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Recent News and Articles on the Keywords: heart + failure + raise  Related to the article below (Last Update: 8/5/2008)

Take care of your pets they too run heart attack risk
Press Trust of India, India - Aug 3, 2008
The statistics indicate a critical need to raise general awareness about congestive heart failure in dogs. If more dog owners are aware of the disease and ...
Craig W. Philips Takes Helm at CTI
FOXBusiness -
However, they may cause cumulative heart damage that limits lifetime dosage and does not allow for retreatment. Pixantrone has been designed to reduce the ...CTIC - OTC:CMTX
T. Boone Pickens ?Encouraged? by Obama?s Energy Speech
FOXNews -
It?s also a threat that goes to the very heart of who we are as a nation, and who we will be. Will we be the generation that leaves our children a planet in ...KDQ:095910 - SEO:010950

Financial Times
The Dissident
FrontPage magazine.com, CA -
One of the last century?s most important writers, he survived Hitler?s army, Stalin?s death camps and a bout with cancer, before succumbing to heart failure ...
RussiaToday
Nobel laureate Alexander Solzhenitsyn dead Telegraph.co.uk
all 2,380 news articles »
A Practical "ABCDE" Approach to the Metabolic Syndrome
RedOrbit, TX -
Yusuf S, Ostergren JB, Gerstein HC, et al, Candesartan in Heart Failure-Assessment of Reduction in Mortality and Morbidity Program (CHARM) Investigation. ...
MURRIETA: Numbing the pain
North County Times, CA -
The Keating family is starting a foundation to raise money for scholarships and promote awareness of the danger of drug addiction. (Photo by Steve Thornton ...
Response Biomedical Receives US FDA Clearance for RAMP(R) NT ...
FOXBusiness - Jul 22, 2008
"NT-proBNP is emerging as a superior marker for the diagnosis of heart failure," said S. Wayne Kay, Chief Executive Officer. "The introduction of the ...TSE:RBM - OTC:CMTX

Ortho SuperSite
Hemiarthroplasty is a good, but not easy option
Ortho SuperSite, NJ -
Concerns with ORIF and pinning, however, include: humeral plate disengagements; the danger of pin migration into other locales including the heart; ...
Get involved, help the hungry
Allentown Morning Call, PA -
First, admit that the ''trickle down economics'' of the last 15 years is a miserable failure. Admit that at the heart of all of our most pressing issues is ...
Raising awareness of mitochondrial disorders
Sulphur Southwest Daily News, LA - Aug 3, 2008
?In children and adults, we see organ failure. It could be hearing, vision, gastrointestinal, liver, or brain.? According to Manley, 10 to 20 percent of all ...
Source: Google News

… of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure -
S Haq, G Choukroun, H Lim, KM Tymitz, F del Monte, … - Circulation, 2001 - Am Heart Assoc
... apoptosis in these hearts and have postulated that apoptosis may play a role in
the progression of heart failure. 7 These data raise questions regarding the ...

Amiodarone or an Implantable Cardioverter-Defibrillator for Congestive Heart Failure -
GH Bardy, KL Lee, DB Mark, JE Poole, DL Packer, R … - New England Journal of Medicine, 2005 - content.nejm.org
... Our findings raise the standard of care for many patients with CHF ... Amiodarone in
patients with congestive heart failure and asymptomatic ventricular arrhythmia ...

Actin Mutations in Dilated Cardiomyopathy, a Heritable Form of Heart Failure -
TM Olson, VV Michels, SN Thibodeau, YS Tai, MT … - Science, 1998 - sciencemag.org
... dilated cardiomyopathy, these results raise the possibility that defective transmission
of force in cardiac myocytes is a mechanism underlying heart failure. ...

Circulating Cardiac Troponin I in Severe Congestive Heart Failure -
E Missov, C Calzolari, B Pau - Circulation, 1997 - Am Heart Assoc
... Clinical Implications The cardiac troponin I levels in heart failure patients raise
several important hypotheses: specifically, whether serial cardiac troponin ...

A systematic review of randomized trials of disease management programs in heart failure -
FA McAlister, FME Lawson, KK Teo, PW Armstrong - The American Journal of Medicine, 2001 - Elsevier
... out by Goodman [28], systematic reviews should ?raise research and ... an area.? Given
the current enthusiasm for establishing heart failure disease management ...

Neurohumoral control mechanisms in congestive heart failure.
JN Cohn, TB Levine, GS Francis, S Goldsmith - Am Heart J, 1981 - ncbi.nlm.nih.gov
... vasoconstrictor systems may play an important role in the hemodynamic derangement
and natural history of congestive heart failure (CHF) by raising impedance to ...

Differential Effects of ?-Blockers in Patients With Heart Failure A Prospective, Randomized, Double … -
M Metra, R Giubbini, S Nodari, E Boldi, MG Modena, … - Circulation, 2000 - Am Heart Assoc
... recommended for use in all patients with mild to moderate heart failure caused by ...
increase the density of ?-receptors and tend to raise cardiac norepinephrine ...

Cytokines and Cytokine Receptors in Advanced Heart Failure An Analysis of the Cytokine Database from … -
A Deswal, NJ Petersen, AM Feldman, JB Young, BG … - Circulation, 2001 - Am Heart Assoc
... observations raise the interesting possibility that episodic bouts of myocardial
ischemia may contribute to the total cytokine burden in heart failure and thus ...

… and Implantable Cardioversion Defibrillation in Advanced Chronic Heart Failure The MIRACLE ICD … -
JB Young, WT Abraham, AL Smith, AR Leon, R … - JAMA, 2003 - Am Med Assoc
... Heart failure decompensation was the most common complication ... death and hospitalization
for worsening failure was higher ... These results raise the question of a ...

Arrhythmogenesis and Contractile Dysfunction in Heart Failure Roles of Sodium-Calcium Exchange, … -
SM Pogwizd, K Schlotthauer, L Li, W Yuan, DM Bers - Circulation Research, 2001 - Am Heart Assoc
... This work and novel paradigm (Figure 7 ) raise the issue of molecular ... Packer M. Sudden
unexpected death in patients with congestive heart failure: a second ...

Source: Google Scholar

High-dose diuretics raise mortality in heart failure

NEW YORK (Reuters Health) - As the dosage of loop diuretics increases in patients with advanced heart failure, the risk of death also increases, according to findings of a study conducted at the University of California at Los Angeles.

"This is the very first study to look specifically at the relationship between various doses of loop diuretics and mortality," lead investigator Dr. Gregg C. Fonarow told Reuters Health."When studying whether a medication may be contributing to adverse clinical outcomes in a patient population," he noted, demonstrating whether or not the relationship is dose dependent is critical."

Diuretics are a class of commonly prescribed drugs that are used to treat heart disease and other illnesses. The drugs stimulate the kidneys to remove more water from the body, which is then passed through the urine. Loop diuretics are a strong type of diuretics.

Fonarow and his colleagues studied a group of 1,354 patients with advanced heart failure receiving treatment at their institution between 1985 and 2004. The average age was 53 years, 76 percent were male and the heart's ability to pump blood was reduced to an average of 24 percent.

The investigators divided the group into four sections, according to loop diuretic dosage. The four groups were similar in terms of age, gender, body mass index, cause of heart failure, history of high blood pressure and previous use of the diuretic spironolactone. The highest dose group had, on average, the lowest ability to pump blood, a well as lower levels of sodium and hemoglobin levels and higher levels of biomarkers of kidney disease.

As reported in the June 15th issue of the American Journal of Cardiology, there was a decrease in survival with increasing dose of loop diuretic. Survival estimates at 2 years were 83 percent with the lowest dose, 81 percent in the second group, 68 percent in the third group and 53 percent in the highest group.

Even after the data were adjusted to remove the effects factors that could also increase mortality -- including age, strength of other drug treatments, kidney function, smoking history and blood pressure -- diuretic dosage remained an independent predictor of mortality. For the high-dose group compared with the low-dose group, the mortality risk was increased by four-fold, the team reports.

Fonarow offered an explanation for the link between loop diuretics and mortality in heart failure. Loop diuretics, especially when given at higher doses, activate a part of the nervous system known to increase the risk of death in heart failure patients. Loop diuretics, especially at higher doses, can also contribute to worsened kidney function and electrolyte abnormalities.

Nonetheless, "loop diuretics currently are one of the only therapies for heart failure patients for the treatment of congestion along with dietary sodium restriction," Fonarow acknowledged.

He recommends that physician use loop diuretics at the lowest dose possible dose to relieve congestion. Some physicians (in the study) favored using higher than necessary doses of loop diuretics to keep their heart failure patients' free of fluid. 'This study suggests that this practice should be avoided."

SOURCE: The American Journal of Cardiology

 

Women often stop asthma therapy in early pregnancy

NEW YORK (Reuters Health) - Many women significantly reduce their use of asthma medications in early pregnancy, placing them and their infants at risk, according to a report in the July issue of American Journal of Obstetrics and Gynecology. However, national treatment guidelines recommend continued use of these potentially life-saving drugs.

"Many women will assume that continued use of asthma medications during pregnancy is bad and will discontinue their medications on their own," Dr. Tina V. Hartert from Vanderbilt University School of Medicine, Nashville, Tennessee told Reuters Health.

Hartert and colleagues used data from more than 8,000 pregnant women with asthma who were enrolled in the Tennessee Medicaid program to investigate whether women alter their use of asthma medications during pregnancy.

By 13 weeks of pregnancy, the use of inhaled anti-inflammatory drugs had fallen by 22.9 percent; the use of short-acting beta-agonist, such as albuterol, for quick relief of symptoms, had fallen by 13.2 percent; and the use of rescue corticosteroids (steroids) had decreased by 54.3 percent, the authors report. The use of all classes of asthma medication increased from weeks 6 to 13 and from weeks 13 to 26 of pregnancy, the researchers note, but only the use of short-acting beta-agonists showed a statistically significant rebound by week 26.

"The results of this study suggest that women on Medicaid decrease and/or stop asthma medications during early pregnancy despite national guidelines recommending continued use," the investigators conclude.

Both primary care physicians, as well as providers that care for women during pregnancy, should educate women early and frequently about the importance of continuing to control their asthma and ensure that they are using appropriate medication," Hartert said.

"Pregnant women already know that they are 'eating for two'; a useful message is that they are also 'breathing for two.'"

"The Bureau of TennCare (Tennessee Medicaid) now requires managed care organizations to provide disease management to both high-risk pregnant women and high-risk asthmatics," Hartert explained. "While asthma during pregnancy has not been specifically addressed, we hope that publication of this peer-reviewed study will communicate the risks identified in this paper to managed care organizations."

 
 
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