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Recent News and Articles on the Keywords: dosage calculation + blood + computer  Related to the article below (Last Update: 8/5/2008)

Computers Lead To Safer Blood Transfusions, Chemotherapy
Science Daily (press release) - Jul 23, 2008
?Dosage for chemotherapy depends on body surface area, an important calculation based on the patient?s height and weight,? says Clarke. ...
Detecting defects
packagingnews.co.uk, UK - Jul 30, 2008
For peelable lids on containers such as yoghurt pots and daily-dose drink bottles, companies such as Mecmesin, Lloyd Instruments and Stable Micro Systems ...
Visiting Veterinarian : Hard to digest
Martha's Vineyard Times, MA - Jul 16, 2008
I put the caller on hold and went back to the computer. Hmmm. Not much information. A few worrisome comments about methemoglobinemia, a blood disorder that ...
Sildenafil Treatment of Women With Antidepressant-Associated ...
Journal of American Medical Association (subscription), IL - Jul 22, 2008
Intervention Forty-nine patients were randomly assigned to take sildenafil or placebo at a flexible dose starting at 50 mg adjustable to 100 mg before ...
CT scans save lives. Can they also save money and cut radiation ...
OCRegister, CA - Jul 10, 2008
Low-dose radiation might even help protect against cancer, because the body responds to it by continually repairing its genes. Estimates such as Brenner's ...
Source: Google News

Computer support for determining drug dose: systematic review and meta-analysis -
R Walton, S Dovey, E Harvey, N Freemantle - BMJ: British Medical Journal, 1999 - pubmedcentral.nih.gov
... 1 and their computational skills may be inadequate to perform calculations about
drug dose. ... 82 of 150 hospital doctors were unable to calculate how many ...

The effects of low-dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic … -
A Meier-Hellmann, DL Bredle, M Specht, C Spies, L … - Intensive Care Medicine, 1997 - Springer
... 0.24 mg/h) and midazolam (maximum dosage 6.0 mg ... ABL 3, Radiometer, Copenhagen, Denmark)
to calculate the pHi according the Henderson?Hasselbalch equation. ...

COMPUTER CONTROLLED INFUSION OF PROPOFOL -
RM TACKLEY, GTR LEWIS, C PRYS-ROBERTS, RW BOADEN, … - British Journal of Anaesthesia, 1989 - British Jrnl Anaesthesia
... of distribution for the infusion rate calculation in a ... parameters derived from a
single dose study [6 ... an early overshoot of propofol blood concentration (dark ...

Computer simulation of the effects of alterations in blood flows and body composition on thiopental … -
DR Wada, S Bjorkman, WF Ebling, H Harashima, SR … - Anesthesiology, 1997 - anesthesiology.org
... may benefit by adjustment of the dose for cardiac ... for in separate organs, or a
calculation based on ... LR, Leggett RW: Reference values for resting blood flow to ...

Benchmark dose calculations of methylmercury-associated neurobehavioural deficits -
E Budtz-Jrrgensen, P Grandjean, N Keiding, RF … - Toxicology Letters, 2000 - Elsevier
... An attractive approach in this regard is to calculate so-called ... 2.3. Benchmark
calculations. In examining dose-response relationships, we have used the approach ...

A general method for calculating the dosage scheme in linear pharmacokinetics -
H Schwilden - European Journal of Clinical Pharmacology, 1981 - Springer
... is not always sufficient for calculating dosage schemes, as ... Moreover this equation
is model independent in the framework ... 1.3) may be the basis to calculate Gi(t ...

KINETICS OF INDOCYANINE GREEN REMOVAL FROM THE BLOOD*
G Paumgartner, P Probst, R Kraines, CM Leevy - Annals of the New York Academy of Sciences, 1970 - Blackwell Synergy
... our data and to calculate the maximum initial removal rate (vmm) and ... FIGURE 4.
Relationship between the dose and hepatic uptake of ... Michaelis-Menten equation. ...

Controlled multicenter study on the effect of computer assistance in intensive insulin therapy of … -
J Schrezenmeir, K Dirting, P Papazov - Computer Methods and Programs in Biomedicine, 2002 - Elsevier
... The simple blood glucose (BG) determining methods allow an ... [17] presented a computer
system which ... it used additionally a linear dose calculation and variable ...

Phase I Trial of Multiple Cycles of High-Dose Chemotherapy Supported by Autologous Peripheral-Blood … -
RJ Schilder, S Johnson, J Gallo, S Kindsfather, B … - Journal of Clinical Oncology, 1999 - jcojournal.org
... repeated infusions of autologous peripheral-blood progenitor cells ... LA, et al:
Carboplatin dosage: Prospective evaluation of a simple formula based on ...

Computer analysis of factors influencing frequency of infection in systemic lupus erythematosus -
E Ginzler, H Diamond, D Kaplan, M Weiner, M … - Arthritis Rheum, 1978 - doi.wiley.com
... COMPUTER ANALYSIS OF INFECTION FACTORS IN SLE 39 ... infections (Table 6). How- ever,
when intervals are divided into subsets by steroid dose, calculation of the ...

Source: Google Scholar

Computer Dosage Calculation Of Blood Thinning Drugs Found To Be Safe
The largest ever study into the administration of blood thinning drugs like Warfarin has concluded that dosages calculated by computer are at least as safe and reliable as those provided by trained medical professionals.

Increasing evidence of the value of these anticoagulant drugs in a wide range of clinical disorders such as abnormal heart rhythm, or atrial fibrillation, has led to a rapid rise in their use around the world.

However, prescribing the right oral dose of anticoagulant to patients, even for experienced medical staff, can be problematic as individuals differ greatly in response to a given dose: too high a dose for an individual and the blood becomes too thin and can lead to internal bleeding, too low and the blood clots too readily.
Previous studies supporting the use of computer-assisted dosage have depended solely on laboratory results and have not been sufficiently large to determine whether observed improvements in normal blood clotting time -- known as the 'international normalised ratio' or INR -- resulted in clinical benefit and improved safety.

But now results from a four-year clinical trial organised from The University of Manchester have shown that computer-assisted dosage is as good, if not better, at prescribing the correct dosage to normalise and maintain the correct INR in patients as dosages given by medical professionals.

"The need for computer assistance arises from the massive demand for oral anticoagulants following their success at treating an increasing number of thrombotic and embolic conditions," said Professor Leon Poller, who headed the research in Manchester's Faculty of Life Sciences.

"This increased demand has been overwhelming and stretched medical facilities worldwide to their limits. Computer dosage was introduced as a way to meet this demand but its safety and effectiveness had never been established."

The study, carried out in 32 medical centres across the European Union and involving more than 13,000 patients, analysed nearly 400,000 INR tests, divided evenly between manual and computer-assisted dosage.

The percentage of manual tests to give the correct INR was 64.7%, compared to 65.9% for computer-assisted dosage, confirming the effectiveness of the two programs tested by the team.

In terms of safety, the number of INR tests that resulted in clinical complications was 7.6% lower in all clinical groups with computer-assisted dosage, dispelling any safety concerns.

Indeed, while this overall figure may not be deemed significant, in the 3,208 patients with deep vain thrombosis or pulmonary embolism, the number of clinical events following treatment were significantly lower for computer dosage -- 9.1 per 100 patient-years with medical staff dosage was reduced to 6.1 in the computer arm.

"The results are even more impressive when you consider that the comparisons were made against medical professionals based at centres that specialised in prescribing oral anticoagulants," said Professor Poller.
"At the very least, our study confirms the clinical safety and effectiveness of computer-assisted dosage using the two systems we tested and should help to bring relief to overstretched medical professionals while providing reassurance to patients."

The 32 centres with a special interest in oral anticoagulation recruited 13,219 patients, providing 18,617 patient-years.

INR tests numbered 193,890 with manual dosage and 193,424 with computer-assistance, giving 'time-in-range' of 64.7% and 65.9% respectively.

The two computer programs tested were PARMA 5 and DAWN AC.

The results of the study have just been presented to the International Society on Thrombosis and Haemostasis conference in Geneva, Switzerland.

Source: Aeron Haworth
University of Manchester
 
 
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