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Recent News and Articles on the Keywords: new + asthma + esrf  Related to the article below (Last Update: 8/5/2008)

Parents hopeful renovations improve Corona del Sol air
Arizona Republic, AZ -
"I'm very aware because he has asthma," she said. If he gets sick, she said she will reassess his school choice. But for now, she remains "confident" about ...
Chest Journal: August news briefs
EurekAlert (press release), DC -
A new study suggests that people who are obese with asthma may carry a specific trait or phenotype that causes them to have poorer asthma control than ...
New, more affordable TB vaccine by 2015
Jamaica Observer, Jamaica - Aug 3, 2008
MEXICO CITY, Mexico - A new vaccine to prevent tubercolosis (TB) infection could be available within the next seven years, if the current ongoing trials are ...

Washington Post
Air Pollution Bad in Beijing, Not Great in New York State
ReadMedia (press release), NY -
"Higher pollution levels in New York State make people sick and even cut lives short," added Seilback. In particular, people with asthma, COPD (emphysema ...
AssociatedPress
all 568 news articles »
High-tech helps athletes breathe easy
Globe and Mail, Canada -
There was an article in the British Medical Journal about a New Zealand group [of researchers] that did measurements in Beijing. ...
Combination therapy best for severe asthma, studies find
American Medical News (subscription) - Aug 3, 2008
"There is nothing new here, but it will get a lot of scary newspaper headlines." It has long been known what will happen if a person with asthma relies ...
Putting health on the menu
Los Angeles Times, CA -
Obesity has been linked to heart disease, high blood pressure, cancer, strokes, asthma, diabetes and reduced life expectancy. According to the Centers for ...
FOX Files: New Asthma Inhalers
MyFox Saint Louis, MO - Jul 16, 2008
It could be deadly for the people with asthma. After the new year, you won't even be able to buy the old kind. One patient told us, "It would be nice if ...
Centre to change children?s lives
Journal Live, UK -
THE mother of a boy who suffers from a severe form of asthma has given her backing to a Journal-backed appeal to raise funds for a new childhood respiratory ...
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Baltimore Sun, United States - 35 minutes ago
"Asthma and heart disease are things we are just beginning to get a handle on." Cancer registries contain information on the age, race, gender, ...
Source: Google News

[PDF] Experiment title -
C Nemoz, P Suortti, PDC Nemoz, EMSL Porra - esrf.eu
... Christian Nemoz, ESRF * MSc. ... Experimental Biology Meeting, New Orleans, USA, April
2002, Faseb journal Vol. ... Self-organized patchiness in asthma as a prelude to ...

[PDF] Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen … -
ARN Ibrahim, S Kawamoto, Y Shimada, S Rikimaru, I … - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
either wheeze without a cold, nocturnal attack of shortness of breath or ...
-

[PDF] Coagulation factor XII (Hageman factor): a new angioedema gene -
G Dewald, K Bork - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
either wheeze without a cold, nocturnal attack of shortness of breath or ...
-

[PDF] ASTHMA EPIDEMIOLOGY -
A Morikawa, H Tadaki, H Arakawa, M Sugiyama - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
either wheeze without a cold, nocturnal attack of shortness of breath or ...
-

[PDF] Asthma and allergy development in mono-zygotic twins discordant for severe respiratory syncytial …
P Poorisrisak, LB Halkjaer, SF Thomsen, LG … - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
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[PDF] Asthma management in real life; preliminary data from CPD-ARGA project -
L Guerra, F Braido, I Valle, A Coccini, P Guerrera … - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
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[PDF] Prevalence of asthma and allergy in Swedish school employees 1993 and 2003.
G Smedje, D Norback - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
either wheeze without a cold, nocturnal attack of shortness of breath or ...
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[PDF] … characterization of a wheat serine proteinase-inhibitor as a novel allergen in baker's asthma -
C Constantin, S Quirce, A Touraev, I Swoboda, A … - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
either wheeze without a cold, nocturnal attack of shortness of breath or ...
-

[PDF] Depression, anxiety and quality of life in pediatric asthma in a Hungarian pediatric university … -
A Szab?, G Mezei, E Cserh?ti - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
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-

[PDF] Atopy in young children with asthma.
L Xiang, Z Qi, K Shen - waojournal.org
... New asthma and wheeze at the follow-up was studied, excluding those (N = 1605) with
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-

Source: Google Scholar

ESRF lightsource helps tailoring new treatments against asthma

PRESS RELEASE- Researchers from Sweden and France have deciphered the crystal structure of a human membrane protein which has a major influence on the development of asthma. They used the highly automated ESRF macromolecular crystallography experimental stations (beamlines) to determine the structure of this pharmaceutically important protein, only the third human membrane protein to be solved. The scientists now believe that their work will enable the development of new and better therapeutic drugs targeting inflammation of the respiratory tract.

Asthma affects 300 million people worldwide and, according to World Health Organization, it killed 255 000 people in 2005. Asthma attacks are caused by an acute inflammatory reaction in the airways, a reaction that is largely due to actions of LTC4 synthase (an enzyme which catalyzes a synthesis process). For this reason asthma medicines often aim to block the downstream effects of LTC4 synthase.

However, there is a need for new pharmaceutical alternatives, since not all patients respond to the existing medicines. Thanks to the research partly carried out at the European Synchrotron Radiation Facility (ESRF), it is now possible to tailor new molecules that can block the LTC4 synthase. “I believe this breakthrough will speed up drug discovery against this disease”, explains Andrew McCarthy, one of the researchers in the team.

Scientists from the Karolinska Institute and the University of Stockholm in Sweden, together with colleagues from the European Molecular Biology Laboratory in France have solved the three dimensional structure of the LTC4 synthase at 2.0 Ångstrom resolution . The protein has three identical subunits, each consisting of four helical structures that span the membrane. The structure finally allows the exact position and characteristics of the active sites, where activating or blocking molecules can bind, to be identified.

The study of this protein at the ESRF proved a challenge for the team. The crystallization of membrane proteins is quite a complex process and even more challenging if they are human. So far only three human membrane proteins have been structurally characterized. The team carried out experiments at the ESRF to screen crystals several times before finally being able to determine the 3D structure.

Structure of LTC4 synthase

LTC4 synthase overall structure. a) Left, front view of LTC4 synthase protomer in ribbon representation showing helices 1–5 in successive colouring. The entire LTC4 synthase polypeptide, except for the last residue (the last four in the GSH-complexed structure), can be traced in the electron density maps. Right, the homotrimer with protomers coloured orange, green and blue. Bound glutathione, indicating the position of the active site, is in ball and stick representation. Approximate membrane positions indicated by blue lines. b) Cytosolic view of the trimer, showing the position of the three active sites with loop 1 covering each binding pocket. Glutathione is shown in ball and stick representation together with modelled detergent (DDM). Image credit: D. Martinez Molina.

 

Membrane proteins- an open door to new pharmaceuticals

The new results can lead the way for the development of new and more effective medications against other diseases. Some 40 % of the proteins of interest for pharmaceutical developments are membrane proteins.

Until now detailed structural information on these proteins has been absent, and therefore it has been difficult to fully understand their function. The present study is likely to lead the way for the determination of structures of other human membrane proteins. Unravelling the secrets of more membrane protein structures will help understand fundamental processes that take place in the cell membranes.

Reference

"Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase", Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggström JZ, Nordlund P, Nature AOP 15 july 2007.

For more information, please contact Montserrat Capellas ( email or +33 (0)476882663).

 
 
 
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