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Recent News and Articles on the Keywords: reduction + side + risks  Related to the article below (Last Update: 8/5/2008)

Risk Reduction
Wall Street Journal - Aug 3, 2008
"I really want the risk on the stock side [of the portfolio], not on the bond side," she says. For the biggest accounts, she buys individual, ...
Indevus Pharmaceuticals Announces Third Quarter Fiscal 2008 ...
MarketWatch - 20 minutes ago
Except for the descriptions of historical facts contained herein, this press release contains forward-looking statements that involve risks and ...IDEV
Ulysses Diversified Holdings Corp. Board of Directors Approves a ...
MarketWatch -
These forward-looking statements involve certain risks and uncertainties that could cause actual results to differ, including, without limitation, ...

E Canada Now
US Panel Questions Prostate Screening
Washington Post, United States -
"And on the other side, the risks are large and dramatic." The task force and other groups had concluded previously that it was unclear whether the benefits ...
Embargoed news from Annals of Internal Medicine Genetic Engineering News (press release)
all 322 news articles »

ABS CBN News
Risk transfer: Saving the gov't the cost of calamity damage
ABS CBN News, Philippines -
As long as you do risk reduction measures like risk transfer or insurance, then losses during a disaster might be transferred to the insurers. ...
The Evening Wrap
Wall Street Journal -
"The last meeting statement described the transition from an easing Fed to a Fed on hold, as growth risks abated and inflation risks increased. ...
Lydall Announces Financial Results for the Second Quarter and Six ...
CNNMoney.com - Aug 4, 2008
This improvement was primarily due to a reduction in accounts receivable due to improved collection results, and to a lesser extent, the reduction of ...
Six Flags Announces Second Quarter Results CNNMoney.com (press release)
Beasley Broadcast Group Reports Second Quarter Revenue of $31.0 ... Primenewswire (press release)
Silverleaf Resorts, Inc. Reports Second Quarter 2008 Results ... MarketWatch
FOXBusiness - istockAnalyst.com
all 227 news articles »  BBGI - SIX - LDL

AFP
Rich, poor gap in Asia putting children's lives at risk: UN
AFP -
The Asia Pacific as a whole has seen a 34 percent reduction in the under-fives mortality rate since 1990. Out of every 1000 births in the region in 2006, ...

BBC News
Microfinance project reduces HIV risk in South African women, gold ...
Aidsmap, UK -
A microfinance and training project designed to empower South African women was associated with a significant reduction in HIV risk behaviour and partner ...
Global HIV stats called into question by US study New Scientist (subscription)
Mexico's Evolving HIV Epidemic Journal of American Medical Association (subscription)
Interview: Beyond Condoms to Truth in the AIDS Debate Catholic Online
all 413 news articles »
Otter Tail Corporation Announces Second Quarter Earnings; Lowers ...
FOXBusiness - 34 minutes ago
The decline in sales is due to a reduction in sales to European customers temporarily served in 2007 due to a European crop problem in 2006 and soft demand ...
Pzena Investment Management Inc. Q2 2008 Earnings Call Transcript Seeking Alpha
The Churchill Corporation Delivers Record Quarterly Profit Canada NewsWire (press release)
Marlin Business Services Corp. Reports Second Quarter 2008 Net ... Stockhouse
all 24 news articles »  MRLN - OTTR - PZN
Source: Google News

[CITATION] Incidence and risk factors for side effects of spinal anesthesia -
RL Carpenter, RA Caplan, DL Brown, C Stephenson, R … - Anesthesiology, 1992
... Side effects. Vomiting: nausea.) Although spinal anesthesia has long been consid-
ered a safe technique, it is not without risk or side effect. ...

… of Clinical Oncology Technology Assessment on Breast Cancer Risk Reduction Strategies: Tamoxifen and … -
RT Chlebowski, DE Collyar, MR Somerfield, DG … - Journal of Clinical Oncology, 1999 - jco.ascopubs.org
... formal literature review was conducted for tamoxifen and raloxifene on the following
topics: breast cancer risk reduction; tamoxifen side effects and toxicity ...

Risk reduction from low osmolality contrast media: what do patients think it is worth -
LJ Appel, EP Steinberg, NR Powe, GF Anderson, SA … - Med Care, 1990 - JSTOR
... ef- fects. Moreover, WTP for minor side effect risk reduction was not
associated with any patient characteristic. However, one must ...

Valuing Mortality-Risk Reduction: Using Visual Aids to Improve the Validity of Contingent Valuation -
PS Corso, JK Hammitt, JD Graham - Journal of Risk and Uncertainty, 2001 - Springer
... of risk reduction, and so yield CV estimates that are more consistent with economic
theory. We estimate WTP for an automobile-safety device (a side-impact ...

… pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease … -
CJL Murray, JA Lauer, RCW Hutubessy, L Niessen, N … - The Lancet, 2003 - Elsevier
... The absolute-risk approach to management of blood pressure ... only 20% while more than
halving side-effects. ... concentration are due largely to the reduction in the ...

… of Pharmacologic Interventions for Breast Cancer Risk Reduction Including Tamoxifen, Raloxifene, … -
RT Chlebowski, N Col, EP Winer, DE Collyar, SR … - Journal of Clinical Oncology, 2002 - jcojournal.org
... trial setting, given the uncertainty regarding long-term side effects of ... with raloxifene
or aromatase inhibitors for breast cancer risk reduction has either ...

Selective Estrogen Receptor Modulation and Reduction in Risk of Breast Cancer, Osteoporosis, and … -
VC Jordan, S Gapstur, M Morrow - jnci, 2001 - jnci.oxfordjournals.org
... A 45% reduction in fractures of the hip (RR = 0.55; 95 ... breast cancer incidence, it
also has side effects, some ... When one is evaluating the risks and benefits of ...

[BOOK] Harm Reduction: Pragmatic Strategies for Managing High-Risk Behaviors -
GA Marlatt - 1998 - books.google.com
... In its modern dress, harm reduction takes on special ... unproved emotional assumptions
on either side of the ... matching interventions to levels of risk, focusing on ...

Environment of infants during sleep and risk of the sudden infant death syndrome: results of 1993-5 … -
PJ Fleming, PS Blair, C Bacon, D Bensley, I Smith, … - BMJ, 1996 - websciences.org
... the sudden infant death syndrome after a national risk reduction campaign ...
RESULTS--Prone and side sleeping positions both carried increased risks of death ...
-

Risk Reduction in Pediatric Procedural Sedation by Application of an American Academy of Pediatrics/ … -
GM Hoffman, R Nowakowski, TJ Troshynski, RJ Berens … - Pediatrics, 2002 - Am Acad Pediatrics
... The finding that risk reduction by adherence to guidelines was ... of a linked sedation
and risk continuum. ... sedation before serious physiologic side effect occurs. ...

Source: Google Scholar

Reduction In Risks And Side Effects From Anaesthetics Likely With Better Understanding Of How Anaesthetics Work
An important clue to how anaesthetics work on the human body has been provided by the discovery of a molecular feature common to both the human brain and the great pond snail nervous system, scientists report. Researchers hope that the discovery of what makes a particular protein in the brain sensitive to anaesthetics could lead to the development of new anaesthetics with fewer side effects.

The study focuses on a particular protein found in neurons in the brain, known as a potassium channel, which stabilises and regulates the voltage across the membrane of the neuron. Communication between the millions of neurons in the brain -- which is the basis of human consciousness and perception, including perception of pain -- involves neurons sending nerve impulses to other neurons. In order for this to happen, the stabilising action of the potassium channel has to be overcome. Earlier studies on great pond snails by the same team identified that anaesthetics seemed to selectively enhance the regulating action of the potassium channel, preventing the neuron from firing at all -- meaning the neuron was effectively anaesthetised.

The new research has identified a specific amino acid in the potassium channel which, when mutated, blocks anaesthetic activation. Lead author, Biophysics Professor Nick Franks from Imperial College London, explains how this will allow the importance of the potassium channel in anaesthetic action to be established:

"We've known for over 20 years now that these potassium channels in the human brain may be important anaesthetic targets.

However, until now, we've had no direct way to test this idea. Because a single mutation can block the effects of anaesthetics on this potassium channel without affecting it in any other way, it could be introduced into mice to see if they also become insensitive to anaesthetics. If they do, then this establishes the channel as a key target."

The group carried out their new study, published in the 20 July issue of the Journal of Biological Chemistry, by cloning the potassium channel from a great pond snail and then making a series of chimeric channels -- part snail and part human.

The chimeras were used to identify the location of the precise amino acid to which the anaesthetic binds on the potassium channel, giving the team a clearer picture than ever before of the precise mechanism by which anaesthetics work.

This kind of research, explains Professor Franks, is important because understanding exactly how anaesthetics work may pave the way for the development of a new generation of anaesthetics which solely affect specific anaesthetic targets, which could potentially reduce the risks and side effects associated with current anaesthetics.

"At the moment, anaesthetics have many unwanted side-effects on the human body such as nausea and effects on the heart. This is because our current drugs are relatively non-selective and bind to several different targets in the body. A better understanding of how anaesthetics exert their desirable effects could lead to much more specific, targeted alternatives being developed, which could greatly reduce these problems," he said.


Source: Danielle Reeves
Imperial College London

 
 
 
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