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Recent News and Articles on the Keywords: lung cancer + cancer + nicotine  Related to the article below (Last Update: 8/5/2008)

American Lung Association Offers Olympic Spectators Tips to Stay ...
MarketWatch -
It can also increase the risk of heart attacks, strokes, lung cancer and even early death. Before spectators leave for Beijing, the American Lung ...
Tobacco Use a Deadly Choice for Millions Worldwide
NewsBlaze, CA -
Smoking also is a risk factor for six of the eight leading causes of death globally, including cancer and heart disease. Smoking tobacco kills more than any ...
My Dear Krauts Igniting Europe's smoking revolution
The Local - Hamburg, Germany -
One of the biggest surges of research into lung cancer came under the Nazis and he was a militant anti-smoker. Lenin did his bit for the cause too, ...

Nigerian Tribune
Special Features
Nigerian Tribune, Nigeria - Aug 1, 2008
This is what makes lung cancer dangerous and difficult to treat. Medical reports also say that at present, one heavy cigarette smoker out of every ten will ...
Anti-smoking group has mixed feelings about Big Tobacco fines CBC.ca
all 3 news articles »
Exercise cuts some of smoking's risks -- but it's a fact that ...
Los Angeles Times, CA - Aug 1, 2008
Lung cancer is a prime example. Although smoking increases the risk of the disease, exercise seems to provide a protective effect. In a 2006 study published ...
At Your Service
Times Colonist, Canada - Aug 3, 2008
Lung Cancer Survivors' Group: A support group for patients. Meets Tuesday, Aug. 5, 3:30-5 pm, in the Quiet Room, 2nd floor of the Vancouver Island Cancer ...
New Cancer Society DVD Helps Put Focus on Tobacco Retail Displays
RedOrbit, TX - Jul 30, 2008
In the same year there were 22 cases of lung cancer diagnosed in the region and two of cancer of the larynx, which is also often associated with smoking. ...

dBTechno
House Overwhelmingly Votes in Favor of Tobacco Regulation
eFluxMedia - Jul 31, 2008
This type of smoke, carrying numerous dangerous chemicals, is responsible for the increase by at least 20 percent of lung cancer risk and for that of heart ...
House passes bill to control tobacco Connecticut Post
House Votes To Let FDA Regulate Tobacco Products Enews 2.0
google news commentComment by M. Cass Wheeler Chief Executive Officer,American Heart Association
MarketWatch - The Ledger
all 557 news articles »
Self-help groups: August 5, 2008
Naples Daily News, FL -
Bosom Buddies, breast cancer and lymphedema support group meets 7 pm second and last Wednesday, Telford Education Building, 350 Seventh Ave. ...
Scotland smoking ban credited with fewer heart attacks
USA Today - Jul 30, 2008
Smoke-free laws also protect people from cancer, although it can take longer for cancer rates to drop, Glynn says. Lung cancer rates in California, ...
Source: Google News

Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. -
R Maneckjee, JD Minna - Proceedings of the National Academy of Sciences of the …, 1990 - pubmedcentral.nih.gov
... Due to the almost universal exposure of patients with lung cancer to nicotine, we
tested whether nicotine affected the response of lung cancer cell growth to ...

Tobacco Smoke Carcinogens and Lung Cancer -
SS Hecht - jnci, 1999 - jnci.oxfordjournals.org
... means of simplifying and clarifying the relevant information that provides a
mechanistic framework linking nicotine addiction with lung cancer through exposure ...

Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. -
R Maneckjee, JD Minna - Cell Growth Differ, 1910 - ncbi.nlm.nih.gov
... Previously, we have shown that opioids acting via specific receptors inhibit the
growth of human lung cancer cells while nicotine, acting through nicotinic ...

Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells -
WL Heusch, R Maneckjee - Carcinogenesis, 1998 - Oxford Univ Press
... 2). However, further investigation is required to determine the exact cause of this
heterogeneous response of lung cancer cells to nicotine, which appears to ...

Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients -
MR Spitz - J Natl Cancer I, 1998 - jnci.oxfordjournals.org
... allele (B1 and B2) of the D2 dopamine receptor gene in 157 lung cancer case patients ...
the less common A1 and B1 alleles are more vulnerable to nicotine addiction ...

The changing epidemiology of smoking and lung cancer histology -
EL Wynder, JE Muscat - Environ Health Perspect, 1995 - pubmedcentral.nih.gov
... two concepts that are regarded as contributors to this change in the histological
types of lung cancer. One factor is the decrease in average nicotine and tar ...

[PDF] Differences in lung cancer risk between men and women: examination of the evidence -
EA Zang, EL Wynder - Journal of the National Cancer Institute, 1996 - jnci.oxfordjournals.org
Page 1. Differences in Lung Cancer Risk Between ... Background: Lung cancer incidence
is gradually leveling off in US men but is continuing to rise in US women. ...
-

[PDF] The accumulated evidence on lung cancer and environmental tobacco smoke -
AK Hackshaw, MR Law, NJ Wald - British Medical Journal, 1997 - ash.org.nz
... from the risk in smokers We estimated the risk of lung cancer in non ... using the urine
or saliva concentrations of cotinine and nicotine (both sufficiently ...
-

Non-smoking wives of heavy smokes have a higher risk of lung cancer: a study from Japan -
T Hirayama - Bulletin of the World Health Organization, 2000 - SciELO Public Health
... PAPERS AND SHORT REPORTS. Non-smoking wives of heavy smokes have a higher risk
of lung cancer: a study from Japan Takeshi Hirayama. Abstract. ...
-

… Nation on the Status of Cancer, 1973-1996, With a Special Section on Lung Cancer and Tobacco Smoking -
PA Wingo, LAG Ries, GA Giovino, DS Miller, HM … - jnci, 1999 - jnci.oxfordjournals.org
... Because experimentation with cigarette smoking and nicotine addiction usually occurs ...
prevalence and the progression in age-specific lung cancer incidence and ...

Source: Google Scholar

Nicotine May Help Spur Lung Cancer

  FRIDAY, July 21 (HealthDay News) -- While the nicotine in tobacco and in nicotine-replacement patches and gums doesn't cause lung cancer, it may help it along, a new study finds.

"Nicotine can promote the growth of new blood vessels and new cells -- two things that are correlated with the progression of cancer -- and our study shows how this actually happens," said study co-author Srikumar P. Chellappan, an associate professor in the Drug Discovery Program with the H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, in Tampa.

The finding raises questions about the use by lung cancer patients of nicotine-containing interventions aimed at helping smokers quit, such as popular patches and gums.

Chellappan's team identified a key binding process taking place between nicotine and receptors found on cells lining the lung's air passages, and in lung cancer cells themselves. The bond between nicotine and these receptors provokes further lung cancer cell proliferation, the researchers report in the August issue of the Journal of Clinical Investigation.

The Florida group conducted their lab work on cancer cells taken from patients afflicted with non-small cell lung cancer (NSCLS).

According to the American Cancer Society, lung cancer accounts for 13 percent of all new cancers and is the leading cancer killer of American men and women. Non-small cell cancers comprise 85 percent of the nearly 175,000 new cases of lung cancer diagnosed in the United States each year.

But while tobacco smoke is the direct cause of eight out of 10 lung malignancies, nicotine -- the addictive chemical in tobacco -- does not have cancer-causing properties. The role, if any, of nicotine in lung cancer has long been the subject of debate.

In previous work, Chellapan found that nicotine exposure among lung cancer patients did appear to undermine chemotherapy's effectiveness in killing off cancer cells. Because so many patients use nicotine patches or gums to help them quit, this raise the troubling notion that these interventions might actually help encourage the disease.In this study, Chellappan's focused on NSCLS cells and adjacent cells from the lung's air passages also known as bronchial cells. They exposed both cell types to nicotine in the test tube. The amount of nicotine used was the equivalent to what would typically be present in the bloodstream of a patient who smokes one pack of cigarettes a day.

In addition to binding with what are known as nicotinic acetylcholine receptors, the nicotine appeared to help create signaling pathways that promoted the cancer cell growth cycle. This growth activated and recruited other cell machinery known to stimulate tumor growth.

The researchers concluded that, in the test-tube setting, nicotine appears to go beyond simply protecting cancer cells as had been previously observed. Instead, it appears to promote cancer-cell proliferation and tumor progression.

"We found that a normal amount of nicotine that is typically present in the blood of smokers can really induce a proliferation of cancer cells, and we have identified some proteins in the cell that facilitate this proliferation," said Chellappan.

"So, smokers should be staying away from all products that contain nicotine," he cautioned. "Not just cigarettes -- anything. I can not say that this is just about smoking. This is about exposure to any nicotine. Even a patch to help quit smoking may not be the best idea."

Nevertheless, one expert is still on the fence when it comes to the risks and benefits for lung cancer patients in using nicotine-replacement therapies.

"You can't necessarily say whether nicotine-replacement therapy is a good or bad idea," said Dr. Norman H. Edelman, chief medical officer with the American Lung Association.

"My guess is that it's a good idea to engage in smoking cessation," he said. "Smoking cessation is a much healthier way to go rather than avoiding the nicotine in smoking-cessation therapies based on the theoretical risk shown in test tubes that nicotine can promote tumors."

Edelman emphasized, however, that the current study is "an important biologic finding" that will need to be followed up with research in animals and ultimately humans.

Two other major groups agreed. The U.S. National Cancer Institute's Web site states that "any potential risks of short-term use of nicotine-replacement therapy to stop smoking are far outweighed by the significant and known benefits that accrue to patients who stop smoking."

And the American Cancer Society's Web site notes that "numerous studies have shown that these products are safe and effective in helping smokers quit." Society experts also point out that the use of nicotine-replacement products, alongside in-person and phone counseling, can double a smoker's chances of successfully quitting.

Health Highlights: July 21, 2006

  Here are some of the latest health and medical news developments, compiled by the editors of HealthDay:

HHS Chief's Foundation Got Tax Breaks, Gave Little to Charity: Report

A charitable foundation set up by U.S. Health and Human Services Secretary Mike Leavitt and his relatives enabled them to claim millions of dollars in tax deductions while providing little to charity, The Washington Post reported Friday.

The foundation was set up in 2000 with almost $9 million from Leavitt family assets. Much of that money went into investments or loans to the family's business interests and real estate holdings.

Less than 1 percent of the Leavitt Foundation's assets were donated to charity in 2002, 2003 and 2004, the Post reported. And since 2000, Mike Leavitt alone has claimed about $1.2 million in tax write-offs.

"They're basically sitting on all this money, getting a charitable write-off and doing nothing with it," said Rick Cohen, executive director of the National Committee for Responsive Philanthropy.

The Post had asked Cohen to review the Leavitt Foundation's records and tax returns.

Christina Pearson, an HHS spokeswoman, said the foundation's activities are 'totally legal and proper.'

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Senators Peck at U.S. Bird Flu Testing Program

The voluntary nature of the U.S. Agriculture Department's bird flu testing program threatens the U.S. poultry industry, a group of U.S. Senators (five Democrats and one Republican) wrote in a letter to Agriculture Secretary Mike Johanns.

The letter cited a federal audit that found that the U.S. government does not have a comprehensive plan for bird flu testing and monitoring in the commercial poultry industry, the Associated Press reported. A plan will be in place by October, says the Agriculture Department.

"It is surprising that USDA does not have a program that monitors and collects data on what testing is taking place," the senators wrote in the letter. "We are deeply concerned that the agency has waited until this year to begin to develop a comprehensive surveillance plan for avian influenza, which will not be complete until October."

They contend that USDA is relying too heavily on states and noted that many states don't have enough staff help to coordinate a bird flu surveillance program, the AP reported.

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More U.S. Doctors Using Electronic Medical Records

In 2005, 23.9 percent of office-based American doctors were using partial or full electronic medical records (EMRs), an increase of 31 percent from the number of doctors using them in 2001, according to a U.S. Centers for Disease Control and Prevention report released Friday.

The survey of about 1,900 doctors found that those in the Midwest (26.9 percent) and West (33.4 percent) were more likely to use EMRs than those in the Northeast (14.4 percent).

Doctors in metropolitan areas (24.8 percent) were more likely to use EMRs than those in non-metropolitan areas (16.9 percent).

Solo practitioners -- who account for a third of doctors but for two-thirds of medical practices -- were least likely to used EMRs.

Despite increased use, the report noted that only 9.3 percent of doctors used EMRs with all four of the basic functions considered necessary for a complete EMR system. The four functions are: computerized orders for prescriptions, computerized orders for tests, reporting of test results, and physician notes).

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Study Finds High Lead Levels in Paints

Some paints used in China, India and Malaysia have lead levels that are much higher than the legal limit in the United States and pose a serious health hazard to children, says a University of Cincinnati study in the September issue of the journal Environmental Research.

These dangerously-high lead levels pose a threat to children around the world because the paints may be used on products that are shipped to other countries. Lead can cause brain damage and other health problems in children.

The researchers sampled 80 paints in four countries. They found that about 50 percent of paint sold in China, India and Malaysia had lead levels 30 times greater than the U.S. limit of 600 parts per million, and some of the paints had levels as much as 300 times the U.S. limit, Agence France Presse reported.

About 10 percent of paint sold in Singapore had lead levels higher than the U.S. limit.

Previous research found high lead levels in paint sold in Indonesia, Peru and the Seychelles.

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FDA Scientists Cite Agency Shortcomings in Poll

The U.S. Food and Drug Administration seems to care more about speeding new drugs to market than ensuring medication safety, more than one-third (37 percent) of the agency's scientists said in a new survey.

The poll, conducted by the Union of Concerned Scientists, also found that 39 percent of the 997 FDA scientists surveyed said the agency wasn't "acting effectively to protect public health," the Baltimore Sun reported Friday. Another 32 percent said the FDA didn't always release complete and accurate information to the public, the newspaper reported.

An FDA spokeswoman called the survey unscientific and "a counterproductive exercise based on leading questions and innuendo."

Senate Finance Committee Chairman Charles Grassley (R-Iowa) issued a statement saying the FDA was in need of "a major overhaul and a culture change at the highest levels," the Sun reported.

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U.S. Warns of Unapproved Lyme Disease Remedy

Citing at least one death from an unapproved remedy for Lyme disease, the U.S. Food and Drug Administration warned doctors and consumers Friday against use of the product, called "bismacine," and also known as chromacine.

The agency issued a statement saying the injected product is not FDA-approved to treat any condition whatsoever. The product contains high amounts of bismuth, a heavy metal used in some pill remedies to treat bacteria that cause stomach ulcers. But the agency said the substance is not approved to be injected.

Poisoning from bismuth can lead to cardiovascular collapse and kidney failure, the FDA warned.

In April, one person died after using the product, and at least one other person has been hospitalized after receiving bismacine, the agency said. The product isn't considered a pharmaceutical and has been dispensed by individual druggists, alternative health practitioners, or by people claiming to be medical doctors, the FDA added.

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Drugmakers Given OK to Color Pills

Drugmakers have been granted U.S. Food and Drug Administration approval to begin using pigments to color pills, tablets, and liquids to brighten their appeal, the Associated Press reported.

The pearlescent pigments, similar to those that give cosmetics a pearly sheen, can produce metallic, satiny, and shimmery finishes, the wire service said. The FDA approved their use some eight years after a New Jersey firm first petitioned the agency, the AP added.

Similar pigments are used in lipsticks, eye shadows, nail polishes and automobile paints, the wire service said. Four years ago, the FDA approved their use in coloring contact lenses.

The new rule specifies that the pigments cannot comprise more than 3 percent of the drug's weight, the AP noted.

 
 
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