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Recent News and Articles on the Keywords: fat accumulation + effects + side  Related to the article below (Last Update: 8/5/2008)


eFluxMedia
Growth hormone may help some HIV patients
Reuters -
NEW YORK (Reuters Health) - The side effects of AIDS drugs -- including increases in belly fat, elevated blood pressure, and high triglyceride levels -- are ...
Growth Hormone Reduces Abdominal Fat, but Increases Risk of ... DG News
Daily Doses of Growth Hormone May Aid HIV Patients eFluxMedia
IAC: Effects of Growth Hormone Raise Caution Flag MedPage Today
Medical News Today
all 279 news articles »
Switch to atazanavir does not reduce belly fat
Aidsmap, UK -
Switching from other protease inhibitors to atazanavir/ritonavir does not significantly reduce visceral fat accumulation in the abdomen ? a feature of the ...
Theratechnologies Reports on Positive Body Image Parameters at the ...
FOXBusiness -
The changes in body composition include excess visceral fat accumulation and loss of subcutaneous fat in the limbs and in the face. ...TSE:TH - OTC:CMTX
Might science soon help stave off the decay of old age?
Globe and Mail, Canada - Aug 1, 2008
Some hold that aging is driven by hormones or the accumulation of genetic mutations over time. Another major hypothesis blames oxidative stress. ...
Wake-up call for sleep apnea
Science News - Jul 31, 2008
?Fat accumulation in the airway makes the airway walls thicker, softer and more likely to collapse,? says Michael Twery, director of the National Center on ...
Effects of Short-Term High-Fat, High-Energy Diet on Hepatic and ...
Journal of Clinical Endocrinology and Metabolism, MD - Jul 10, 2008
... the effects of an elevation of plasma NEFA by a high-fat, high-energy (HFHE) diet on hepatic and myocardial TG accumulation, and on myocardial function. ...BOM:504176
What's New in Orthopaedic Research
Journal of Bone and Joint Surgery (subscription) - Aug 1, 2008
A reduction in muscle-loading delayed the development of the tendon-to-bone insertion site by impeding the accumulation of mineralized bone and ...

Natural News.com
Chemical Causes of Diabetes: Overeating Is Not the Only Problem
Natural News.com, AZ - Jul 24, 2008
In addition, an increase in body fat, diabetes, and blood pressure were also noted. These effects were strongly associated with TCDD levels in the serum. ...
Fructose Converts Quickly to Lipids Triggering Hyperlipidemia
MedPage Today, NJ - Jul 25, 2008
Chronic elevation of triacylglycerol levels could lead to accumulation of atherogenic lipoprotein remnants, the authors said. Replacement of glucose with ...
Growth Hormone Therapy May Decrease Diabetes Risk in Girls With ...
RMGH Health News, CA - Jul 24, 2008
"The untreated group demonstrated a striking accumulation of intraabdominal fat, or visceral abdominal fat tissue, that was not seen in the GH-treated girls ...
Source: Google News

[PDF] Visceral abdominal-fat accumulation associated with use of indinavir -
KD Miller, E Jones, JA Yanovski, R Shankar, I … - Lancet, 1998 - hawaii.edu
... Protease inhibitor?s metabolic side effects: cholesterol, triglycerides, blood sugar,
and ... K, Tarui S. Contribution of intra-abdominal fat accumulation to the ...
-

… Hormone on Body Composition and Glucose Metabolism in HIV-Infected Patients with Fat Accumulation -
JC Lo, K Mulligan, MA Noor, JM Schwarz, RA … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc
... The most common side effects seen during the study were arthralgias and edema ...
recommended at this time as treatment for HIV-infected men with fat accumulation. ...

… of Recombinant Human Growth Hormone in the Treatment of Visceral Fat Accumulation in HIV Infection. -
ES Engelson, MJ Glesby, D Mendez, JB Albu, J Wang, … - JAIDS Journal of Acquired Immune Deficiency Syndromes, 2002 - jaids.org
... completed and significant adverse side effects were observed ... However, adverse effects
are common, and ... HIV-associated pathologic visceral fat accumulation may be ...

Suppression of body fat accumulation in myostatin-deficient mice -
AC McPherron, SJ Lee - Journal of Clinical Investigation, 2002 - pubmedcentral.nih.gov
... determined by fluorometry using either the left or the right side of the ... In support
of an indirect mechanism, similar effects on fat accumulation have been ...

Adverse effects of antiretroviral therapy -
A Carr, DA Cooper - The Lancet, 2000 - Elsevier
... nevirapine, and stavudine withdrawal might improve fat accumulation and lipoatrophy ...
Ritonavir can cause numerous dose-dependent side-effects, including perioral ...

The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. -
P Marin, S Holmang, L Jonsson, L Sjostrom, H Kvist … - Int J Obes Relat Metab Disord, 1992 - ncbi.nlm.nih.gov
... were unchanged and no adverse functional side-effects were found. ... in these changes
might act either via effects on visceral fat accumulation, followed by ...

Self-Reported Symptoms and Medication Side Effects Influence Adherence to Highly Active … -
A Ammassari, R Murri, P Pezzotti, MP Trotta, L … - JAIDS Journal of Acquired Immune Deficiency Syndromes, 2001 - jaids.org
... Almost all symptoms and medication side effects were reported more often by ... for anxiety
(30%), fatigue (24%), abnormal fat accumulation (19%), diarrhea (17 ...

Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians? -
VD Longo, CE Finch - Science, 2003 - sciencemag.org
... or attenuates cancer, immunosenescence, and inflammation without irreversible side
effects. ... life-span but also cause glycogen or fat accumulation and dwarfism. ...

Prospective evaluation of the effects of antiretroviral therapy on body composition in HIV-1- … -
PWG Mallon, J Miller, DA Cooper, A Carr - AIDS, 2003 - aidsonline.com
... one secondary to paronychia and one secondary to other side effects). ... Most of the
components of HIVLD, such as central fat accumulation, peripheral lipoatrophy ...

Redistribution of body fat in HIV-infected women undergoing combined antiretroviral therapy. -
C Gervasoni, AL Ridolfo, G Trifirn, S … - AIDS, 1999 - aidsonline.com
... 1-5]. Reports of some unexpected side-effects have, however ... in the dorsocervical
region [10], the accumulation of visceral abdominal fat [11], and an ...

Source: Google Scholar

Protein Accumulation Might Cause Fat Deposits, Other Side Effects In HIV-Positive People Taking Protease Inhibitors, Study Says
Similarities between genetic conditions that cause early aging and side effects experienced by some HIV-positive people when taking protease inhibitors might explain the fat accumulation associated with the drugs, according to a study published Monday in the Proceedings of the National Academy of Sciences, Reuters reports. Protease inhibitors can cause metabolic complications -- such as an unhealthy accumulation of cholesterol in the blood, high blood pressure and an increased risk of diabetes -- Reuters reports. The drugs also can cause a condition called lipodystrophy -- an abnormal redistribution of body fat that gives some HIV-positive people gaunt cheeks and limbs, as well as an accumulation of fat on the back of the neck.
Study Findings
For the study, researchers at the University of California-Los Angeles and Purdue University treated mouse and human cells with protease inhibitors and found that they accumulated a clumpy form of the protein prelamin A. According to the researchers, the drug triggered the development of this protein by blocking the action of another protein, called ZMPSTE24, that converts prelamin A into its effective form. According to the study, cells with lower levels of ZMPSTE24 were particularly affected by protease inhibitors.

Christine Hrycyna, a researcher from Purdue University who worked on the study, said that blocking ZMPSTE24 might contribute to the metabolic side effects of protease inhibitors. She also said that people with early aging syndromes, including Hutchinson-Gilford progeria, have symptoms that imitate the side effects associated with protease inhibitors. According to Hrycyna, prelamin A accumulates in the cells of people with early aging syndromes, but she added that the effect on metabolism is not clear. "The side effects are probably due not to just one simple thing," she said.

Charles Flexner of Johns Hopkins University School of Medicine, who was not involved with the study, said that the side effects of protease inhibitors occur among tens of thousands of HIV-positive people worldwide and that the study's findings might "provide new insights into possible mechanisms" of the drugs.

The researchers also tested some of the drugs that are used in highly active antiretroviral therapy and found that they did not trigger the same protein accumulation, even though they have the ability to cause similar side effects. "They are probably due to a combination of all these different drugs," Hrycyna said. According to Reuters, the researchers plan to conduct further studies among humans, as well as investigate if versions of protease inhibitors that block ZMPSTE24 to a lesser extent cause fewer side effects (Ganguli, Reuters, 7/17).

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.
 
 
 
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