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Recent News and Articles on the Keywords: gene + alcohol + identify  Related to the article below (Last Update: 8/5/2008)


Oneindia
Molecular Basis Of Alcohol
Oneindia, India -
The study showed that the BK gene variants were destroyed exhibited high alcohol sensitivity, while those that remained showed significantly lower ...
CHEMOPREVENTION GENE THERAPY (CGT), PANCREATIC CANCER CELLS
Newswise (press release) -
The cytokine used in this study was melanoma differentiation associated gene-7/interleukin-24, known as mda-7/IL-24. The dietary agent, perillyl alcohol ...OTC:CTHP - BIT:MLM
Mack tough might be best for Longhorns
SportingNews.com - Aug 3, 2008
A Georgia player was arrested for an alcohol-related offense Saturday morning, and two other players were hospitalized with injuries from an unrelated brawl ...
Breast cancer: What you need to know
Food Consumer, IL -
Weight loss: A study indicates that women with a mutation in the gene BRCA1, which predisposes women to breast cancer, should avoid putting weight in early ...
At Least One MicroRNA Mediates Brain's Alcohol Tolerance
GenomeWeb News (subscription), NY - Aug 1, 2008
?Moreover, since adaptation, or tolerance, to the drug likely contributes to alcohol abuse, our findings identify a potential molecular target for ...
Pass the Manischewitz, Please
Newsweek - Aug 2, 2008
Or it could be genetic: some Jews do have a form of a gene, also common in Asians, which can protect against alcohol abuse. Weinreb says he sees drunkenness ...
Gene found that limits alcohol risk
guardian.co.uk, UK - Jul 19, 2008
But those 20 to 25 per cent of people who have one or both are gene variants - if they drink alcohol, their risk of getting these head and neck cancers is ...
Gene secret of heavy but sensible drinkers Metro
all 4 news articles »

ABC News
Firebombs target UC-Santa Cruz scientists who use animals in research
San Jose Mercury News,  USA - Aug 3, 2008
Assemblyman Gene Mullin, D-San Mateo, who has been championing legislation to increase civil and criminal penalties in cases where academic researchers are ...
University researchers firebombed, animal rights activists blamed Fort Worth Star Telegram
all 589 news articles »
DRD2 and ANKK1 genotype in alcohol-dependent patients with ...
British Journal of Psychiatry (subscription), UK - Jul 31, 2008
The TaqI-A of the ANKK1 gene and the C957T of the DRD2 gene are epistatically associated with psychopathic traits in alcohol-dependent patients.
Lawson date is Aug. 19
News & Observer, NC -
He is scheduled to appear in a Chapel Hill court then on charges of driving after consuming alcohol while underage and driving with a revoked license. ...
Source: Google News

Identifying genes for alcohol and drug sensitivity: recent progress and future directions -
JC Crabbe, TJ Phillips, KJ Buck, CL Cunningham, JK … - Trends in Neurosciences, 1999 - Elsevier
... genes that affect murine responses to alcohol and drugs have been used to identify
many provisional ... indicates the presence of a relevant gene or genes at ...

Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family -
G Duester, J Farr?s, MR Felder, RS Holmes, JO … - Biochemical Pharmacology, 1999 - Elsevier
... properties or expression patterns to identify orthologs [39 ... for the same
protein/gene in different ... is recommended that the enzyme ?alcohol dehydrogenase? ...

… Polymorphism of the mu-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol- … -
DW Oslin, W Berrettini, HR Kranzler, H Pettinati, … - nature.com
... T (Ala6Val) SNPs in the gene encoding the ... in the reinforcing properties of alcohol
and that ... these results would help to identify alcohol-dependent individuals ...
-

Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene … -
F Fumeron, D Betoulle, G Luc, I Behague, S Ricard, … - Journal of Clinical Investigation, 1995 - pubmedcentral.nih.gov
... of the CETP gene failed to identify them. The effect of B2 on plasma HDL cholesterol
was absent in subjects drinking < 25 grams/d of alcohol but increased ...

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale -
JL DeRisi, VR Iyer, PO Brown - Science, 1997 - sciencemag.org
... gene families are functionally specialized and differentially regulated. The major
alcohol dehydrogenase genes, ADH1 and ADH2, share 88% nucleotide identity. ...

Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a< 1 Centimorgan Interval … -
C Fehr, RL Shirley, JK Belknap, JC Crabbe, KJ Buck - Journal of Neuroscience, 2002 - neuroscience.org
... results fine-map QTLs on mouse chromosome 4 involved in acute alcohol withdrawal
and ... Our results identify Mpdz as a promising candidate gene, but additional ...

… and Confirmation of Quantitative Trait Loci Regulating Alcohol Consumption in Congenic Strains of … -
VJ Whatley, TE Johnson, VG Erwin - Alcoholism: Clinical and Experimental Research, 1999 - Blackwell Synergy
... RI) strains have been used in an effort to identify genes responsible for ALCP.
Goldman et al. (1987) identified a gene (Ltw-4) associated with alcohol intake. ...

… Cultures: Generation of a Gene Bank for Genes Conferring Alcohol Oxidoreductase Activity on … -
A Knietsch, T Waschkowitz, S Bowien, A Henne, R … - Applied and Environmental Microbiology, 2003 - pubmedcentral.nih.gov
... Sinorhizobium meliloti, and the partial orf12 gene product showed 31% identity to
a putative NAD + -dependent zinc-containing (type I) alcohol dehydrogenase of ...

Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and … -
A Yokoyama, T Muramatsu, T Omori, T Yokoyama, S … - Carcinogenesis, 2001 - Oxford Univ Press
... (1999) Alcohol and aldehyde dehydrogenase gene polymorphisms influence ... Ethanol patch
test: A simple and sensitive method for identifying ALDH phenotype ... Alcohol. ...

Alcohol and Aldehyde Dehydrogenase Gene Polymorphisms Influence Susceptibility to Esophageal Cancer … -
A Yokoyama, T Muramatsu, T Omori, S Matsushita, H … - Alcoholism: Clinical and Experimental Research, 1999 - Blackwell Synergy
... 2 and 87.9% correct in identifying ALDH2*1 ... for the highest risk gene combination
(ADH2 ... Key Words: Alcohol Dehydrogenase, Aldehyde Dehydrogenase, Flushing Response ...

Source: Google Scholar

Scientists identify gene that influences alcohol consumption

A variant of a gene involved in communication among brain cells has a direct influence on alcohol consumption in mice, according to a new study by scientists supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), and the U.S. Army.

Scientists do not know yet whether a similar gene variant, with a similar effect on alcohol consumption, exists in humans.

Known as Grm7, the gene encodes a receptor subtype that inhibits the release of glutamate and other neurotransmitter molecules that brain cells use to communicate with one another. Researchers identified a gene variant, or polymorphism, that reduces the abundance of Grm7 messenger RNA (mRNA) in brain tissue. mRNA is the molecular intermediate between a gene and its protein product. Mice that possess this gene variant drink more alcohol than do mice with higher brain levels of Grm7 mRNA. A report of the study appears as an online Article in Press in Genomics.

“This is a noteworthy contribution, particularly since identifying genes that predispose to alcohol-related behaviors is such an arduous task,” says NIAAA Director Ting-Kai Li, M.D.

Scientists have long known that genes account for a significant proportion of the risk for alcoholism. However, the fact that there are multiple such genes that interact with each other and with multiple environmental factors to influence drinking behavior has hampered studies aimed at isolating individual genes.

“Controlling for this background noise -- the various gene-gene and gene-environment interactions -- presents considerable methodological challenges,” notes first author Csaba Vadasz, Ph.D., professor of psychiatric research in the department of psychiatry at New York University School of Medicine, and Director of the NeuroBehavioral Genetic Research Program at the Nathan Kline Institute in Orangeburg, N.Y.

To overcome these difficulties, Dr. Vadasz and colleagues applied a variety of genetic and analytic techniques to animals having nearly identical genetic background, but differing in their preference for alcohol, to identify a chromosomal region, and ultimately the Grm7 gene, associated with alcohol preference.

“Our findings support emerging evidence of the critical role that the brain’s glutamate pathways play in addiction,” says Dr. Vadasz. “While dopamine has traditionally been cast as a central actor in the neurochemistry of substance use and abuse, recent studies indicate that glutamate systems play an important role in reinforcement and addiction.”

If further studies show that a similar gene variant is relevant to alcohol problems in humans, the finding by Dr. Vadasz and colleagues may lead to new opportunities for developing drugs to treat alcohol dependence. Dr. Vadasz speculates that such drugs might be designed to control the level of the Grm7 gene product or modulate the activity of the gene product itself.

###

The National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health, is the primary U.S. agency for conducting and supporting research on the causes, consequences, prevention, and treatment of alcohol abuse, alcoholism, and alcohol problems and disseminates research findings to general, professional, and academic audiences. Additional alcohol research information and publications are available at www.niaaa.nih.gov.

The National Institutes of Health (NIH) — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary Federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.
 
 
 
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