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Recent News and Articles on the Keywords: protein + 130,000 + found  Related to the article below (Last Update: 8/5/2008)

Intensive Lipid Intervention in the Post-ENHANCE Era
RedOrbit, TX -
Although ezetimibe with simvastatin reduced low-density lipoprotein cholesterol (LDL-C) by 16.5% and C-reactive protein (CRP) by 25.7% beyond the changes ...
It's a Good Time to Be a Scientist
RedOrbit, TX - Jul 21, 2008
With more than 7000 employees in 35 countries, Sigma-Aldrich produces 130000 different chemicals used by researchers all over the world. ...
Eel makes for tasty meal in summer
GulfNews, United Arab Emirates - Jul 29, 2008
Japan consumes around 130000 tonnes of eel a year, culminating in the summer season. This is 70 per cent of the world's consumption. ...
Homegrown corn flows as ethanol at GPRE facility
Estherville Daily News, Iowa - Jul 15, 2008
Plant manager Al Meister of Estherville said when the plant gets up to full production, 130000 gallons of ethanol will be produced daily. ...GPRE
MA Developer Aims to Build New England?s Largest Life-Sci Campus ...
BioRegion News, NY - Jul 28, 2008
The maker of protein therapeutics for patients with chronic gastrointestinal and metabolic diseases would occupy an 83000-square-foot office building and an ...
Source: Google News

Thermal denaturation of the core protein of lac repressor -
SP Manly, KS Matthews, JM Sturtevant - Biochemistry, 1985 - pubs.acs.org
... After the work reported here was completed, it was found that no exotherm ... in column
5 by multiplying by the molecular weight of the tetrameric protein, 130000. ...

Properties of the Purified Polymerase -
T KRISTENSEN, J HOLTLUND - European Journal of Biochemistry, 1978 - Blackwell Synergy
... pg protein was applied to each gel. ... weight of poly- (ADP-ribose) polymerase of about
130000. The sedi- mentation coefficient found for the polymerase under ...

Demonstration of cGMP-dependent protein kinase and cGMP-dependent phosphorylation in cell-free … -
R WALDMANN, S BAUER, C GOBEL, F HOFMANN, KH JAKOBS … - European Journal of Biochemistry, 1986 - Blackwell Synergy
... of rat and human platelets were found to contain ... major proteins with apparent M,
of 130000, 50000 and ... antibody against the cGMP-dependent protein kinase was ...

Human pre-a-trypsin inhibitor-precursor heavy chain cDNA and deduced amino-acid sequence -
J BOURGUIGNON, M DIARRA-MEHRPOUR, L THIBERVILLE, F … - European Journal of Biochemistry, 1993 - Blackwell Synergy
... Pre-a-trypsin inhibitor (Pal) is a serine-proteinase inhibitor of M, 130000 found
in human serum. This protein belongs to the family of proteins called inter-a ...

[PDF] Crystal-Forming Proteins ofBacillus thuringiensis -
GG CHESTUKHINA, IA ZALUNIN, LIKTS KOTOVA, SP … - Biochem. J, 1980 - biochemj.org
... exception of the serotype V, contain only one protein with a mol.wt. of
145 000, 135000 or 130000, depending on the strain. The ...

CURRENT PROBLEMS OF CHRONIC COLD HEMAGGLUTININ DISEASE -
H Schubothe - Annals of the New York Academy of Sciences, 1965 - Blackwell Synergy
... gel, using specific antisera, T. N. Mehrotra (1960) found individually specific ...
Macroglobulins % of Total Serum Protein 130000 32000 8 000 2 000 512 128 32 8 2 ...

Some Peptide Bonds Are Particularly Susceptible to Proteolytic Attack -
KA MOSHKOV, S LAKATOS, J HAJDU, P ZAVODSZKY, SA … - European Journal of Biochemistry, 1979 - Blackwell Synergy
... into two major protein components with molecular weights of 130000 (7) and ... If more
protein, about 100 - 200 pg, is applied to the gel an ... 3, IV) is found. ...

Differential Activation of Two Protease-Activated Protein Kinases from Reticulocytes by a Ca2+- … -
SM TAHARA, JA TRAUGH - European Journal of Biochemistry, 1982 - Blackwell Synergy
... substrates, eIF-5 was found to be modified (data not shown). Since the CAMP- dependent
protein kinases have been shown to phosphorylate the 130000-M, subunit ...

[PDF] Substrate Stabilization ofthe Palmitoyl-Coenzyme A Hydrolase Activity of Rat Submaxillary Gland
TE KNAUER, JJ GURECKI, GR KNAUER - biochemj.org
... hydrolase activity was found to be extremely labile, but ... a higher-molecular-weight
species of approx.- 130000 ... 20-70,ug of submaxillary gland protein and 88nmol ...

Further Studies on the Protein Bound to the Messenger RNA in Mammalian Polysomes -
S Olsnes - European Journal of Biochemistry, 1971 - Blackwell Synergy
... liberated from polysomes by treatment with sodium deoxycholate was found to move ...
558 Protein Bound to Messenger RNA Eur ... of 1 M sucrose in buffer A at 130000 x g ...
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Source: Google Scholar

Proteins' 'Breaking Point' Found, UK
Scientists from Oxford University have discovered the watery secrets of what makes proteins unstable.

Their fundamental research into the 'critical condition' at which the biological function of proteins is destroyed could have a profound impact on many areas of science - including biology, materials science and medicine: In particular it could give fresh insights into diseases caused by proteins misfolding and how to mimic the properties of tissues such as cartilage and collagen.

The discovery comes from quantum mechanics simulations developed by Dr David Porter and Professor Fritz Vollrath of Oxford's Department of Zoology. 'The interaction of water with proteins is central to all biology, and the point at which water-protein interactions become unstable is arguably nature's most important 'critical condition',' said Dr David Porter. 'We can use these simulations to examine the physics and chemistry of hydrogen bonding between water and amide groups in a specific protein. The predictions from our models can then be translated into real biological stress conditions - of temperature, mechanical load and chemistry - that will cause this protein to become unstable and stop functioning.'
The new research also sheds light on how the amount of water in a protein tissue affects its relative 'softness' and overall structural properties. Proteins with relatively little water will be stiff but tough - like a hard plastic - whereas a larger fraction of water (above 30 per cent) makes tissues such as elastin highly flexible and strong.

Dr Porter and Professor Vollrath originally created the simulations to try to understand how spiders 'tease' a normally stable protein solution into a solid silk thread using a combination of stress mechanisms; temperature, mechanical load and chemistry. 'It soon became clear that our silk model could be applied to many other protein stability problems,' said Professor Fritz Vollrath. 'A key innovation is that our models can map how instability develops over a time period of anything from a few seconds to a hundred years. Understanding the role of water in biological materials will be very important as we try to create new materials with predictable properties.'

The innovative use of new ways to extract critical conditions from their quantum simulations could have many other important applications in materials science: They could be used to predict the conditions under which materials will melt or move between an ordered and a less ordered state. Professor Vollrath said: 'Clearly we can learn much more from spider silk than how to make a tough material.'

Notes:

- A report of the research, 'The role of kinetics of water and amide bonding in protein instability', is published in a forthcoming issue of the RSC journal Soft Matter, an advance copy of the article is available online here.



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