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Recent News and Articles on the Keywords: pain + neuropathic + provide  Related to the article below (Last Update: 8/5/2008)

Delayed quote data
MarketWatch -
XTL is developing Bicifadine, a serotonin and norepinephrine reuptake inhibitor, for the treatment of diabetic neuropathic pain, which is currently in a ...
VALLEY COTTAGE, NY, Aug. 5 NY-XTL-&-Presidio-lic
Earthtimes (press release), UK -
XTL is developing Bicifadine, a serotonin and norepinephrine reuptake inhibitor, for the treatment of diabetic neuropathic pain, which is currently in a ...XTLB
Marinus Pharmaceuticals Appoints John Krayacich as President and ...
Earthtimes (press release), UK -
He has led teams involved in the development and marketing of products for epilepsy, Parkinson's disease, Alzheimer's disease, neuropathic pain, depression, ...
Competitive Technologies Signs Agreement for Distribution In India ...
MarketWatch - Jul 29, 2008
The device is a non-invasive method for rapid treatment of high-intensity oncologic and neuropathic pain, including pain resistant to morphine and other ...CTT - PINK:LFSC
Neuropathic Pain - NSL-043 Achieves Success In Phase I Multiple ...
Medical News Today (press release), UK - Jul 23, 2008
As the currently available treatments for neuropathic pain provide only partial pain relief, there is a strong need for new agents with novel mechanisms of ...ASX:NDL
HIV programme in Western Kenya successfully delivers isoniazid ...
Aidsmap, UK -
Dr Diero noted that a small number of discontinuations were due to adverse events, in particular hepatitis and peripheral neuropathy. ...
NSL-043 Achieves Success in Phase I Multiple Ascending Dose Trial
PharmaLive.com (press release), PA - Jul 21, 2008
As the currently available treatments for neuropathic pain provide only partial pain relief, there is a strong need for new agents with novel mechanisms of ...ASX:NDL
Medical Marijuana: Whole Plant Better Than Isolated Components in ...
Drug War Chronicle, DC - Jul 24, 2008
Scientists at the University of Milan have published a study finding that whole-plant marijuana extracts provide better relief for neuropathic pain than ...
NeurogesX Initiates Dosing in Phase 1 Clinical Trial for NGX-1998 ...
SunHerald.com, MS - Jul 11, 2008
NGX-1998 is a topically applied, high-concentration liquid formulation of capsaicin designed to treat pain associated with neuropathic pain conditions. ...NGSX
Support groups
GoErie.com, PA - Aug 4, 2008
Peripheral neuropathy support group meets third Wednesday of every month except January, February and March, from 3 to 5 pm, Springhill Retirement Center, ...
Source: Google News

An Overview of Neuropathic Pain: Syndromes, Symptoms, Signs, and Several Mechanisms. -
RH Dworkin - The Clinical Journal of Pain, 2002 - clinicalpain.com
... to preventing neuropathic pain and the great interest in the pharmaceutical industry
in developing new treatments for neuropathic pain provide a basis for ...

… and preliminary validation of a pain measure specific to neuropathic pain: the Neuropathic Pain … -
BS Galer - Neurology, 1997 - AAN Enterprises
... Moreover, the NPS items appear to be sensitive to treatments known to impact
neuropathic pain. These findings provide support for the further development of ...

Topical Lidocaine Patch Relieves a Variety of Neuropathic Pain Conditions: An Open-Label Study. -
A Devers, BS Galer - The Clinical Journal of Pain, 2000 - clinicalpain.com
... that the topical lidocaine patch can also provide clinically meaningful pain relief
in a variety of other peripheral neuropathic pain conditions, including ...

[PDF] Neuropathic pain: aetiology, symptoms, mechanisms, and management -
CJ Woolf, RJ Mannion - Lancet, 1999 - anat.ucl.ac.uk
... Patients with neuropathic pain do not respond to non-steroidal anti ... is controversial,
although transcutaneous nerve stimulation may provide some relief. ...
-

Advances in Neuropathic Pain Diagnosis, Mechanisms, and Treatment Recommendations -
RH Dworkin, M Backonja, MC Rowbotham, RR Allen, CR … - Archives of Neurology, 2003 - Am Med Assoc
... of neuropathic pain still require translation and confirmation in human neuropathic
pain syndromes, the results from these models provide valuable insights ...

… review of controlled clinical trials for peripheral neuropathic pain and complex regional pain … -
WS Kingery - Pain, 1997 - ncbi.nlm.nih.gov
... clinical trial data for peripheral neuropathic pain (PNP) and complex regional pain
syndromes (CRPS). ... phentolamine all failed to provide analgesia in ...

Spared nerve injury: an animal model of persistent peripheral neuropathic pain. -
I Decosterd, CJ Woolf - Pain, 2000 - ncbi.nlm.nih.gov
... The spared nerve injury model may provide, therefore, an additional resource for
unraveling the mechanisms responsible for the production of neuropathic pain. ...

… Study Comparing the Efficacy of Gabapentin With Amitriptyline on Diabetic Peripheral Neuropathy Pain -
CM Morello, SG Leckband, CP Stoner, DF Moorhouse, … - Archives of Internal Medicine, 1999 - Am Med Assoc
... Conclusions Although both drugs provide pain relief, mean pain score and global ... be
an alternative for treating diabetic peripheral neuropathy pain, yet does ...

Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, … -
J Lai, MS Gold, CS Kim, D Bian, MH Ossipov, JC … - Pain, 2002 - ncbi.nlm.nih.gov
... or response to acute pain. These data provide direct evidence linking
NaV1.8 to neuropathic pain. As NaV1.8 expression is restricted ...

Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats -
ED Milligan, C Twining, M Chacur, J Biedenkapp, KO … - J Neurosci, 2003 - Soc Neuroscience
... These results provide the first evidence that ipsilateral and mirror-image inflammatory
neuropathy pain are created both acutely and chronically through glial ...

Source: Google Scholar

Protein Found That May Provide Relief from Neuropathic Pain

A New Protein Found in the Blood May Provide Relief from Neuropathic Pain
Neuropathic pain is caused by injury to the peripheral nerves in diseases such as HIV/AIDS, shingles, and cancer or in repetitive motion disorders and trauma, and does not respond well to conventional pain-relieving drugs.

Research in rodents by scientists from the University of California, San Diego (UCSD) School of Medicine has provided evidence that a protein called LRP1 may help to ease neuropathic pain by blocking the response of glial cells that support and protect sensory neurons in the peripheral nervous system. Their findings, which could represent a novel target for neuropathic pain therapy, are published in the December 3 issue of the Journal of Clinical Investigation.

“Neuropathic pain differs from ordinary pain in that it is usually perceived as ongoing burning or as ‘pins and needles’ electric-shock type of sensation,” said Wendy Campana, Ph.D., associate professor in UCSD’s Department of Anesthesiology, who led the study. “It is caused by nerve damage that can be associated with chronic inflammation or direct nerve injury.”

The UCSD studies show that a form of LRP1 that is present in body fluids such as blood counteracts the activity of inflammatory cytokines, proteins which are involved in developing and sustaining chronic pain states. Cytokines act as messengers to either stimulate or inhibit the immune response, are produced by many cell types including white blood cells present during infection and inflammation

“We think that the anti-inflammatory activity of LRP1 can be harnessed to decrease chronic pain,” said Campana. “By decreasing the presence of cytokines in the area of nerve damage, LRP1 calms the pain signals that are sent to the spinal cord.”
In-vitro analysis confirmed that LRP1 works to modify the response of glial cells that results in neuropathic pain, according to Campana, who added that interactions of neurons and glial cells are very important in determining pain.

Campana worked with post-doctoral scholar Alban Gaultier, Ph.D., and Steven L. Gonias, M.D., chair of UCSD’s Department of Pathology, who are exploring other aspects of LRP1 function. The UCSD scientists observed that injured peripheral nerves in both mice and rats release LRP1 into the surrounding tissue.

Administration of LRP1 into the rodents’ sciatic nerves prior to injury provided a protective effect, decreasing the level and activity of injury-induced proinflammatory cytokines, such as TNF-alpha, in the local environment and inhibiting spontaneous pain.

In addition to decreasing inflammatory cytokines locally, treatment with LRP1 also decreased inflammatory cytokines in a region called the spinal dorsal horn, where central pain processing occurs.

“TNF-alpha has some positive properties in infection, so you may not want to block its activity entirely,” said Campana. “It appears that LRP1 limits, but doesn’t completely block, the increase in proinflammatory cytokines produced by glial cells after nerve injury. We think this research opens up a number of new research directions for understanding and treating chronic neuropathic pain.”

Additional contributors to this study include Sanja Arandjelovic and Nikola Dragojiovic, UCSD Department of Pathology; Robert R. Myers, UCSD Departments of Pathology and Anesthesiology; and Xiaoqing Li, Julie Janes, George P. Zhou and Jenny Dolkas, UCSD Department of Anesthesiology. The research was supported in part by grants from the National Institutes of Health.
 
 
 
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