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Recent News and Articles on the Keywords: hemoglobin + 0.33 + web  Related to the article below (Last Update: 8/5/2008)

US Congress slams FDA for off-label promotion control failures
Pharma Times (subscription), UK - Aug 4, 2008
The US Food and Drug Administration has been rapped by Congressional watchdog the Government Accountability Office (GAO) for failing to track the ...
Amgen Told to Reword Drug Label
New York Times, United States - Jul 30, 2008
The new labels will say that treatment with the drugs should not begin until a patient?s hemoglobin drops to 10 grams per deciliter of blood. ...AMGN

Chatter Shmatter
FDA Wants Amgen to Update Drug Label For Aranesp
Chatter Shmatter, Canada - Aug 1, 2008
These risks include dangerous side effects for cancer patients also receiving chemotherapy, and those with hemoglobin levels greater than, or equal to, ...AMGN
FDA Orders Changes In Labeling of Anemia Drug
Wall Street Journal - Jul 30, 2008
It also ordered inclusion of a statement that the drugs aren't to be administered when hemoglobin levels are greater to or equal to 10 grams per deciliter ...AMGN - JNJ
FDA Commands Amgen to Change Darbepoetin Alfa (Aranesp) Label
MedPage Today, NJ - Jul 31, 2008
The therapy should not be initiated at hemoglobin levels >10 g/dL. It marked the first time that the FDA has used a newly granted authority that allows it ...AMGN
US FDA orders Amgen to add new anemia drug warning
guardian.co.uk, UK - Jul 30, 2008
The new prescribing instructions say patients should not begin treatment with the drugs if their hemoglobin levels are greater than, or equal to, ...AMGN

Gather.com
Have high blood pressure? Then get tested for diabetes
Gather.com, MA -
... two hours after you drink a sugary beverage or by testing for the percentage of sugar-coated hemoglobin in the bloodstream (known as hemoglobin A1c). ...
Hemoglobin A1c test better than current tools for detecting ...
Palm Beach Daily News, FL - Aug 2, 2008
"Both these problems are eliminated if hemoglobin A1c is used," Saudek said. The HbA1c test helps diabetics monitor their blood sugar by showing how much ...
Community Briefs
BlueRidgeNow.com, NC -
... C1, BUN/cr sugar), comprehensive metabolic (everything in the basic plus total protein, albu, liver fx); complete blood count (hemoglobin, hematocrit, ...
Exercise cuts some of smoking's risks -- but it's a fact that ...
Los Angeles Times, CA - Aug 1, 2008
It compromises the ability of the blood's hemoglobin to transport oxygen from the lungs to the body, especially the muscles, during exercise. ...
Source: Google News

… 1 1 This article has been selected for the open discussion forum on the STS Web Site: http://www. …
AF Rossi, HS Seiden, RP Gross, RB Griepp - The Annals of Thoracic Surgery, 1999 - Soc Thorac Surgeons
... for the open discussion forum on the STS Web Site: http ... with packed red blood cells
to keep the hemoglobin level higher ... DORV 7 LV to AO baffle RA 0.33 0.43 0.34 ...
-

The Anesthetic Management of a Patient with Hemoglobin MIwate -
A Kuji, Y Satoh, K Kikuchi, K Satoh, S Joh - Anesthesia & Analgesia, 2001 - IARS
... We noticed her systemic cyanosis, low hemoglobin (10.7 g/dL), and high ... With aFIO
2 of 0.33, the pulse oximeter occasionally indicated either values of 31%?36 ...

… 1 1 This article has been selected for the open discussion forum on the STS Web site: http://www. …
PE Stensrud, GA Nuttall, MA de Castro, MD Abel, MH … - The Annals of Thoracic Surgery, 1999 - Soc Thorac Surgeons
... for the open discussion forum on the STS Web site: http ... Hemoglobin after 24 hours
in ICU (g/dL) 10.6, 6.9?12.8 ... degrees) 49.5, 26?68 50, 27?70 0.33 2 ( 5, 3 ...

[CITATION] CALTAG LABORATORIES
MATOHF HEMOGLOBIN
-

… mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin -
JF Flores, CR Fisher, SL Carney, BN Green, JK … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences
... currently accepted paradigm of annelid hemoglobin evolution and ... as supporting
information on the PNAS web site ... Table 2). The remaining sulfide, 0.33 HS ? /heme ...

Determination of Hemoglobin Saturation in Patients With Acute Sickle Chest Syndrome* A Comparison of … -
JP Kress, AS Pohlman, JB Hall - Chest, 1999 - Am Coll Chest Phys
... Search for citing articles in: ISI Web of Science ... Co-ox and SpO 2 was +0.33 ? 0.78%
(95 ... a significant discrepancy between arterial hemoglobin oxygen saturation ...

Comparison of effects of two hemoglobin-based O2 carriers on intestinal integrity and microvascular … -
AL Baldwin, EB Wiley, AI Alayash - American Journal of Physiology- Heart and Circulatory …, 2002 - Am Physiological Soc
... Search for citing articles in: ISI Web of Science ... with diaspirin cross-linked human
hemoglobin (DBBF-Hb ... mean microvascular leak number [2.41 ? 0.33 (SE) ? 10 ...

Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forces -
JT Berg, S Deem, ME Kerr, ER Swenson - American Journal of Physiology- Heart and Circulatory …, 2000 - Am Physiological Soc
... However, blood was present in those studies and, since hemoglobin (Hb) avidly binds
NO (14 ... by ear-vein injection of ketamine (15 mg/kg) and xylazine (0.33 mg/kg ...

Erythrocyte Organic Phosphates and Hemoglobin Function in Birds, Reptiles, and Fishes 1 -
RE ISAACKS, DR HARKNESS - Integrative and Comparative Biology, 1980 - Soc Integ Comp Biol
... 0.97 1.06 1.70 1.45 1.00 0.97 0.92 0.76 0.46 0.33 0.41 0.19 1.48 0.20 1.26 0.31
1.41 0.74 0.23 0.59 ATP+ inositol- P4 1.39 Hemoglobin" Inositol- p ? 0.06 0.06 ...

Sodium selenite reduces hemoglobin-induced venular leakage in the rat mesentery -
AL Baldwin, EB Wiley, AG Summers, AI Alayash - American Journal of Physiology- Heart and Circulatory …, 2003 - Am Physiological Soc
... Search for citing articles in: ISI Web of Science (7 ... Hemoglobin Solutions. ... 2 SeO 3
significantly reduced the microvascular leak number from 2.41 ? 0.33 ? 10 3 ...

Source: Google Scholar

Study Questions Impact of Hemoglobin Variations on Mortality in Dialysis Patients

For patients with dialysis-related anemia, the risk of death is increased when hemoglobin levels remain persistently low over a period several months—not necessarily when they fluctuate over time, according to a study in the January Clinical Journal of the American Society of Nephrology.

"Our results show that the effect of hemoglobin variability on mortality, beyond the absolute level of hemoglobin, may not confer much additional risk, after adjusting for other illnesses and hospitalizations," comments David T. Gilbertson, Ph.D., of the Minneapolis Medical Research Foundation, Minneapolis, Minn.

Dr. Gilbertson and colleagues used data on nearly 160,000 dialysis patients to analyze the effects of variations in hemoglobin level on the risk of death. Patterns of hemoglobin variability during the first six months of 2004 were analyzed and compared with mortality rates over the subsequent six months.

Hemoglobin is the oxygen-carrying compound in the blood. Anemia, or low hemoglobin levels, is one of the most frequent complications of kidney failure and is associated with an increased risk of death in dialysis patients. Treatment including erythropoietin and intravenous iron has been a major advance in the management of kidney failure-related anemia, yet low blood counts and variation in hemoglobin levels continue to be a problem for many dialysis patients.

In the study, patients who developed low hemoglobin levels during the monitoring period were at increased risk of death. This was true both for patients with temporary reductions in hemoglobin and those whose hemoglobin level was persistently low. This risk was considerably greater than any risk associated with fluctuations in hemoglobin levels.

On further analysis, the key risk factor seemed to be the amount of time spent with a low hemoglobin level—not the hemoglobin variations themselves. Patients who spent three months or longer with low hemoglobin levels had the highest mortality rates.

"A number of research groups have shown that variability of hemoglobin levels is very common in patients receiving dialysis for end-stage renal disease," says Dr. Gilbertson. "Low hemoglobin levels, which are an indication of anemia, have been shown to be associated with poor outcomes. It is relatively unknown whether fluctuations in hemoglobin levels add additional risk." If so, then more intensive treatment might be needed to keep hemoglobin levels within a relatively narrow range.

"Our results suggest that fluctuations in hemoglobin levels probably do not add much to the mortality risk for patients with dialysis-related anemia," Dr. Gilbertson concludes. "Low hemoglobin levels show significantly greater associations with increased risk of death than fluctuations in hemoglobin levels." More research will be needed to evaluate the causes of variations in hemoglobin levels, including what proportion of the variability is under the control of doctors and dialysis centers.

This study was supported by a research contract from Amgen, Inc., Thousand Oaks, Calif. The contract provides for the investigators of the Minneapolis Medical Research Foundation to have the final determination of the content of this publication. The following study authors have received consulting fees from Amgen: David T. Gilbertson, Robert N. Foley, and Allan J. Collins. Study author Brian D. Bradbury works in the Department of Epidemiology at Amgen, Inc.

The study entitled, "Hemoglobin Level Variability: Associations with Mortality" is available online at http://cjasn.asnjournals.org and in print in the January issue of the Clinical Journal of the American Society of Nephrology (CJASN).

The ASN is a not-for-profit organization of 10,500 physicians and scientists dedicated to the study of nephrology and committed to providing a forum for the promulgation of information regarding the latest research and clinical findings on kidney diseases.
 
 
 
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