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Recent News and Articles on the Keywords: disease + huntingtons + sleep  Related to the article below (Last Update: 8/5/2008)


New York Daily News
Radio jocks do a bangup job at softball
New York Daily News, NY - Jul 31, 2008
The annual event raises funds for the Huntington's Disease Society of America. Pardavila, who lost his father to the disease, said the game raised $20000. ...
News briefs
Pasadena Star-News, CA - Jul 21, 2008
ARCADIA - "Sleep Apnea and Heart Diseases," an informational session, will take place at 2 pm Wednesday at Methodist Hospital, 300 W. Huntington Drive. ...
Author Learns To Leave Well Enough Alone
NPR - Jul 7, 2008
I did not have lupus, multiple sclerosis, Huntington's disease or Hodgkin's, Crohn's disease, diabetes, myelitis, or muscular dystrophy. ...
Body's identity confirmed
Wairarapa Times Age, New Zealand - Jul 15, 2008
His father suffered Huntington's disease, a rare and incurable neurological disorder that progressively worsens while causing uncontrollable, ...
Source: Google News

… dyskinetic movements of Parkinson's disease, Gilles de la Tourette syndrome, Huntington's disease, … -
DR Fish, D Sawyers, PJ Allen, JD Blackie, AJ Lees, … - Archives of Neurology, 1991 - Am Med Assoc
... Disintegration of the Sleep-Wake Cycle and Circadian Timing in Huntington's Disease
Morton et al. J. Neurosci. 2005;25:157-163. ABSTRACT | FULL TEXT. ...

Nocturnal sleep in huntington's disease -
M Wiegand, AA M?ller, CJ Lauer, S Stolz, W … - Journal of Neurology, 1991 - Springer
... Springer-Verlag 1991 Nocturnal sleep in Huntington's disease ... Key words: Huntington's
disease - Sleep EEG - Basal ganglia disorders Introduction ...

Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease -
AJ Morton, NI Wood, MH Hastings, C Hurelbrink, RA … - J Neurosci, 2005 - websciences.org
Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease.
MORTON AJ, WOOD NI, HASTINGS MH, HURELBRINK C, BARKER RA, MAYWOOD ES. ...

Sleep disturbances and severity of Huntington's disease -
P Hansotia - Neurology, 1985 - AAN Enterprises
... ARTICLES. Sleep disturbances and severity of Huntington's disease. P Hansotia,
R Wall and J Berendes. We studied sleep functions in ...

On Chorea -
G Huntington - Journal of Neuropsychiatry and Clinical Neurosciences, 2003 - Am Neuropsych Assoc
... Key Words: Classic Articles ? Huntington's Disease. ... The disease, as it is commonly
seen, is by ... generally, though not always, granting a respite during sleep. ...

Changes in nocturnal sleep in Huntington's and Parkinson's disease -
W Emser, M Brenner, T Stober, K Schimrigk - Journal of Neurology, 1988 - Springer
... Changes in nocturnal sleep in Huntington's and Parkinson's disease ... Key words: Sleep -
Spindle density - Huntington's disease - Parkinson's disease Introduction ...

Sleep and quantitative EEG in neurodegenerative disorders -
D Petit, JF Gagnon, ML Fantini, L Ferini-Strambi, … - Journal of Psychosomatic Research, 2004 - Elsevier
... caudate nucleus. In patients with Huntington's disease, a disturbed sleep
pattern has been reported. Specifically, patients showed ...

… protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington?s disease -
SH Li, ZX Yu, CL Li, HP Nguyen, YX Zhou, C Deng, … - J. Neurosci, 2003 - Soc Neuroscience
... NI Wood, MH Hastings, C. Hurelbrink, RA Barker, and ES Maywood Disintegration of
the Sleep-Wake Cycle and Circadian Timing in Huntington's Disease J. Neurosci ...

SLEEP AND DEGENERATIVE NEUROLOGIC DISORDERS -
S Chokroverty - Neurologic Clinics, 1996 - Elsevier
... that in mildly to moderately affected PD patients, levodopa or a dopamine agonist
was responsible for sleep disruption in PD patients. Huntington's Disease. ...

Brain morphology and sleep EEG in patients with Huntington's disease -
M Wiegand, AA M?ller, W Schreiber, C Lauer, JC … - European Archives of Psychiatry and Clinical Neuroscience, 1991 - Springer
... These findings are in line with previous studies on sleep in Huntington's disease,
eg by Hansotia et al. (1985). ... Nocturnal sleep in Huntington's disease. ...

Source: Google Scholar

Huntington's Disease Sufferers Need Focussed Management Of Sleep Symptoms In Their Treatment
Mice carrying the genetic mutation that causes Huntington's Disease (HD) showed marked improvements in alertness and their ability to learn after they were given drugs that put them to sleep.

Researchers at the University of Cambridge found that daily treatments of Alprazolam or chloral hydrate, two different sedative drugs, enabled them to develop a regular sleep pattern and improved their cognitive function -- their ability to understand and act on information.
According to the Cambridge neuroscientists conducting the research, HD mice have abnormal circadian rhythms; their daily sleeping and waking cycles are disrupted and irregular. Since sleep disruption contributes to problems with perception and learning in healthy people, the team wondered whether the circadian disruption and cognitive disturbances in HD mice were linked.

To test this, drugs were administered to regulate sleep patterns in the mice. The results, published today in the Journal of Neuroscience, show that both drugs caused a noticeable improvement in learning and Alprazolam also improved arousal. The study shows for the first time that treatments aimed at restoring normal sleep-wake activity could slow the cognitive decline that is such a devastating feature of the disease.

Dr. Jenny Morton, lead author of the study, said: "In the future, more attention should be paid to understanding sleep and circadian disturbance in HD. Management of these patterns may not only improve patients ability to think, learn and perform, but would also improve quality of life for both them and their carers."

The results have short-and long-term implications for treatment of HD and for the reversal of the disease's impairments. Recognising that sleep disturbance is a part of the disease means that clinicians should include focussed management of sleep symptoms in their treatment of HD patients.

Source: Genevieve Maul
University of Cambridge
 
 
 
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