the balance between the protective white blood, or T, cell response and one that is pathological and out of control.

While IL-10 has long been recognized as a major anti-inflammatory factor, the events that lead to its production have been poorly understood. According to the researchers’ findings, messenger proteins Interleukin 27, or a combination of Interleukin 6 and another type of messenger molecule called transforming growth factor beta, induce production of IL-10. These results suggest that modulating these messenger molecules could increase IL-10 concentrations that temper overactive immune responses.

This information sheds new light on the immune-system response and may provide directed means to intervene in severe autoimmune diseases such as colitis, multiple sclerosis and arthritis.

“The deeper we delve into the role of cytokines in the immune system response, the more we realize that they are part of an elaborately balanced system kept in check by the conflicting regulatory functions of the cytokines themselves,” Hunter said. “When combined with the work from our colleagues at Schering Plough, Harvard and Jefferson University, these studies provide new insights into the pathways that can be used to temper autoimmune inflammation.”

Although there are many sources of IL-10 in the body, the details of how it is synthesized were poorly understood. Hunter’s team determined that the process begins with cytokines IL-27 and IL-6 inducing production Th1 , Th2 and Th17 T cells and concludes that cytokines like IL-27 can promote the ability of these cells to produce IL-10. The effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6.

Researchers tested this hypothesis by removing the IL-27 receptor from genetically engineered mice. Once infected with disease, the mice were unable to generate T cells producing IL-10.

In prior studies, Penn researchers learned that Interluekin-27 was involved in the immune-system response by limiting the duration and intensity of white blood activation, an "off switch" to the cascade of messenger proteins that serve to further activate the immune system. Prior to their research, the general assumption among scientists was that IL-27 promoted inflammation.

###

The research was performed by Jason Stumhofer, Jonathan Silver, Tajie Harris and Hunter of the Department of Pathobiology at Penn Vet; Arian Laurence and John O'Shea of the Molecular Immunology and Inflammation Branch of the National Institute of Arthritis and Muskoskeletal and Skin Diseases; Paige Porrett and Laurence Turka of Penn’s School of Medicine; Matthias Ernst of the Ludwig Institute for Cancer Research in Victoria, Australia; and Christiaan Saris of the Department of Inflammation Research in Thousand Oaks, Calif.

The study was supported by the National Institutes of Health, Scholler Foundation, Marie Lowe Cancer Center, Commonwealth of Pennsylvania and National Health and Medical Research Council of Australia.


 
 
 
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