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Recent News and Articles on the Keywords: turns + mice + metabolism  Related to the article below (Last Update: 8/5/2008)


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Oneindia
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BBC News
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Posted | Comment | Recommend
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Source: Google News

Herpes simplex virus turns off the TAP to evade host immunity. -
A Hill, P Jugovic, I York, G Russ, J Bennink, J … - Nature, 1995 - ncbi.nlm.nih.gov
Nature. 1995 Jun 1;375(6530):411-5. Click here to read Herpes simplex virus
turns off the TAP to evade host immunity. Hill A, Jugovic ...

… )-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice -
MA Morse - Cancer Research, 1990 - AACR
... The effects of I3C pretreatment on NNK metabolism were also investigated. ...
1-(3-pyridyl)-1-butanol in the lungs of I3C-treated mice which, in turn, may be ...

Cholesterol metabolism in the brain. -
JM Dietschy, SD Turley - Current Opinion in Lipidology, 2001 - co-lipidology.com
... recycling and apolipoprotein E expression within the central nervous system, which,
in turn, may affect ... Cholesterol balance and metabolism in mice with loss ...

Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in … -
K Dorfman, D Carrasco, M Gruda, C Ryan, SA Lira, R … - Oncogene, 1996 - ncbi.nlm.nih.gov
... is activated in response to external signals and in turn phosphorylates proteins ...
and its function in signal transduction we have generated mice, embryonic stem ...

The mechanism of interaction of filaggrin with intermediate filaments. The ionic zipper hypothesis. -
JW Mack, AC Steven, PM Steinert - J Mol Biol, 1993 - ncbi.nlm.nih.gov
... mouse and human filaggrins consist of multiple repeating elements. The first level
consists of a tetrapeptide beta-turn motif in which about 35% of the turns ...

… cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice
EC Dudley, HT Petrie, LM Shah, MJ Owen, AC Hayday - Immunity, 1994 - ncbi.nlm.nih.gov
... The identification is made in normal mice of the stages in T cell ... cell cycle regulation
during early thymocyte differentiation, which may in turn explain why ...

… of the endogenous hprt gene and lacI transgene in benzo [a] pyrene-treated Big Blue B6C3F1 mice. -
TR Skopek, KL Kort, DR Marino, LV Mittal, DR … - Environ Mol Mutagen, 1996 - ncbi.nlm.nih.gov
... Western blot analysis of liver samples from B[a]P-treated mice suggests that the
reduced adduct load in turn may be due to lower P450 1A1 levels in BB mice. ...

[CITATION] A Model of Compartmentation in Mouse Brain Based on Glucose and Acetate Metabolism
CJ VAN DEN BERG - Metabolic Compartmentation in The Brain. Proceedings of a …, 1972
-

Iron imports. IV. Hepcidin and regulation of body iron metabolism -
T Ganz, E Nemeth - American Journal of Physiology- Gastrointestinal and Liver …, 2006 - Am Physiological Soc
... Overexpression of hepcidin 2 in mice had no effect on iron metabolism, suggesting
that ... In turn, hepcidin secretion is regulated by iron stores, oxygenation ...

… of Regional Brain Metabolism and Gene Expression After Middle Cerebral Artery Occlusion in Mice -
R Hata, K Maeda, D Hermann, G Mies, KA Hossmann - Journal of Cerebral Blood Flow & Metabolism, 2000 - nature.com
... provoke relative tissue hypoxia which, in turn, would be ... in the periinfarct area
with normal metabolism, and c ... has been reported that in mutant mice that lack A ...

Source: Google Scholar

Protein turns up metabolism in mice - U.S. study

Last Updated: 2007-12-05 13:01:04 -0400 (Reuters Health)

CHICAGO - Tricking muscle tissue to burn rather than store fat has succeeded in increasing the average life span of mice and staved off some age-related diseases, U.S. researchers said on Tuesday.

Mice bred to make too much of a protein known as uncoupling protein 1 released food energy as heat instead of storing it as fat.

"What we're uncoupling is the process of burning energy from storing energy," said Dr. Clay Semenkovich of Washington University School of Medicine in St. Louis, Missouri whose research appears in the journal Cell Metabolism.

"Normally when you metabolize food, you take the energy that comes from that food and you store it. In essence, you are coupling the energy in the food into a stored form," Semenkovich said in a telephone interview.

Mice that overproduced this uncoupling protein in their muscle tissue weighed less and had less fat tissue, even though they ate the same amount as normal mice in the study.

"They lived about three months longer on average, which translates into six or seven years in human life, which is pretty good," Semenkovich said.

The protein did not extend the maximum life span of the mice, but it did increase their average life span, perhaps because they were less prone to age-related diseases, Semenkovich said.

Mice in the study had a lower incidence of vascular disease, hypertension and lymphoma, a type of cancer.

Semenkovich said these same uncoupling proteins occur in humans, and genetic variations in the proteins have been linked with people weighing more or less.

"It may be possible to accelerate metabolism and find an alternative way of treating diseases," he said.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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