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Recent News and Articles on the Keywords: gene + web + 0.30  Related to the article below (Last Update: 8/5/2008)

Gartner Reports Financial Results for Second Quarter 2008
TMC Net, CT - Jul 30, 2008
Gene Hall, Gartner's chief executive officer, commented, "During the second quarter we continued to experience solid demand for our services. ...IT
Source: Google News

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression … -
TR Golub, DK Slonim, P Tamayo, C Huard, M … - Science, 1999 - sciencemag.org
... a weighting factor that reflects how well the gene is correlated ... are described in
(19, 20) and on the Web site. ... of genes with correlation P(g,c) > 0.30 was 709 ...

Mapping of a Gene for Parkinson's Disease to Chromosome 4 q 21-q 23 -
MH Polymeropoulos? - Science, 1996 - sciencemag.org
... using a browser that does not support current Web standards. ... D4S421 and the disease
locus places the PD gene between markers ... 0.00, 0.01, 0.05, 0.10, 0.20, 0.30, 0.40 ...

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene -
A Caspi, K Sugden, TE Moffitt, A Taylor, IW Craig, … - Science, 2003 - sciencemag.org
... that does not support current Web standards. ... actually reflect a gene x "gene"
interaction between ... of childhood maltreatment was significant (b = 0.30, SE = 0.10 ...

Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in … -
L Faure-Delanef, B Baudin, B Beneteau-Burnat, JC … - Clinical Chemistry, 1998 - Am Assoc Clin Chem
... parallel to an insertion/deletion (I/D) polymorphism in its gene, in French ... and were
not different between centenarians and controls, ie, 0.30 ? 0.03 mmol/L ...

Requirement of the Activation-Induced Deaminase (AID) Gene for Immunoglobulin Gene Conversion -
H Arakawa, J Hauschild, JM Buerstedde - Science, 2002 - sciencemag.org
... you are using a browser that does not support current Web standards ... suggests that
AID expression is essential for Ig gene conversion ... 0.30%, 1.95%, 0.04%, 0.14%, 1.74 ...

… Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene -
M Elchebly, P Payette, E Michaliszyn, W Cromlish, … - Science, 1999 - sciencemag.org
... using a browser that does not support current Web standards ... 1. Gene targeting of
the PTP-1B locus ... Insulin (ng/ml), 0.30 ? 0.02, 0.98 ? 0.32, ND, 0.97 ? 0.30, 0.33 ...

A Gene Expression Map for Caenorhabditis elegans -
SK Kim, J Lund, M Kiraly, K Duke, M Jiang, JM … - Science, 2001 - sciencemag.org
... 21, 154, 0.30, Lipid metabolism (10?). ... of genes that cluster in the same mountain
on the gene expression terrain map are shown in Table 1 and listed in Web table ...

Brain monoamine oxidase A inhibition in cigarette smokers -
JS Fowler, ND Volkow, GJ Wang, N Pappas, J Logan, … - Proceedings of the National Academy of Sciences, 1996 - National Acad Sciences
... MAO exists in two subtypes (MAO A and B) that are different gene products (8, 9).
In ... Global, 0.30 ? 0.07, 0.28 ? 0.05, 0.3, 0.18 ? 0.04, 0.13 ? 0.03, 28, 0.0003. ...

[PDF] Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression … -
TG Graeber, D Eisenberg - Nat Genet, 2001 - doe-mbi.ucla.edu
... and colon datasets (Tables 2 and 3; Web Tables A ... of mRNA measured using oligo-based
gene expression arrays ... 0.30 0.45 0.40 0.15 0.0024 0.00079 0.31 0.087 0.092 ...
-

[PDF] 2 ForageValue
R Hathaway, G Pirelli - extension.oregonstate.edu
... Ron Hathaway and Gene Pirelli Page 2. ... Phone: 541-737-3431. Web: http://osu.orst.
edu/dept/animal-sciences/foraglib.htm Page 5. ... 34 74 18 0.50 0.30 ...

Source: Google Scholar

Protein Protects Anti-Cancer Gene From Chemical Shutdown
A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced, researchers at The University of Texas M. D. Anderson Cancer Center report in the July 20 edition of Molecular Cell.

The protein IKKα, expressed at reduced levels in aggressive squamous cell carcinomas both in mice and humans, prevents a vital "checkpoint" gene from being chemically shut down, says Yinling Hu, Ph.D., senior author of the paper and assistant professor in M. D. Anderson's Department of Carcinogenesis at the Science Park - Research Division in Smithville, Texas.
Expression of the checkpoint gene, called 14-3-3ơ, normally is triggered by the cancer-preventing gene p53 in response to DNA damage in the cell, Hu says. The protein expressed by the checkpoint gene helps to block a defective cell from dividing, allowing its genetic errors to be repaired rather than repeated in a new cell. Cells with damaged genes or genes that are behaving abnormally are the drivers of cancer.

"What we've identified is a mechanism that promotes genetic instability in keratinocytes, a critical type of skin cell that makes up 90 percent of epidermal cells, during the development of human skin cancers," Hu says. They found that the absence or weak expression of IKKα leaves the checkpoint gene vulnerable to silencing.

In a series of experiments reported in the Molecular Cell paper, Hu and colleagues show how IKKα prevents silencing of the checkpoint gene by a chemical process known as methylation. Methyl groups, consisting of a carbon atom surrounded by three hydrogen atoms, attach to specific locations on a gene and prevent it from expressing its protein without altering the gene. The team restored the checkpoint gene's activity by first restoring the expression of IKKα in deficient cells by infecting the cells with a virus designed to express IKKα.

"DNA methylation is largely responsible for shutting down the checkpoint gene expression in human cancer cells," Hu says. "Our finding opens a new avenue for identifying new therapeutic targets for battling cancer. Although IKKa can protect the checkpoint gene 14-3-3ơ from silencing, IKKα itself is frequently impaired in cancer cells. So we are going to define specific downstream targets of IKKα involved in regulating DNA methylation of the checkpoint gene. Those targets may be used to prevent silencing of the gene in cancer cells and so allow us to eliminate those cells."

In addition to understanding a critical component in skin cancer, the team notes that other researchers have shown that the checkpoint gene 14-3-3ơ is silenced in a variety of other human epithelial cancers. Epithelial cells make up the outer layers of skin and the inner linings of many organs, including the lungs and the gastrointestinal, reproductive and urinary tracts.
The checkpoint gene had been known to be silenced by methylation, but the mechanism had not been understood. DNA methylation is known as an epigenetic process, because it affects a gene's activity without changing or damaging the gene itself.

Hu's research group has focused on IKKα, which is an important component of a molecular complex that regulates the development of the lymph and immune systems. Hu and colleagues earlier showed that IKKa is essential for embryonic skin development.

Co-authors with Hu are first author Feng Zhu, Ph.D., Xiaojun Xia, Ph.D., Bigang Liu, Jianjun Shen, Ph.D., and Yuhui Hu, all of M. D. Anderson's Science Park - Research Division; and Maria Person, Ph.D., of the Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin.

University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd., Box 229
Houston, TX 77030
United States
http://www.mdanderson.org
 
 
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