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Recent News and Articles on the Keywords: liver cancer + cancer + molecule  Related to the article below (Last Update: 8/5/2008)

Nastech Pharmaceutical Company Inc. Q2 2008 Earnings Call Transcript
Seeking Alpha, NY -
In oncology, we are pursuing indications in bladder cancer and lung cancer. Bladder cancer is the fifth most common cancer in the United States and seventh ...MRNA
Nexavar Approved for Liver Cancer in China
FOXBusiness - Jul 28, 2008
"China has the highest number of liver cancer patients worldwide with more than 340000 new cases diagnosed each year and the incidence is continuing to rise ...ONXX - OTC:CMTX
Celera Appoints Jean Amos Wilson, Ph.D., as Vice President of ...
MarketWatch - Aug 4, 2008
... with Abbott and has licensed other relevant diagnostic technologies developed to provide personalized disease management in cancer and liver diseases. ...CRA
Jennerex Publishes Clinical Trial Data With Lead Product JX-594 ...
MarketWatch - Jul 22, 2008
A Phase II clinical trial is now underway for JX-594 in liver cancer. The data were published in the journal Molecular Therapy. "These clinical results with ...SEO:006280 - OTC:CMTX
China Biotech in Review: Company Profiles and Drug Advancement
Seeking Alpha, NY - Aug 3, 2008
The drug was indicated for unresectable or metastatic hepatocellular carcinoma [HCC], or liver cancer. The approval was based on two international Phase III ...
Renowned Immunologists Join Medical Center
Media Newswire (press release), NY - Aug 1, 2008
The groups are currently setting up new laboratories in the new James P. Wilmot Cancer Center building. The move should be completed by the end of August, ...
Progen Terminates PATHWAY Trial & Confirms Focus on Potential High ...
FOXBusiness - Jul 23, 2008
Progen targets the multiple mechanisms of cancer across its three technology platforms, angiogenesis, epigenetics and cell proliferation. ...PGLA - OTC:CMTX
Onyx Pharmaceuticals to Present at Bank of America 2008 Specialty ...
PR Newswire (press release), NY - Jul 31, 2008
... developing and marketing Nexavar(R), a small molecule drug. Nexavar is currently approved for the treatment of liver cancer and advanced kidney cancer. ...ONXX - BAC
Public research funding is sought for Erie man's cancer treatment ...
Pittsburgh Post Gazette, PA - Jul 30, 2008
"We've proven we can get nanoparticles inside to kill cancer cells," said Dr. Curley, a liver cancer surgeon and researcher at the MD Anderson Cancer Center ...
Part of Phase 2 at $1.5B NC Research Campus
BioRegion News, NY -
Earlier this year, LabCorp licensed from Duke a blood-based assay for early detection of lung cancer. In 2006, LabCorp partnered with Duke to create the ...
Source: Google News

Invasion and metastasis of liver cancer: expression of intercellular adhesion molecule 1. -
JJ Sun, XD Zhou, YK Liu, ZY Tang, JX Feng, G Zhou, … - J Cancer Res Clin Oncol, 1999 - ncbi.nlm.nih.gov
Click here to read Invasion and metastasis of liver cancer: expression of intercellular
adhesion molecule 1. Sun JJ, Zhou XD, Liu YK, Tang ZY, Feng JX, Zhou G ...

Detection of Aberrant p16 Methylation in the Plasma and Serum of Liver Cancer Patients 1 -
IHN Wong, YM Dennis Lo, J Zhang, CT Liew, MHL Ng, … - Cancer Research, 1999 - AACR
... S., Wu L., Hamilton SR, Sidransky D., Jen J. Molecular detection of ... Specific mutations
of hepatitis B virus in plasma predict liver cancer development PNAS ...

Functional inactivation but not structural mutation of p 53 causes liver cancer -
H Ueda, SJ Ullrich, JD Gangemi, CA Kappel, L Ngo, … - Nature Genetics, 1995 - nature.com
... Hosono, S., Lee, CS, Chou, MJ, Yang, CS & Shin, C. Molecular analysis of the ... T. &
Jay, G., The HBx gene of hepatitis B virus induces liver cancer in transgenic ...

… Expression in Normal Liver Blood Sinusoids and Down-Regulation in Human Liver Cancer and Cirrhosis 1 -
CM Carreira, SM Nasser, E di Tomaso, TP Padera, Y … - Cancer Research, 2001 - AACR
... ligand for LYVE-1 is HA, a ubiquitous extracellular matrix molecule with
proinflammatory ... evidence for regulation of LYVE-1 in human liver cancer and cirrhosis. ...

… , and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous … -
BZ Yuan - Cancer Research, 1998 - AACR
... molecular basis of cancer. We report here the isolation of the full-length cDNA
and chromosomal localization of a new gene frequently deleted in liver cancer ( ...

HBx gene of hepatitis B virus induces liver cancer in transgenic mice -
CM Kim, K Koike, I Saito, T Miyamura, G Jay - Nature, 1991 - nature.com
... model appears ideal for defining the molecular events that follow the expression
of the viral HBx gene and are responsible for the development of liver cancer. ...

[PDF] Angiogenesis in cancer and other diseases -
P Carmeliet, RK Jain - Nature, 2000 - cmbi.bjmu.edu.cn
... and overcome the pressure barrier to the deliveryof molecular medicine in ... vessels
enlarge and become tortuous) epithelia liver regeneration, cancer ...
-

… Endothelial Growth Factor Receptor Inhibits the Growth of Colon Cancer Liver Metastasis and Induces … -
RM Shaheen, DW Davis, W Liu, BK Zebrowski, MR … - Cancer Research, 1999 - AACR
... Several small molecule inhibitors that target these growth factor receptors are ... of
the growth, vascularity, and proliferation of colon cancer liver metastases. ...

Molecular detection of genetic alterations in the serum of colorectal cancer patients -
K Hibi - Cancer Research, 1998 - AACR
... in the Plasma and Serum of Liver Cancer Patients: Implications for Cancer Detection
and ... Serum: Biology and Applications to Molecular Diagnosis and ...

Dissemination and growth of cancer cells in metastatic sites -
AF Chambers, AC Groom, IC MacDonald? - Nat Rev Cancer, 2002 - microarray1.princeton.edu
... Some molecular factors that influence the ability of colon and other cancer
cells to grow in the liver have also been identified. ...

Source: Google Scholar

MOLECULE BLOCKS GENE, SHEDS LIGHT ON LIVER CANCER

COLUMBUS , Ohio – New research shows how a particular small molecule blocks the activity of a cancer-suppressing gene, allowing liver-cancer cells to grow and spread.

This molecule is a microRNA, a recently discovered class of tiny molecules used by cells to help control the kinds and amounts of proteins they make. More than 250 different microRNAs have been discovered, and several have been linked to cancer.

These findings show exactly how one specific microRNA, called miR-21, helps cancer develop.

This molecule occurs at unusually high levels in many kinds of cancer cells. The study looked at a gene called PTEN (pronounced P-TEN), which normally protects cells from becoming cancerous. Researchers know that the abnormal silencing of this tumor-suppressor gene contributes to the development of liver cancer and other malignancies.

The researchers showed that adding high levels of miR-21 to normal liver cells caused PTEN levels to drop. They also traced the chemical pathways that increased the cells' abilities to proliferate, migrate and invade other tissues.

The findings help explain how liver cancer develops and may identify new drug targets for treating the disease. This particular microRNA might also provide a marker to help determine a patient's prognosis.

The study, led by researchers at the Ohio State University Comprehensive Cancer Center, is published in the August issue of the journal Gastroenterology.

“Our findings essentially describe a new mechanism used by cells to regulate PTEN,” says principal investigator Tushar Patel, professor of internal medicine, director of hepatology and a liver-cancer specialist at Ohio State University Medical Center.

They show that high levels of miR-21 block the PTEN gene, he explained. This, in turn, activates chemical pathways that enable cancer cells to proliferate, migrate and invade other tissues, all of which are features of tumor formation.

Patel and his collaborators began the study by measuring the relative levels of 197 microRNAs in normal liver cells and in liver cancer cells from human tumors and in four liver cancer cell lines.

Levels of miR-21 were up to nine times greater in liver-tumor tissue compared with normal liver tissue, twice that of the next highest microRNA.

Earlier research led by Patel had shown that miR-21 probably targeted PTEN, and this study confirmed that.

Furthermore, the researchers showed that adding high levels of miR-21 to normal liver cells caused PTEN levels to drop. They also traced the chemical pathways that increased the cells' abilities to proliferate, migrate and invade other tissues.

“Our findings indicate that miR-21 plays a fundamental role in tumor-cell behavior and cancer development,” Patel says, “and this may also be relevant to other tumors in which miR-21 is overexpressed. If this work is reproduced in investigations of other cancers, it could be a big step forward,” he says.

Funding from the National Cancer Institute, the National Institute of Diabetes and Digestive and Kidney Diseases and the Scott and White Hospital Foundation supported this research.

#

Contact: Eileen Scahill, Medical Center Communications, 614-293-3737, or Eileen.Scahill@osumc.edu
 
 
 
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