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Recent News and Articles on the Keywords: nerves peripheral + peripheral + pain  Related to the article below (Last Update: 8/5/2008)

NeuroMetrix, Inc. Reports Total Revenues of $8.5 Million for the ...
MarketWatch -
Neuropathies affect the peripheral nerves and parts of the spine and are frequently caused by or associated with carpal tunnel syndrome, diabetes, sciatica, ...NURO
Saint Francis opening pain relief center
Daily Mail - Charleston, WV -
By using cutting-edge technologies such as spinal cord and peripheral nerve field stimulation, the medical professionals are able to offer treatment options ...
I-Flow Reports 21% Increase in Total Revenues for the Second ...
Business Wire (press release), CA -
Our ON-Q C-bloc? Continuous Nerve Block System, which is optimized for anesthesiologists and continuous peripheral nerve blocks primarily used for ...

Daily Mail
My life was saved by the same knife-wielding robot that treated ...
Daily Mail, UK -
'The type I had was called a peripheral nerve tumour, which meant that it affected the sheath of the nerves in the area where it was located. ...
Painful feet may indicate neuropathy
Connecticut Post, CT - Jul 29, 2008
Neuropathy from Latin means something abnormal with your nerves ? literally "abnormal nerves." The most common form is peripheral neuropathy. ...
Easing Pain And Numbness Associated With Diabetes
Science Daily (press release) - Jul 18, 2008
Diabetics often suffer from this condition because of high blood sugar levels that damage nerve cells. Those with peripheral neuropathy often endure chronic ...
Botox's dangerous origins
Santa Rosa Press Democrat, CA -
The toxin acts on peripheral nerve endings, preventing the release of the neurotransmitter acetylcholine, which conveys signals to muscles. ...
Behavioral Comorbidities in Rheumatoid Arthritis
Psychiatric Times, NY - Aug 4, 2008
One study showed that poor sleep is temporally associated with an overnight increase in tenderness in the peripheral joints in patients with RA who are ...
Shelton Biotech Raises $12 Million
Connecticut Business News Journal, CT - Aug 4, 2008
With the investment, Cara Therapeutics will begin launching patient trials of two pain-relief medications that work on peripheral nerve endings to relieve ...
Femoral Nerve Block for Diaphyseal and Distal Femoral Fractures in ...
Journal of Bone and Joint Surgery (subscription) - Aug 1, 2008
Ultrasound is being increasingly used for nerve localization in patients receiving peripheral nerve blocks and is available in our emergency department. ...
Femoral Nerve Block for Diaphyseal and Distal Femoral Fractures in ... Journal of Bone and Joint Surgery (subscription)
all 3 news articles »
Source: Google News

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the … -
SH Kim, JM Chung - Pain, 1992 - ncbi.nlm.nih.gov
... to develop an experimental animal model for peripheral neuropathic pain. Under sodium
pentobarbital anesthesia, both the L5 and L6 spinal nerves (group 1) or ...

Spared nerve injury: an animal model of persistent peripheral neuropathic pain. -
I Decosterd, CJ Woolf - Pain, 2000 - ncbi.nlm.nih.gov
1: Pain. 2000 Aug;87(2):149-58. Spared nerve injury: an animal model of
persistent peripheral neuropathic pain. Decosterd I, Woolf CJ. ...

Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia -
EM McLachlan, W J?nig, M Devor, M Michaelis - Nature 363, 1993 - nature.com
... In some patients local anaesthesia of the relevant peripheral nerve 6 does not
alleviate pain, implying that ectopic impulses arise either within the central ...

Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury -
J Sato, ER Perl - Science, 1991 - sciencemag.org
... Science articles. Adrenergic excitation of cutaneous pain receptors induced
by peripheral nerve injury. J Sato and ER Perl University ...

Neuropathic pain and injured nerve: Peripheral mechanisms -
M Devor - British Medical Bulletin, 1991 - British Council
... Pain 1985; 22: 127-137 30 Devor M, Govrin-Lippmann R. Axoplasmic transport block
reduces ectopic impulse generation in injured peripheral nerves. Pain 1983; 16 ...

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. -
GJ Bennett, YK Xie - Pain, 1988 - ncbi.nlm.nih.gov
... A peripheral mononeuropathy was produced in adult rats ... constrictive ligatures around
the common sciatic nerve. ... and, possibly, spontaneous pain (or dysesthesia ...

Peripheral nerve injury triggers central sprouting of myelinated afferents -
CJ Woolf, P Shortland, RE Coggeshall - Nature, 1992 - nature.com
... relationship between a low-intensity stimulus and an innocuous sensation and a noxious
stimulus and pain. We now show that after peripheral nerve injury the ...

The Control of Pain in Peripheral Tissue by Opioids -
C Stein - New England Journal of Medicine, 1995 - content.nejm.org
... Specifically, these studies indicate that the immune system can interact
with peripheral sensory-nerve endings to inhibit pain. ...

Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano- … -
M Tal, GJ Bennett - Pain, 1994 - ncbi.nlm.nih.gov
... abnormal pain sensations that accompany peripheral neuropathies are sometimes found
in a distribution that does not coincide with the territories of nerves or ...

Painful neuropathy: altered central processing maintained dynamically by peripheral input. -
RH Gracely, SA Lynch, GJ Bennett - Pain, 1992 - ncbi.nlm.nih.gov
... We propose a model of neuropathic pain in which ongoing nociceptive afferent input
from a peripheral focus dynamically maintains altered central processing ...

Source: Google Scholar

Protein found that may provide relief from neuropathic pain

 

Neuropathic pain is caused by injury to the peripheral nerves in diseases such as HIV/AIDS, shingles, and cancer or in repetitive motion disorders and trauma, and does not respond well to conventional pain-relieving drugs.

Research in rodents by scientists from the University of California, San Diego (UCSD) School of Medicine has provided evidence that a protein called LRP1 may help to ease neuropathic pain by blocking the response of glial cells that support and protect sensory neurons in the peripheral nervous system. Their findings, which could represent a novel target for neuropathic pain therapy, are published in the December 3 issue of the Journal of Clinical Investigation.

“Neuropathic pain differs from ordinary pain in that it is usually perceived as ongoing burning or as ‘pins and needles’ electric-shock type of sensation,” said Wendy Campana, Ph.D., associate professor in UCSD’s Department of Anesthesiology, who led the study. “It is caused by nerve damage that can be associated with chronic inflammation or direct nerve injury.”

The UCSD studies show that a form of LRP1 that is present in body fluids such as blood counteracts the activity of inflammatory cytokines, proteins which are involved in developing and sustaining chronic pain states. Cytokines act as messengers to either stimulate or inhibit the immune response, are produced by many cell types including white blood cells present during infection and inflammation

“We think that the anti-inflammatory activity of LRP1 can be harnessed to decrease chronic pain,” said Campana. “By decreasing the presence of cytokines in the area of nerve damage, LRP1 calms the pain signals that are sent to the spinal cord.”

In-vitro analysis confirmed that LRP1 works to modify the response of glial cells that results in neuropathic pain, according to Campana, who added that interactions of neurons and glial cells are very important in determining pain.

Campana worked with post-doctoral scholar Alban Gaultier, Ph.D., and Steven L. Gonias, M.D., chair of UCSD’s Department of Pathology, who are exploring other aspects of LRP1 function. The UCSD scientists observed that injured peripheral nerves in both mice and rats release LRP1 into the surrounding tissue. Administration of LRP1 into the rodents’ sciatic nerves prior to injury provided a protective effect, decreasing the level and activity of injury-induced proinflammatory cytokines, such as TNF-alpha, in the local environment and inhibiting spontaneous pain.

In addition to decreasing inflammatory cytokines locally, treatment with LRP1 also decreased inflammatory cytokines in a region called the spinal dorsal horn, where central pain processing occurs.

“TNF-alpha has some positive properties in infection, so you may not want to block its activity entirely,” said Campana. “It appears that LRP1 limits, but doesn’t completely block, the increase in proinflammatory cytokines produced by glial cells after nerve injury. We think this research opens up a number of new research directions for understanding and treating chronic neuropathic pain.”

###

Additional contributors to this study include Sanja Arandjelovic and Nikola Dragojiovic, UCSD Department of Pathology; Robert R. Myers, UCSD Departments of Pathology and Anesthesiology; and Xiaoqing Li, Julie Janes, George P. Zhou and Jenny Dolkas, UCSD Department of Anesthesiology. The research was supported in part by grants from the National Institutes of Health.

 
 
 
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