Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: mental + 28,600 + web  Related to the article below (Last Update: 8/5/2008)

Hormone treatment for early cancer may do harm, study says
Baltimore Sun, United States - Jul 9, 2008
About 186000 new cases are diagnosed and about 28600 deaths attributed to prostate cancer each year, according to the American Cancer Society. ...
Source: Google News

[CITATION] Conferences and Symposia, short courses
R Hall - Water Wheel, 2002 - Sabinet Online

Dramatic Effects of the Substituents on the Solid-state Fluorescence Properties of Structural … -
Y Ooyama, Y Harima - Chemistry Letters, 2006 - J-STAGE
... characterized by 1 H NMR, IR, and ele- mental analysis. ... 24400) 513, 480 0.99 11
415(16600), 355(28600) 1,4 ... Published on the web (Advance View) July 8, 2006; doi ...

[PDF] Perspectives in Diabetes
ID Dukes, LH Philipson - DIABETES, 1996 - diabetes.org
... is a well-established treatment for PHHI resistance to medical management, a disorder
that frequently leads to seizures and mental retardation second- ary to ...

Metal concentrations in soil and invertebrates in the vicinity of a metallurgical factory near Tula … -
NM van Straalen, RO Butovsky, AD Pokarzhevskii, AS … - Pedobiologia-International Journal of Soil Biology, 2001 - Elsevier
... of soil invertebrates and their distribution in the food-web. ... column chromatography
and an ele- mental analyzer (Carlo ... Fe Total 54600 a ?7300 28600 b ? 3663 ...

[PDF] Absolute Configuration in 4-Alkyl-and 4-Aryl-3, 4-dihydro-2 (1H)-pyrimidones: A Combined Theoretical … -
G Uray, P Verdino, F Belaj, CO Kappe, WMF Fabian - Chirality, 1999 - webdb.uni-graz.at
... 10.1021/jo010491l CCC: $20.00 ? 2001 American Chemical Society Published on Web
09/01/2001 Page 2. ... 32300 cm -1 (ab initio) and ?26300 - 28600 cm -1 (AM1), ...
-

[PDF] COMPLETE 2006 RULES INDEX BY AGENCY (CODE NUMBER) AND BY KEYWORD (SUBJECT) -
RIBY AGENCY - rules.utah.gov
... inspection at the Division of Administrative Rules (4120 State Office Building,
Salt Lake City, UT), or may be viewed online at the Division?s web site (http ...
-

Partitioning of F between H 2 O and CO 2 fluids and topaz rhyolite melt -
JD Webster - Contributions to Mineralogy and Petrology, 1990 - Springer
... The results of phase equilibri- um experiments conducted on sample SM-1 are described
in Web- ster et al. ... GS886P 2.0 798 5.7 358 50200 28600 1.07 0.57 0.44 5 ...

SERT I1 Spacecraft
WR Kerslake, LR Ignaczak - pdf.aiaa.org
... in space. operation was stopped on cdch ion thruster when a web erosion fragment
of the accelerator grid caused an electrical short. ...

[BOOK] Families and Health
WJ Doherty, TL Campbell - 1988 - Sage Publications

[PDF] Development and Flight History of SERT II Spacecraft
O Cleveland - ntrs.nasa.gov
... in space. Operation was stopped on each ion thruster when a web erosion fragment
of the accelerator grid caused an electrical short. ...

Source: Google Scholar

Rutgers Scientists Discover Brain Cell Development Process Implicated in Mental Retardation, Finding May Lead to New Drug Therapies

Professor Firestein may be contacted at 732-445-8045 or e-mail firestein@biology.rutgers.edu

New Brunswick, N.J. – Scientists at Rutgers, The State University of New Jersey, have discovered a biological process in brain cell development that may help explain some causes of mental retardation. This understanding may one day help other researchers develop therapies that can reduce specific forms of retardation.

In a paper published in The Journal of Neuroscience, Rutgers cell biologists Hongxin Chen and Bonnie Firestein show that proteins of the Rho family, when excessively present in developing brain cells known as neurons, inhibit another protein that promotes healthy neuron development. Firestein earlier demonstrated how this protein, called cypin, promotes healthy branching patterns in the tree-like structures at the end of neurons that receive signals. Inadequate branching in these structures, called dendrites, has been observed in conditions such as Alzheimer’s disease, autism and some types of mental retardation.

“Imbalances of Rho proteins have been known to affect dendrite branching, and therefore have been implicated in causing mental retardation,” said Firestein, associate professor of cell biology and neuroscience. “How this happens, however, has not been clear. Now we’re seeing that Rho proteins signal other proteins downstream. In our case, we discovered that a type of Rho protein called RhoA is inhibiting cypin production when it is overactive or present in excess. The resulting lack of cypin is detrimental to healthy branching development in dendrites.”

Firestein and Chen, a postdoctoral research fellow, believe that this finding offers a new potential target for future drug therapies aimed at promoting healthier dendrite branching. “Scientists could try to block Rho activity, but since Rho is present in lots of different types of cells, reducing Rho activity could have widespread side effects,” said Firestein. “Looking for a protein that Rho is signaling to could result in a more targeted treatment.”

Cypin is restricted to a few regions in the brain, most notably the hippocampus, which controls learning and memory. Faulty dendrite branching there is likely to cause retardation. Therefore, a therapy that focuses specifically on development of hippocampal neurons might be more effective and less harmful to other organs and tissues.

Firestein first identified and isolated cypin in 1999, and has recently focused on how it works in the hippocampus. Cypin assembles protein molecules called tubulin into microtubules, which form the long chain molecules that are structural basis, or the “skeleton,” of a dendrite. An effective assembly process is needed to form the branching patterns needed for proper functioning.

Contact: Carl Blesch
Rutgers University
732-932-7084, ext. 616
E-mail: cblesch@ur.rutgers.edu
 
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.