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Recent News and Articles on the Keywords: cervical cancer + cancer + cervical  Related to the article below (Last Update: 8/5/2008)

German Association of Gynecology and Obstetrics Recommends HPV ...
MarketWatch -
"By using both tests for women 30 and over, when cervical cancer is most common, we hope to greatly reduce the number of women suffering and dying from this ...
A survivor?s battle with cervical cancer Inquirer.net
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Kenya lacks guidlines to manage cervical cancer
Africa Science News Service, Kenya -
Although cervical cancer is killing close to 2, 000 Kenyans annually, there is no guideline to help manage the ever threatening disease that mostly afflict ...
Does the Pill Increase the Risk of Cervical Cancer?
InjuryBoard.com, FL -
There has been much talk about recent studies that find that women who use birth control pills have an increased risk of developing cervical cancer. ...

BBC News
Christina Applegate's Breast Cancer: FAQ
WebMD -
Applegate, star of the ABC comedy Samantha Who?, has a family history of cancer -- her mother has had breast cancer and cervical cancer. ...
AssociatedPress
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Now Magazine Online - Reuters
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The Pill Raises Cervical Cancer Risk
Newsinferno.com, NY -
A recent study states that women who use birth control pills have an increased risk of developing cervical cancer. Although the risk does fall once the pill ...
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New Scientist (subscription), UK - 24 minutes ago
... the safety of giving intravenous vitamin C, plus other antioxidants given orally, on top of existing therapies for ovarian, cervical or uterine cancer. ...
Bay girls offered cancer jab
Hawke's Bay Today, New Zealand -
From next month, young women who were born in 1990 and 1991 will be offered a vaccine that offers protection from a virus that can cause cervical cancer in ...
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TV 'giving a warped view of cancer rates'
NEWS.com.au, Australia - Aug 2, 2008
An investigation of news and current affairs shows has found that cancers affecting women, like breast, ovarian and cervical cancer, and stories about ...
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Cervical cancer
Globe and Mail, Canada - Aug 1, 2008
Cervical cancer is one of the most common types of cancer a woman can get, and oncologists say it is increasingly striking at younger ages. ...
Crisis in Newfoundland raises alarm
Globe and Mail, Canada - Aug 4, 2008
Considering the nature of gynecologic oncology, the high degree of specialty and prevalence - nearly 4000 new cases of ovarian and cervical cancer are ...
Source: Google News

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective -
FX Bosch, MM Manos, N Munoz, M Sherman, AM Jansen, … - jnci, 1995 - jnci.oxfordjournals.org
... R. Pfeiffer, and RD Burk Age-Related Changes of the Cervix Influence Human ... Mouchawar,
K. Bischoff, MU Yood, J. Gilbert, and SH Taplin Cervical Cancer in Women ...

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer -
N Munoz, FX Bosch, S de Sanjose, R Herrero, X … - New England Journal of Medicine, 2003 - content.nejm.org
... Impact of the Human Papilloma Vaccine on Cervical Cancer. ... Concentrations and Clearance
of Incident Oncogenic Human Papillomavirus Infection of the Cervix. ...

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide -
JMM Walboomers, MV Jacobs, MM Manos, FX Bosch, JA … - The Journal of Pathology, 1999 - doi.wiley.com
... of integrated human papillomavirus type 16 DNA in cervical cancer: amplification
of ... 8. zur Hausen H. Molecular pathogenesis of cancer of the cervix and its ...

… Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer -
M Morris, PJ Eifel, J Lu, PW Grigsby, C Levenback, … - New England Journal of Medicine, 1999 - content.nejm.org
... Carcinoma of the Uterine Cervix: Twice- versus Once-weekly High-Dose-Rate Brachytherapy. ...
Cervical Cancer: Prevention, Diagnosis, and Therapeutics. ...

Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer -
PG Rose, BN Bundy, EB Watkins, JT Thigpen, G Deppe … - New England Journal of Medicine, 1999 - content.nejm.org
... locally advanced cervical cancer. Women with primary untreated invasive
squamous-cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix ...

Relation of human papillomavirus status to cervical lesions and consequences for cervical-cancer … -
MA Nobbenhuis, JM Walboomers, TJ Helmerhorst, L … - Lancet, 1999 - ncbi.nlm.nih.gov
... BACKGROUND: A relation has been established between infection with high-risk types
of human papillomavirus and development of cervical cancer. ...

The causal relation between human papillomavirus and cervical cancer -
FX Bosch, A Lorincz, N Munoz, C Meijer, KV Shah - British Medical Journal, 2002 - jcp.bmj.com
... presented separately for squamous cell carcinomas and adenocarcinomas of the cervix. ...
association of human papillomavirus (HPV) DNA and cervical cancer in the ...

… -Specific Persistence of Human Papillomavirus DNA before the Development of Invasive Cervical Cancer -
KL Wallin, F Wiklund, T Angstrom, F Bergman, U … - New England Journal of Medicine, 1999 - content.nejm.org
... in a population-based screening program for cancer of the cervix in Sweden from
1969 to 1995, we compared the proportion of normal cervical smears (Pap smears ...

… DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. -
M Boshart, L Gissmann, H Ikenberg, A Kleinheinz, W … - The EMBO Journal, 1984 - pubmedcentral.nih.gov
... Copyright notice. A new type of papillomavirus DNA, its presence in genital cancer
biopsies and in cell lines derived from cervical cancer. ...

The Papanicolaou test for cervical cancer detection. A triumph and a tragedy -
LG Koss - JAMA, 1989 - Am Med Assoc
... treatment of precancerous lesions and early cancer of the uterine cervix is described ...
is the screening and interpretation of cervical (Papanicolaou) smears ...

Source: Google Scholar

Worldwide distribution of cervical cancer virus is consistent with vaccine targets

CHAPEL HILL – The variety of human papilloma viruses that cause invasive cervical cancer cases worldwide are largely consistent across continents, according to a new study from the University of North Carolina at Chapel Hill. 

This finding means that prophylactic vaccines currently available against these two most prevalent types of human papillomavirus (HPV) – which can cause cervical cancer – could prevent about 70 percent of invasive cervical cancer (ICC) cases around the world, the researchers found.

“Our data confirm that HPV types 16 and 18 are the most common in invasive cancer and strengthen the data on the estimated number of cases that could be prevented with vaccination,” said lead study author Jennifer Smith, Ph.D., a research assistant professor of epidemiology in the UNC School of Public Health and a member of the UNC Lineberger Comprehensive Cancer Center. “As a result of this analysis, we now have additional information about other high-risk HPV types that cause invasive cancer to target for future HPV vaccine development.”

The results were published in the Aug. 1, 2007, issue of the International Journal of Cancer.

HPV is a sexually transmitted virus that can cause high-grade cervical lesions, increasing a woman’s risk of developing invasive cervical cancer. There are approximately 14 high-risk types of HPV that cause invasive cervical cancer, Smith explains. The two most common types are 16 and 18, named for their genetic patterns. These virus types are responsible for about 70 percent of invasive cervical cancer and 50 percent of high-grade lesions worldwide, the study shows.

To estimate the prevalence of different virus types in cancer, the researchers conducted a meta-analysis of data on the distribution of HPV infection in more than 14,000 invasive and 7,000 high-grade cases throughout the world. A meta-analysis combines statistics from smaller studies to develop information with greater statistical significance.

The scientists reported that ICC HPV16 was the most common, and HPV18 the second most-common type in all continents. Combined HPV 16/18 prevalence among ICC cases was slightly higher in Europe, North America and Australia, from 74 to 77 percent, than in Africa, Asia and South/Central America, where the rates were between 65 and 70 percent. Data on HPV-typed ICC and high-grade lesions were particularly scarce from large regions of Africa and Central Asia.

Gardasil, a Merck & Co. vaccine approved last year by the Food and Drug Administration, protects against HPV 16 and 18. A similar vaccine developed by GlaxoSmithKline also protects against these types of HPV.

“While having these vaccines represents a significant step forward, HPV-vaccinated women will need to receive clear messages that they still need to obtain their recommended Pap smears for cervical cancer prevention, given that HPV vaccines will not prevent all invasive cancer or high-grade lesions,” Smith said.
 
Other study authors include: Brooke Hoots and Jessica Keys, in the UNC School of Public Health’s department of epidemiology; Lisa Lindsay of GlaxoSmithKline Biologicals in Belgium; Silvia Franceschi and Gary Clifford, with the International Agency for Research on Cancer in Lyon, France; and Rachel Winer, at the University of Washington.

Note: Jennifer Smith may be reached at (919) 966-7450 or jsssmith@email.unc.edu.

School of Public Health contact: Ramona DuBose (919) 966-7467 or ramona_dubose@unc.edu
UNC Lineberger contact: Dianne Shaw (919) 966-5905 or dgs@med.unc.edu
News Services contact: Clinton Colmenares (919) 843-1991 or clinton_colmenares@unc.edu
 
 
 
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