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Recent News and Articles on the Keywords: transplantation + getting + pig  Related to the article below (Last Update: 8/5/2008)

Public to get say on pig cell therapy
Stuff.co.nz, New Zealand - Jul 10, 2008
The National Health Committee is consulting on an application by Living Cell Technologies to conduct a clinical trial of pig cell transplantation at ...
Firm boosts pig breeding for human implants
Stuff.co.nz, New Zealand - Jul 22, 2008
Prof Elliot originally made similar transplants in 1996 and 1997, but the clinical trials were blocked by regulators because of fears that the animal ...
From practice to OR
Philadelphia Inquirer, PA - Aug 4, 2008
We practice on pig and rabbit eyes, and will soon get a computer mannequin simulator, but working on real patients - especially the first few times - is a ...
Young lung transplant candidate marks time in Seattle
Anchorage Daily News (subscription), AK - Jul 30, 2008
Like any transplant patient, Tews is a frequent guinea pig for ongoing drug studies and knows that, as the cystic fibrosis population ages, problems with ...
At abuse shelters, girls just wanna have fun!
renewamerica.us, DC - Aug 3, 2008
Then with a dramatic flourish, Cephas phoned the shelter to let them know she'd just had a kidney transplant and the life support was about to be turned off ...

E! Online
Spoiler Chat: Chuck's Same-Sex Kiss, Lost's Season Five and Heroes ...
E! Online - Jul 28, 2008
(Here's a hint: Homer Simpson had a pig version.) Augusta in Phoenix: Missing Battlestar Galactica real bad. Any scoop to tide me over? ...

News & Observer
With pizza dough, collards get a good wrap
News & Observer, NC - Jul 18, 2008
Now that I'm a collard convert, I can think of many ways to use this hearty-flavored vegetable that don't involve pig and a daylong commitment. ...
Hog heaven: Spring Point still on track for 2009 human trials
New Richmond News, WI - Jul 11, 2008
Pictured at four weeks of age, these young pigs at the Spring Point facility in New Richmond will likely be used in the first human transplantation trials ...
Spring Point Project Gains Support of Lions Clubs
PR Newswire (press release), NY - Jul 29, 2008
The Diabetes Institute for Immunology and Transplantation of the University of Minnesota works in conjunction with Spring Point Project by conducting the ...
There Ought To Be a Law: Here?s your championship-caliber hot dog ...
Murfreesboro Post, TN - Jul 14, 2008
I got up and had a couple chocolate Pop-tarts for breakfast and grabbed a slice of bologna on the way out the door so I wouldn?t get hungry and make a pig ...
Source: Google News

… spinal cord by transplantation of H-transferase transgenic adult pig olfactory ensheathing cells -
C Radtke, Y Akiyama, J Brokaw, KL Lankford, K … - The FASEB Journal, 2003 - FASEB
... remyelination was not observed in six transplant sites. ... negative due to surgical
difficulties in getting the cell ... that selectively labeled the grafted pig OECs ...

Xenotransplantation and animal welfare -
K Olsson - Transplantation Proceedings, 2000 - Elsevier
... Transplantation of whole organs (and probably also cells) necessitates ... breeding programs
for the commercial pig have also aimed at getting pigs that grow ...

Hemodynamics alterations during orthotopic liver experimental transplantation in pigs -
OJM Torres, PB Pantoja, ES Barbosa, C de Almeida … - Acta Cir. Bras, 2008 - SciELO Brasil
... In pigs, vascular clamping induced a significant decline of cardiac output ... groups,
and levels of electrolytes were getting better after transplantation. ...

CLONING: After Dolly, a Pharming Frenzy
E Pennisi - Science, 1998 - sciencemag.org
... or tissue to help meet the large unfilled demand for transplant organs ... work has been
lagging, partly because researchers have had trouble getting pig oocytes to ...

XENO-TRANSPLANTATION AND XENOZOONOSES
EJ Ruitenberg - Transmissible Diseases and Transfusion, 2002 - books.google.com
... Infection by porcine en- dogenous retrovirusafter islet transplantation. ... endogenous
Type C retrovirus in pigs rebated to ... with the disease, so getting hold of ...

Farming for Spare Body Parts
WH Allen - BioScience, 1995 - JSTOR
... of us the thought that we could do this in transplantation," he says. ... and most other
xenotransplantation re- searchers have focused on getting pigs to express ...
-

This Little Piggy Went to the Biotech Market
N Careers, C Fairs, C Advice, S Wizard, S On, C … - community.nursingspectrum.com
... The transplant team must work with patients and their families to ... techniques, the
organ waiting list is getting shorter for ... Of or similar to a swine or a pig. ...

Encapsulated cell technology: from research to market -
G Orive, RM Hern?ndez, AR Gasc?n, M Igartua, JL … - Trends in Biotechnology, 2002 - Elsevier
... 11 will die each day without getting a transplant ... used, as well as approaches and
transplantation sites must ... 160 patients treated with living pig tissues 12 ...

Glycosphingolipid expression in pig aorta: identification of possible target antigens for human … -
EC Hallberg - Glycobiology, 1998 - Soc Glycobiology
... the rejection seen in ABO incompatible organ transplantation was, among ... pig aorta
as a simple means of getting large numbers of pig endothelial cells ...

Xenograft transplantation -
Z Khalpey, CA Koch, JL Platt - Anesthesiology Clinics of North America, 2004 - Elsevier
... The shortage of organs is getting worse, and hence ... can infect a human liver transplant
but not ... The optimal species for clinical xenotransplantation is the pig. ...

Source: Google Scholar

Pig To Human Transplantation Getting Closer
Experiments using pigs genetically engineered for compatibility with the human immune system have raised hopes that cross-species transplantation could soon become an option for patients with diabetes and other currently incurable diseases. However, many scientific hurdles remain before the ultimate goal of inducing long-term tolerance of animal tissues and organs in human recipients, according to a special paper in the July 15 issue of the journal Transplantation, published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

"The potential benefits of successful xenotransplantation to large numbers of patients with very differing clinical conditions remain immense, fully warranting the current efforts being made to work towards its clinical introduction," concludes the article. The lead author is Dr. David Cooper of Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center.
Dr. Cooper and colleagues review progress to date with a strain of pigs genetically engineered in the hope of addressing chronic shortages of organs and tissues for transplantation. The animals lack the gene responsible for "alpha-1,3-galactosyltransferase" (GT) an enzyme normally present in the pig vascular system. Humans have natural, preformed antibodies to GT, resulting in immediate (acute) rejection of any pig-to-human transplant.

The fact that these genetically engineered "GT-knockout" pigs lack GT removes one obstacle to cross-species transplantation, or xenotransplantation, between pigs and humans. Apart from the possible transplantation of organs such as the kidney or heart, pigs are also viewed as a potentially invaluable source of islet cells the insulin-producing cells of the pancreas for use in transplantation as a treatment for type 1 diabetes.

Preliminary studies have reported encouraging results with transplantation of organs from GT-KO pigs into nonhuman primates. Hearts transplanted from GT-KO pigs into baboons have survived for several months, without the need for intensive drug treatment to suppress the recipient animal's immune system.

However, many obstacles remain to be overcome before exploratory studies of xenotransplantation from GT-KO pigs to humans can begin. The transplanted hearts do not show the pattern of acute, overwhelming rejection typical of cross-species transplantation. However, there is evidence of another type of rejection, characterized by blood clots developing in the small blood vessels.

This suggests a possible "coagulation dysregulation" between pigs and primates. New approaches will be needed to address the problem: either improved approaches to immunosuppressant drug therapy or further genetic manipulation of the donor animals. Studies may also explore techniques of inducing immune tolerance between the animal donor and human recipient before the transplantation procedure is done an approach that is not generally possible in human-to-human transplantation.

The development of GT-KO pigs has been a significant advance toward making xenotransplantation a reality. However, "these organ-source pigs have not proved the 'quantum leap' that had been hoped, and there are clearly other immunologic problems that require resolution before a clinical trial can be initiated," according to Dr. Cooper and colleagues. More research is needed to identify the nature of the human antibodies to GT, and perhaps to further modify the GT-KO pigs to overcome the observed blood clotting problems.
"Advances in these areas might allow the initiation of clinical trials of xenotransplantation, at least for cell or islet transplantation or for the use of a pig organ to 'bridge' a patient until a human organ is obtained," Dr. Cooper and coauthors write. They conclude, "The potential benefits of successful xenotransplantation to large numbers of patients with very differing clinical conditions remain immense, fully warranting the current efforts being made to work towards its clinical introduction."

About Transplantation: The Official Journal of The Transplantation Society

The most cited and influential journal in the field (with over 20,000 citations a year), Transplantation (http://www.transplantjournal.com), a Lippincott Williams & Wilkins journal, is published twice monthly and provides extensive coverage of the most important advances in transplantation. Consistently ranked among the top journals in transplantation, surgery and immunology, the journal covers areas including cell therapy and islet transplantation, clinical transplantation, experimental transplantation, immunobiology and genomics, and xenotransplantation.

About Lippincott Williams & Wilkins

Lippincott Williams & Wilkins (http://LWW.com) is a leading international publisher for healthcare professionals and students with nearly 300 periodicals and 1,500 books in more than 100 disciplines publishing under the LWW brand, as well as content-based sites and online corporate and customer services. LWW is part of Wolters Kluwer Health, a leading provider of information for professionals and students in medicine, nursing, allied health, pharmacy and the pharmaceutical industry. Wolters Kluwer Health is a division of Wolters Kluwer, a leading global information services and publishing company with annual revenues (2006) of €3.7 billion and approximately 19,900 employees worldwide. Visit WoltersKluwer.com.

Lippincott Williams & Wilkins
530 Walnut St.
Philadelphia, PA 19106
United States
http://www.lww.com
 
 
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