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Recent News and Articles on the Keywords: narcolepsy + levels + 1,050  Related to the article below (Last Update: 8/5/2008)

Hypersomnia: 'My doctor thought I was on drugs'
Independent, UK - Jul 28, 2008
After that, people started asking me if I had narcolepsy. I looked it up and recognised many of the symptoms, from excessive daytime sleepiness and ...
Lowell Man Faces Misdemeanor Charges for December Fatal Accident
The Morning News, AR - Aug 2, 2008
Smith also told authorities he suffered from narcolepsy, a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles ...
How smart are 'smart drugs'?
Times Online, UK - Jul 19, 2008
A group of pharmaceuticals designed for sufferers of narcolepsy, Alzheimer?s and ADHD, smart drugs are increasingly being used ?off label? (unsupervised, ...
Feeling sleepy during the day? You can blame it on your genes
Livemint, India - Jul 17, 2008
Narcolepsy (excessive day-time sleepiness) remains poorly diagnosed in India as neither the doctor nor the patient understands the disorder. ...
Variety of sleep disorders affect 40 million Americans
Southtown Star, IL - Jul 22, 2008
Some of the most common sleep disorders are insomnia, sleep apnea, restless leg syndrome and narcolepsy. Symptoms of these disorders can be as mild as ...
Health Watch: What's new at CMC's accredited sleep center
Ithaca Journal, NY - Jul 17, 2008
Researchers have also made significant advancements in understanding the causes of narcolepsy. We now know that narcolepsy is related to deficiency in the ...

Popular Science
Photo by Michael Steele/Getty Images
Popular Science, NY - Jul 14, 2008
White?s postrace blood tests, however, turned up higher-than-allowed levels of modafinil, a prescription anti-narcolepsy stimulant that helped her jump out ...
Local Scrabble addict competes nationally
EastOregonian.info (subscription), OR - Jul 30, 2008
"I sometimes suffer from narcolepsy." He won the game when she ran out of time. Lauck, one of nine Oregonians at the tournament and the only competitor from ...
YOUR BIRTHDAY: Is it purely coincidence?
Colorado Daily, CO - Jul 9, 2008
Literature reviews, meanwhile, show that more patients with schizophrenia, Alzheimer's disease, epilepsy and narcolepsy are born in December and January. ...
Stimulant Info
TransWorldNews (press release), GA - Jul 19, 2008
Some of these controlled substances are available by prescription for legitimate medical use in the treatment of obesity, narcolepsy, and attention deficit ...
Source: Google News

… Necrosis Factor {alpha} and Soluble Tumor Necrosis Factor Receptors in Patients With Narcolepsy -
H Himmerich, PA Beitinger, S Fulda, R Wehrle, J … - Archives of Internal Medicine, 2006 - archinte.highwire.org
... a representative study of the Bavarian population (N = 1050). ... plasma level elevation
in patients with narcolepsy may be ... to have lower TNF- plasma levels in vivo ...
-

Hypocretin Deficiency in Narcoleptic Humans Is Associated with Abdominal Obesity -
SW Kok, S Overeem, TLS Visscher, GJ Lammers, JC … - Obesity Research, 2003 - NAASO
... of clinical symptoms on quality of life in patients with narcolepsy. ... to cardio- vascular
disease risk factors and sex hormone levels in men ... 1987;80:1050?5. 35 ...

Transient narcolepsy-cataplexy syndrome after discontinuation of the antidepressant venlafaxine -
F Password - Journal of Sleep Research, 2005 - Blackwell Synergy
... took bupropione (150 mg) and valproic acid (1050 mg), the ... CSF hypocretin-1 (orexin
A) levels were not attenuated as described for narcolepsy (Nishino et al ...

Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy … -
T Aoyama, H Kotaki, T Sasaki, Y Sawada, Y Honda, T … - European Journal of Clinical Pharmacology, 1993 - Springer
... orally in the dose range 1050 mg (0.12 ... Long-term treat- ment of narcolepsy with
methylphenidate ... GR (1984) Clinical correlates of methylphenidate blood levels. ...

Patient Drug Information
H Himmerich, S Fulda, J Linseisen, H Seiler, G … - Eur Psychiatry, 2008 - ncbi.nlm.nih.gov
... The disease history of its 1050 participants was ... tumor necrosis factor receptors
in patients with narcolepsy. ... 2006]; Increased levels of soluble tumor necrosis ...

Orexin and psychiatric symptoms in suicide attempters -
L Brundin, ? Peters?n, M Bj?rkqvist, L Tr?skman- … - Journal of Affective Disorders, 2007 - Elsevier
... Orexins have an important role in the regulation of sleep, since humans with the
disabling condition narcolepsy have low to undetectable levels of orexin in ...
-

Orexin A in the nucleus accumbens stimulates feeding and locomotor activity -
AJ Thorpe, CM Kotz - Brain Research, 2005 - Elsevier
... Brain Research Volume 1050, Issues 1-2, 19 July 2005 ... and that the canine condition
of narcolepsy is due ... increased feeding as compared to control levels (100 pmol ...

[CITATION] The Risks and Implications of Excessive Daytime Sleepiness in Resident Physicians. -
SK Howard, DM Gaba, MR Rosekind, VP Zarcone - ACADEMIC MEDICINE, 2002
... sleepiness approaching the level seen in patients with narcolepsy or sleep ... of
individuals to subjectively determine the true level of sleepiness ... 1999;6:1050-3 ...

CALENDAR OF EVENTS
A Richardson, F Schoen, W Walz - Sat - doi.wiley.com
... a full-time tenure-track position at the level of assistant ... for Basic Research in
Developmental Disabilities, 1050 Forest Hill ... Funding For Narcolepsy Research. ...

Case Study: Hypersomnolence and Precocious Puberty in a Child with Pica and Chronic Lead … -
NW BORIS, OR HAGINO, GP STEINER - Journal of the American Academy of Child & Adolescent …, 1996 - jaacap.com
... We review 1050 J. AM. ... 1 Lead levels in a child with precocious puberty and idiopathic ...
of abnormal sleep into normal waking hours, as is seen in narcolepsy. ...

Source: Google Scholar

Persons with narcolepsy with cataplexy have low levels of CSF hypocretin-1

WESTCHESTER, Ill. -- Persons with narcolepsy with cataplexy have low levels of cerebrospinal fluid (CSF) hypocretin-1, a protein thought to help regulate sleep and wakefulness, according to a study published in the August 1st issue of the journal SLEEP.

The study, authored by Mona Skard Heier, MD, PhD, of Ullevål University Hospital in Oslo, Norway, focused on 64 previously diagnosed patients: 47 with narcolepsy with cataplexy, seven with narcolepsy without cataplexy and 10 with idiopathic central nervous system (CNS) hypersomnia, a condition characterized by recurrent daytime sleepiness without the abrupt sleep attacks classically seen in narcolepsy. The patients answered a questionnaire that asked about sleep habits, daytime sleepiness, accessory symptoms, duration and treatment.

Low hypocretin-1 values were found in 72 percent of those patients with narcolepsy and cataplexy. Patients with low CSF hypocretin-1 levels reported more extensive muscular involvement during cataplectic attacks than patients with normal levels.

Patients with narcolepsy without cataplexy and idiopathic CNS hypersomnia all had normal hypocretin-1 levels. No significant clinical or biochemical differences were found between these patient groups.

“Although hypnagogic hallucinations and sleep paralysis were most frequently reported by patients with narcolepsy with cataplexy than in the other patient groups, there was no correlation to low hypocretin-1 values,” said Heier. “Hypnagogic hallucinations and sleep paralysis are usually thought to be isolated components of REM sleep in the waking state. Similarly, cataplexy has been considered as an isolated manifestation of REM sleep atonia, triggered by emotional stimuli.”

Narcolepsy is a sleep disorder that causes people to fall asleep uncontrollably during the day. It also includes features of dreaming that occur while awake. Other common symptoms include sleep paralysis, hallucinations and cataplexy.

About one out of every 2,000 people is known to have narcolepsy. The chance that you have narcolepsy is higher when a relative also has it. It is very rare for more than two people in the same family to have this sleep disorder. It affects the same number of men and women.

Those who suspect they might be suffering from narcolepsy, or another sleep disorder, are urged to consult with their primary care doctor or a sleep specialist.
 
 
 
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