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Recent News and Articles on the Keywords: uab + birmingham + 51,700  Related to the article below (Last Update: 8/5/2008)

TechBirmingham names key speakers for IT training day
The Birmingham News - al.com, AL -
Birmingham serial entrepreneur Gary York and UAB Health Systems spokeswoman Joan C. Hicks will be the keynote speakers for TechMixer University, ...
UAB-led study shows attentive parenting can keep early-maturing ...
The Birmingham News - al.com, AL -
The study was conducted with 330 fifth-grade girls and their parents from Birmingham, Los Angeles and Houston. One-fourth of these girls had matured early, ...
Five shot in western Birmingham tonight, 1 girl in critical condition
The Birmingham News - al.com, AL - Aug 3, 2008
Five people were shot in western Birmingham tonight, including a juvenile female listed in critical condition at UAB Hospital. The girl and two males, ...
Police Investigate Tripple Shooting NBC13.com
all 2 news articles »
Business brief
The Birmingham News - al.com, AL -
... adding to a growing number of downtown hotel projects planned or in the works, stretching from UAB to the Birmingham-Jefferson Convention Complex. ...
Health calendar
The Birmingham News - al.com, AL - Aug 4, 2008
... Wednesday, 8 am-2 pm; Thursday, 12-6 pm; and Friday, 8 am-2 pm UAB information: 934-1740. LifeSouth Community Blood Centers Birmingham Donor Center, ...
Influenza drug from BioCryst in clinical trials
The Kaleidoscope, AL - Aug 4, 2008
Greg Salinas, Ph.D., a scientist in the UAB department of behavioral neuroscience, feels that community education is just as necessary as vaccinations and ...
The Stanley Robinson Situation
Hartford Courant, United States - Aug 3, 2008
Back at home, it's coming out in newspapers that I'm going to Alabama or UAB. I just called and I was like, 'Don't put any more rumors in the paper. ...
Business Briefs - Richard Berliner has been appointed president of ...
The Birmingham News - al.com, AL -
Richard Berliner of Homewood, a senior real estate officer at UAB, has been appointed as president of Kiwanis Club of Homewood-Mountain Brook. ...
Career move requires more learning for Goff
The Birmingham News - al.com, AL -
The Mobile native and former UAB baseball player spent three years as a coach with the Mariners, and each year the club got better: 69 wins in 2005, ...

The Birmingham News - al.com
Mississippi exec to head UAB Health system
Biloxi Sun Herald,  USA - Aug 1, 2008
AP A Mississippi health care executive will take over as the new chief executive officer of the UAB Health System in Birmingham. The board at the University ...
UAB Health System selects alum as CEO Bizjournals.com
UAB Health System announces hiring of new CEO The Birmingham News - al.com
all 20 news articles »
Source: Google News

[PDF] Safety, Pharmacokinetic and Pharmacodynamic Results of a Phase 1 Single and Double Dose-Escalation … -
… U Wake Forest, NC Winston-Salem, B UAB, OC OMRF, U … - hgsi.com
... Manhasset, NY; 2 USC, Los Angeles, CA; 3 SUNY Downstate, Brooklyn, NY; 4 U Chicago,
Chicago, IL; 5 Wake Forest U, Winston-Salem, NC; 6 UAB, Birmingham, AL; 7 ...

Experimental Therapyof Human Prostate Cancerby Inhibiting MDM2 ExpressionWith Novel Mixed-Backbone … -
… , R Zhang, UAB andGeneTherapyCenter, A Birmingham, … - The Prostate, 2003 - doi.wiley.com
... University of Alabama at Birmingham, VH 113, Box 600, 1670 University Boulevard,
Birming- ham, AL 35294-0019. E-mail: Ruiwen.Zhang@ccc.uab.edu Received 7 June ...

Impact of atrial fibrillation on mortality and readmission in older adults hospitalized with heart … -
A Ahmed, P Thornton, GJ Perry, RM Allman, JF … - European Journal of Heart Failure, 2004 - Elsevier
... and Division of Gerontology and Geriatric Medicine, Department of Medicine, School
of Medicine, and Geriatric Heart Failure Clinic, UAB, Birmingham, AL, USA c ...

Conditionally Replicative Adenovirus Expressing p53 Exhibits Enhanced Oncolytic Potency 1 -
VW van Beusechem, PB van den Doel, J Grill, HM … - Cancer Research, 2002 - AACR
... Universit?t, Munster, Germany); Dr. E. Boven (VUMC, Amsterdam, the Netherlands);
Dr. JT Douglas (Gene Therapy Center, UAB, Birmingham, AL); Dr. R. Brakenhoff ...

Phase transformations and equation of state of praseodymium metal to 103 GPa -
GN Chesnut, YK Vohra - Physical Review B, 2000 - APS
Gary N. Chesnut and Yogesh K. Vohra Department of Physics, University of Alabama
at Birmingham (UAB), Birmingham, Alabama 35294-1170 Received 10 February 2000 ...

Electrical and Mechanical Properties of C_ {70} Fullerene and Graphite under High Pressures Studied … -
JR Patterson, SA Catledge, YK Vohra, J Akella, ST … - Physical Review Letters, 2000 - APS
... Yogesh K. Vohra Department of Physics, University of Alabama at Birmingham (UAB),
Birmingham, Alabama 35294-1170 Jagannadham Akella and Samuel T. Weir Lawrence ...

[PDF] Interfacial adhesion and toughness of nanostructured diamond coatings -
N Toprani, S Catledge - Journal of Materials Research, 2000 - heisenberg.phy.uab.edu
... Neeta Toprani, Shane A. Catledge, and Yogesh K. Vohra Department of Physics, University
of Alabama at Birmingham (UAB), Birmingham, Alabama 35294-1170 Raymond ...
-

Novel Therapies Based on Mechanisms of HIV-1 Cell Entry -
JM Kilby, JJ Eron - New England Journal of Medicine, 2003 - content.nejm.org
... Address reprint requests to Dr. Kilby at 908 20th St. S., UAB, Birmingham,
AL 35294-2050, or at mkilby@uab.edu. Related Letters: ...

[PDF] A concise representation of geometry suitable for mesh generation -
LP Chew, S Vavasis, S Gopalsamy, TY Yu, B Soni - Proceedings, 11th International Meshing Roundtable - imr.sandia.gov
... Science, Cornell University, Ithaca, NY 14853, vavasis@cs.cornell.edu 3 Mechanical
Engineering, University of Alabama at Birmingham (UAB), Birmingham, AL 35294 ...

Current Concepts in the Pathophysiology of Abnormal Pain Perception in Fibromyalgia. -
DA WEIGENT, LA BRADLEY, JE BLALOCK, GS ALARCON - The American Journal of the Medical Sciences, 1998 - amjmedsci.com
... Birmingham, Alabama. Correspondence: Laurence A. Bradley, PhD, 615 MEB,
UAB, Birmingham, AL 35294. Email:larry.bradley@ccc.uab.edu. ...

Source: Google Scholar

Researchers Say New Stem Cell Technique Cures Sickle Cell in Mice

 

Researchers at UAB (University of Alabama at Birmingham), along with a team from the Whitehead Institute, report successfully treating sickle cell anemia in mouse models using induced pluripotent stem (iPS) cells, a new stem cell technique that uses skin cells and does not require embryos. The findings, published in Science Express Online on Dec. 6, are the first to actually use the iPS technique to treat disease in an animal model.

The iPS technique received widespread attention in November when two laboratories reported using the process to turn human skin cells into stem cells, cells which can then be induced to form any other type of cell. Scientists believe stem cells have great potential in treating a variety of human diseases.

“The UAB/Whitehead teams took skin cells from mouse models genetically engineered to have sickle cell disease and reprogrammed them into iPS cells by adding four genes to each cell,” said Tim M. Townes, Ph.D., professor and chair of the Department of Biochemistry and Molecular Genetics at UAB and co-senior author of the study. “The new genes remodeled the chromosomes that instruct a skin cell to be a skin cell, so that the cells revert to stem cells.”

The researchers then used a DNA fragment engineered by Townes’ laboratory in 2006 to correct the basic sickle mutation in the cells. The corrected iPS cells were then induced to become blood stem cells (capable of making any type of blood cell) and were transplanted back into the diseased mice.

“The new blood stem cells began to function properly, making normal red blood cells that did not sickle,” Townes said. “The animals showed no symptoms of the disease and did not reject the transplanted cells.”

Previous work with iPS cells showed simply that the process worked and skin cells could be transformed into stem cells. Townes and colleague Rudolf Jaenisch, Ph.D., with the Whitehead Institute and a professor of biology at MIT and co-senior author of the study, say this “proof of principle” is the first example of creating iPS cells derived from a disease model and using these cells to correct a genetic mutation and treat a disease.

“These findings are a major step forward in developing a cure for sickle cell anemia,” Townes said. “We anticipate that this therapy will work in humans as it works in mice. And it cured sickle cell in mice.”

There are obstacles to be overcome. The added genes that transform regular cells into iPS cells are delivered by retroviruses and there are inherent risks in the use of retroviruses. The process also uses a cancer gene to stimulate cell division – sort of like a starter for sourdough bread. That gene has to be regulated, so it does not stimulate uncontrolled cell division, potentially causing a risk for cancer.

Townes says researchers are already at work in resolving these issues, although it may be years before iPS is a viable approach to treat disease in humans.

This research was funded by the National Heart, Lung and Blood Institute, one of the National Institutes of Health (NIH).
 
 
 
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