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Recent News and Articles on the Keywords: osteoarthritis knee + knee + web  Related to the article below (Last Update: 8/5/2008)

Patients Can Provide a Valid Assessment of Quality of Life ...
Journal of Bone and Joint Surgery (subscription) - Aug 1, 2008
In her commentary, Professor Lingard 2 expresses concern over our decision to report the Knee Injury and Osteoarthritis Outcome (KOOS) score as an overall ...
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FOXBusiness - Jul 29, 2008
Ankle replacements, however, are not as durable as hip and knee replacements. The ankle is a more challenging joint to replace. It's smaller and moves in ...
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Journal of Bone and Joint Surgery (subscription) - Aug 1, 2008
Total knee replacements intended to facilitate increased knee flexion have been available in the United States since 2002. In a biplane fluoroscopic ...
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Journal of Bone and Joint Surgery (subscription) - Aug 1, 2008
We evaluated the effectiveness and cost of care of home-based compared with inpatient rehabilitation following primary total hip or knee joint replacement. ...
PEOPLE'S PHARMACY Beware unexpected drug side effects
Houston Chronicle, United States - Jul 26, 2008
I have bad osteoarthritis pain in my right knee and hip and would love to take ibuprofen instead of Tylenol, but I don't want to take omeprazole long term ...
Reader enjoys arthritis relief after bee stings
Bradenton Herald,  United States - Jul 28, 2008
I have osteoarthritis in my left knee, and the pain has been gone since I was stung. I'm hoping that it will last! If I had a choice, though, ...
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Battle Creek Enquirer, MI - Jul 9, 2008
Primary discussion will focus on current surgical approaches in treatment of hip and knee arthritis and future biotechnology-oriented approaches to ...
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Orlando Sentinel, FL - Jul 27, 2008
He said it gave him a new respect for her knee and the pain she had been going through after battling osteoarthritis for many years. ...
Q-Med AB: Invitation to half-year report conference call
istockAnalyst.com, OR - Jul 14, 2008
... contouring and creating volume in the face, Macrolane? for body contouring, Durolane? for the treatment of osteoarthritis of the hip and knee joints, ...
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Source: Google News

Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis A 3-Year, Randomized, … -
K Pavelka, J Gatterova, M Olejarova, S Machacek, G … - Archives of Internal Medicine, 2002 - Am Med Assoc
... are seeing this message because your Web browser does not support basic Web standards. ...
Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis ...

Intra-articular Hyaluronic Acid in Treatment of Knee Osteoarthritis A Meta-analysis -
GH Lo, M LaValley, T McAlindon, DT Felson - JAMA, 2003 - Am Med Assoc
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… and Symptomatic Efficacy of Glucosamine and Chondroitin in Knee Osteoarthritis A Comprehensive Meta … -
F Richy, O Bruyere, O Ethgen, M Cucherat, Y … - Archives of Internal Medicine, 2003 - Am Med Assoc
... message because your Web browser does not support basic Web standards ... Structural
and Symptomatic Efficacy of Glucosamine and Chondroitin in Knee Osteoarthritis ...

Efficacy of Rofecoxib, Celecoxib, and Acetaminophen in Osteoarthritis of the Knee A Randomized Trial -
GP Geba, AL Weaver, AB Polis, ME Dixon, TJ … - JAMA, 2002 - Am Med Assoc
... Efficacy of Rofecoxib, Celecoxib, and Acetaminophen in Osteoarthritis of
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The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis -
L Sharma, J Song, DT Felson, S Cahue, E Shamiyeh, … - JAMA, 2001 - Am Med Assoc
... The Role of Knee Alignment in Disease Progression and Functional Decline
in Knee Osteoarthritis Leena Sharma, MD ; Jing Song, MS ...

Knee replacement surgery for osteoarthritis: effectiveness, practice variations, indications and … -
P Dieppe, HD Basler, J Chard, P Croft, J Dixon, M … - Rheumatology, 1999 - Br Soc Rheumatology
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Outcomes after hip or knee replacement surgery for osteoarthritis -
LM March, MJ Cross, H Lapsley, A Brnabic, KL Tribe … - Medical Journal of Australia, 1999 - mja.com.au
... Patients with osteoarthritis booked for primary total hip or knee replacement surgery
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-

… for the role of exercise in the management of osteoarthritis of the hip or knee-the MOVE consensus -
E Roddy, W Zhang, M Doherty, NK Arden, J Barlow, F … - Rheumatology, 2005 - Br Soc Rheumatology
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… Sodium on Pain and Physical Functioning in Osteoarthritis of the Knee A Randomized, Double-blind, … -
RJ Petrella, MD DiSilvestro, C Hildebrand - Archives of Internal Medicine, 2002 - Am Med Assoc
... message because your Web browser does not support basic Web standards. ... of Hyaluronate
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Therapeutic Effects of Hyaluronic Acid on Osteoarthritis of the Knee A Meta-Analysis of Randomized … -
CT Wang, J Lin, CJ Chang, YT Lin, SM Hou - The Journal of Bone and Joint Surgery, 2004 - JBJS
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Source: Google Scholar

New Research: Study Shows Pycnogenol® Naturally Reduces Osteoarthritis Knee Pain
Pycnogenol® improved physical function by 52 percent

GENEVA, Switzerland – Affecting more than 10 million Americans, Osteoarthritis of the knee (OA) is one of the five leading causes of disability among the elderly. While OA mainly affects most people over 45, it can occur at any age. A double-blind, placebo-controlled study published in the journal Nutrition Research reveals Pycnogenol®, (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, improved physical function by 52 percent in patients suffering from OA.

When OA develops, the cartilage gradually looses elasticity and begins to harden and crack, subsequently becoming more prone to damage and erosion by use or injury and often leads to pain, swelling, a decrease in motion at the joint, stiffness, or the formation of bone spurs (tiny growths of new bone). Current treatments include regular exercise and pain relievers such as NSAIDS and COX-2 inhibitor pills to help ease pain and stiffness. In more severe cases, cortisone shots can help decrease inflammation in the joint and extreme cases consist of joint replacement. There are currently no drugs that treat osteoarthritis directly.
“Pycnogenol® was chosen due to a history of studies of the extract to alleviate inflammation by inhibiting COX-1, COX-2 and the pro-inflammatory "master-switch" nuclear factor-kappa B,” said lead researcher Dr. Ronald Watson from the University of Arizona. “Pycnogenol® offers a safe nutritional approach to significantly reduce pain and improve physical function of arthritic joints. It controls inflammation and thus ideally complements existing strategies that comprise delivery of ‘building blocks’ for replacement of degenerated cartilage.”

The study was conducted at the rheumatology department of Mashhad Medical University, Iran. Thirty-five volunteers (average age 42) were randomly assigned a daily dose of Pycnogenol® (50mg, 3 times a day) or placebo for three months. Patients were to report arthritic pain using the Western Ontario and McMasters Universities (WOMAC) Osteoarthritis Index after 30, 60 and 90 days. Participants also were instructed to indicate the frequency and dosage of NSAIDS and COX-2 inhibitor usage.

After two months of supplementation, physical function and pain scores improved in the Pycnogenol® group. After three months in the Pycnogenol® group, there was a reduction of 43 percent in pain, 35 percent in stiffness, 52 percent in physical function subscales and 49 percent composite WOMAC. The placebo group showed no significant scores throughout the entire study. Additionally, further reduction in the number of NSAIDS and COX-2 inhibitor pills and number of days taking medication was noted in the Pycnogenol® group.

“Pycnogenol’s® natural anti-inflammatory and antioxidant properties were responsible for delivering these excellent results,” said Watson. “This study shows that supplementing with Pycnogenol® can fight joint inflammation and soothe the pain and stiffness, thus pave the path for cartilage renewal with substances such as glucosamine.”

A previous study on Pycnogenol® published in the Journal of Inflammation demonstrated that the ingredient effectively prevented inflammation disorders in patients by moderating the immune system response. While the wear and tear is responsible for the initial degeneration of cartilage, the more advanced stage of osteoarthritis involves inflammation. The cells of the cartilage (chondrocytes) respond to mechanical impact by generating pro-inflammatory molecules (cytokines). This process is initiated by the pro-inflammatory "master-switch" called NF-kappaB. Pycnogenol® was shown to lower the sensitivity for NF-kappaB in humans last year.

The cytokines released from chondrocytes recruits immune cells (leukocytes) to the joints where they cause more harm than good. Leukocytes release harmful substances such as free radicals and enzymes that break down connective tissue and speed up the degeneration of cartilage. These processes alike are under control by NF-kappaB, and the effect of Pycnogenol® to suppress NF-kappaB will help to limit the damage caused by leukocytes.

Researchers believe this study is the first randomized clinical trial to show Pycnogenol’s® effectiveness in alleviating the clinical symptoms of knee osteoarthritis. There are several more breakthrough studies on Pycnogenol® and osteoarthritis expected to be published next year allowing for development of innovative, natural formulas for joint health.

Additionally, Horphag Research, the exclusive worldwide distributor of Pycnogenol® has filed for several patents for Pycnogenol’s® application for COX-1, COX-2 and treating osteoarthritis.

About Pycnogenol®
Pycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits. The extract has been widely studied for the past 35 years and has more than 220 published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol® is available in more than 600 dietary supplements, multi-vitamins and health products worldwide. For more information, visit www.pycnogenol.com.

###

Horphag Research Ltd. is the exclusive worldwide supplier of Pycnogenol® (pic-noj-en-all) French maritime pine bark extract. Pycnogenol® is a registered trademark of Horphag Research Ltd.; Guernsey and its applications are protected by U.S. patents #5,720,956 / #6,372,266 and other international patents. For more information about Pycnogenol® visit our Web site at www.pycnogenol.com
 
 
 
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