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Recent News and Articles on the Keywords: fragile + skin + test  Related to the article below (Last Update: 8/5/2008)

G8 failed the climate change test
Daily Nation, Kenya - Jul 15, 2008
We must also comprehend what it would mean to live in a world with growing levels of water stress as our sources dry up, malaria and skin cancer becoming ...

The News - International
Detoxify your body
The News - International, Pakistan - Jul 29, 2008
Over a period of time, these effects build up and emerge in many different forms; everything from passing infections, skin eruptions, headaches and ...
What Should You Know About Massage Therapy
American Chronicle, CA - Aug 2, 2008
These include pregnancy, cancer, fragile skin, heart problems, dermatomyositis and a history of physical abuse. There are certain side effects associated ...
Researcher seeking syphilis vaccine dreams of finding a cure ...
Globe and Mail, Canada - Jul 30, 2008
"There are no other bacteria that are that fragile," she said. "It's one of the few bacteria that can't be cultured in a test tube, you can't use ...

ITBusiness.ca
Three tough notebooks that can withstand daily abuse
ITBusiness.ca, Canada - Jul 29, 2008
The design is topped off with a magnesium-aluminum skin that is 20 times stronger than the flimsy plastic that most notebooks use. ...
CITY BLOGS
The Post, Pakistan - Jul 25, 2008
After shampooing your hair, take care as wet hair is fragile and can break easily. After washing your hair, conditioning is a must. Don't brush instantly. ...

Telegraph.co.uk
Michelle Obama interview: I'm nothing special
Telegraph.co.uk, United Kingdom - Jul 25, 2008
'She is a person who is comfortable in her skin. She's clear and direct without ever being over-emotional.' The hairdresser made a few nervous stabs with a ...

The Daily Star
Scented Worlds
The Daily Star, Bangladesh - Jul 18, 2008
Her fair, round-faced Nani ruffled Sharmila's plaited hair with her fragile fingers. ?Nani, what will I look like when I am old? Will I look like you? ...
Anticoagulation After Cardioembolic Stroke To Bridge or Not to Bridge?
Archives of Neurology - Jul 14, 2008
We hypothesize that the vessels in the ischemic territory were rendered fragile by the ischemic insult to the vasa vasorum, thus promoting microhemorrhage. ...
Cape cancer survivor busy gearing up for next Challenge
Cape Cod Times, MA - Jul 12, 2008
I never thought of my dad as fragile." Sheehan had been working at Cape Medical Supply, founded by his parents in 1977, for several years before taking it ...
Source: Google News

Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of … -
S Chakravarti, T Magnuson, JH Lass, KJ Jepsen, C … - The Journal of Cell Biology, 1998 - Rockefeller Univ Press
... mutants had extremely loose and fragile skin apparent during ... any visible lesions
were chosen for skin testing. Test samples were produced in duplicate using a ...

Defects in collagen fibrillogenesis causing hyperextensible, fragile skin in dogs.
RR Minor, DH Lein, DF Patterson, L Krook, TG … - J Am Vet Med Assoc, 1983 - ncbi.nlm.nih.gov
... male and female offspring also had fragile, hyperextensible skin ... collagen into fibrils
and fibers in affected skin. ... A clinical test, the skin extensibility index ...

Mechanical Properties and Morphological Correlates of Fragile Skin in Gekkonid Lizards -
AM BAUER, AP RUSSELL, RE SHADWICK - Journal of Experimental Biology, 1989 - jeb.biologists.org
... of the species suspected of having fragile skins (marked ... determine the work of fracture
of skin samples from (A ... The configuration of the test sample isshown in A ...

Cultured skin as a ?smart material?for healing wounds: experience in venous ulcers -
ML Sabolinski, O Alvarez, M Auletta, G Mulder, NL … - Biomaterials, 1996 - Elsevier
... Safety testing is performed at the point of tissue acquisition and at the master ...
the insert determine the size and shape of the resultant cultured skin tissue. ...

Skin reactions during radiotherapy for breast cancer: the use and impact of topical agents and … -
F Password - European Journal of Cancer Care, 1999 - Blackwell Synergy
... To test for covariance, all topical agents and dressings used during the larger ... to
the use of retention tape dressings to prevent fragile skin from breaking ...

Noninvasive Test for Fragile X Syndrome, Using Hair Root Analysis -
R Willemsen, B Anar, YDD Otero, BBA de Vries, Y … - The American Journal of Human Genetics, 1999 - Elsevier
... by the identification of two fragile X patients ... hair roots affords the opportunity
of testing a different ... In contrast, both neurons and skin develop from the ...

Epithelial Desquamation in Asthma Artifact or Pathology? -
C ORDON~ EZ, RON FERRANDO, DM HYDE, HH WONG, JV … - American Journal of Respiratory and Critical Care Medicine, 2000 - Am Thoracic Soc
... than that of the diluent control, the skin test was considered ... Spearman's rank order
test was used to determine ... to basal cells represent a more fragile and a ...

Microneedle array for transdermal biological fluid extraction and in situ analysis -
EV Mukerjee, SD Collins, RR Isseroff, RL Smith - Sensors & Actuators: A. Physical, 2004 - Elsevier
... At the tip of the microneedle, the silicon walls around the widened 15-micron bore
opening are 3?5 ?m thick and relatively fragile. ... Skin puncture test. ...

… , Heart Rate and Temperature in Very Low Birthweight Infants during Skin-to-Skin Contact with Their … -
D ACOLET, K SLEATH, A WHITELAW - Acta Paediatrica, 1989 - Blackwell Synergy
... West Germany and Holland, but some concern has been felt about the safety of taking
such fragile infants out of ... Prone horizontal Skin-to-skin ?-test variance ...

… of a Moisturizing Cream. A Half-Side Test of Biophysical Skin Parameters, Cytokine Expression … -
K Kikuchi, H Kobayashi, T Hirao, A Ito, H … - Dermatology, 2003 - content.karger.com
... scores from 0 to 4. Since morphologically fragile CEs were ... compared with the Wilcoxon
signed-ranks test between the ... The values of the skin surface lipid levels ...

Source: Google Scholar

Screen test for fragile skin

White Dorper breeders and owners are hoping to eradicate a genetic disorder causing a lethal fragile skin condition among some of their drought-hardy flocks.

The disease dermatosparaxis also exists in other breeds but White Dorper breeders are the first to opt for a mass flock screening program in Australia.

"Their early adoption of a newly developed test should ensure this disease is effectively managed," NSW DPI research scientist, Dr Tracey Berg, said.

Dermatosparaxis is an inherited connective tissue disorder attributable to abnormal collagen in the skin which causes extreme skin fragility. Normal collagen provides elasticity and strength.

Dermatosparaxis most often affects lambs. They suffer tearing of the skin, usually in their inner thighs and under armpits. The severity of the condition results in death or euthanasia.

Attempts to stitch the skin usually fall apart, exacerbated when animals are handled to check the repair. Mild forms of the disease have been seen in adult sheep.

"If unchecked now, there could be a potential problem for the sheep industry in the future," Angus McTaggart, federal board president of the Dorper Sheep Breeders Society of Australia, said.

The disease has been reported elsewhere in Merino, South African White Dorper and Border Leicester-Southdown sheep.

Similar conditions occur in cattle, cats and humans (Ehlers- Danlos Syndrome type VIIC).

After Brendon O’Rourke and Dr Berg confirmed and defined the disorder in Australian White Dorper flocks at the Elizabeth Macarthur Agricultural Institute (EMAI) at Camden in 2006, they then developed a DNA test to screen individual sheep for the defective gene.

They developed the test in mid-2006 at the request of breeder Malcolm Green with subsequent support from the Breeders’ Society.

"The mutation exists in sheep from most of the Australian flocks we’ve tested," Dr Berg said.

"Of the substantial number of sheep tested, 20 per cent were carriers.

"We have also received overseas submissions and detected carriers from several countries, so it is a world wide problem."

Dr Berg and her colleagues at EMAI are consequently recommending screening of all breeding stock, or at the very minimum, screening of all sires.

"The latter is the first step in managing both damage to reputations and economic loss," former head of the Regional Veterinary Laboratory at EMAI, Dr Keith Walker, said.

"The DNA test provides an avenue for genetically smarter breeding programs."

The breed society is taking advantage of reduced rate testing by being responsible for administering samples, invoicing and reporting results.

It will also note all results on its stud book registration records, to enable public scrutiny of both positive and negative pedigree discrimination by all breeders.

A number of cattle breed societies have embraced this approach, to reduce the incidence of genetic disorders. The new genetic test is available commercially from the Genetics laboratory at EMAI.

Contact Dr Rod Reece, Camden, (02) 4640 6309, for veterinary advice about the disease, or Ian Marsh, (02) 4640 6502, about testing. 

- Ron Aggs
 
 
 
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